Effects of H-Phe-Ile-Tyr-His-Ser-Tyr-Lys-OH on the in vitro uptake and release of radiolabelled dopamine, noradrenaline and serotonin in rat brain hypothalamic slices.

abstract：:This study found that dynorphin had a biphasic concentration response relationship on N-methyl-D-aspartate (NMDA) receptor-mediated currents in the CA3 region of the guinea pig hippocampal slice. A previous study demonstrated that the inhibitory effect was mediated by a kappa 2 opioid receptor. In the present study, t...

journal_title：Neuropeptides

authors： Caudle RM,Dubner R

更新日期：1998-02-01 00:00:00

abstract：:Orexins are neuropeptides that are localized to neurons in the lateral and dorsal hypothalamus but its receptors are distributed to many different regions of the central nervous system. Orexins are implicated in a variety of physiological functions including sleep regulation, energy homeostats, and stress reactions. F...

journal_title：Neuropeptides

authors： Toyama S,Shimoyama N,Shimoyama M

更新日期：2017-02-01 00:00:00

abstract：:Bombesin (BN) and its mammalian counterpart gastrin-releasing peptide act as neuroregulatory hormones and tissue-specific growth factors, and have been implicated as peripheral and central satiety-inducing agents. In the present study, the immunohistochemical expression of BN in submandibular, sublingual and parotid g...

journal_title：Neuropeptides

authors： Aalto Y,Kjörell U,Henriksson R,Franzén L,Forsgren S

更新日期：1997-04-01 00:00:00

abstract：:We have previously shown that one of the major determinants directing the expression of the preprotachykinin-A (TAC1) gene, which encodes the neuropeptide substance P, is the transcription factor Neuronal Restrictive Silencer Factor (NSRF), which is also termed Repressor Element-1 Silencing Factor (REST). In rodent mo...

journal_title：Neuropeptides

authors： Gillies S,Haddley K,Vasiliou S,Bubb VJ,Quinn JP

更新日期：2009-08-01 00:00:00

abstract：:The role of somatostatin and a stable analogue, sandostatin (Octreotide), on the responses of spinal cord neurones in vivo was investigated in the rat. Electrical C-fibre stimulation was used as a model of acute nociception and the response to subcutaneous formalin was used as a model of longer term events. Intratheca...

journal_title：Neuropeptides

authors： Chapman V,Dickenson AH

更新日期：1992-11-01 00:00:00

abstract：:Inoculation of rats at the tail-base with Mycobacterium led to arthritic swelling and inflammation of all four limbs. Immunoreactive (ir)-dynorphin (DYN) increased in anterior but not neurointermediate pituitary. In the brain, only thalamus showed a rise and, in spinal cord, a large elevation was seen. Ir-vasopressin ...

journal_title：Neuropeptides

authors： Millan MJ,Millan MH,Pilcher CW,Colpaert FC,Herz A

更新日期：1985-02-01 00:00:00

abstract：:Neuropeptides form the largest family of modulators of synaptic transmission. Until 1995 some 60 different neuropeptides had been found. With the recognition that all neuropeptides act by binding to G protein coupled receptors (GPCRs), a new approach relying on the use of orphan GPCRs as targets was designed to identi...

journal_title：Neuropeptides

authors： Chung S,Civelli O

更新日期：2006-08-01 00:00:00

abstract：:Alarin is a newly identified member of the galanin family of neuropeptides that includes galanin-like peptide (GALP) and galanin. Alarin was discovered as an alternate transcript of the GALP gene in neuroblastoma cells, and subsequently alarin mRNA was detected in the brain of rodents. GALP and galanin are important c...

journal_title：Neuropeptides

authors： Van Der Kolk N,Madison FN,Mohr M,Eberhard N,Kofler B,Fraley GS

更新日期：2010-08-01 00:00:00

abstract：:Neuropeptide Y (NPY) is involved in multiple processes such as behavior, energy and bone metabolism. Previous studies have relied on global NPY depletion to examine its effects on bone. However, this approach is unable to distinguish the central or local source of NPY influencing bone. Our aim was to identify which ce...

journal_title：Neuropeptides

authors： Wee NKY,Sinder BP,Novak S,Wang X,Stoddard C,Matthews BG,Kalajzic I

更新日期：2019-02-01 00:00:00

abstract：:The orexins (hypocretins) are lateral hypothalamic (LH) neuropeptides that have been implicated in a variety of behaviors ranging from feeding to sleep and arousal. Evidence from animal models suggests a role for orexins in reward processing and drug addiction. In the present study, we investigated the direct effect o...

journal_title：Neuropeptides

authors： Zarepour L,Fatahi Z,Sarihi A,Haghparast A

更新日期：2014-06-01 00:00:00

abstract：:Paired-pulse stimulation was used to evaluate the effects of the sulfated octapeptide of cholecystokinin (CCK8-S), the gamma-aminobutyric acidB (GABAB) agonist (-) baclofen, and the GABAA antagonist (-) bicuculline on hippocampal dentate gyrus (DG) granule cell excitability. Evoked action potentials (EAPs) and excitat...

journal_title：Neuropeptides

authors： Rich-Bennett E,Dahl D,Lecompte BB 3rd

更新日期：1993-05-01 00:00:00

abstract：:Available data concerning the effect of oxytocin on memory are often inconsistent. In the present study it was found that oxytocin, intracerebroventricularly injected to adult male rats in a dose range of 1 fg-10 ng/rat immediately after a 5-minute encounter with a juvenile, significantly reduces the social investigat...

journal_title：Neuropeptides

authors： Benelli A,Bertolini A,Poggioli R,Menozzi B,Basaglia R,Arletti R

更新日期：1995-04-01 00:00:00

abstract：:The recent surge of scientific interest in 5-hydroxytryptamine3 (5-HT3) receptors can be attributed largely to the rapid increase in the number of potent and selective 5-HT3 receptor antagonists. The availability of a large variety of chemically diverse 5-HT3 compounds allows for a unique opportunity to apply computer...

journal_title：Neuropeptides

authors： Peroutka SJ

更新日期：1991-07-01 00:00:00

abstract：:In the hot plate test the intracerebroventricular (i.c.v.) injection of oxytocin produced a significant decrease in nociception, starting from the dose of 1 microgram/rat. A comparable effect was obtained with 10-200 times higher intraperitoneal (i.p.) doses. The i.c.v. injection of the oxytocin antagonist d(CH2)5-Tyr...

journal_title：Neuropeptides

authors： Arletti R,Benelli A,Bertolini A

更新日期：1993-03-01 00:00:00

abstract：:Using canine spleen and lung membranes as model systems, we have shown the presence of subtypes of ETB receptors. This classification was done based on the binding profiles of various analogs of ET-1 that have been identified as ETB-selective. Saturation binding experiments performed with [125I] ET-3 and [125I] IRL-12...

journal_title：Neuropeptides

authors： Nambi P,Pullen M,Brooks DP,Gellai M

更新日期：1995-12-01 00:00:00

abstract：:There is now unequivocal evidence that the angiotensin-converting enzyme 2(ACE2)-Ang-(1-7)-Mas axis is a key component of the renin-angiotensin system (RAS) cascade, which is closely correlated with ischemic insult occurrence. Our previous studies demonstrated that the Ang-(1-7), was an active member of the brain RAS....

journal_title：Neuropeptides

authors： Lu J,Jiang T,Wu L,Gao L,Wang Y,Zhou F,Zhang S,Zhang Y

更新日期：2013-10-01 00:00:00

abstract：:The effect of the neurokinin-1 (NK1) receptor antagonist RP67580 in modulating inflammatory oedema formation has been investigated in guinea-pig skin. Oedema formation was measured over 30 min by the extravascular accumulation of intravenously-injected 125I-albumin in the anaesthetised guinea-pig. RP67580 was injected...

journal_title：Neuropeptides

authors： Wilsoncroft P,Euzger H,Brain SD

更新日期：1994-06-01 00:00:00

abstract：:We studied head-injured patients assessed after admission to the hospital according to the Glasgow coma scale (3-8 points). All of them underwent surgical procedure after neuroradiological examination. Due to therapeutic problems, some of these patients had lumbar puncture on the fourth day following surgery. The cont...

journal_title：Neuropeptides

authors： Stachura Z,Obuchowicz E,Herman ZS

更新日期：1997-02-01 00:00:00

abstract：:DPDPE ([D-Pen2, D-Pen5]-Enkephalin) and DPLPE ([D-Pen2, L-Pen5]-Enkephalin) are conformationally-constrained cyclic analogs of enkephalin with high selectivity for delta opioid receptors. Intracerebroventricular (i.c.v.) administration of each analog acutely produces a complex EEG response in rats characterized by a d...

journal_title：Neuropeptides

authors： Tortella FC,Robles L,Mosberg HI,Holaday JW

更新日期：1984-12-01 00:00:00

abstract：:Cholecystokinin (CCK) is co-localized with dopamine (DA) in mesolimbic neurons of the CNS and appears to selectively regulate the output of this system. In an attempt to characterize the nature of CCK interactions with mesolimbic DA-containing nerve terminals, we have investigated CCK regulation of [3H]DA overflow fro...

journal_title：Neuropeptides

authors： Vickroy TW,Bianchi BR

更新日期：1989-01-01 00:00:00

abstract：:We investigated the effect of sulphated cholecystokinin octapeptide (CCK-8S) on free intracellular calcium concentration, phosphatidylinositol metabolism, and protein phosphorylation in C6 cells, a rat glioma cell line which was shown to express CCKB type receptors. Increase in [Ca2+]i by both influx across the cell m...

journal_title：Neuropeptides

authors： Kaufmann R,Schöneberg T,Lindschau C,Haller H,Ott T

更新日期：1995-11-01 00:00:00

abstract：:The effects of stimulation and blockade of neurotensin receptors on striatal acetylcholine release were examined in anaesthetized rats using microdialysis. Local perfusion with neurotensin (100 nM) did not influence the release of acetylcholine. Application of neurotensin (100 nM) 30 min after haloperidol (125 microgr...

journal_title：Neuropeptides

authors： Steinberg R,Rodier D,Mons G,Gully D,Le Fur G,Soubrié P

更新日期：1995-07-01 00:00:00

abstract：:Social conflict and defeat in mice leads to an activation of endogenous opiate systems. The effects of intracerebroventricular administration of the peptide FMRFamide (Phe-Met-Arg-Phe-NH2) and the opiate antagonist naloxone, on aggressive encounters, defeat-induced analgesia and defeat-induced feeding were examined in...

journal_title：Neuropeptides

authors： Kavaliers M,Hirst M

更新日期：1985-12-01 00:00:00

abstract：:In critical patients, sepsis-induced muscle wasting is considered to be an important contributor to complications and mortality. Previous work mainly focuses on the peripheral molecular mechanism of muscle degradation, however little evidence exists for the role of central nervous system in the process. In the present...

journal_title：Neuropeptides

authors： Duan K,Yu W,Lin Z,Tan S,Bai X,Gao T,Xi F,Li N

更新日期：2014-12-01 00:00:00

abstract：:Galanin, a 29 residue peptide found in the hypothalamus, causes orexigenic effects in a variety of species. In the present study, we investigated appetite-associated effects of galanin in chicks from lines which have been selected from a common founder population for either low or high body weight. The low line consis...

journal_title：Neuropeptides

authors： Hagen CJ,Newmyer BA,Webster RI,Gilbert ER,Siegel PB,Tachibana T,Cline MA

更新日期：2013-08-01 00:00:00

abstract：:Orexins/hypocretins are neuropeptides that have various physiological effects, including the regulation of feeding behavior, neuroendocrine functions and sleep-wake cycles. Recent studies have suggested that the orexin system may also be involved in brain ischemic reactions. It is also known that changes in sleep patt...

journal_title：Neuropeptides

authors： Dohi K,Nishino S,Nakamachi T,Ohtaki H,Morikawa K,Takeda T,Shioda S,Aruga T

更新日期：2006-08-01 00:00:00

abstract：:Immune system function has been shown to be under the influence of various neuromodulators and endocrine system peptides. This in vitro study describes the stimulatory effect of thyrotropin releasing hormone (thyroliberin, TRH) on thyrotropin (TSH) release from cultured human peripheral blood monocytes. The stimulator...

journal_title：Neuropeptides

authors： Komorowski J,Stepień H,Pawlikowski M

更新日期：1993-07-01 00:00:00

abstract：:The opioid receptor antagonists, naloxone and beta-chlornaltrexamine, were used to determine whether activation of endogenous opioid peptide containing pathways produced pharmacologically reversible opioid actions. Extracellularly recorded responses of the hippocampal CA3 pyramidal cells were evoked by stimulation of ...

journal_title：Neuropeptides

authors： Chavkin C,Bloom FE

更新日期：1986-01-01 00:00:00

abstract：:During neonatal development exogenous oxytocin increases ERalpha immunoreactivity in the hypothalamus of female prairie voles. The purpose of this study was to determine if the increase in ERalpha is associated with an increase in ERalpha mRNA expression and to determine if the effect is specific to ER subtype or if o...

journal_title：Neuropeptides

authors： Pournajafi-Nazarloo H,Carr MS,Papademeteriou E,Schmidt JV,Cushing BS

更新日期：2007-02-01 00:00:00

abstract：:Alzheimer's disease (AD) is a progressive neurodegenerative disease that deeply affects patients, their family and society. Although scientists have made intense efforts in seeking the cure for AD, no drug available today is able to stop AD progression. In this context, compounds isolated from animal venom are potenti...

journal_title：Neuropeptides

authors： Camargo LC,Campos GAA,Galante P,Biolchi AM,Gonçalves JC,Lopes KS,Mortari MR

更新日期：2018-02-01 00:00:00