Abstract:
:Our previous studies showed the modulation of cocaine and amphetamine regulated transcript (CART) positive neurons and CART mRNA by adrenalectomy and corticosterone replacement in hypothalamic nuclei of male rat brain. More recently, we have shown by CART immunohistochemistry that restraint and forced swim (FS) stress have sexually dimorphic and regionally specific effects on CART expression in the hypothalamic nuclei of male and female Sprague-Dawley rats. This study aimed to evaluate the effects of FS stress on CART peptide expression in hypothalamus, amygdala and hippocampus of male and female (in or near estrus) Sprague-Dawley rats. Initially basal CART levels in regions of interest were determined in male and female rats; no sex differences were observed. In FS test, rats were forced to swim on two consecutive days, in a Plexiglas cylinder for 15 and 6 min, respectively. Rats were decapitated on the second day, 10 min after the stress procedure. Hypothalami, amygdalae and hippocampi were dissected and homogenized. CART peptide expression in these regions was measured by Western blotting. In males, FS increased CART expression in hypothalamus and amygdala. On the other hand, in females, FS lowered CART expression in amygdala. CART expression in hippocampus was not affected by the stress procedure in either sex. Our results suggest sexually dimorphic modulation of CART expression in hypothalamus and amygdala by FS procedure. Although modulation of the CART peptide by glucocorticoids and gonadal hormones appears likely, future studies are needed to elucidate the underlying mechanisms in the involvement of CART peptide in stress response.
journal_name
Neuropeptidesjournal_title
Neuropeptidesauthors
Balkan B,Gozen O,Yararbas G,Koylu EO,Akinturk S,Kuhar MJ,Pogun Sdoi
10.1016/j.npep.2006.02.001subject
Has Abstractpub_date
2006-06-01 00:00:00pages
185-93issue
3eissn
0143-4179issn
1532-2785pii
S0143-4179(06)00016-3journal_volume
40pub_type
杂志文章相关文献
NEUROPEPTIDES文献大全abstract::Opiates have been shown to affect prolactin secretion directly at the pituitary level. However, opiate binding sites have not been characterized on anterior pituitary tissue. In the present work we show that a soluble factor present in anterior pituitary membrane preparation inhibit opiate binding on striatal membrane...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(86)90009-0
更新日期:1986-11-01 00:00:00
abstract::The effects of acute and chronic treatment with LSD and acute treatment with mescaline, m-CPP, citalopram and fenfluramine on leu-enkephalin (LENK) content in rat brain were examined. The acute LSD treatment was found to decrease and chronic treatment to increase the LENK content in the frontal cortex. In the thalamus...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(86)90028-4
更新日期:1986-05-01 00:00:00
abstract::Obesity is a global public health problem. Orexin and endocannabinoid signaling in the hypothalamus have been shown to regulate feeding and are promising molecular targets for obesity treatment. In this study, we attempted to analyze effects of orexin-A and endocannabinoid signaling modulation in the arcuate nucleus (...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/j.npep.2018.04.001
更新日期:2018-06-01 00:00:00
abstract::The orally active, α-hemoglobin derived hemopressin (PVNFKFLSH, Hp(1-9)) and its truncated (PVNFKFL, Hp(1-7) and PVNFKF, Hp(1-6)) and extended ((R)VDPVNFKFLSH, VD-Hp(1-9) and RVD-Hp(1-9)) derivatives have been postulated to be the endogenous peptide ligands of the cannabinoid receptor type 1 (CB1). In an attempt to cr...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/j.npep.2016.02.001
更新日期:2016-08-01 00:00:00
abstract::Endothelins (ET) are a family of highly active neuropeptides with manifold influences via ET receptors (ETR) in both the peripheral and central nervous systems. We have shown previously that satellite glial cells (SGCs) in mouse trigeminal ganglia (TG) are extremely sensitive to ET-1 in evoking [Ca2+]in increase, appa...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/j.npep.2017.03.002
更新日期:2017-06-01 00:00:00
abstract::We have previously shown that one of the major determinants directing the expression of the preprotachykinin-A (TAC1) gene, which encodes the neuropeptide substance P, is the transcription factor Neuronal Restrictive Silencer Factor (NSRF), which is also termed Repressor Element-1 Silencing Factor (REST). In rodent mo...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/j.npep.2009.05.004
更新日期:2009-08-01 00:00:00
abstract::Several studies suggest that prenatal ethanol exposure (PEE) facilitates ethanol intake. Opioid peptides play a main role in ethanol reinforcement during infancy and adulthood. However, PEE effects upon motor responsiveness elicited by an ethanol challenge and the participation of opioids in these actions remain to be...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/j.npep.2016.11.006
更新日期:2017-04-01 00:00:00
abstract::Neuromedin U (NMU), a neuropeptide implicated in feeding, inflammation, pain control and anxiety-related behaviours, is widely distributed in peripheral organs and the CNS. These effects are thought to be mediated by its receptors NMU(1) and NMU(2). Since its precise sites of interaction in the CNS were to date unknow...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/j.npep.2008.04.008
更新日期:2008-08-01 00:00:00
abstract::3H-Bradykinin binding sites with the characteristics of receptors were identified in homogenates of bovine hippocampus and PC-12 cells. The characteristics of the binding were similar in both types of tissue and paralleled those of the B2 bradykinin receptor. Following exposure to nerve growth factor for 72 hours, the...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(88)90056-x
更新日期:1988-11-01 00:00:00
abstract::The effects of several doses of porcine brain natriuretic peptide-32 (pBNP-32) administered into the lateral brain ventricle were tested as regards the consolidation of passive avoidance learning in rats. The peptide was found to increase the passive avoidance latency in a dose-dependent manner. In order to clarify wh...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(92)90064-4
更新日期:1992-06-01 00:00:00
abstract::Prader-Willi syndrome (PWS) is the predominant genetic cause of obesity in humans and is associated with several behavioural phenotypes such as altered motoric function, reduced activity, and learning disabilities. It can include mood instability and, in some cases, psychotic episodes. Recently, the Snord116 gene has ...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/j.npep.2015.06.009
更新日期:2015-10-01 00:00:00
abstract::The effect of the neurokinin-1 (NK1) receptor antagonist RP67580 in modulating inflammatory oedema formation has been investigated in guinea-pig skin. Oedema formation was measured over 30 min by the extravascular accumulation of intravenously-injected 125I-albumin in the anaesthetised guinea-pig. RP67580 was injected...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(94)90026-4
更新日期:1994-06-01 00:00:00
abstract::[3H]-Dynorphin A (1-8) was degraded in brain homogenates at 25 degrees and even at 0 degree C. The peptidase inhibitors bestatin and captopril almost completely protected[3H]-dynorphin A (1-8) from degradation at 0 degree C but had only little effect on binding at this temperature. At 25 degrees C, the binding of [3H]...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(85)90072-1
更新日期:1985-02-01 00:00:00
abstract::Nociceptin/Orphanin FQ (N/OFQ) is a 17-amino acid peptide that binds to the nociceptin receptor (NOP). N/OFQ and NOP receptors are expressed in numerous brain areas. The generation of specific agonists, antagonists and receptor-deficient mice or rats has enabled progress in elucidating the biological functions of N/OF...
journal_title:Neuropeptides
pub_type: 杂志文章,评审
doi:10.1016/j.npep.2015.03.005
更新日期:2015-04-01 00:00:00
abstract::D-Arg containing dipeptides, H-Tyr-D-Arg-OMe and H-Tyr (Et)-D-Arg-OMe, and D-Arg2 substituted N-terminal tetrapeptides of dermorphin, H-Tyr-D-Arg-Phe-Gly-OEt and H-Tyr (Et)-D-Arg-Phe-Gly-OEt administered intracerebroventricularly exhibited dose-dependent antinociceptive activities in mice as measured by the tail press...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(84)90001-5
更新日期:1984-06-01 00:00:00
abstract::Microchemotaxis chambers were used to investigate whether one aspect of ciliary neurotrophic factor CNTF's role as a lesion factor might be to promote the initial early recruitment of macrophages, which express the signal transducing receptor components, gp130 and LIFRbeta. CNTFRalpha alone, or in combination with CNT...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1054/npep.2000.0829
更新日期:2000-12-01 00:00:00
abstract::Somatostatin is a neuropeptide that in several experimental models of epilepsy has been suggested to modulate epileptic activity. The purpose of the present study was to investigate the role of somatostatin in seizure phenomena. We measured the somatostatin-like immunoreactivity (SLI) by radioimmunoassay of the cister...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(87)90027-8
更新日期:1987-01-01 00:00:00
abstract::Dynorphin 1-8 (DYN 1-8) and Dynorphin B (DYN B) have been immunocytochemically localized to neuronal perikarya throughout the adult rat central nervous system (CNS). In order to determine if any DYN 1-8 and DYN B immunoreactive (DYN-I) cell bodies have long projections, indirect immunofluorescence was used in combinat...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(86)90043-0
更新日期:1986-08-01 00:00:00
abstract::The effects of forskolin or phorbol-13-myristate (PMA) injected intrathecally (i.t.) or intracerebroventricularly (i.c.v.) on the inhibition of the tail-flick and hotplate responses induced by morphine or beta-endorphin administered i.c.v. were studied. Animals pretreated with forskolin (20 micrograms) i.t. for 10 min...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/s0143-4179(96)90085-2
更新日期:1996-04-01 00:00:00
abstract::Stretching-yawning syndrome (SYS) and penile erections (PE) are typical components of the behavioral picture induced by intracerebroventricular (i.c.v.) injection of ACTH 1-24. The present study shows that pretreatment with alpha-difluoromethylornithine (DFMO), and irreversible inhibitor of mammalian ornithine decarbo...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(84)90105-7
更新日期:1984-05-01 00:00:00
abstract::Male Wistar rats were injected intraperitoneally with chlorpromazine (2 or 10 mg/kg), haloperidol (0.5 or 2 mg/kg), sulpiride (50 or 100 mg/kg) or clozapine (10 or 25 mg/kg) once, for 14 or 28 consecutive days. Hypothalamic neuropeptide Y-like (NPY-like) immunoreactivity (NPY-LI) was determined 24 h after the last dos...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/s0143-4179(96)90012-8
更新日期:1996-10-01 00:00:00
abstract::Neuropeptide Y (NPY) neurons abundantly innervate the hypothalamus, where NPY is involved in the regulation and integration of a broad range of homeostatic functions. In order to understand NPY-mediated behavioral, autonomic and neuroendocrine effects, it is important to characterize in detail the distribution of the ...
journal_title:Neuropeptides
pub_type: 杂志文章,评审
doi:10.1016/j.npep.2004.05.009
更新日期:2004-08-01 00:00:00
abstract::Orexins are neuropeptides that are localized to neurons in the lateral and dorsal hypothalamus but its receptors are distributed to many different regions of the central nervous system. Orexins are implicated in a variety of physiological functions including sleep regulation, energy homeostats, and stress reactions. F...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/j.npep.2016.12.007
更新日期:2017-02-01 00:00:00
abstract::The desire of the pharmaceutical industry to obtain more selective agents for the treatment of anxiety with fewer or diminished side effects and a profile consistent with safety during long-term use resulted in a search which has identified the azapirones as a new class of anxiolytics which lack structural or biochemi...
journal_title:Neuropeptides
pub_type: 临床试验,杂志文章,评审
doi:10.1016/0143-4179(91)90078-w
更新日期:1991-07-01 00:00:00
abstract::The effects of FMRFamide on passive avoidance behaviour and electroshock-induced amnesia following intracerebroventricular administration were studied in rats. FMRFamide given immediately after the learning trial, or 20 min before the retention trial, attenuated the avoidance response, thereby impairing the consolidat...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(87)90017-5
更新日期:1987-08-01 00:00:00
abstract::The effect of the selective non-peptide antagonist for NK1 receptors (+/-)CP 96,345 on cellular transduction mechanisms elicited by the NK1 selective agonist [Sar9]-substance P-sulfone ([Sar9]-SP) was investigated in a stabilized culture of human skin fibroblasts (HF) and compared to the effects of two peptide antagon...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/s0143-4179(96)90023-2
更新日期:1996-08-01 00:00:00
abstract::Brain extracts from 3 to 4 day old final (eighth) instar larvae of Opisina arenosella (Lepidoptera) stimulate amylase release from midgut preparations maintained in vitro. This effect of the brain extract was both time and dose dependent. The brain factor stimulating enzyme release may be a peptide as it is heat stabl...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/s0143-4179(03)00025-8
更新日期:2003-06-01 00:00:00
abstract::125I-Neuropeptide Y (NPY) bound specifically with high affinity to rat atrial and ventricular membranes. Scatchard analysis revealed the presence of single class of binding sites in both atrial and ventricular membranes. The apparent Kd and Bmax for atrial membranes were 0.63 nM and 70 fmol/mg protein, respectively; v...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(90)90148-r
更新日期:1990-03-01 00:00:00
abstract::Guinea-pigs were chronically treated with morphine by subcutaneous implantation of a compounded morphine pellet. After 7 days, the animals were sacrificed, and the small intestine was removed and extracted for the assay of 6 neuropeptides (substance P, vasoactive intestinal peptide, galanin, dynorphin A (1-8), dynorph...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(88)90063-7
更新日期:1988-11-01 00:00:00
abstract::Release of [3H]-acetylcholine (3H-ACh) and muscle contractions in response to cholecystokinin (CCK) were measured and recorded simultaneously from isolated guinea-pig gallbladder. Cholecystokinin octapeptide (CCK8) (10(-10)-10(-7) M) enhanced the release of [3H]ACh and the contractions of the muscle. TTX (10(-6) M) in...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(93)90043-a
更新日期:1993-11-01 00:00:00