Interactive effects of cholecystokinin-8S and various serotonin receptor agonists on the firing activity of neostriatal neuronesin rats.


:In rats anaesthetized with urethane single unit activity was extracellularly recorded in the neostriatum, and several drugs were microiontophoretically ejected. Separate administration of the sulfated octapeptide cholecystokinin (CCK-8S), serotonin (5-HT) or 8-OH-DPAT (a 5-HT(1A/7) receptor agonist) predominantly induced increases in the neuronal discharge rates (Wilcoxon test significant P<0.05), whereas the 5-HT(2A/2C) receptor agonist DOI affected only a few neurones and mainly reduced firing. After coadministration of CCK-8S and serotonin, activating effects also predominated (Wt P<0.05), but the neuronal responsiveness was significantly reduced (Chi2P<0.01). Similarly, concomitant application of CCK-8S and 8-OH-DPAT led to significant activation accompanied with a reduction of inhibitory effects. The block of serotonin- or 8-OH-DPAT-effects through specific 5-HT(1A) receptor antagonists implies the involvement of this receptor subtype within the striatum. In conclusion, concomitant action of CCK-8S and serotonin induces a mean level of neuronal activation that might promote normal function.






Wilms K,Vierig G,Davidowa H





Has Abstract


2001-10-01 00:00:00














  • The analgesic effect of orexin-A in a murine model of chemotherapy-induced neuropathic pain.

    abstract::Orexins are neuropeptides that are localized to neurons in the lateral and dorsal hypothalamus but its receptors are distributed to many different regions of the central nervous system. Orexins are implicated in a variety of physiological functions including sleep regulation, energy homeostats, and stress reactions. F...


    pub_type: 杂志文章


    authors: Toyama S,Shimoyama N,Shimoyama M

    更新日期:2017-02-01 00:00:00

  • A comparison of opioid peptide precursors in guinea pig, rat and bovine striata and guinea pig adrenal.

    abstract::In this study guinea pig, rat and bovine striatal extracts have been shown to contain putative opioid peptide precursors in the molecular weight (Mr) range 2000-greater than 70000. The material eluting greater than 70 kDalton contained bioassayable opioid activity but not Met- or Leu-enkephalin-like immunoreactivities...


    pub_type: 杂志文章


    authors: Metters KM,Beaumont A,Rossier J,Hughes J

    更新日期:1985-02-01 00:00:00

  • Failure to demonstrate mu-isoreceptors.

    abstract::Attempts have been made to confirm reports that naloxonazine and Mr2034 are able to selectively antagonise morphine-induced analgesia and respiratory depression respectively. In the present studies these antagonists proved to be equi-effective against both the analgesic and respiratory depressant effects of morphine, ...


    pub_type: 杂志文章


    authors: Rourke JD,Shaw JS

    更新日期:1984-12-01 00:00:00

  • Blockade of calcitonin gene-related peptide release after superior sagittal sinus stimulation in cat: a comparison of avitriptan and CP122,288.

    abstract::The pathophysiological basis for the pain of migraine has been the subject of substantial attention and must include activation of elements of the trigeminal innervation of the cranial vessels, the trigeminovascular system. Recently, consideration of trigeminal-evoked neurogenic plasma protein extravasation (PPE) as a...


    pub_type: 杂志文章


    authors: Knight YE,Edvinsson L,Goadsby PJ

    更新日期:1999-02-01 00:00:00

  • Acute and persistent effects of beta-funaltrexamine on the binding and agonist potencies of opioids in the myenteric plexus of the guinea-pig ileum.

    abstract::In binding assays with homogenates of the myenteric plexus-longitudinal muscle of the guinea-pig, beta-funaltrexamine is more potent at displacing mu-binding than kappa-binding. Incubation of homogenates with beta-funaltrexamine (100 or 1000 nM) for 30 min at 37 degrees C followed by repeated washing with drug-free Tr...


    pub_type: 杂志文章


    authors: McKnight AT,Paterson SJ,Corbett AD,Kosterlitz HW

    更新日期:1984-12-01 00:00:00

  • Pharmacological characterization of desensitization in scratching behavior induced by intrathecal administration of hemokinin-1 in the rat.

    abstract::Desensitization is induced by the repeated administration of high doses of substance P (SP) or hemokinin-1 (HK-1). However, little information is available about the mechanisms involved in the induction of desensitization by these peptides. Thus, to characterize this desensitization, we examined the dose-dependent eff...


    pub_type: 杂志文章


    authors: Naono R,Nakayama T,Ikeda T,Matsusima O,Nishimori T

    更新日期:2008-02-01 00:00:00

  • An investigation into the discriminative stimulus and reinforcing properties of the CCKB-receptor antagonist, L-365,260 in rats.

    abstract::The discriminative stimulus properties of the selective CCKB-receptor antagonist, L-365,260 were evaluated in rats trained to discriminate diazepam (2 mg/kg) or morphine (5 mg/kg) from vehicle, using a two-lever food reinforced technique. In the diazepam drug discrimination, the benzodiazepine-receptor agonist FG8205 ...


    pub_type: 杂志文章


    authors: Jackson A,Tattersall D,Bentley G,Rycroft W,Bourson A,Hargreaves R,Tricklebank M,Iversen S

    更新日期:1994-05-01 00:00:00

  • Prenatal ethanol exposure modifies locomotor activity and induces selective changes in Met-enk expression in adolescent rats.

    abstract::Several studies suggest that prenatal ethanol exposure (PEE) facilitates ethanol intake. Opioid peptides play a main role in ethanol reinforcement during infancy and adulthood. However, PEE effects upon motor responsiveness elicited by an ethanol challenge and the participation of opioids in these actions remain to be...


    pub_type: 杂志文章


    authors: Abate P,Reyes-Guzmán AC,Hernández-Fonseca K,Méndez M

    更新日期:2017-04-01 00:00:00

  • Comparison of soluble and membrane-bound pyroglutamyl peptidase I activities in rat brain tissues in the presence of detergents.

    abstract::Pyroglutamyl peptidase I activity from soluble and membrane-bound fractions of rat brain homogenates is inhibited by the presence of sodium deoxycholate but not by triton X-100. Biobeads SM2, a polystyrene adsorbent reported to be useful in removing detergents from aqueous solutions, inhibits enzymatic activity in bot...


    pub_type: 杂志文章


    authors: Alba F,Arenas JC,Lopez MA

    更新日期:1995-08-01 00:00:00

  • Orexin-A and endocannabinoid signaling regulate glucose-responsive arcuate nucleus neurons and feeding behavior in obese rats.

    abstract::Obesity is a global public health problem. Orexin and endocannabinoid signaling in the hypothalamus have been shown to regulate feeding and are promising molecular targets for obesity treatment. In this study, we attempted to analyze effects of orexin-A and endocannabinoid signaling modulation in the arcuate nucleus (...


    pub_type: 杂志文章


    authors: Yang D,Xu L,Guo F,Sun X,Zhang D,Wang M

    更新日期:2018-06-01 00:00:00

  • Calcitonin gene-related peptide (CGRP) and its role in hypertension.

    abstract::Hypertension is still presently the number one "silent killer" in the Western World, and a major risk factor for the development of secondary diseases contributing to cardiovascular disease (CVD). However, despite a broad range of therapies, the mechanisms involved in the onset of hypertension remains unclear, therefo...


    pub_type: 杂志文章,评审


    authors: Smillie SJ,Brain SD

    更新日期:2011-04-01 00:00:00

  • Differential effects of substance P or hemokinin-1 on transient receptor potential channels, TRPV1, TRPA1 and TRPM8, in the rat.

    abstract::Two tachykinin peptides, substance P (SP) and hemokinin-1 (HK-1), and three transient receptor potential (TRP) channels, TRPV1, TRPA1 and TRPM8, are similarly localized in the spinal dorsal horn and dorsal root ganglion, suggesting that TRP channels may be related or modulated by these tachykinin peptides. Thus, to cl...


    pub_type: 杂志文章


    authors: Naono-Nakayama R,Sunakawa N,Ikeda T,Nishimori T

    更新日期:2010-02-01 00:00:00

  • Skeletal phenotype of the neuropeptide Y knockout mouse.

    abstract::Neuropeptide Y (NPY) is involved in multiple processes such as behavior, energy and bone metabolism. Previous studies have relied on global NPY depletion to examine its effects on bone. However, this approach is unable to distinguish the central or local source of NPY influencing bone. Our aim was to identify which ce...


    pub_type: 杂志文章


    authors: Wee NKY,Sinder BP,Novak S,Wang X,Stoddard C,Matthews BG,Kalajzic I

    更新日期:2019-02-01 00:00:00

  • Partial blockade of neurotensin-induced hypotension in rats by nephrectomy captopril and saralasin. Possible mechanisms.

    abstract::We have assessed the influence of acute bilateral nephrectomy, of captopril and saralasin, on the hypotensive activity of neurotensin (NT) and of various hypotensive drugs in pentobarbital-anesthetized rats. The results show that the hypotensive activity of NT and of compound 48/80 (C48/80), in contrast to that of his...


    pub_type: 杂志文章


    authors: Kérouac R,St-Pierre S,Manning M,Rioux F

    更新日期:1983-04-01 00:00:00

  • Neuropharmacological actions of the superactive agonist analog D-TRP-6-LH-RH after peripheral injection into mice.

    abstract::The neuropharmacological actions of the agonist analog D-Trp-6-LH-RH were investigated in several tests after subcutaneous administrations to male mice. The doses applied were in the range 1-1000 micrograms/kg. D-Trp-6-LH-RH doses of 10 micrograms/kg and higher induced significant analgesic effects in the hot-plate an...


    pub_type: 杂志文章


    authors: Kádár T,Telegdy G,Schally AV

    更新日期:1990-10-01 00:00:00

  • Effect of loxiglumide (CR 1505) on CCK-induced contractions and 3H-acetylcholine release from guinea-pig gallbladder.

    abstract::Release of [3H]-acetylcholine (3H-ACh) and muscle contractions in response to cholecystokinin (CCK) were measured and recorded simultaneously from isolated guinea-pig gallbladder. Cholecystokinin octapeptide (CCK8) (10(-10)-10(-7) M) enhanced the release of [3H]ACh and the contractions of the muscle. TTX (10(-6) M) in...


    pub_type: 杂志文章


    authors: Rakovska A,Sgaragli G,Mantovani P,Valoti M,Milenov K

    更新日期:1993-11-01 00:00:00

  • Effect of a neurokinin-1 (NK1) receptor antagonist on oedema formation induced by tachykinins, carrageenin and an allergic response in guinea-pig skin.

    abstract::The effect of the neurokinin-1 (NK1) receptor antagonist RP67580 in modulating inflammatory oedema formation has been investigated in guinea-pig skin. Oedema formation was measured over 30 min by the extravascular accumulation of intravenously-injected 125I-albumin in the anaesthetised guinea-pig. RP67580 was injected...


    pub_type: 杂志文章


    authors: Wilsoncroft P,Euzger H,Brain SD

    更新日期:1994-06-01 00:00:00

  • The expression of angiotensin-converting enzyme 2-angiotensin-(1-7)-Mas receptor axis are upregulated after acute cerebral ischemic stroke in rats.

    abstract::There is now unequivocal evidence that the angiotensin-converting enzyme 2(ACE2)-Ang-(1-7)-Mas axis is a key component of the renin-angiotensin system (RAS) cascade, which is closely correlated with ischemic insult occurrence. Our previous studies demonstrated that the Ang-(1-7), was an active member of the brain RAS....


    pub_type: 杂志文章


    authors: Lu J,Jiang T,Wu L,Gao L,Wang Y,Zhou F,Zhang S,Zhang Y

    更新日期:2013-10-01 00:00:00

  • Preoperative concentration of beta-lipotropin immunoreactive material in cerebrospinal fluid: a predictor of postoperative pain?

    abstract::Levels of beta-endorphin immunoreactive material (IRM) in cerebrospinal fluid (CSF) have been reported to correlate inversely with postoperative morphine requirement. Considering proopiomelanocortin (POMC) derivatives as predictors for sensitivity to postoperative pain, we determined authentic beta-endorphin (beta-end...


    pub_type: 杂志文章


    authors: Matejec R,Schulz A,Mühling J,Uhlich H,Bödeker RH,Hempelmann G,Teschemacher H

    更新日期:2006-02-01 00:00:00

  • Central administration of neuropeptide Y differentially regulates monoamines and corticosterone in heat-exposed fed and fasted chicks.

    abstract::Recently, we demonstrated that brain neuropeptide Y (NPY) mRNA expression was increased in heat exposed chicks. However, the functions of brain NPY during heat stress are unknown. This study was conducted to investigate whether centrally administered NPY affects food intake, rectal temperature, monoamines, stress horm...


    pub_type: 杂志文章


    authors: Bahry MA,Chowdhury VS,Yang H,Tran PV,Do PH,Han G,Ikeda H,Cockrem JF,Furuse M

    更新日期:2017-04-01 00:00:00

  • The effect of C-terminus and N-terminus iodination on avian pancreatic polypeptide (APP) binding to its chicken brain receptor.

    abstract::In previous studies, membranes from chicken gastrointestinal tissues failed to bind appreciable levels of 125I-APP labeled at the C-terminus. In order to address the suggestion that this was due to steric hindrance of the critical C-terminus, N-terminally labeled 125I-APP was utilized in in vitro membrane binding assa...


    pub_type: 杂志文章


    authors: Adamo ML,Hazelwood RL

    更新日期:1992-04-01 00:00:00

  • Effect of alpha-difluoromethylornithine (DFMO) on the behavioral syndrome induced by intracerebroventricular injection of ACTH 1-24, in rats.

    abstract::Stretching-yawning syndrome (SYS) and penile erections (PE) are typical components of the behavioral picture induced by intracerebroventricular (i.c.v.) injection of ACTH 1-24. The present study shows that pretreatment with alpha-difluoromethylornithine (DFMO), and irreversible inhibitor of mammalian ornithine decarbo...


    pub_type: 杂志文章


    authors: Genedani S,Bernardi M,Bertolini A

    更新日期:1984-05-01 00:00:00

  • Differences in the expression of neurokinin receptor in neural and bone marrow mesenchymal cells: implications for neuronal expansion from bone marrow cells.

    abstract::The neurokinin-1 (NK-1) receptor interacts with peptides that belong to the tachykinin family. NK-1 is inducible in bone marrow (BM) stroma. In neural cells, its expression is high to constitutive. Screening of three cDNA libraries indicated that this different in NK-1 expression in neural and BM cells could not be ex...


    pub_type: 杂志文章


    authors: Bandari PS,Qian J,Yehia G,Seegopaul HP,Harrison JS,Gascon P,Fernandes H,Rameshwar P

    更新日期:2002-02-01 00:00:00

  • Effects of intrathecal amylin on formalin-induced nociception and on cAMP accumulation in the rat embryonic spinal cells.

    abstract::Amylin (AMY) is a member of calcitonin family of peptides. In this study, the effects of intrathecal (i.t) injection of AMY on the inflammatory pain and on the cAMP accumulation in the rat spinal cells were investigated. By using AMY receptor antagonists, we also studied the pharmacology of AMY receptors in the spinal...


    pub_type: 杂志文章


    authors: Khoshdel Z,Takhshid MA,Owji AA

    更新日期:2016-06-01 00:00:00

  • Neuropeptides are associated with pain threshold and bone microstructure in ovariectomized rats.

    abstract:OBJECTIVES:Postmenopausal osteoporosis (PMO) is a metabolic skeletal disorder with impaired bone density and bone quality in postmenopausal women. The aim of the present study was to investigate the correlation between neuropeptides, bone microstructure and pain threshold in ovariectomized (OVX) rats. METHODS:Female r...


    pub_type: 杂志文章


    authors: Xie W,Li F,Han Y,Li Z,Xiao J

    更新日期:2020-06-01 00:00:00

  • BDNF expression with functional improvement in transected spinal cord treated with neural stem cells in adult rats.

    abstract::Neural stem cells (NSC) could promote the repair after spinal cord transection (SCT), the underlying mechanism, however, still keeps to be defined. This study reported that NSC grafts significantly improved sensory and locomotor functions in adult rats with SCT in acute stage after injury. NSC could survive; different...


    pub_type: 杂志文章


    authors: He BL,Ba YC,Wang XY,Liu SJ,Liu GD,Ou S,Gu YL,Pan XH,Wang TH

    更新日期:2013-02-01 00:00:00

  • Simultaneous release of neurotensin, somatostatin, enkephalins and catecholamines from perfused cat adrenal glands.

    abstract::Acid extracts of cat adrenal medullae were found to contain neurotensin-like (0.71 +/- 0.21nmol/gm), met-enkephalin-like (11.71 +/- 2.87nmol/gm), leu-enkephalin-like (1.95 +/- 0.11nmol/gm) and somatostatin-like (1.57 +/- 0.63pmol/gm) immunoreactivities. Using isolated retrogradely perfused cat adrenal glands the secre...


    pub_type: 杂志文章


    authors: Corder R,Mason DF,Perrett D,Lowry PJ,Clement-Jones V,Linton EA,Besser GM,Rees LH

    更新日期:1982-10-01 00:00:00

  • Polymodal dose-response curve for oxytocin in the social recognition test.

    abstract::Available data concerning the effect of oxytocin on memory are often inconsistent. In the present study it was found that oxytocin, intracerebroventricularly injected to adult male rats in a dose range of 1 fg-10 ng/rat immediately after a 5-minute encounter with a juvenile, significantly reduces the social investigat...


    pub_type: 杂志文章


    authors: Benelli A,Bertolini A,Poggioli R,Menozzi B,Basaglia R,Arletti R

    更新日期:1995-04-01 00:00:00

  • Characterization of human placental opioid receptors by 3H-ethylketocyclazocine and 3H-naloxone binding.

    abstract::The human placenta contains membrane bound opioid receptors. The binding of the antagonist naloxone and the fairly kappa-selective agonist EKC were studied in the microvillous membrane fraction. In both cases high affinity binding sites were detected with Kd values in the nanomolar range. A series of kappa-selective l...


    pub_type: 杂志文章


    authors: Agbas A,Simon J,Avni Oktem H,Varga E,Borsodi A

    更新日期:1988-10-01 00:00:00

  • Pituitary adenylate cyclase-activating polypeptide (PACAP-27) enhances tyrosine hydroxylase activity in the nucleus accumbens of the rat.

    abstract::Pituitary adenylate cyclase-activating polypeptide (PACAP-27) was incubated in a tyrosine hydroxylase (TyrOH) assay with a homogenate preparation of the nucleus accumbens of the rat. TyrOH activity was determined in vitro by measuring the production of L-dopa with HPLC-ECD. Only in the presence of adenosine nucleotide...


    pub_type: 杂志文章


    authors: Moser A,Scholz J,Gänsle A

    更新日期:1999-12-01 00:00:00