Characterization of human placental opioid receptors by 3H-ethylketocyclazocine and 3H-naloxone binding.

abstract：:Cocaine- and amphetamine-regulated transcript (CART) peptides have a wide CNS distribution and appear to play an important role in a number of physiological processes including reward and reinforcement, feeding, locomotion, stress responses and perception of pain. We have further investigated the expression of CART pe...

journal_title：Neuropeptides

authors： Press DA,Wall MJ

更新日期：2008-02-01 00:00:00

abstract：:Neuropeptide Y (NPY) is a 36 amino acid peptide, which among others, plays a pivotal role in stress response. Although previous studies confirmed that NPY release is increased by stress in several species, the exact mechanism of the stress-induced NPY release has not been elucidated yet. In the present study, we exami...

journal_title：Neuropeptides

authors： Ko L,Rotoli G,Grignol G,Hu W,Merchenthaler I,Dudas B

更新日期：2011-06-01 00:00:00

abstract：:Bone cancer pain (BCP) is a common source of pain in patients with advanced stage and metastatic cancer; however, existing treatment for this kind of pain remains deficient. Being closely related to sensory change and inflammatory pain in both the central and peripheral nervous systems, endothelin A receptor (ETAR) pl...

journal_title：Neuropeptides

authors： Han MM,Yang CW,Cheung CW,Li J

更新日期：2018-04-01 00:00:00

abstract：:Specific antagonists were used to determine NK1 and NK2 receptor mediation of the expression of c-Jun and c-Fos inducible transcription factors. (ITFs) in dorsal horn neurons. The induction of c-Jun by C-fiber stimulation was strongly reduced in the superficial laminae by NK1 and NK2 antagonists, but only weakly in th...

journal_title：Neuropeptides

authors： Redburn JL,Leah JD

更新日期：1999-04-01 00:00:00

abstract：:Using the latency for tail-flick after thermal stimulation we have assessed the effects of alpha-, gamma(1)- and gamma(2)-MSH on nociceptive threshold in the mice. Intracisternal injections of gamma(2)-MSH induced a distinct analgesia, while gamma(1)-MSH in the same doses gave only a minor analgesia. Intracisternal al...

journal_title：Neuropeptides

authors： Klusa V,Germane S,Svirskis S,Opmane B,Wikberg JE

更新日期：2001-02-01 00:00:00

abstract：:Abnormal aggregation of beta-amyloid (Aβ) peptide into amyloid plaques in the brain has been identified as one of the key factors in instigating AD pathogenesis. Inhibition of Aβ aggregation can be an important therapeutic strategy in disease management. In this work, we demonstrate the application of structure-based ...

journal_title：Neuropeptides

authors： Pandey G,Morla S,Kumar S,Ramakrishnan V

更新日期：2020-06-01 00:00:00

abstract：:The regulation of neuropeptide gene expression and their receptors in a tissue specific and stimulus inducible manner will determine in part behaviour and physiology. This can be a dynamic process resulting from short term changes in response to the environment or long term modulation imposed by epigenetically determi...

journal_title：Neuropeptides

authors： Quinn JP,Warburton A,Myers P,Savage AL,Bubb VJ

更新日期：2013-12-01 00:00:00

abstract：OBJECTIVE:Neuropeptide Y, a widely circulating neurotransmitter, plays a pivotal role in energy balance, immunomodulation and asthma, and several NPY polymorphisms are promising genetic risk factors for asthma and obesity. We explored the associations of candidate NPY gene polymorphisms with prevalent asthma and its re...

journal_title：Neuropeptides

authors： Lu Y,Andiappan AK,Lee B,Ho R,Lim TK,Kuan WS,Goh DY,Mahadevan M,Sim TB,Wang Y,Van Bever HP,Rotzschke O,Larbi A,Ng TP

更新日期：2016-10-01 00:00:00

abstract：:The discriminative stimulus properties of the selective CCKB-receptor antagonist, L-365,260 were evaluated in rats trained to discriminate diazepam (2 mg/kg) or morphine (5 mg/kg) from vehicle, using a two-lever food reinforced technique. In the diazepam drug discrimination, the benzodiazepine-receptor agonist FG8205 ...

journal_title：Neuropeptides

authors： Jackson A,Tattersall D,Bentley G,Rycroft W,Bourson A,Hargreaves R,Tricklebank M,Iversen S

更新日期：1994-05-01 00:00:00

abstract：:A role for beta-endorphin (beta-END) in the pathophysiology of major depressive disorder (MDD) is suggested by both animal research and studies examining clinical populations. The major etiological theories of depression include brain regions and neural systems that interact with opioid systems and beta-END. Recent pr...

journal_title：Neuropeptides

authors： Hegadoren KM,O'Donnell T,Lanius R,Coupland NJ,Lacaze-Masmonteil N

更新日期：2009-10-01 00:00:00

abstract：:Amylin (AMY) is a member of calcitonin family of peptides. In this study, the effects of intrathecal (i.t) injection of AMY on the inflammatory pain and on the cAMP accumulation in the rat spinal cells were investigated. By using AMY receptor antagonists, we also studied the pharmacology of AMY receptors in the spinal...

journal_title：Neuropeptides

authors： Khoshdel Z,Takhshid MA,Owji AA

更新日期：2016-06-01 00:00:00

abstract：:Oxytocin, intraperitoneally injected to 26-month-old male rats 60 min before testing, significantly improved social memory (at doses of 3 and 6 ng/kg) and reduced the duration of immobility in the behavioral despair test (at doses of 50 and 500 micrograms/kg). These results are in agreement with previous data obtained...

journal_title：Neuropeptides

authors： Arletti R,Benelli A,Poggioli R,Luppi P,Menozzi B,Bertolini A

更新日期：1995-09-01 00:00:00

abstract：:The effects of several protein modifying reagents, including phenoxybenzamine, N-ethylmaleimide (NEM), 5,5'-dithiobis (2-nitro)--benzoic acid (DTNB), p-chloromercuryphenyl sulfonic acid (PCMP) and p-bromophenacylbromide (PBPB), on the binding of 125I-Bolton Hunter substance P (125I-BHSP), 125I-Bolton Hunter eledoisin ...

journal_title：Neuropeptides

authors： Bergström L,Beaujouan JC,Torrens Y,Saffroy M,Glowinski J

更新日期：1987-02-01 00:00:00

abstract：:We have used [3H]Senktide, a selective Neurokinin B receptor ligand, for the characterization of NK-3 receptors in rat and guinea pig CNS membranes. Scatchard analysis of saturation binding studies in cerebral cortex membranes indicated that this ligand bound to a single site with apparent high affinity (KD = 4.6 +/- ...

journal_title：Neuropeptides

authors： Renzetti AR,Barsacchi P,Criscuoli M,Lucacchini A

更新日期：1991-03-01 00:00:00

abstract：:We examined gene expression of corticotropin-releasing hormone and neuropeptide Y level in the hypothalamic paraventricular nucleus of mouse bearing a human oral squamous cell carcinoma. A cell line derived from a human oral squamous cell carcinoma was inoculated into the lower dorsal area of nude mice. Body weight, t...

journal_title：Neuropeptides

authors： Lee JH,Cha MJ,Choi SH,Hwang SJ,Kim DG,Jahng JW

更新日期：2004-12-01 00:00:00

abstract：:The desire of the pharmaceutical industry to obtain more selective agents for the treatment of anxiety with fewer or diminished side effects and a profile consistent with safety during long-term use resulted in a search which has identified the azapirones as a new class of anxiolytics which lack structural or biochemi...

journal_title：Neuropeptides

authors： Taylor DP,Moon SL

更新日期：1991-07-01 00:00:00

abstract：:We have previously shown that the kappa-opioid agonist, asimadoline, produces time-dependent changes in neuropeptide concentrations in the joints of rats with chronic arthritis. We hypothesized that asimadoline acts on peripheral terminals to modulate substance P (SP) release. To address this hypothesis, here we have ...

journal_title：Neuropeptides

authors： Walker JS,Scott C,Bush KA,Kirkham BW

更新日期：2000-06-01 00:00:00

abstract：:Dynorphin 1-8 (DYN 1-8) and Dynorphin B (DYN B) have been immunocytochemically localized to neuronal perikarya throughout the adult rat central nervous system (CNS). In order to determine if any DYN 1-8 and DYN B immunoreactive (DYN-I) cell bodies have long projections, indirect immunofluorescence was used in combinat...

journal_title：Neuropeptides

authors： Code RA,Fallon JH

更新日期：1986-08-01 00:00:00

abstract：:Intrathecal administration of VIP to the thoracic spinal cord in the urethane anaesthetized rat provoked a dose-dependent increase in heart rate without any change in arterial pressure. The cardioacceleration observed following administration of 6.5 nmol of VIP at the T9 level (n = 8) occurred within 1-2 min of admini...

journal_title：Neuropeptides

authors： Rochford J,Henry JL

更新日期：1989-11-01 00:00:00

abstract：:Alzheimer's disease (AD) is a progressive neurodegenerative disease that deeply affects patients, their family and society. Although scientists have made intense efforts in seeking the cure for AD, no drug available today is able to stop AD progression. In this context, compounds isolated from animal venom are potenti...

journal_title：Neuropeptides

authors： Camargo LC,Campos GAA,Galante P,Biolchi AM,Gonçalves JC,Lopes KS,Mortari MR

更新日期：2018-02-01 00:00:00

abstract：:Striatal neuropeptide Y-like immunoreactivity (NPY-LI) levels were investigated in naive rats after acute, subchronic (14 days) or chronic (28 days) intraperitoneal (i.p.) treatment with chlorpromazine (2 or 10mg/kg), haloperidol (0.5 or 2 mg/kg), (+/-)sulpiride (50 or 100 mg/kg) or clozapine (10 or 25 mg/kg), and in ...

journal_title：Neuropeptides

authors： Obuchowicz E,Turchan J

更新日期：1998-10-01 00:00:00

abstract：:Somatostatin, substance P, and vasoactive intestinal polypeptide were incubated in an adenylate cyclase assay with a particulate fraction of caudate-putamen tissue of the rat in order to examine the effect of the neuropeptides on G-protein coupled adenylate cyclase in vitro. Somatostatin induced an enhancement of cycl...

journal_title：Neuropeptides

authors： Moser A,Cramer H

更新日期：1992-07-01 00:00:00

abstract：:The effect of the neurokinin-1 (NK1) receptor antagonist RP67580 in modulating inflammatory oedema formation has been investigated in guinea-pig skin. Oedema formation was measured over 30 min by the extravascular accumulation of intravenously-injected 125I-albumin in the anaesthetised guinea-pig. RP67580 was injected...

journal_title：Neuropeptides

authors： Wilsoncroft P,Euzger H,Brain SD

更新日期：1994-06-01 00:00:00

abstract：:The anatomical distribution of Substance P (SP) has been investigated since the development of antibodies against it in the 1970s. Although initial studies were performed with antibodies that also recognised the other endogenous neurokinins, most of the initial descriptions are surprisingly still valid today. In this ...

journal_title：Neuropeptides

authors： Ribeiro-da-Silva A,Hökfelt T

更新日期：2000-10-01 00:00:00

abstract：:Orexins/hypocretins are neuropeptides that have various physiological effects, including the regulation of feeding behavior, neuroendocrine functions and sleep-wake cycles. Recent studies have suggested that the orexin system may also be involved in brain ischemic reactions. It is also known that changes in sleep patt...

journal_title：Neuropeptides

authors： Dohi K,Nishino S,Nakamachi T,Ohtaki H,Morikawa K,Takeda T,Shioda S,Aruga T

更新日期：2006-08-01 00:00:00

abstract：:Fracture repair is a complex yet well orchestrated regenerative process involving numerous signaling and cell types including osteoblasts. Here we showed that NPY, a neurotransmitter with regulatory functions in bone homeostasis, may contribute to the post-fracture bone healing in patients with traumatic brain injury-...

journal_title：Neuropeptides

authors： Gu XC,Zhang XB,Hu B,Zi Y,Li M

更新日期：2016-12-01 00:00:00

abstract：:The effects of intravenous self-administration of 30 micrograms infusions of either heroin or cocaine, or saline on the concentrations of beta-endorphin-immunoreactivity (beta E-IR) in the anterior part of the rat brain limbic system were studied. Self-administration of heroin and cocaine for 5 daily sessions resulted...

journal_title：Neuropeptides

authors： Sweep CG,Van Ree JM,Wiegant VM

更新日期：1988-11-01 00:00:00

abstract：:Levels of beta-endorphin immunoreactive material (IRM) in cerebrospinal fluid (CSF) have been reported to correlate inversely with postoperative morphine requirement. Considering proopiomelanocortin (POMC) derivatives as predictors for sensitivity to postoperative pain, we determined authentic beta-endorphin (beta-end...

journal_title：Neuropeptides

authors： Matejec R,Schulz A,Mühling J,Uhlich H,Bödeker RH,Hempelmann G,Teschemacher H

更新日期：2006-02-01 00:00:00

abstract：:We have described the binding of [125I]endothelin-1 (ET-1) to cultured rat cerebellar granule cells. Binding of [125I]ET-1 was specific, saturable, and time-dependent. Scatchard analysis of saturation binding data indicated a single class of high affinity binding site with a KD of 95 pM, and a Bmax of 8110 receptors/c...

journal_title：Neuropeptides

authors： Lysko PG,Feuerstein G,Pullen M,Wu HL,Nambi P

更新日期：1991-02-01 00:00:00

abstract：:Cholecystokinin-B (CCK-8) is an octapeptide that was initially described in the gastrointestinal tract. Recent studies have shown that this peptide also has an extensive distribution in the central nervous system, including the cerebellum of the opossum. In addition to the protein, binding sites for CCK-8 also have be...

journal_title：Neuropeptides

authors： Bishop GA

更新日期：1996-12-01 00:00:00