Effect of a neurokinin-1 (NK1) receptor antagonist on oedema formation induced by tachykinins, carrageenin and an allergic response in guinea-pig skin.

abstract：:To find out, whether microheterogeneity of neurophysins is due to aging of neurosecretory granules we investigated neurophysin proteins of porcine origin from newly formed and aged granules, as well as from two different extraction methods from whole posterior pituitary glands by high performance liquid chromatography...

journal_title：Neuropeptides

authors： Richter WO,Schwandt P

更新日期：1983-12-01 00:00:00

abstract：:The distribution of beta-endorphin (1-27) immunoreactive cell bodies and fibres was studied in the diencephalon of the cat using an indirect immunoperoxidase technique. In the thalamus, almost all the immunoreactive fibres were found in the midline region and in nuclei located near the midline, whereas in the hypothal...

journal_title：Neuropeptides

authors： Coveñas R,de León M,Narváez JA,Tramu G,Aguirre JA,González-Barón S

更新日期：1996-06-01 00:00:00

abstract：:The orally active, α-hemoglobin derived hemopressin (PVNFKFLSH, Hp(1-9)) and its truncated (PVNFKFL, Hp(1-7) and PVNFKF, Hp(1-6)) and extended ((R)VDPVNFKFLSH, VD-Hp(1-9) and RVD-Hp(1-9)) derivatives have been postulated to be the endogenous peptide ligands of the cannabinoid receptor type 1 (CB1). In an attempt to cr...

journal_title：Neuropeptides

authors： Dvorácskó S,Tömböly C,Berkecz R,Keresztes A

更新日期：2016-08-01 00:00:00

abstract：:Information on the physiological functions of neuropeptide FF; NPFF, a morphine modulating octapeptide in avians is lacking. Thus, we designed a study to investigate the effects of central NPFF with particular emphasis on appetite-related processes. Cobb-500 chicks were intracerebroventricularly (ICV) injected with 0,...

journal_title：Neuropeptides

authors： Cline MA,Nandar W,Rogers JO

更新日期：2007-12-01 00:00:00

abstract：:Development of transgenic mice overexpressing GH and GHR-KO mice with GH resistance provided novel animal models for study of the somatotropic axis and for identifying GH actions that may be relevant to its current and contemplated use in medicine and agriculture. Studies of phenotypic characteristics of these animals...

journal_title：Neuropeptides

authors： Bartke A,Chandrashekar V,Bailey B,Zaczek D,Turyn D

更新日期：2002-04-01 00:00:00

abstract：:Somatostatin is a neuropeptide that in several experimental models of epilepsy has been suggested to modulate epileptic activity. The purpose of the present study was to investigate the role of somatostatin in seizure phenomena. We measured the somatostatin-like immunoreactivity (SLI) by radioimmunoassay of the cister...

journal_title：Neuropeptides

authors： Pitkänen A,Jolkkonen J,Honkanen KL,Riekkinen P

更新日期：1987-01-01 00:00:00

abstract：:Perivascular sensory nerves release calcitonin gene-related peptide (CGRP) and substance P, the dilator actions of which can be regulated by nitric oxide (NO). This study investigated the role of NO in the vasodilation caused by sensory nerve stimulation, by capsaicin, or exogenous CGRP and substance P in the isolated...

journal_title：Neuropeptides

authors： Mitchell JA,Williams FM,Williams TJ,Larkin SW

更新日期：1997-08-01 00:00:00

abstract：:Familial dysautonomia (FD) patients have diminished sensory C-fibers. Calcitonin gene related peptide (CGRP) is a widely distributed neuropeptide and prominent neurotransmitter in C-fibers. We show that plasma CGRP levels measured by radioimmunoassay is significantly lower in 51 FD patients compared to controls (P<0.0...

journal_title：Neuropeptides

authors： Maayan C,Becker Y,Gesundheit B,Girgis SI

更新日期：2001-06-01 00:00:00

abstract：:Hypertension is still presently the number one "silent killer" in the Western World, and a major risk factor for the development of secondary diseases contributing to cardiovascular disease (CVD). However, despite a broad range of therapies, the mechanisms involved in the onset of hypertension remains unclear, therefo...

journal_title：Neuropeptides

authors： Smillie SJ,Brain SD

更新日期：2011-04-01 00:00:00

abstract：:Hippocampal neurogenesis is important for modulating the behavioural responses to stress and for certain forms of learning and memory. The mechanisms underlying the necessary coupling of neuronal activity to neural stem/progenitor cell (NSPC) function remain poorly understood. Within the dentate subgranular stem cell ...

journal_title：Neuropeptides

authors： Zaben MJ,Gray WP

更新日期：2013-12-01 00:00:00

abstract：:D-Arg containing dipeptides, H-Tyr-D-Arg-OMe and H-Tyr (Et)-D-Arg-OMe, and D-Arg2 substituted N-terminal tetrapeptides of dermorphin, H-Tyr-D-Arg-Phe-Gly-OEt and H-Tyr (Et)-D-Arg-Phe-Gly-OEt administered intracerebroventricularly exhibited dose-dependent antinociceptive activities in mice as measured by the tail press...

journal_title：Neuropeptides

authors： Sato T,Sakurada S,Sakurada T,Furuta S,Nakata N,Kisara K,Sasaki Y,Suzuki K

更新日期：1984-06-01 00:00:00

abstract：:Ghrelin (gh) is a peptide hormone that may affect learning and memory. There is some evidence that ghrelin can have antiepileptic effects. So we decided to investigate the possible effects of ghrelin on spatial memory following PTZ-induced seizures in male rats. Ninety male rats were divided into 9 groups including co...

journal_title：Neuropeptides

authors： Babri S,Amani M,Mohaddes G,Mirzaei F,Mahmoudi F

更新日期：2013-10-01 00:00:00

abstract：:We have described the binding of [125I]endothelin-1 (ET-1) to cultured rat cerebellar granule cells. Binding of [125I]ET-1 was specific, saturable, and time-dependent. Scatchard analysis of saturation binding data indicated a single class of high affinity binding site with a KD of 95 pM, and a Bmax of 8110 receptors/c...

journal_title：Neuropeptides

authors： Lysko PG,Feuerstein G,Pullen M,Wu HL,Nambi P

更新日期：1991-02-01 00:00:00

abstract：:Glucocorticoid deficiency is associated with a decrease of food intake. Orexigenic peptides, neuropeptide Y (NPY) and agouti related protein (AgRP), and the anorexigenic peptide proopiomelanocortin (POMC), expressed in the arcuate nucleus of the hypothalamus (ARC), are regulated by meal-induced signals. Orexigenic neu...

journal_title：Neuropeptides

authors： Uchoa ET,Silva LE,de Castro M,Antunes-Rodrigues J,Elias LL

更新日期：2012-06-01 00:00:00

abstract：:Neuropeptide Y (NPY) -receptor subtypes were studied in the rat kidney in vivo by systemic administration of NPY, the two agonists [Leu(31), Pro(34)]NPY (Y1-receptor agonist) and NPY (13-36) (Y2-receptor agonist), or the Y1-receptor antagonist BIBP 3226. Effects on mean arterial blood pressure (MAP) and renal arterial...

journal_title：Neuropeptides

authors： Modin A,Malmström RE,Meister B

更新日期：1999-08-01 00:00:00

abstract：:Oxytocin, either intraperitoneally injected (200 ng/rat) or intracerebroventricularly infused (1 ng/rat in 4 microliters saline) 60 and 15 min respectively before testing, significantly increased the lordosis response to the mounting male of ovariectomized, estrogen/progesterone treated rats. The intracerebroventricul...

journal_title：Neuropeptides

authors： Arletti R,Bertolini A

更新日期：1985-06-01 00:00:00

abstract：:The effect of the selective non-peptide antagonist for NK1 receptors (+/-)CP 96,345 on cellular transduction mechanisms elicited by the NK1 selective agonist [Sar9]-substance P-sulfone ([Sar9]-SP) was investigated in a stabilized culture of human skin fibroblasts (HF) and compared to the effects of two peptide antagon...

journal_title：Neuropeptides

authors： Ziche M,Parenti A,Amerini S,Zawieja D,Maggi CA,Ledda F

更新日期：1996-08-01 00:00:00

abstract：:The pathophysiological basis for the pain of migraine has been the subject of substantial attention and must include activation of elements of the trigeminal innervation of the cranial vessels, the trigeminovascular system. Recently, consideration of trigeminal-evoked neurogenic plasma protein extravasation (PPE) as a...

journal_title：Neuropeptides

authors： Knight YE,Edvinsson L,Goadsby PJ

更新日期：1999-02-01 00:00:00

abstract：:AtT-20 cells are known to synthesize two molecular weight forms of the prohormone converting enzyme PC1 with molecular masses of 87 and 66 kDa. In this study we have analyzed basal and stimulated secretion of these proteins. Western blot results show that basal secretion medium of cultured AtT-20 cells contained low c...

journal_title：Neuropeptides

authors： Vindrola O,Lindberg I

更新日期：1993-08-01 00:00:00

abstract：RATIONALE:Cholecystokinin and its analogs generate anxiety in humans and measurable anxiety-like behaviors in rats. Cholecystokinin receptor blockers have been reported to have variable effects in the treatment of anxiety disorders. We demonstrated that intracerebroventricular administration of Cholecystokinin-antisens...

journal_title：Neuropeptides

authors： Cohen H,Matar MA,Buriakovsky I,Zeev K,Kotler M,Bourin M

更新日期：2002-10-01 00:00:00

abstract：:Lysine-vasopressin (LVP) at different concentrations (2 ng, 200 pg) was injected into the lateral ventricle and cisterna magna. The effect on hypothalamic self-stimulation was studied in rats. LVP (2 ng) decreased the self-stimulation rate after intracerebroventricular and cisternal application. Injection of 200 pg LV...

journal_title：Neuropeptides

authors： Günther O,Schwarzberg H

更新日期：1987-11-01 00:00:00

abstract：:Nociceptin-opioid peptide (NOP) receptor, also known as opioid receptor like-1 (ORL1), was identified following the cloning of the kappa-opioid peptide (KOP) receptor, and the characterization of these receptors revealed high homology. The endogenous ligand of NOP, nociceptin (NOC), which shares high homology to dynor...

journal_title：Neuropeptides

authors： Mika J,Obara I,Przewlocka B

更新日期：2011-08-01 00:00:00

abstract：:The effects of the GABAergic drugs nipecotic acid, Gabrene, baclofen and metatolylcarbamide (MTC), when given alone or in combination at subthreshold doses with AT II also at a subthreshold dose effective on PTZ-kindling in mice were studied. PTZ-kindling was provoked by intraperitoneal (i.p.) injections of PTZ (40 mg...

journal_title：Neuropeptides

authors： Georgiev VP,Lazarova MB,Kambourova TS

更新日期：1995-01-01 00:00:00

abstract：:In this study, we examined whether the mechanisms mediating the induction of grooming behavior by oxytocin (OT) is similar to mechanisms mediating the effects of OT on uterine contractility. Sprague-Dawley strain female rats were injected intracerebroventricularly (ICV) with OT or OT analogues and then were observed f...

journal_title：Neuropeptides

authors： Caldwell JD,Hruby VJ,Hill P,Prange AJ Jr,Pedersen CA

更新日期：1986-07-01 00:00:00

abstract：:There is now considerable evidence that putative neuropeptides are involved in epileptogenic processes. Neurotensin (NT), which affects neuronal excitability in many parts of the CNS, is potentially relevant to the kindling phenomenon, but has not previously been studied in the kindling model of epilepsy. This study c...

journal_title：Neuropeptides

authors： Shulkes A,Harris QL,Lewis SJ,Vajda JE,Jarrott B

更新日期：1988-02-01 00:00:00

abstract：:Previous behavioural and electrophysiological studies have indicated an antinarcotic action of thyrotropin-releasing hormone (TRH) and its analogues in antagonizing the action of CNS depressant drugs, including baclofen and a variety of anesthetics. While beta-adrenergic receptors are implicated in the level of anaest...

journal_title：Neuropeptides

authors： Clarke KA,Djouhri L

更新日期：1991-09-01 00:00:00

abstract：:Experiments were performed to determine whether the renal nerve mediates the renin release induced by intracerebroventricular administration of angiotensin II (ANG II), bradykinin (BK), leucine-enkephalin (Leu-ENK) and neurotensin (NT). In sham-operated rats, both ANG II and NT suppressed plasma renin activity (PRA), ...

journal_title：Neuropeptides

authors： Iwata T,Hiwada K,Kokubu T

更新日期：1985-09-01 00:00:00

abstract：:Brain insulin receptors adsorb to and are recoverable from wheat germ agglutinin-agarose (WGA) columns. Similar results are obtained using dissuccinimidyl suberate (DSS)-crosslinked receptors or photo-affinity labeled receptors. WGA can be used for partial purification of brain insulin receptors provided the appropria...

journal_title：Neuropeptides

authors： Shemer J,LeRoith D

更新日期：1987-01-01 00:00:00

abstract：:The effects of several doses of porcine brain natriuretic peptide-32 (pBNP-32) administered into the lateral brain ventricle were tested as regards the consolidation of passive avoidance learning in rats. The peptide was found to increase the passive avoidance latency in a dose-dependent manner. In order to clarify wh...

journal_title：Neuropeptides

authors： Bidzseranova A,Várga J,Telegdy G

更新日期：1992-06-01 00:00:00

abstract：:Bombesin (BN) and its mammalian counterpart gastrin-releasing peptide act as neuroregulatory hormones and tissue-specific growth factors, and have been implicated as peripheral and central satiety-inducing agents. In the present study, the immunohistochemical expression of BN in submandibular, sublingual and parotid g...

journal_title：Neuropeptides

authors： Aalto Y,Kjörell U,Henriksson R,Franzén L,Forsgren S

更新日期：1997-04-01 00:00:00