Abstract:
:The effects of 6-hydroxydopamine (6-OHDA) injected into either the ventral tegmental area (VTA) or the nucleus accumbens on dopamine and its metabolite DOPAC and CCK-immunoreactivity in the nucleus accumbens were studied. Measurements were made 1, 3 and 6 weeks after the lesion in both the anterior and posterior part of the nucleus accumbens. 6-OHDA applied in the VTA reduced the level of DA and DOPAC, but did not affect the CCK content in the nucleus accumbens. 6-OHDA lesions in the anterior part of the nucleus accumbens produced depletion of DA and DOPAC from one week after the injection, and decreased the CCK content 6 weeks after the injection. The results suggest that in the nucleus accumbens DA and CCK are localized, at least for the major part, in different nerve terminals.
journal_name
Neuropeptidesjournal_title
Neuropeptidesauthors
Igarashi Y,Wiegant VM,Van Ree JMdoi
10.1016/0143-4179(89)90061-9subject
Has Abstractpub_date
1989-08-01 00:00:00pages
71-6issue
2eissn
0143-4179issn
1532-2785pii
0143-4179(89)90061-9journal_volume
14pub_type
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