Abstract：
:The effects of a potent serine protease inhibitor, Boc-D-Phe-Pro-Arg-H, on the secretion and content of ACTH and beta-endorphin-like immunoreactivities of cultured rat anterior pituitary cells were studied. Basal release of the hormones was not affected by the drug but secretion in response to stalk-median eminence extracts was inhibited. The inhibitor did not effect the amount of ACTH or beta-endorphin in the medium plus the cells, nor did it change the ratio of the lipotropin and beta-endorphin-like immunoreactivities. Thus the compound seems to affect the release of ACTH and beta-endorphin, but not the processing of lipotropin to beta-endorphin.
journal_name
Neuropeptidesjournal_title
Neuropeptidesauthors
Barna I,Gráf L,Makara GB,Rappay Gdoi
10.1016/0143-4179(82)90066-xsubject
Has Abstractpub_date
1982-10-01 00:00:00pages
65-70issue
1eissn
0143-4179issn
1532-2785pii
0143-4179(82)90066-Xjournal_volume
3pub_type
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