Abstract:
:Here we report that chicken pineal membranes express high affinity receptors for Vasoactive Intestinal Peptide (VIP), as revealed by competitive displacement analysis of [3-iodotyrosyl-125I]-VIP by native VIP. These binding sites were further characterized by covalent cross-linking of radioiodinated VIP to chicken pineal cell membranes, using dithiobis(succinimidylpropionate) as a cross-linking reagent. Sodium dodecyl sulfate electrophoresis after solubilization of the cross-linked membranes, reveals the existence of two polypeptides, P1 and P2, with a similar labelling intensity and apparent molecular weights of Mr = 57,000 and Mr = 70,000 respectively. These two components behave like high affinity binding sites for VIP.
journal_name
Neuropeptidesjournal_title
Neuropeptidesauthors
Meunier AC,Voisin P,Van Camp G,Cenatiempo Y,Muller JMdoi
10.1016/0143-4179(91)90066-rkeywords:
subject
Has Abstractpub_date
1991-05-01 00:00:00pages
1-8issue
1eissn
0143-4179issn
1532-2785journal_volume
19pub_type
杂志文章相关文献
NEUROPEPTIDES文献大全abstract::The effect of opioid peptide, D-alanine2-leucine-enkephalin and opioid homolog peptide, des-tyrosine-methionine-enkephalin in concentrations of 1 x 10(-6) and 1 x 10(-5) M was investigated on the action potential parameters of frog sciatic nerve. Des-tyrosine-methionine-enkephalin was used as the control to prove the ...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/j.npep.2004.03.003
更新日期:2004-04-01 00:00:00
abstract::The present study was undertaken to determine whether neurotensin is involved in the regulation of the intestinal postprandial motor response and, if so, whether the regulatory pathway depends upon peripheral or central neurotensin secretion. Neurotensin, injected by the i.v. route (5 micrograms/kg) during the fasting...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/s0143-4179(96)90002-5
更新日期:1996-10-01 00:00:00
abstract::The relative roles of hypothalamic corticotropin-releasing-hormone (CRH) and vasopressin (AVP) as mediators of the stimulant effect of vasoactive intestinal peptide (VIP) and peptide histidine isoleucine (PHI) on ACTH and corticosterone (CORT) secretion, were examined using receptor blockade of endogenous CRH and AVP....
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(95)90112-4
更新日期:1995-03-01 00:00:00
abstract::Stretching-yawning syndrome (SYS) and penile erections (PE) are typical components of the behavioral picture induced by intracerebroventricular (i.c.v.) injection of ACTH 1-24. The present study shows that pretreatment with alpha-difluoromethylornithine (DFMO), and irreversible inhibitor of mammalian ornithine decarbo...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(84)90105-7
更新日期:1984-05-01 00:00:00
abstract::Fracture repair is a complex yet well orchestrated regenerative process involving numerous signaling and cell types including osteoblasts. Here we showed that NPY, a neurotransmitter with regulatory functions in bone homeostasis, may contribute to the post-fracture bone healing in patients with traumatic brain injury-...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/j.npep.2016.09.005
更新日期:2016-12-01 00:00:00
abstract::The effects of a potent serine protease inhibitor, Boc-D-Phe-Pro-Arg-H, on the secretion and content of ACTH and beta-endorphin-like immunoreactivities of cultured rat anterior pituitary cells were studied. Basal release of the hormones was not affected by the drug but secretion in response to stalk-median eminence ex...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(82)90066-x
更新日期:1982-10-01 00:00:00
abstract::CSF methionine and leucine enkephalins were measured by high performance liquid chromatography and radioimmunoassay in diabetic patients with painful neuropathy (n = 22) and painless neuropathy (n = 5), and non-diabetic subjects with low back pain (n = 11). Wide variations in CSF enkephalin levels were found and they ...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(92)90067-7
更新日期:1992-06-01 00:00:00
abstract::D-Arg containing dipeptides, H-Tyr-D-Arg-OMe and H-Tyr (Et)-D-Arg-OMe, and D-Arg2 substituted N-terminal tetrapeptides of dermorphin, H-Tyr-D-Arg-Phe-Gly-OEt and H-Tyr (Et)-D-Arg-Phe-Gly-OEt administered intracerebroventricularly exhibited dose-dependent antinociceptive activities in mice as measured by the tail press...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(84)90001-5
更新日期:1984-06-01 00:00:00
abstract::Nociceptin-opioid peptide (NOP) receptor, also known as opioid receptor like-1 (ORL1), was identified following the cloning of the kappa-opioid peptide (KOP) receptor, and the characterization of these receptors revealed high homology. The endogenous ligand of NOP, nociceptin (NOC), which shares high homology to dynor...
journal_title:Neuropeptides
pub_type: 杂志文章,评审
doi:10.1016/j.npep.2011.03.002
更新日期:2011-08-01 00:00:00
abstract::In critical patients, sepsis-induced muscle wasting is considered to be an important contributor to complications and mortality. Previous work mainly focuses on the peripheral molecular mechanism of muscle degradation, however little evidence exists for the role of central nervous system in the process. In the present...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/j.npep.2014.10.002
更新日期:2014-12-01 00:00:00
abstract::Our previous study showed that intracerebroventricular (ICV) administration of corticotropin-releasing hormone (CRH) produced a significant increase in locomotor activity at a dose of 1 microgram and slow stereotypy with prominent grooming at a dose of 10 micrograms. In addition, the ICV administration of CRH caused a...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(91)90016-c
更新日期:1991-12-01 00:00:00
abstract::Acid extracts from mouse Neuroblastoma x rat Glioma hybrid cells have been purified by means of Sep-Pak C-18 and fractionated by high performance liquid chromatography. Each fraction has been submitted to a sensitive beta-endorphin radioimmunoassay and an immunoreactivity peak at camel beta-endorphin retention time wa...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(85)90130-1
更新日期:1985-03-01 00:00:00
abstract::Specific antagonists were used to determine NK1 and NK2 receptor mediation of the expression of c-Jun and c-Fos inducible transcription factors. (ITFs) in dorsal horn neurons. The induction of c-Jun by C-fiber stimulation was strongly reduced in the superficial laminae by NK1 and NK2 antagonists, but only weakly in th...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1054/npep.1999.0005
更新日期:1999-04-01 00:00:00
abstract::Galanin and the N-terminal fragment Galanin(1-15) are involved in central cardiovascular regulation. The present paper reviews the recent cardiovascular results obtained by intracisternal injections of Galanin and Galanin(1-15) showing that: (A) the Galanin antagonist M40 blocks the central cardiovascular responses in...
journal_title:Neuropeptides
pub_type: 杂志文章,评审
doi:10.1016/j.npep.2004.12.009
更新日期:2005-06-01 00:00:00
abstract::The present study is designed to elucidate the involvement of neuronal mechanisms in corticotropin-releasing factor (CRF)-induced anti-oedema effects. Oedema was induced in the rat hind paw by subcutaneous injection of 3 nmol of serotonin (5-HT). A single dose of CRF (9.4, 37.5 or 75 pmol) was given either ipsilateral...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1054/npep.2000.0800
更新日期:2000-04-01 00:00:00
abstract::The aim of the present investigation was to determine if chronic activation of kappa-opioid receptor induces development of tolerance and dependence to kappa-opioid agonists on the isolated right atrium of the rat. Tolerance to the kappa-agonist was induced by chronic administration of U-50,488H, a selective kappa-ago...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/s0143-4179(97)90047-0
更新日期:1997-10-01 00:00:00
abstract::In situ hybridisation histochemistry was used to study the effect of intra-peritoneal reserpine administration on messenger RNA (mRNA) levels in the locus coeruleus (LC) of the rat. 48h after injection, levels of mRNA encoding tyrosine hydroxylase (TH) and neuropeptide Y (NPY) in the LC increased to approximately 250%...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(91)90105-r
更新日期:1991-03-01 00:00:00
abstract::[3H]-Dynorphin A (1-8) was degraded in brain homogenates at 25 degrees and even at 0 degree C. The peptidase inhibitors bestatin and captopril almost completely protected[3H]-dynorphin A (1-8) from degradation at 0 degree C but had only little effect on binding at this temperature. At 25 degrees C, the binding of [3H]...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(85)90072-1
更新日期:1985-02-01 00:00:00
abstract::Oxytocin, either intraperitoneally injected (200 ng/rat) or intracerebroventricularly infused (1 ng/rat in 4 microliters saline) 60 and 15 min respectively before testing, significantly increased the lordosis response to the mounting male of ovariectomized, estrogen/progesterone treated rats. The intracerebroventricul...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(85)90095-2
更新日期:1985-06-01 00:00:00
abstract::Pituitary adenylate cyclase-activating polypeptide (PACAP-27) was incubated in a tyrosine hydroxylase (TyrOH) assay with a homogenate preparation of the nucleus accumbens of the rat. TyrOH activity was determined in vitro by measuring the production of L-dopa with HPLC-ECD. Only in the presence of adenosine nucleotide...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1054/npep.1999.0768
更新日期:1999-12-01 00:00:00
abstract::Nociceptin/Orphanin FQ (N/OFQ) is a 17-amino acid peptide that binds to the nociceptin receptor (NOP). N/OFQ and NOP receptors are expressed in numerous brain areas. The generation of specific agonists, antagonists and receptor-deficient mice or rats has enabled progress in elucidating the biological functions of N/OF...
journal_title:Neuropeptides
pub_type: 杂志文章,评审
doi:10.1016/j.npep.2015.03.005
更新日期:2015-04-01 00:00:00
abstract::We have evaluated the peripheral blood natural killer (NK) cell activity and the in vitro effect of recombinant gamma-interferon (r gamma-IFN) on NK cell activity in 23 patients with a neuroendocrine tumour of the pancreas, small intestine or liver, and 23 healthy controls. Patients with a gastrinoma showed a NK cell ...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(91)90033-f
更新日期:1991-09-01 00:00:00
abstract:OBJECTIVE:Potential physiological correlates of stress and the role of stress neuropeptides, other than those of the hypothalamic-pituitary-adrenal axis, in critical illness have not been addressed. We investigated: (a) serum levels of stress neuropeptides (ACTH, substance P (SP), neuropeptide Y (NPY), cortisol, prolac...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/j.npep.2012.07.007
更新日期:2013-02-01 00:00:00
abstract::The desire of the pharmaceutical industry to obtain more selective agents for the treatment of anxiety with fewer or diminished side effects and a profile consistent with safety during long-term use resulted in a search which has identified the azapirones as a new class of anxiolytics which lack structural or biochemi...
journal_title:Neuropeptides
pub_type: 临床试验,杂志文章,评审
doi:10.1016/0143-4179(91)90078-w
更新日期:1991-07-01 00:00:00
abstract::Nesfatin-1, a newly discovered satiety peptide, has recently been reported to be involved in the stress response. Stress-induced expression of nesfatin-1 has been reported and few studies focus on its expression in the hypothalamus, which is the center of the stress response. To test our hypothesis that peripheral and...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/j.npep.2015.08.003
更新日期:2015-12-01 00:00:00
abstract::PTHrP and its receptor PTHR1 are found in the CNS and peripheral nervous system. The presence of PTHrP mRNA has been detected in the superior cervical ganglion (SCG), but there are no data on the cellular distribution of PTHrP and PTHR1 in the SCG. Although it is known that ovarian activity and reproductive status inf...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/j.npep.2014.09.005
更新日期:2014-12-01 00:00:00
abstract::The level of opioid peptides in several brain areas and in the pituitary was estimated in WAG/Rij rats, which are considered to be a genetic animal model for human absence epilepsy. In comparison with three groups of non-epileptic controls, these epileptic rats had an elevated level of the proenkephalin-derived peptid...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(92)90037-w
更新日期:1992-03-01 00:00:00
abstract::Neuropeptide Y (NPY) is a 36 amino acid peptide, which among others, plays a pivotal role in stress response. Although previous studies confirmed that NPY release is increased by stress in several species, the exact mechanism of the stress-induced NPY release has not been elucidated yet. In the present study, we exami...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/j.npep.2011.02.001
更新日期:2011-06-01 00:00:00
abstract::The effects of FMRFamide on passive avoidance behaviour and electroshock-induced amnesia following intracerebroventricular administration were studied in rats. FMRFamide given immediately after the learning trial, or 20 min before the retention trial, attenuated the avoidance response, thereby impairing the consolidat...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(87)90017-5
更新日期:1987-08-01 00:00:00
abstract::We examined the effects of gestational cocaine treatment on oxytocin levels in the whole hippocampus (HIP), ventral tegmental area (VTA), medial preoptic area (MPOA) and amygdala (AMY) in rat dams on postpartum days (PPDs) 1 and 2. Cocaine treatment significantly reduced oxytocin levels in the MPOA within 12-16 h of d...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/s0143-4179(97)90037-8
更新日期:1997-10-01 00:00:00