Molecular characterization and peptide specificity of two vasoactive intestinal peptide (VIP) binding sites in the chicken pineal.

Abstract:

:Here we report that chicken pineal membranes express high affinity receptors for Vasoactive Intestinal Peptide (VIP), as revealed by competitive displacement analysis of [3-iodotyrosyl-125I]-VIP by native VIP. These binding sites were further characterized by covalent cross-linking of radioiodinated VIP to chicken pineal cell membranes, using dithiobis(succinimidylpropionate) as a cross-linking reagent. Sodium dodecyl sulfate electrophoresis after solubilization of the cross-linked membranes, reveals the existence of two polypeptides, P1 and P2, with a similar labelling intensity and apparent molecular weights of Mr = 57,000 and Mr = 70,000 respectively. These two components behave like high affinity binding sites for VIP.

journal_name

Neuropeptides

journal_title

Neuropeptides

authors

Meunier AC,Voisin P,Van Camp G,Cenatiempo Y,Muller JM

doi

10.1016/0143-4179(91)90066-r

keywords:

subject

Has Abstract

pub_date

1991-05-01 00:00:00

pages

1-8

issue

1

eissn

0143-4179

issn

1532-2785

journal_volume

19

pub_type

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