Interactions between adrenergic systems, anaesthetic and TRH analogue induced analeptic effects on VBT transmission.

abstract：:There is now unequivocal evidence that the angiotensin-converting enzyme 2(ACE2)-Ang-(1-7)-Mas axis is a key component of the renin-angiotensin system (RAS) cascade, which is closely correlated with ischemic insult occurrence. Our previous studies demonstrated that the Ang-(1-7), was an active member of the brain RAS....

journal_title：Neuropeptides

authors： Lu J,Jiang T,Wu L,Gao L,Wang Y,Zhou F,Zhang S,Zhang Y

更新日期：2013-10-01 00:00:00

abstract：:Cholecystokinin-B (CCK-8) is an octapeptide that was initially described in the gastrointestinal tract. Recent studies have shown that this peptide also has an extensive distribution in the central nervous system, including the cerebellum of the opossum. In addition to the protein, binding sites for CCK-8 also have be...

journal_title：Neuropeptides

authors： Bishop GA

更新日期：1996-12-01 00:00:00

abstract：:Pituitary adenylate cyclase-activating polypeptide (PACAP-27) was incubated in a tyrosine hydroxylase (TyrOH) assay with a homogenate preparation of the nucleus accumbens of the rat. TyrOH activity was determined in vitro by measuring the production of L-dopa with HPLC-ECD. Only in the presence of adenosine nucleotide...

journal_title：Neuropeptides

authors： Moser A,Scholz J,Gänsle A

更新日期：1999-12-01 00:00:00

abstract：:The level of opioid peptides in several brain areas and in the pituitary was estimated in WAG/Rij rats, which are considered to be a genetic animal model for human absence epilepsy. In comparison with three groups of non-epileptic controls, these epileptic rats had an elevated level of the proenkephalin-derived peptid...

journal_title：Neuropeptides

authors： Lasoń W,Przewłocka B,Van Luijtelaar EL,Coenen AM,Przewłocki R

更新日期：1992-03-01 00:00:00

abstract：:Obesity is a global public health problem. Orexin and endocannabinoid signaling in the hypothalamus have been shown to regulate feeding and are promising molecular targets for obesity treatment. In this study, we attempted to analyze effects of orexin-A and endocannabinoid signaling modulation in the arcuate nucleus (...

journal_title：Neuropeptides

authors： Yang D,Xu L,Guo F,Sun X,Zhang D,Wang M

更新日期：2018-06-01 00:00:00

abstract：:We have previously shown that the kappa-opioid agonist, asimadoline, produces time-dependent changes in neuropeptide concentrations in the joints of rats with chronic arthritis. We hypothesized that asimadoline acts on peripheral terminals to modulate substance P (SP) release. To address this hypothesis, here we have ...

journal_title：Neuropeptides

authors： Walker JS,Scott C,Bush KA,Kirkham BW

更新日期：2000-06-01 00:00:00

abstract：:We have used [3H]Senktide, a selective Neurokinin B receptor ligand, for the characterization of NK-3 receptors in rat and guinea pig CNS membranes. Scatchard analysis of saturation binding studies in cerebral cortex membranes indicated that this ligand bound to a single site with apparent high affinity (KD = 4.6 +/- ...

journal_title：Neuropeptides

authors： Renzetti AR,Barsacchi P,Criscuoli M,Lucacchini A

更新日期：1991-03-01 00:00:00

abstract：:Using the latency for tail-flick after thermal stimulation we have assessed the effects of alpha-, gamma(1)- and gamma(2)-MSH on nociceptive threshold in the mice. Intracisternal injections of gamma(2)-MSH induced a distinct analgesia, while gamma(1)-MSH in the same doses gave only a minor analgesia. Intracisternal al...

journal_title：Neuropeptides

authors： Klusa V,Germane S,Svirskis S,Opmane B,Wikberg JE

更新日期：2001-02-01 00:00:00

abstract：:In rat preprogalanin, galanin is C-terminally flanked by a 60 amino acid long peptide: galanin message-associated peptide (GMAP). GMAP sequences in different species show high degree of homology, suggesting a biological role. However, the study of the physiological and pharmacological actions of this peptide have been...

journal_title：Neuropeptides

authors： Andell-Jonsson S,Bartfai T

更新日期：1998-04-01 00:00:00

abstract：:Kyotorphin (KTP), first isolated in the bovine brain and now having been identified in a variety of species, is known most extensively for its analgesic-like properties. KTP indirectly stimulates opioid receptors by releasing methionine enkephalin (met-enkephalin). Stimulation of opioid receptors is linked to hunger p...

journal_title：Neuropeptides

authors： Webster RI,Newmyer BA,Furuse M,Gilbert ER,Cline MA

更新日期：2013-06-01 00:00:00

abstract：:The aim of the present investigation was to study the effects of pituitary adenylate cyclase-activating polypeptide (PACAP) on morphine withdrawal-induced behavioral changes and hypothermia in male CFLP mice. Elevated plus maze (EPM) and jump tests were used to assess naloxone-precipitated morphine withdrawal-induced ...

journal_title：Neuropeptides

authors： Lipták N,Dochnal R,Babits A,Csabafi K,Szakács J,Tóth G,Szabó G

更新日期：2012-02-01 00:00:00

abstract：:The action of corticotropin-releasing factor (CRF) is mediated by two recently identified receptors, CRFR1 and CRFR2, that differ with respect to their anatomical distribution and pharmacologic ligand-binding properties. Here we show by an analysis of circadian heartbeat interval fluctuations that CRFR2-deficiency in ...

journal_title：Neuropeptides

authors： Stiedl O,Meyer M

更新日期：2003-02-01 00:00:00

abstract：:HPLC techniques were used to identify peptides that possess vasopressin-like immunoreactivity in the chicken neurohypophysis. The presence of arginine vasotocin (AVT) was confirmed together with arginine vasopressin (AVP). That the presence of AVP may be confined to the chicken, and not other avian species, was conclu...

journal_title：Neuropeptides

authors： Choy VJ,Watkins WB

更新日期：1986-08-01 00:00:00

abstract：:The effects of several mu and kappa opioid receptor agonists on urinary excretion were examined in the water-loaded rat. Mu agonists induced anti-diuresis whereas kappa agonists caused diuresis. Furthermore, high efficacy kappa agonists eg. U50, 488H and tifluadom, produced marked diuretic effects, whereas kappa parti...

journal_title：Neuropeptides

authors： Skingle M,Hayes AG,Tyers MB

更新日期：1985-02-01 00:00:00

abstract：:Endothelins (ET) are a family of highly active neuropeptides with manifold influences via ET receptors (ETR) in both the peripheral and central nervous systems. We have shown previously that satellite glial cells (SGCs) in mouse trigeminal ganglia (TG) are extremely sensitive to ET-1 in evoking [Ca2+]in increase, appa...

journal_title：Neuropeptides

authors： Feldman-Goriachnik R,Hanani M

更新日期：2017-06-01 00:00:00

abstract：:Neuromedin U (NMU), a neuropeptide implicated in feeding, inflammation, pain control and anxiety-related behaviours, is widely distributed in peripheral organs and the CNS. These effects are thought to be mediated by its receptors NMU(1) and NMU(2). Since its precise sites of interaction in the CNS were to date unknow...

journal_title：Neuropeptides

authors： Mangold C,Ksiazek I,Yun SW,Berger E,Binkert C

更新日期：2008-08-01 00:00:00

abstract：:Immunoreactive substance P (SPI) and somatostatin (SOMI) are found in spinal cord but their physiological roles remain speculative. Several classes of neuropeptides, including endogenous opioids and thyrotropin-releasing hormone (TRH), have been implicated in the pathogenesis or recovery from spinal cord injury. In th...

journal_title：Neuropeptides

authors： Faden AI,Jacobs TP,Helke CJ

更新日期：1985-06-01 00:00:00

abstract：:Lysine-vasopressin (LVP) at different concentrations (2 ng, 200 pg) was injected into the lateral ventricle and cisterna magna. The effect on hypothalamic self-stimulation was studied in rats. LVP (2 ng) decreased the self-stimulation rate after intracerebroventricular and cisternal application. Injection of 200 pg LV...

journal_title：Neuropeptides

authors： Günther O,Schwarzberg H

更新日期：1987-11-01 00:00:00

abstract：:Hippocampal neurogenesis is important for modulating the behavioural responses to stress and for certain forms of learning and memory. The mechanisms underlying the necessary coupling of neuronal activity to neural stem/progenitor cell (NSPC) function remain poorly understood. Within the dentate subgranular stem cell ...

journal_title：Neuropeptides

authors： Zaben MJ,Gray WP

更新日期：2013-12-01 00:00:00

abstract：:Neuropeptide Y (NPY) is known to bind to at least two types of receptors (Y1 & Y2). One type (Y2) is able to bind and undergo activation by both NPY and its C-terminal fragments with good potency while the other (Y1) requires the full length of NPY for good potency. For most NPY analogs that have been examined, potenc...

journal_title：Neuropeptides

authors： Krstenansky JL,Owen TJ,Payne MH,Shatzer SA,Buck SH

更新日期：1990-11-01 00:00:00

abstract：:In order to study the morphological localization of the endogenous benzodiazepine ligand octadecaneuropeptide (ODN) in rat brain, we have developed antibodies against this peptide. Using a radioimmunoassay for ODN, we have observed that synthetic ODN and serial dilutions of several brain areas gave parallel displaceme...

journal_title：Neuropeptides

authors： Tonon MC,Désy L,Nicolas P,Vaudry H,Pelletier G

更新日期：1990-01-01 00:00:00

abstract：:Development of transgenic mice overexpressing GH and GHR-KO mice with GH resistance provided novel animal models for study of the somatotropic axis and for identifying GH actions that may be relevant to its current and contemplated use in medicine and agriculture. Studies of phenotypic characteristics of these animals...

journal_title：Neuropeptides

authors： Bartke A,Chandrashekar V,Bailey B,Zaczek D,Turyn D

更新日期：2002-04-01 00:00:00

abstract：:The intracerebrally administered dynorphin-B produced not only an antinociceptive response but a motor dysfunction such as "barrel-rolling", circling, jumping or ataxia in mice. These two effects were observed in a same dose range. Both responses were also produced by a nonopioid fragment, des-Tyr-dynorphin-B. Bestati...

journal_title：Neuropeptides

authors： Nakazawa T,Ikeda M,Kaneko T,Yamatsu K,Kitagawa K,Kiso Y

更新日期：1989-05-01 00:00:00

abstract：:In situ hybridisation histochemistry was used to study the effect of intra-peritoneal reserpine administration on messenger RNA (mRNA) levels in the locus coeruleus (LC) of the rat. 48h after injection, levels of mRNA encoding tyrosine hydroxylase (TH) and neuropeptide Y (NPY) in the LC increased to approximately 250%...

journal_title：Neuropeptides

authors： Foster OJ,Biswas S,Lightman SL

更新日期：1991-03-01 00:00:00

abstract：:Angiotensin I-converting enzyme (ACE) is recognized as one of the main effector molecules involved in blood pressure regulation. In the last few years some polymorphisms of ACE such as the insertion/deletion (I/D) polymorphism have been described, but their physiologic relevance is poorly understood. In addition, few ...

journal_title：Neuropeptides

authors： Almeida SS,Barros CC,Moraes MR,Russo FJ,Haro AS,Rosa TS,Alves MF,Pesquero JB,Carmona AK,Bacurau RF,Araújo RC

更新日期：2010-04-01 00:00:00

abstract：:During neonatal development exogenous oxytocin increases ERalpha immunoreactivity in the hypothalamus of female prairie voles. The purpose of this study was to determine if the increase in ERalpha is associated with an increase in ERalpha mRNA expression and to determine if the effect is specific to ER subtype or if o...

journal_title：Neuropeptides

authors： Pournajafi-Nazarloo H,Carr MS,Papademeteriou E,Schmidt JV,Cushing BS

更新日期：2007-02-01 00:00:00

abstract：:Orexins are neuropeptides that are localized to neurons in the lateral and dorsal hypothalamus but its receptors are distributed to many different regions of the central nervous system. Orexins are implicated in a variety of physiological functions including sleep regulation, energy homeostats, and stress reactions. F...

journal_title：Neuropeptides

authors： Toyama S,Shimoyama N,Shimoyama M

更新日期：2017-02-01 00:00:00

abstract：:Considerable evidence supports the existence of modulatory interactions between cholecystokinin and dopamine in the striatum. In order to explore further the nature of such interactions, the anatomical localization of CCK receptors in rat striatum was investigated autoradiographically following selective lesions. Infu...

journal_title：Neuropeptides

authors： Beresford IJ,Hall MD,Clark CR,Hill RG,Hughes J,Sirinathsinghji DJ

更新日期：1987-08-01 00:00:00

abstract：:Alzheimer's disease (AD) is a progressive neurodegenerative disease that deeply affects patients, their family and society. Although scientists have made intense efforts in seeking the cure for AD, no drug available today is able to stop AD progression. In this context, compounds isolated from animal venom are potenti...

journal_title：Neuropeptides

authors： Camargo LC,Campos GAA,Galante P,Biolchi AM,Gonçalves JC,Lopes KS,Mortari MR

更新日期：2018-02-01 00:00:00

abstract：:Neural stem cells (NSC) could promote the repair after spinal cord transection (SCT), the underlying mechanism, however, still keeps to be defined. This study reported that NSC grafts significantly improved sensory and locomotor functions in adult rats with SCT in acute stage after injury. NSC could survive; different...

journal_title：Neuropeptides

authors： He BL,Ba YC,Wang XY,Liu SJ,Liu GD,Ou S,Gu YL,Pan XH,Wang TH

更新日期：2013-02-01 00:00:00