Abstract：
:[3H]-Dynorphin A (1-8) was degraded in brain homogenates at 25 degrees and even at 0 degree C. The peptidase inhibitors bestatin and captopril almost completely protected[3H]-dynorphin A (1-8) from degradation at 0 degree C but had only little effect on binding at this temperature. At 25 degrees C, the binding of [3H]-dynorphin A (1-8) was markedly improved by addition of bestatin, captopril and L-leucyl-L-arginine, which afforded some, but not complete protection from degradation. The results of saturation binding assays at 25 degrees C in the presence of the peptidase inhibitors were variable. However, it was found from saturation binding assays at 0 degree C that the maximum binding capacity for [3H]-dynorphin A (1-8) at the kappa-site is similar to that of [3H]-(-)-bremazocine and [3H]-dynorphin A (1-9).
journal_name
Neuropeptidesjournal_title
Neuropeptidesauthors
Gillan MG,Robson LE,McKnight AT,Kosterlitz HWdoi
10.1016/0143-4179(85)90072-1subject
Has Abstractpub_date
1985-02-01 00:00:00pages
533-6issue
4-6eissn
0143-4179issn
1532-2785pii
0143-4179(85)90072-1journal_volume
5pub_type
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