Abstract:
:Humanin (HN) is an endogenous 24-residue peptide. A highly potent HN derivative, S14G-HN, which has a substitution of serine 14 to glycine, reduced amyloid burden and suppressed cognitive impairment in a mouse model of Alzheimer's disease. S14G-HN also suppressed amnesia induced by a muscarinic receptor antagonist in rodents. To understand the effects of HN on brain function, we tested the effect of S14G-HN on diazepam (DZP)-induced memory impairment and anxiety in mice using the object recognition test and zero-maze test, respectively. Intraperitoneal injection of S14G-HN reversed the DZP-induced memory deficit, whereas no significant change was observed in behavioral markers of anxiety. S14G-HN had no effect on locomotor activity in either test, indicating that S14G-HN did not affect physical functioning or motivation. These results suggest that HN preferentially influences cognitive function but not emotional function in the central nervous system.
journal_name
Neuropeptidesjournal_title
Neuropeptidesauthors
Murakami M,Nagahama M,Maruyama T,Niikura Tdoi
10.1016/j.npep.2016.10.008subject
Has Abstractpub_date
2017-04-01 00:00:00pages
65-70eissn
0143-4179issn
1532-2785pii
S0143-4179(16)30119-6journal_volume
62pub_type
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