Aged rats are still responsive to the antidepressant and memory-improving effects of oxytocin.

abstract：:Neuromedin U (NMU), a neuropeptide implicated in feeding, inflammation, pain control and anxiety-related behaviours, is widely distributed in peripheral organs and the CNS. These effects are thought to be mediated by its receptors NMU(1) and NMU(2). Since its precise sites of interaction in the CNS were to date unknow...

journal_title：Neuropeptides

authors： Mangold C,Ksiazek I,Yun SW,Berger E,Binkert C

更新日期：2008-08-01 00:00:00

abstract：:The pathophysiological basis for the pain of migraine has been the subject of substantial attention and must include activation of elements of the trigeminal innervation of the cranial vessels, the trigeminovascular system. Recently, consideration of trigeminal-evoked neurogenic plasma protein extravasation (PPE) as a...

journal_title：Neuropeptides

authors： Knight YE,Edvinsson L,Goadsby PJ

更新日期：1999-02-01 00:00:00

abstract：:The opioid receptor antagonists, naloxone and beta-chlornaltrexamine, were used to determine whether activation of endogenous opioid peptide containing pathways produced pharmacologically reversible opioid actions. Extracellularly recorded responses of the hippocampal CA3 pyramidal cells were evoked by stimulation of ...

journal_title：Neuropeptides

authors： Chavkin C,Bloom FE

更新日期：1986-01-01 00:00:00

abstract：:Abnormal aggregation of beta-amyloid (Aβ) peptide into amyloid plaques in the brain has been identified as one of the key factors in instigating AD pathogenesis. Inhibition of Aβ aggregation can be an important therapeutic strategy in disease management. In this work, we demonstrate the application of structure-based ...

journal_title：Neuropeptides

authors： Pandey G,Morla S,Kumar S,Ramakrishnan V

更新日期：2020-06-01 00:00:00

abstract：:The desire of the pharmaceutical industry to obtain more selective agents for the treatment of anxiety with fewer or diminished side effects and a profile consistent with safety during long-term use resulted in a search which has identified the azapirones as a new class of anxiolytics which lack structural or biochemi...

journal_title：Neuropeptides

authors： Taylor DP,Moon SL

更新日期：1991-07-01 00:00:00

abstract：:Orexins are neuropeptides that are localized to neurons in the lateral and dorsal hypothalamus but its receptors are distributed to many different regions of the central nervous system. Orexins are implicated in a variety of physiological functions including sleep regulation, energy homeostats, and stress reactions. F...

journal_title：Neuropeptides

authors： Toyama S,Shimoyama N,Shimoyama M

更新日期：2017-02-01 00:00:00

abstract：:Pituitary adenylate cyclase-activating polypeptide (PACAP-27) was incubated in a tyrosine hydroxylase (TyrOH) assay with a homogenate preparation of the nucleus accumbens of the rat. TyrOH activity was determined in vitro by measuring the production of L-dopa with HPLC-ECD. Only in the presence of adenosine nucleotide...

journal_title：Neuropeptides

authors： Moser A,Scholz J,Gänsle A

更新日期：1999-12-01 00:00:00

abstract：:Microchemotaxis chambers were used to investigate whether one aspect of ciliary neurotrophic factor CNTF's role as a lesion factor might be to promote the initial early recruitment of macrophages, which express the signal transducing receptor components, gp130 and LIFRbeta. CNTFRalpha alone, or in combination with CNT...

journal_title：Neuropeptides

authors： Kobayashi H,Mizisin AP

更新日期：2000-12-01 00:00:00

abstract：:Cholecystokinin (CCK) is a widely expressed neuropeptide system originally discovered in the gut. Both cerebral and peripheral neurons as well as endocrine I-cells in the small intestine process proCCK to tyrosyl-O-sulfated and α-carboxyamidated peptides. Recently, we reported that gut endocrine I-cells also synthetiz...

journal_title：Neuropeptides

authors： Agersnap M,Zhang MD,Harkany T,Hökfelt T,Rehfeld JF

更新日期：2016-12-01 00:00:00

abstract：:Regulation of cholecystokinin (CCK) expression was studied in the human neuroepithelioma cell line SK-N-MCIXC and the rat medullary thyroid carcinoma cell line WE 4/2. The cells were treated with the beta-adrenergic agonist isoproterenol and retinoic acid, a natural derivative of vitamin A, which plays a role in cell ...

journal_title：Neuropeptides

authors： Mania-Farnell BL,Botros IW,Davis TP

更新日期：1995-10-01 00:00:00

abstract：:Neural stem cells (NSC) could promote the repair after spinal cord transection (SCT), the underlying mechanism, however, still keeps to be defined. This study reported that NSC grafts significantly improved sensory and locomotor functions in adult rats with SCT in acute stage after injury. NSC could survive; different...

journal_title：Neuropeptides

authors： He BL,Ba YC,Wang XY,Liu SJ,Liu GD,Ou S,Gu YL,Pan XH,Wang TH

更新日期：2013-02-01 00:00:00

abstract：:Several lines of evidence indicate a role for neuropeptide Y (NPY) in the modulation of the corticotroph axis. In two separate studies reported here, the concentrations of NPY and noradrenaline (NA), as well as corticotropin-releasing factor (CRF) and arginine vasopressin (AVP), were measured in extracts of individual...

journal_title：Neuropeptides

authors： Pralong FP,Corder R,Gaillard RC

更新日期：1993-10-01 00:00:00

abstract：:We have assessed the influence of acute bilateral nephrectomy, of captopril and saralasin, on the hypotensive activity of neurotensin (NT) and of various hypotensive drugs in pentobarbital-anesthetized rats. The results show that the hypotensive activity of NT and of compound 48/80 (C48/80), in contrast to that of his...

journal_title：Neuropeptides

authors： Kérouac R,St-Pierre S,Manning M,Rioux F

更新日期：1983-04-01 00:00:00

abstract：:AtT-20 cells are known to synthesize two molecular weight forms of the prohormone converting enzyme PC1 with molecular masses of 87 and 66 kDa. In this study we have analyzed basal and stimulated secretion of these proteins. Western blot results show that basal secretion medium of cultured AtT-20 cells contained low c...

journal_title：Neuropeptides

authors： Vindrola O,Lindberg I

更新日期：1993-08-01 00:00:00

abstract：:The effects of a potent serine protease inhibitor, Boc-D-Phe-Pro-Arg-H, on the secretion and content of ACTH and beta-endorphin-like immunoreactivities of cultured rat anterior pituitary cells were studied. Basal release of the hormones was not affected by the drug but secretion in response to stalk-median eminence ex...

journal_title：Neuropeptides

authors： Barna I,Gráf L,Makara GB,Rappay G

更新日期：1982-10-01 00:00:00

abstract：:Endothelins (ET) are a family of highly active neuropeptides with manifold influences via ET receptors (ETR) in both the peripheral and central nervous systems. We have shown previously that satellite glial cells (SGCs) in mouse trigeminal ganglia (TG) are extremely sensitive to ET-1 in evoking [Ca2+]in increase, appa...

journal_title：Neuropeptides

authors： Feldman-Goriachnik R,Hanani M

更新日期：2017-06-01 00:00:00

abstract：:In equilibrium binding studies, using 3H-etorphine and 3H-diprenorphine, digitonin extracts of frog brain membranes are found to contain two classes of sites, one of which is seen only in the presence of Na+ ions. Centrifugation of the extracts in sucrose gradients separates two macromolecular components (10S and 12S)...

journal_title：Neuropeptides

authors： Puget A,Frances B,Jauzac P,Meunier JC

更新日期：1984-12-01 00:00:00

abstract：:Intravenous injections of neurotensin (NT) (0.5, 1 and 2 nmoles kg-1) evoked dose-dependent increases in histaminemia and hematocrit, and marked hypotensive effect, in anesthetized rats. The increase of plasma histamine was rapid in onset (within sec), peak plasma histamine being reached in less than 2 min. The declin...

journal_title：Neuropeptides

authors： Kérouac R,St-Pierre S,Rioux F

更新日期：1982-12-01 00:00:00

abstract：:The effects of several mu and kappa opioid receptor agonists on urinary excretion were examined in the water-loaded rat. Mu agonists induced anti-diuresis whereas kappa agonists caused diuresis. Furthermore, high efficacy kappa agonists eg. U50, 488H and tifluadom, produced marked diuretic effects, whereas kappa parti...

journal_title：Neuropeptides

authors： Skingle M,Hayes AG,Tyers MB

更新日期：1985-02-01 00:00:00

abstract：OBJECTIVE:To explore the orexinergic pathway from the lateral hypothalamus (LHA) to the nucleus accumbens (NAc) and its regulation on the palatable food intake. METHODS:Fluorescent gold retrograde tracing combined with fluoro-immunohistochemical staining were used to observe the projection of orexinergic neurons from ...

journal_title：Neuropeptides

authors： Liu X,Gao S,Zhang N,Jin T,Sun X,Luan X,Xu L,Guo F

更新日期：2020-04-01 00:00:00

abstract：:The progesterone metabolite, allopregnanolone (AlloP), is a GABAA receptor modulating steroid and is known to have orexigenic and pro-obesity effects. The neurobiological mechanisms underpinning these effects are most likely due to enhanced GABAergic signaling in the lateral arcuate nucleus (ARC) and medial paraventri...

journal_title：Neuropeptides

authors： Löfgren M,Holmberg E,Bäckström T,Egecioglu E,Dickson SL

更新日期：2019-08-01 00:00:00

abstract：:The effects of forskolin or phorbol-13-myristate (PMA) injected intrathecally (i.t.) or intracerebroventricularly (i.c.v.) on the inhibition of the tail-flick and hotplate responses induced by morphine or beta-endorphin administered i.c.v. were studied. Animals pretreated with forskolin (20 micrograms) i.t. for 10 min...

journal_title：Neuropeptides

authors： Suh HW,Song DK,Sim YB,Chung KM,Kim YH

更新日期：1996-04-01 00:00:00

abstract：:The effects of vasoactive intestinal peptide (VIP) on spatial cognitive deficits induced in the rat by injections of scopolamine were examined in a radial arm maze. A single intraperitoneal (i.p.), subcutaneous (s.c.) or intracerebroventricular (i.c.v.) injection of VIP inhibited the reduction in the number of initial...

journal_title：Neuropeptides

authors： Yamaguchi Y,Kobayashi H

更新日期：1994-03-01 00:00:00

abstract：:Neuropeptide Y (NPY) is a 36 amino acid peptide, which among others, plays a pivotal role in stress response. Although previous studies confirmed that NPY release is increased by stress in several species, the exact mechanism of the stress-induced NPY release has not been elucidated yet. In the present study, we exami...

journal_title：Neuropeptides

authors： Ko L,Rotoli G,Grignol G,Hu W,Merchenthaler I,Dudas B

更新日期：2011-06-01 00:00:00

abstract：:In this study guinea pig, rat and bovine striatal extracts have been shown to contain putative opioid peptide precursors in the molecular weight (Mr) range 2000-greater than 70000. The material eluting greater than 70 kDalton contained bioassayable opioid activity but not Met- or Leu-enkephalin-like immunoreactivities...

journal_title：Neuropeptides

authors： Metters KM,Beaumont A,Rossier J,Hughes J

更新日期：1985-02-01 00:00:00

abstract：:Galanin, a 29 residue peptide found in the hypothalamus, causes orexigenic effects in a variety of species. In the present study, we investigated appetite-associated effects of galanin in chicks from lines which have been selected from a common founder population for either low or high body weight. The low line consis...

journal_title：Neuropeptides

authors： Hagen CJ,Newmyer BA,Webster RI,Gilbert ER,Siegel PB,Tachibana T,Cline MA

更新日期：2013-08-01 00:00:00

abstract：:The role played by the biologically active CART 55-102 peptide in NAcc AMPH induced locomotion was investigated. When microinjected alone into this site, none of the doses of CART 55-102 tested (0.1, 0.4, 1.0 or 2.5 microg/0.5 microl/side) produced effects on locomotion during a two-h test. However, when co-injected w...

journal_title：Neuropeptides

authors： Kim JH,Creekmore E,Vezina P

更新日期：2003-12-01 00:00:00

abstract：:DPDPE ([D-Pen2, D-Pen5]-Enkephalin) and DPLPE ([D-Pen2, L-Pen5]-Enkephalin) are conformationally-constrained cyclic analogs of enkephalin with high selectivity for delta opioid receptors. Intracerebroventricular (i.c.v.) administration of each analog acutely produces a complex EEG response in rats characterized by a d...

journal_title：Neuropeptides

authors： Tortella FC,Robles L,Mosberg HI,Holaday JW

更新日期：1984-12-01 00:00:00

abstract：:In order to further test whether or not psychostimulant drugs activate CART peptide-containing cells in the nucleus accumbens, we examined the fraction of CART positive cells that co-immunostained for c-Fos after administration of saline or cocaine (10 and 25 mg/kg i.p.). There was about a 45% increase in the fraction...

journal_title：Neuropeptides

authors： Hubert GW,Kuhar MJ

更新日期：2008-06-01 00:00:00

abstract：:The central control of feeding in animals depends upon the alternating actions of orexigenic and anorectic peptides. Studies at understanding the food intake mechanisms have emphasised the role of Neuropeptide Y as a potent orexigenic peptide in the brain. The aim of this study is to investigate the response of NPY sy...

journal_title：Neuropeptides

authors： Shewale S,Ali I,Hadawale K,Bhargava S

更新日期：2018-10-01 00:00:00