Neuropeptides and hippocampal neurogenesis.

abstract：:Oxytocin, intraperitoneally injected to 26-month-old male rats 60 min before testing, significantly improved social memory (at doses of 3 and 6 ng/kg) and reduced the duration of immobility in the behavioral despair test (at doses of 50 and 500 micrograms/kg). These results are in agreement with previous data obtained...

journal_title：Neuropeptides

authors： Arletti R,Benelli A,Poggioli R,Luppi P,Menozzi B,Bertolini A

更新日期：1995-09-01 00:00:00

abstract：:Nerve growth factor (NGF) was reported to be increased in the serum and skin of atopic dermatitis (AD) patients, to the extent that serum nerve growth factor levels were proposed to serve as a marker of disease severity. We studied NGF levels in the serum and dermis using skin microdialysis and attempted to correlate ...

journal_title：Neuropeptides

authors： Papoiu AD,Wang H,Nattkemper L,Tey HL,Ishiuji Y,Chan YH,Schmelz M,Yosipovitch G

更新日期：2011-12-01 00:00:00

abstract：:Cholecystokinin (CCK) is co-localized with dopamine (DA) in mesolimbic neurons of the CNS and appears to selectively regulate the output of this system. In an attempt to characterize the nature of CCK interactions with mesolimbic DA-containing nerve terminals, we have investigated CCK regulation of [3H]DA overflow fro...

journal_title：Neuropeptides

authors： Vickroy TW,Bianchi BR

更新日期：1989-01-01 00:00:00

abstract：:The relative roles of hypothalamic corticotropin-releasing-hormone (CRH) and vasopressin (AVP) as mediators of the stimulant effect of vasoactive intestinal peptide (VIP) and peptide histidine isoleucine (PHI) on ACTH and corticosterone (CORT) secretion, were examined using receptor blockade of endogenous CRH and AVP....

journal_title：Neuropeptides

authors： Alexander LD,Sander LD

更新日期：1995-03-01 00:00:00

abstract：:Desensitization is induced by the repeated administration of high doses of substance P (SP) or hemokinin-1 (HK-1). However, little information is available about the mechanisms involved in the induction of desensitization by these peptides. Thus, to characterize this desensitization, we examined the dose-dependent eff...

journal_title：Neuropeptides

authors： Naono R,Nakayama T,Ikeda T,Matsusima O,Nishimori T

更新日期：2008-02-01 00:00:00

abstract：:Neuropeptide Y (NPY) is a 36 amino acid peptide, which among others, plays a pivotal role in stress response. Although previous studies confirmed that NPY release is increased by stress in several species, the exact mechanism of the stress-induced NPY release has not been elucidated yet. In the present study, we exami...

journal_title：Neuropeptides

authors： Ko L,Rotoli G,Grignol G,Hu W,Merchenthaler I,Dudas B

更新日期：2011-06-01 00:00:00

abstract：:There is now unequivocal evidence that the angiotensin-converting enzyme 2(ACE2)-Ang-(1-7)-Mas axis is a key component of the renin-angiotensin system (RAS) cascade, which is closely correlated with ischemic insult occurrence. Our previous studies demonstrated that the Ang-(1-7), was an active member of the brain RAS....

journal_title：Neuropeptides

authors： Lu J,Jiang T,Wu L,Gao L,Wang Y,Zhou F,Zhang S,Zhang Y

更新日期：2013-10-01 00:00:00

abstract：:Brain insulin receptors adsorb to and are recoverable from wheat germ agglutinin-agarose (WGA) columns. Similar results are obtained using dissuccinimidyl suberate (DSS)-crosslinked receptors or photo-affinity labeled receptors. WGA can be used for partial purification of brain insulin receptors provided the appropria...

journal_title：Neuropeptides

authors： Shemer J,LeRoith D

更新日期：1987-01-01 00:00:00

abstract：:Lysine-vasopressin (LVP) at different concentrations (2 ng, 200 pg) was injected into the lateral ventricle and cisterna magna. The effect on hypothalamic self-stimulation was studied in rats. LVP (2 ng) decreased the self-stimulation rate after intracerebroventricular and cisternal application. Injection of 200 pg LV...

journal_title：Neuropeptides

authors： Günther O,Schwarzberg H

更新日期：1987-11-01 00:00:00

abstract：:In this study, we examined whether the mechanisms mediating the induction of grooming behavior by oxytocin (OT) is similar to mechanisms mediating the effects of OT on uterine contractility. Sprague-Dawley strain female rats were injected intracerebroventricularly (ICV) with OT or OT analogues and then were observed f...

journal_title：Neuropeptides

authors： Caldwell JD,Hruby VJ,Hill P,Prange AJ Jr,Pedersen CA

更新日期：1986-07-01 00:00:00

abstract：:Possible positive reinforcing and aversive effects of intraperitoneally (ip) administered substance P (SP) and its C-terminal heptapeptide analog [pGlu5, MePhe8, Sar9]-SP5-11 (DIME-C7) were investigated in rats. The 'conditioned corral preference and avoidance procedure' was used for assessing positive and negative re...

journal_title：Neuropeptides

authors： Hasenöhrl RU,Gerhardt P,Huston JP

更新日期：1990-12-01 00:00:00

abstract：:Galanin, a 29 residue peptide found in the hypothalamus, causes orexigenic effects in a variety of species. In the present study, we investigated appetite-associated effects of galanin in chicks from lines which have been selected from a common founder population for either low or high body weight. The low line consis...

journal_title：Neuropeptides

authors： Hagen CJ,Newmyer BA,Webster RI,Gilbert ER,Siegel PB,Tachibana T,Cline MA

更新日期：2013-08-01 00:00:00

abstract：:In vitro structure-activity studies with cholecystokinin (CCK)/gastrin-related peptides, including C- and N-terminal fragments of CCK 26-33, were undertaken in guinea pig gallbladder and ileum. The general order of potency in both smooth muscle preparations is CCK 26-33 greater than CCK 1-33 greater than 27-33 much mu...

journal_title：Neuropeptides

authors： Gaudreau P,St-Pierre S,Pert CB,Quirion R

更新日期：1987-07-01 00:00:00

abstract：:Our previous studies showed the modulation of cocaine and amphetamine regulated transcript (CART) positive neurons and CART mRNA by adrenalectomy and corticosterone replacement in hypothalamic nuclei of male rat brain. More recently, we have shown by CART immunohistochemistry that restraint and forced swim (FS) stress...

journal_title：Neuropeptides

authors： Balkan B,Gozen O,Yararbas G,Koylu EO,Akinturk S,Kuhar MJ,Pogun S

更新日期：2006-06-01 00:00:00

abstract：:We have developed an extraction method and radioimmunoassay for the measurement of interleukin-1 beta (IL-1 beta) in rat tissues, using an antibody specific for IL-1 beta, IL-1 beta was detected in the spleen and thymus of control rats. Adrenalectomy (ADX) had no effect upon control levels of IL-1 beta. In animals wit...

journal_title：Neuropeptides

authors： Jessop DS,Chowdrey HS,Lightman SL

更新日期：1993-06-01 00:00:00

abstract：:Social conflict and defeat in mice leads to an activation of endogenous opiate systems. The effects of intracerebroventricular administration of the peptide FMRFamide (Phe-Met-Arg-Phe-NH2) and the opiate antagonist naloxone, on aggressive encounters, defeat-induced analgesia and defeat-induced feeding were examined in...

journal_title：Neuropeptides

authors： Kavaliers M,Hirst M

更新日期：1985-12-01 00:00:00

abstract：:The neuropharmacological actions of the agonist analog D-Trp-6-LH-RH were investigated in several tests after subcutaneous administrations to male mice. The doses applied were in the range 1-1000 micrograms/kg. D-Trp-6-LH-RH doses of 10 micrograms/kg and higher induced significant analgesic effects in the hot-plate an...

journal_title：Neuropeptides

authors： Kádár T,Telegdy G,Schally AV

更新日期：1990-10-01 00:00:00

abstract：:After chronic treatment with morphine, the muscular rigidity mediated by opioid receptors in the striatum, was gradually replaced by stereotypic behaviour indicating an increased nigrostriatal dopaminergic activity. These results suggest that one behavioural pattern, originating in the striatum, was replaced by anothe...

journal_title：Neuropeptides

authors： Themann P,Havemann U,Kuschinsky K

更新日期：1984-12-01 00:00:00

abstract：:Pituitary adenylate cyclase-activating polypeptide (PACAP-27) was incubated in a tyrosine hydroxylase (TyrOH) assay with a homogenate preparation of the nucleus accumbens of the rat. TyrOH activity was determined in vitro by measuring the production of L-dopa with HPLC-ECD. Only in the presence of adenosine nucleotide...

journal_title：Neuropeptides

authors： Moser A,Scholz J,Gänsle A

更新日期：1999-12-01 00:00:00

abstract：:Superfusion of the dorsal surface of the septum with artificial cerebrospinal fluid containing 10(-10) M [Arg8]-vasopressin (VP) significantly increased the negative (N) wave in field potentials (FPs) elicited in the lateral septum (LS) of rats by stimulation of the fimbria-fornix. A similar increase in the FPs negati...

journal_title：Neuropeptides

authors： Urban IJ,De Wied D

更新日期：1986-01-01 00:00:00

abstract：:DPDPE ([D-Pen2, D-Pen5]-Enkephalin) and DPLPE ([D-Pen2, L-Pen5]-Enkephalin) are conformationally-constrained cyclic analogs of enkephalin with high selectivity for delta opioid receptors. Intracerebroventricular (i.c.v.) administration of each analog acutely produces a complex EEG response in rats characterized by a d...

journal_title：Neuropeptides

authors： Tortella FC,Robles L,Mosberg HI,Holaday JW

更新日期：1984-12-01 00:00:00

abstract：:This study investigated the nature of the cholecystokinin-like immunoreactivity (CCKLI) in the dorsal horn of the rat spinal cord. Indeed, using the same antiserum, no variation of radioimmunoassayable CCKLI in the dorsal horn of rats treated neonatally with capsaicin could be seen, whereas the density of immunoreacti...

journal_title：Neuropeptides

authors： Zouaoui D,Benoliel JJ,Conrath M,Cesselin F

更新日期：1990-12-01 00:00:00

abstract：:Attempts have been made to confirm reports that naloxonazine and Mr2034 are able to selectively antagonise morphine-induced analgesia and respiratory depression respectively. In the present studies these antagonists proved to be equi-effective against both the analgesic and respiratory depressant effects of morphine, ...

journal_title：Neuropeptides

authors： Rourke JD,Shaw JS

更新日期：1984-12-01 00:00:00

abstract：:Our previous study showed that intracerebroventricular (ICV) administration of corticotropin-releasing hormone (CRH) produced a significant increase in locomotor activity at a dose of 1 microgram and slow stereotypy with prominent grooming at a dose of 10 micrograms. In addition, the ICV administration of CRH caused a...

journal_title：Neuropeptides

authors： Takamatsu Y,Yamamoto H,Ogunremi OO,Matsuzaki I,Moroji T

更新日期：1991-12-01 00:00:00

abstract：:Chronic stress induces the activation of hippocampal microglia, which produces many inflammatory mediators and mediates the occurrence of depression. Two phenotypes of microglia polarization, the classical M1 and alternative M2, play important regulatory roles in neuroinflammation and are involved in the occurrence an...

journal_title：Neuropeptides

authors： Zhou S,Chen S,Xie W,Guo X,Zhao J

更新日期：2020-06-01 00:00:00

abstract：:The distribution of beta-endorphin (1-27) immunoreactive cell bodies and fibres was studied in the diencephalon of the cat using an indirect immunoperoxidase technique. In the thalamus, almost all the immunoreactive fibres were found in the midline region and in nuclei located near the midline, whereas in the hypothal...

journal_title：Neuropeptides

authors： Coveñas R,de León M,Narváez JA,Tramu G,Aguirre JA,González-Barón S

更新日期：1996-06-01 00:00:00

abstract：:Release of [3H]-acetylcholine (3H-ACh) and muscle contractions in response to cholecystokinin (CCK) were measured and recorded simultaneously from isolated guinea-pig gallbladder. Cholecystokinin octapeptide (CCK8) (10(-10)-10(-7) M) enhanced the release of [3H]ACh and the contractions of the muscle. TTX (10(-6) M) in...

journal_title：Neuropeptides

authors： Rakovska A,Sgaragli G,Mantovani P,Valoti M,Milenov K

更新日期：1993-11-01 00:00:00

abstract：:Exercise at different intensities is able to induce different physical and psychological statuses of the subjects. The β-endorphin (β-EP) in central nervous system is thought to play an important role in physical exercise. However, its expression patterns and physiological effects in the central nuclei under different...

journal_title：Neuropeptides

authors： Xue L,Sun J,Zhu J,Ding Y,Chen S,Ding M,Pei H

更新日期：2020-08-01 00:00:00

abstract：:We have evaluated the peripheral blood natural killer (NK) cell activity and the in vitro effect of recombinant gamma-interferon (r gamma-IFN) on NK cell activity in 23 patients with a neuroendocrine tumour of the pancreas, small intestine or liver, and 23 healthy controls. Patients with a gastrinoma showed a NK cell ...

journal_title：Neuropeptides

authors： Aparicio-Pagés MN,Verspaget HW,Peña AS,Jansen JB,Lamers CB

更新日期：1991-09-01 00:00:00

abstract：:Germline ablation of VGF, a secreted neuronal, neuroendocrine, and endocrine peptide precursor, results in lean, hypermetabolic, and infertile adult mice that are resistant to diet-, lesion-, and genetically-induced obesity and diabetes (Hahm et al., 1999, 2002). To assess whether this phenotype is predominantly drive...

journal_title：Neuropeptides

authors： Jiang C,Lin WJ,Sadahiro M,Shin AC,Buettner C,Salton SR

更新日期：2017-08-01 00:00:00