Failure to demonstrate mu-isoreceptors.

abstract：:Cholecystokinin (CCK) is co-localized with dopamine (DA) in mesolimbic neurons of the CNS and appears to selectively regulate the output of this system. In an attempt to characterize the nature of CCK interactions with mesolimbic DA-containing nerve terminals, we have investigated CCK regulation of [3H]DA overflow fro...

journal_title：Neuropeptides

authors： Vickroy TW,Bianchi BR

更新日期：1989-01-01 00:00:00

abstract：:The effects of several protein modifying reagents, including phenoxybenzamine, N-ethylmaleimide (NEM), 5,5'-dithiobis (2-nitro)--benzoic acid (DTNB), p-chloromercuryphenyl sulfonic acid (PCMP) and p-bromophenacylbromide (PBPB), on the binding of 125I-Bolton Hunter substance P (125I-BHSP), 125I-Bolton Hunter eledoisin ...

journal_title：Neuropeptides

authors： Bergström L,Beaujouan JC,Torrens Y,Saffroy M,Glowinski J

更新日期：1987-02-01 00:00:00

abstract：:Neuropeptide Y (NPY) potentiates noradrenaline (NA)-evoked constriction of circular segments of the rabbit femoral artery. The potentiation occurs exclusively in the lower concentration-range of the agonist NA (10(-8)-3 x 10(-7) M) without any change in maximum contractile effect. NPY per se is without contractile eff...

journal_title：Neuropeptides

authors： Adamsson M,Edvinsson L

更新日期：1991-05-01 00:00:00

abstract：:Enkephalin-immunoreactive neurons have been identified in the central nervous system of the fruit fly Drosophila melanogaster by immunocytochemical techniques. Analyses of fly extracts by high performance liquid chromatography and radioimmunoassay show a relatively complex pattern of immunoreactive compounds. The most...

journal_title：Neuropeptides

authors： Pagés M,Jiménez F,Ferrús A,Peralta E,Ramírez G,Gelpí E

更新日期：1983-12-01 00:00:00

abstract：:In our previous study we have identified PACAP, VIP and their receptors in rat malignant peripheral nerve sheath tumor (MPNST) cells, thus showing anti-apoptotic roles. Recently it has been shown that the tumor suppressor neurofibromin, encoded by the Neurofibromatosis type I (NF1) gene, promotes MPNST cells sensitivi...

journal_title：Neuropeptides

authors： Giunta S,Castorina A,Adorno A,Mazzone V,Carnazza ML,D'Agata V

更新日期：2010-02-01 00:00:00

abstract：:6-Beta-fluoro-6-desoxy-oxymorphone (FOXY) is a fluorinated derivative of oxymorphone originally developed as a potential PET scanning ligand. Preliminary work (Rothman et al., Neuropeptides 4: 311-317, 1984) demonstrated that [3H]FOXY selectively labeled mu opioid binding sites with low levels of nonspecific binding. ...

journal_title：Neuropeptides

authors： Rothman RB,Bykov V,Rice KC,Jacobson AE,Kooper GN,Bowen WD

更新日期：1988-01-01 00:00:00

abstract：:We have developed an extraction method and radioimmunoassay for the measurement of interleukin-1 beta (IL-1 beta) in rat tissues, using an antibody specific for IL-1 beta, IL-1 beta was detected in the spleen and thymus of control rats. Adrenalectomy (ADX) had no effect upon control levels of IL-1 beta. In animals wit...

journal_title：Neuropeptides

authors： Jessop DS,Chowdrey HS,Lightman SL

更新日期：1993-06-01 00:00:00

abstract：:The effect of opioid peptide, D-alanine2-leucine-enkephalin and opioid homolog peptide, des-tyrosine-methionine-enkephalin in concentrations of 1 x 10(-6) and 1 x 10(-5) M was investigated on the action potential parameters of frog sciatic nerve. Des-tyrosine-methionine-enkephalin was used as the control to prove the ...

journal_title：Neuropeptides

authors： Camlica Y,Aşkin A,Cömelekoğlu U

更新日期：2004-04-01 00:00:00

abstract：:Noradrenaline (NA) has been implicated in both increase and reduction of anxiety. Selective destruction of nerve endings of the locus coeruleus projections by DSP-4 has been shown to reduce active behaviour in novel situations by enhancing anxiety. In the present study, DSP-4 (50 mg/kg) treatment reduced locomotor act...

journal_title：Neuropeptides

authors： Kask A,Eller M,Oreland L,Harro J

更新日期：2000-02-01 00:00:00

abstract：:The hypocretins/orexins (hcrts) are two recently described neuropeptides derived from the same precursor and expressed in a few thousand neurons in the perifornical area of the lateral hypothalamus, which project throughout the brain. The hypocretins bind to two G-protein coupled receptors with different selective aff...

journal_title：Neuropeptides

authors： de Lecea L,Sutcliffe JG,Fabre V

更新日期：2002-04-01 00:00:00

abstract：:Hippocampal neurogenesis is important for modulating the behavioural responses to stress and for certain forms of learning and memory. The mechanisms underlying the necessary coupling of neuronal activity to neural stem/progenitor cell (NSPC) function remain poorly understood. Within the dentate subgranular stem cell ...

journal_title：Neuropeptides

authors： Zaben MJ,Gray WP

更新日期：2013-12-01 00:00:00

abstract：:D-Arg containing dipeptides, H-Tyr-D-Arg-OMe and H-Tyr (Et)-D-Arg-OMe, and D-Arg2 substituted N-terminal tetrapeptides of dermorphin, H-Tyr-D-Arg-Phe-Gly-OEt and H-Tyr (Et)-D-Arg-Phe-Gly-OEt administered intracerebroventricularly exhibited dose-dependent antinociceptive activities in mice as measured by the tail press...

journal_title：Neuropeptides

authors： Sato T,Sakurada S,Sakurada T,Furuta S,Nakata N,Kisara K,Sasaki Y,Suzuki K

更新日期：1984-06-01 00:00:00

abstract：:Using the latency for tail-flick after thermal stimulation we have assessed the effects of alpha-, gamma(1)- and gamma(2)-MSH on nociceptive threshold in the mice. Intracisternal injections of gamma(2)-MSH induced a distinct analgesia, while gamma(1)-MSH in the same doses gave only a minor analgesia. Intracisternal al...

journal_title：Neuropeptides

authors： Klusa V,Germane S,Svirskis S,Opmane B,Wikberg JE

更新日期：2001-02-01 00:00:00

abstract：:Our previous studies showed the modulation of cocaine and amphetamine regulated transcript (CART) positive neurons and CART mRNA by adrenalectomy and corticosterone replacement in hypothalamic nuclei of male rat brain. More recently, we have shown by CART immunohistochemistry that restraint and forced swim (FS) stress...

journal_title：Neuropeptides

authors： Balkan B,Gozen O,Yararbas G,Koylu EO,Akinturk S,Kuhar MJ,Pogun S

更新日期：2006-06-01 00:00:00

abstract：:Development of transgenic mice overexpressing GH and GHR-KO mice with GH resistance provided novel animal models for study of the somatotropic axis and for identifying GH actions that may be relevant to its current and contemplated use in medicine and agriculture. Studies of phenotypic characteristics of these animals...

journal_title：Neuropeptides

authors： Bartke A,Chandrashekar V,Bailey B,Zaczek D,Turyn D

更新日期：2002-04-01 00:00:00

abstract：:The effects of a potent serine protease inhibitor, Boc-D-Phe-Pro-Arg-H, on the secretion and content of ACTH and beta-endorphin-like immunoreactivities of cultured rat anterior pituitary cells were studied. Basal release of the hormones was not affected by the drug but secretion in response to stalk-median eminence ex...

journal_title：Neuropeptides

authors： Barna I,Gráf L,Makara GB,Rappay G

更新日期：1982-10-01 00:00:00

abstract：:Lumbar disc herniation is a common cause of radicular pain, but the mechanism remains ambiguous and the treatment stays unsatisfied. Many studies revealed a traditional Chinese medicine puerarin may moderate chronic pain from diabetes and nerve injury. Thus far, the role and mechanism of puerarin in radicular pain is ...

journal_title：Neuropeptides

authors： Zhong Y,Huang YL,Hu YM,Zhu LR,Zhao YS

更新日期：2018-12-01 00:00:00

abstract：:Dynorphins are important neuropeptides with a central role in nociception and pain alleviation. Many mechanisms regulate endogenous dynorphin concentrations, including proteolysis. Proprotein convertases (PCs) are widely expressed in the central nervous system and specifically cleave at C-terminal of either a pair of ...

journal_title：Neuropeptides

authors： Orduna AR,Beaudry F

更新日期：2016-06-01 00:00:00

abstract：:Regulation of cholecystokinin (CCK) expression was studied in the human neuroepithelioma cell line SK-N-MCIXC and the rat medullary thyroid carcinoma cell line WE 4/2. The cells were treated with the beta-adrenergic agonist isoproterenol and retinoic acid, a natural derivative of vitamin A, which plays a role in cell ...

journal_title：Neuropeptides

authors： Mania-Farnell BL,Botros IW,Davis TP

更新日期：1995-10-01 00:00:00

abstract：:Morphine (M) produced a dose-related decrease in metabolic weight loss (MWL) over a three-hour period, despite the fact that it significantly enhanced locomotor activity in male mice. This conservation of energy was specific to opioid receptors because naltrexone HCl (N) blocked it. These receptors were localized main...

journal_title：Neuropeptides

authors： Henry LJ,Walker J,Margules DL

更新日期：1985-02-01 00:00:00

abstract：:The neurokinin-1 (NK-1) receptor interacts with peptides that belong to the tachykinin family. NK-1 is inducible in bone marrow (BM) stroma. In neural cells, its expression is high to constitutive. Screening of three cDNA libraries indicated that this different in NK-1 expression in neural and BM cells could not be ex...

journal_title：Neuropeptides

authors： Bandari PS,Qian J,Yehia G,Seegopaul HP,Harrison JS,Gascon P,Fernandes H,Rameshwar P

更新日期：2002-02-01 00:00:00

abstract：:Brain insulin receptors adsorb to and are recoverable from wheat germ agglutinin-agarose (WGA) columns. Similar results are obtained using dissuccinimidyl suberate (DSS)-crosslinked receptors or photo-affinity labeled receptors. WGA can be used for partial purification of brain insulin receptors provided the appropria...

journal_title：Neuropeptides

authors： Shemer J,LeRoith D

更新日期：1987-01-01 00:00:00

abstract：:The effects of acute and chronic treatment with LSD and acute treatment with mescaline, m-CPP, citalopram and fenfluramine on leu-enkephalin (LENK) content in rat brain were examined. The acute LSD treatment was found to decrease and chronic treatment to increase the LENK content in the frontal cortex. In the thalamus...

journal_title：Neuropeptides

authors： Kmieciak-Kołada K,Kowalski J

更新日期：1986-05-01 00:00:00

abstract：:In rats anaesthetized with urethane single unit activity was extracellularly recorded in the neostriatum, and several drugs were microiontophoretically ejected. Separate administration of the sulfated octapeptide cholecystokinin (CCK-8S), serotonin (5-HT) or 8-OH-DPAT (a 5-HT(1A/7) receptor agonist) predominantly indu...

journal_title：Neuropeptides

authors： Wilms K,Vierig G,Davidowa H

更新日期：2001-10-01 00:00:00

abstract：:Here we report that chicken pineal membranes express high affinity receptors for Vasoactive Intestinal Peptide (VIP), as revealed by competitive displacement analysis of [3-iodotyrosyl-125I]-VIP by native VIP. These binding sites were further characterized by covalent cross-linking of radioiodinated VIP to chicken pin...

journal_title：Neuropeptides

authors： Meunier AC,Voisin P,Van Camp G,Cenatiempo Y,Muller JM

更新日期：1991-05-01 00:00:00

abstract：:Since there are conflicting reports regarding the effects of somatostatin (SS) on cyclic AMP levels in astrocytes derived from rat cerebral cortex and, to date, the SS binding to mature astrocytes is unknown, the present study has determined SS binding and its effect on cyclic AMP accumulation in a fresh astrocyte-ric...

journal_title：Neuropeptides

authors： Colás B,Arilla E,Prieto JP

更新日期：1992-09-01 00:00:00

abstract：:The human placenta contains membrane bound opioid receptors. The binding of the antagonist naloxone and the fairly kappa-selective agonist EKC were studied in the microvillous membrane fraction. In both cases high affinity binding sites were detected with Kd values in the nanomolar range. A series of kappa-selective l...

journal_title：Neuropeptides

authors： Agbas A,Simon J,Avni Oktem H,Varga E,Borsodi A

更新日期：1988-10-01 00:00:00

abstract：:Intrathecal administration of VIP to the thoracic spinal cord in the urethane anaesthetized rat provoked a dose-dependent increase in heart rate without any change in arterial pressure. The cardioacceleration observed following administration of 6.5 nmol of VIP at the T9 level (n = 8) occurred within 1-2 min of admini...

journal_title：Neuropeptides

authors： Rochford J,Henry JL

更新日期：1989-11-01 00:00:00

abstract：:Galanin (GAL) is known to stimulate feeding behavior. This peptide has different properties and functions from other feeding stimulants, e.g., neuropeptide Y and agouti-related protein. Hypothalamic GAL is relatively unresponsive to food deprivation and to changes in corticosterone, glucose utilization, dietary carboh...

journal_title：Neuropeptides

authors： Leibowitz SF

更新日期：2005-06-01 00:00:00

abstract：:In order to further test whether or not psychostimulant drugs activate CART peptide-containing cells in the nucleus accumbens, we examined the fraction of CART positive cells that co-immunostained for c-Fos after administration of saline or cocaine (10 and 25 mg/kg i.p.). There was about a 45% increase in the fraction...

journal_title：Neuropeptides

authors： Hubert GW,Kuhar MJ

更新日期：2008-06-01 00:00:00