Abstract:
:We have developed an extraction method and radioimmunoassay for the measurement of interleukin-1 beta (IL-1 beta) in rat tissues, using an antibody specific for IL-1 beta, IL-1 beta was detected in the spleen and thymus of control rats. Adrenalectomy (ADX) had no effect upon control levels of IL-1 beta. In animals with adjuvant-induced arthritis, IL-1 beta content in the spleen and thymus increased after 14 days. These increases in tissue IL-1 beta contents were not evident in ADX arthritic animals. We conclude that IL-1 beta synthesis is stimulated in tissues of the immune system following the development of adjuvant-induced arthritis. Failure to observe elevated levels of tissue IL-1 beta in ADX arthritic rats may be evidence for tissue depletion due to increased IL-1 beta release in the absence of circulating corticosteroids.
journal_name
Neuropeptidesjournal_title
Neuropeptidesauthors
Jessop DS,Chowdrey HS,Lightman SLdoi
10.1016/0143-4179(93)90008-xsubject
Has Abstractpub_date
1993-06-01 00:00:00pages
367-71issue
6eissn
0143-4179issn
1532-2785pii
0143-4179(93)90008-Xjournal_volume
24pub_type
杂志文章相关文献
NEUROPEPTIDES文献大全abstract::A human brain aminopeptidase, which hydrolyses low molecular weight enkephalin-containing peptides (ECPs), was purified to apparent homogeneity from the homogenate of human brain. The enzyme purification involved DEAE-cellulose chromatography and preparative polyacrylamide gel electrophoresis. The purified aminopeptid...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(88)90033-9
更新日期:1988-08-01 00:00:00
abstract:OBJECTIVE:To explore the orexinergic pathway from the lateral hypothalamus (LHA) to the nucleus accumbens (NAc) and its regulation on the palatable food intake. METHODS:Fluorescent gold retrograde tracing combined with fluoro-immunohistochemical staining were used to observe the projection of orexinergic neurons from ...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/j.npep.2020.102028
更新日期:2020-04-01 00:00:00
abstract::We have previously shown that the kappa-opioid agonist, asimadoline, produces time-dependent changes in neuropeptide concentrations in the joints of rats with chronic arthritis. We hypothesized that asimadoline acts on peripheral terminals to modulate substance P (SP) release. To address this hypothesis, here we have ...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1054/npep.2000.0813
更新日期:2000-06-01 00:00:00
abstract::The effects of H-Phe-Ile-Tyr-His-Ser-Tyr-Lys-OH, a hypothalamic heptapeptide with weak CRF activity were investigated on the in vitro uptake and release of radiolabelled dopamine (DA), noradrenaline (NA) and serotonin (5-HT) in rat brain hypothalamic slices. In a doses of 5 X 10(-6) M and 10(-5) M the heptapeptide sig...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(84)90106-9
更新日期:1984-05-01 00:00:00
abstract::The present study was planned to evaluate role of tachykinins (TKs) and neurokinin (NK) receptors in the regulation of gastric motility in sheep. We examined the effects of intravenous (i.v.) injection of neurokinin A (NKA) and substance P (SP) on motility of the rumen, omasum, and abomasum in conscious sheep and the ...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/j.npep.2012.07.005
更新日期:2013-02-01 00:00:00
abstract::We examined the effects of gestational cocaine treatment on oxytocin levels in the whole hippocampus (HIP), ventral tegmental area (VTA), medial preoptic area (MPOA) and amygdala (AMY) in rat dams on postpartum days (PPDs) 1 and 2. Cocaine treatment significantly reduced oxytocin levels in the MPOA within 12-16 h of d...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/s0143-4179(97)90037-8
更新日期:1997-10-01 00:00:00
abstract::Humanin (HN) is an endogenous 24-residue peptide. A highly potent HN derivative, S14G-HN, which has a substitution of serine 14 to glycine, reduced amyloid burden and suppressed cognitive impairment in a mouse model of Alzheimer's disease. S14G-HN also suppressed amnesia induced by a muscarinic receptor antagonist in ...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/j.npep.2016.10.008
更新日期:2017-04-01 00:00:00
abstract::Specific antagonists were used to determine NK1 and NK2 receptor mediation of the expression of c-Jun and c-Fos inducible transcription factors. (ITFs) in dorsal horn neurons. The induction of c-Jun by C-fiber stimulation was strongly reduced in the superficial laminae by NK1 and NK2 antagonists, but only weakly in th...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1054/npep.1999.0005
更新日期:1999-04-01 00:00:00
abstract::Nesfatin-1, a newly discovered satiety peptide, has recently been reported to be involved in the stress response. Stress-induced expression of nesfatin-1 has been reported and few studies focus on its expression in the hypothalamus, which is the center of the stress response. To test our hypothesis that peripheral and...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/j.npep.2015.08.003
更新日期:2015-12-01 00:00:00
abstract::We studied head-injured patients assessed after admission to the hospital according to the Glasgow coma scale (3-8 points). All of them underwent surgical procedure after neuroradiological examination. Due to therapeutic problems, some of these patients had lumbar puncture on the fourth day following surgery. The cont...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/s0143-4179(97)90012-3
更新日期:1997-02-01 00:00:00
abstract::We have evaluated the peripheral blood natural killer (NK) cell activity and the in vitro effect of recombinant gamma-interferon (r gamma-IFN) on NK cell activity in 23 patients with a neuroendocrine tumour of the pancreas, small intestine or liver, and 23 healthy controls. Patients with a gastrinoma showed a NK cell ...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(91)90033-f
更新日期:1991-09-01 00:00:00
abstract::Arginine vasopressin mediates its effects through vasopressin receptor activation and second messenger production. Recent cloning of the V1a receptor provided the opportunity to investigate the possible signal transduction pathways associated with this single vasopressin receptor subtype. When stably expressed in CHO ...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(94)90017-5
更新日期:1994-07-01 00:00:00
abstract::Cholecystokinin-B (CCK-8) is an octapeptide that was initially described in the gastrointestinal tract. Recent studies have shown that this peptide also has an extensive distribution in the central nervous system, including the cerebellum of the opossum. In addition to the protein, binding sites for CCK-8 also have be...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/s0143-4179(96)90035-9
更新日期:1996-12-01 00:00:00
abstract::Highly purified porcine neurophysin-II, prepared from pig posterior pituitary lobe tissue was injected into fifteen rabbits in the preparation of anti-neurophysin sera. All antisera, when used in association with immunohistochemical procedures, gave an immunoreaction in structures of the rat hypothalamo-neurohypophysi...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(83)90038-0
更新日期:1983-10-01 00:00:00
abstract::The antinociceptive effect of intrathecally (i.t.) administered protease inhibitors was tested against capsaicin (800 ng) injected into the dorsal surface of a hindpaw. Both p-hydroxymercuribenzoate (2-8 nmol), a cysteine protease inhibitor, and phosphoramidon (1-4 nmol), an endopeptidase 24.11 inhibitor in the presen...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/s0143-4179(98)90064-6
更新日期:1998-10-01 00:00:00
abstract::The opioid receptor antagonists, naloxone and beta-chlornaltrexamine, were used to determine whether activation of endogenous opioid peptide containing pathways produced pharmacologically reversible opioid actions. Extracellularly recorded responses of the hippocampal CA3 pyramidal cells were evoked by stimulation of ...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(86)90074-0
更新日期:1986-01-01 00:00:00
abstract::The desire of the pharmaceutical industry to obtain more selective agents for the treatment of anxiety with fewer or diminished side effects and a profile consistent with safety during long-term use resulted in a search which has identified the azapirones as a new class of anxiolytics which lack structural or biochemi...
journal_title:Neuropeptides
pub_type: 临床试验,杂志文章,评审
doi:10.1016/0143-4179(91)90078-w
更新日期:1991-07-01 00:00:00
abstract::In an attempt to determine the localization of the messenger RNA (mRNA) encoding somatostatin in the rat retina, we studied Sprague-Dawley rats by in situ hybridization histochemistry using radiolabelled oligodeoxyribonucleotides complementary for rat somatostatin mRNA. Among the layers of retina, we found specific la...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(90)90135-l
更新日期:1990-09-01 00:00:00
abstract::The effects of FMRFamide on passive avoidance behaviour and electroshock-induced amnesia following intracerebroventricular administration were studied in rats. FMRFamide given immediately after the learning trial, or 20 min before the retention trial, attenuated the avoidance response, thereby impairing the consolidat...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(87)90017-5
更新日期:1987-08-01 00:00:00
abstract::Microchemotaxis chambers were used to investigate whether one aspect of ciliary neurotrophic factor CNTF's role as a lesion factor might be to promote the initial early recruitment of macrophages, which express the signal transducing receptor components, gp130 and LIFRbeta. CNTFRalpha alone, or in combination with CNT...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1054/npep.2000.0829
更新日期:2000-12-01 00:00:00
abstract::Recently, we demonstrated that brain neuropeptide Y (NPY) mRNA expression was increased in heat exposed chicks. However, the functions of brain NPY during heat stress are unknown. This study was conducted to investigate whether centrally administered NPY affects food intake, rectal temperature, monoamines, stress horm...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/j.npep.2016.11.008
更新日期:2017-04-01 00:00:00
abstract::Development of transgenic mice overexpressing GH and GHR-KO mice with GH resistance provided novel animal models for study of the somatotropic axis and for identifying GH actions that may be relevant to its current and contemplated use in medicine and agriculture. Studies of phenotypic characteristics of these animals...
journal_title:Neuropeptides
pub_type: 杂志文章,评审
doi:10.1054/npep.2002.0889
更新日期:2002-04-01 00:00:00
abstract::The neurokinin-1 (NK-1) receptor interacts with peptides that belong to the tachykinin family. NK-1 is inducible in bone marrow (BM) stroma. In neural cells, its expression is high to constitutive. Screening of three cDNA libraries indicated that this different in NK-1 expression in neural and BM cells could not be ex...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1054/npep.2002.0869
更新日期:2002-02-01 00:00:00
abstract::The tetra-peptide FMRF-NH(2) is a cardioexcitatory peptide in the clam. Using the antibody against this peptide, FMRF-NH(2)-like immunoreactive material was detected in mammalian CNS. Subsequently, mammalian FMRF-NH(2) immunoreactive peptides were isolated from bovine brain and characterized to be FLFQPQRF-NH(2) (NPFF...
journal_title:Neuropeptides
pub_type: 杂志文章,评审
doi:10.1016/j.npep.2007.06.004
更新日期:2008-02-01 00:00:00
abstract::Gestational cocaine treatment in rat dams results in decreased oxytocin (OT) levels, up-regulated oxytocin receptor (OTR) binding density and decreased receptor affinity in the whole amygdala, all concomitant with a significant increase in maternal aggression on postpartum day six. Rat dams with no gestational drug tr...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/j.npep.2006.03.002
更新日期:2006-06-01 00:00:00
abstract::We investigated the effect of sulphated cholecystokinin octapeptide (CCK-8S) on free intracellular calcium concentration, phosphatidylinositol metabolism, and protein phosphorylation in C6 cells, a rat glioma cell line which was shown to express CCKB type receptors. Increase in [Ca2+]i by both influx across the cell m...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(95)90033-0
更新日期:1995-11-01 00:00:00
abstract::Here we report that chicken pineal membranes express high affinity receptors for Vasoactive Intestinal Peptide (VIP), as revealed by competitive displacement analysis of [3-iodotyrosyl-125I]-VIP by native VIP. These binding sites were further characterized by covalent cross-linking of radioiodinated VIP to chicken pin...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(91)90066-r
更新日期:1991-05-01 00:00:00
abstract::The effects of several protein modifying reagents, including phenoxybenzamine, N-ethylmaleimide (NEM), 5,5'-dithiobis (2-nitro)--benzoic acid (DTNB), p-chloromercuryphenyl sulfonic acid (PCMP) and p-bromophenacylbromide (PBPB), on the binding of 125I-Bolton Hunter substance P (125I-BHSP), 125I-Bolton Hunter eledoisin ...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(87)90053-9
更新日期:1987-02-01 00:00:00
abstract:OBJECTIVE:Potential physiological correlates of stress and the role of stress neuropeptides, other than those of the hypothalamic-pituitary-adrenal axis, in critical illness have not been addressed. We investigated: (a) serum levels of stress neuropeptides (ACTH, substance P (SP), neuropeptide Y (NPY), cortisol, prolac...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/j.npep.2012.07.007
更新日期:2013-02-01 00:00:00
abstract::There is now considerable evidence that putative neuropeptides are involved in epileptogenic processes. Neurotensin (NT), which affects neuronal excitability in many parts of the CNS, is potentially relevant to the kindling phenomenon, but has not previously been studied in the kindling model of epilepsy. This study c...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(88)90014-5
更新日期:1988-02-01 00:00:00