Abstract:
:The pathophysiological basis for the pain of migraine has been the subject of substantial attention and must include activation of elements of the trigeminal innervation of the cranial vessels, the trigeminovascular system. Recently, consideration of trigeminal-evoked neurogenic plasma protein extravasation (PPE) as a model for the pain has driven the search for compounds with specific anti-extravasation properties. Calcitonin gene-related peptide (CGRP) is a marker for trigeminovascular activation and is released during the headache phase of migraine and cluster headache. CGRP may have a role in migraine through its potent cranial vasodilator effects or by an action on trigeminal nerve activity, both of which are targeted by 5HT(1B/1D)agonist drugs but does not itself produce PPE. It has been suggested that 5HT(1B/1D)agonists may have an anti-migraine effect via inhibition of PPE in the dura mater. Avitriptan and CP122,288 both have strong binding affinities for 5HT(1B/1D)receptors, but only CP122,288 is a potent inhibitor of PPE. In this study we sought to compare the effects of CP122,288 and avitriptan on jugular vein CGRP release after stimulation of the superior sagittal sinus (SSS) in the cat. In eleven anaesthetized cats external jugular vein blood samples were analyzed by radioimmunoassay for CGRP levels in three settings: a) control, b) 1 min after SSS stimulation and c) 1 min after SSS stimulation in presence of drug. Stimulation of the SSS resulted in release of CGRP from the external jugular vein (77+/-1 pmol/L). At a PPE-inhibitory dose in rat (100 ng/kg intravenously) CP122, 288 had no effect on CGRP release (77+/-6 pmol/L) whereas at a clinically relevant dose (50 microgram/kg intravenously) avitriptan blocked CGRP release. This study demonstrates that the potent inhibitor of PPE, CP122, 288, which has been shown in clinical trials to be ineffective in treating acute migraine attacks, had no effect on CGRP release, whereas the effective anti-migraine drug and relatively impotent inhibitor of PPE, avitriptan, blocked CGRP release. These data emphasize the importance of CGRP release and its possible independence from PPE in migraine and more importantly suggest that other non-5HT-based pharmacological targets may account for PPE blockade in animal studies.
journal_name
Neuropeptidesjournal_title
Neuropeptidesauthors
Knight YE,Edvinsson L,Goadsby PJdoi
10.1054/npep.1999.0009keywords:
subject
Has Abstractpub_date
1999-02-01 00:00:00pages
41-6issue
1eissn
0143-4179issn
1532-2785pii
S0143-4179(99)90009-4journal_volume
33pub_type
杂志文章相关文献
NEUROPEPTIDES文献大全abstract::Endothelins (ET) are a family of highly active neuropeptides with manifold influences via ET receptors (ETR) in both the peripheral and central nervous systems. We have shown previously that satellite glial cells (SGCs) in mouse trigeminal ganglia (TG) are extremely sensitive to ET-1 in evoking [Ca2+]in increase, appa...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/j.npep.2017.03.002
更新日期:2017-06-01 00:00:00
abstract::Proenkephalin peptides produced by endocrine and nervous tissues are involved in stress-induced immunosuppression. However, the role of peptides produced by immune cells remains unknown. The present study examines the effect of acute and chronic foot-shock stress on proenkephalin peptide content in bone marrow (BMMC),...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/s0143-4179(98)90058-0
更新日期:1998-08-01 00:00:00
abstract::Using canine spleen and lung membranes as model systems, we have shown the presence of subtypes of ETB receptors. This classification was done based on the binding profiles of various analogs of ET-1 that have been identified as ETB-selective. Saturation binding experiments performed with [125I] ET-3 and [125I] IRL-12...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(95)90004-7
更新日期:1995-12-01 00:00:00
abstract::The present study is designed to elucidate the involvement of neuronal mechanisms in corticotropin-releasing factor (CRF)-induced anti-oedema effects. Oedema was induced in the rat hind paw by subcutaneous injection of 3 nmol of serotonin (5-HT). A single dose of CRF (9.4, 37.5 or 75 pmol) was given either ipsilateral...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1054/npep.2000.0800
更新日期:2000-04-01 00:00:00
abstract::Injection of endothelin-1 (9 pmol) into the lateral cerebral ventricle of rats produced barrel-rotations, convulsions, tonic hindlimb extensions, facial clonus, and kinetic ataxia for up to 45 min. Quantitative metabolic autoradiographs produced from the [14C]deoxyglucose method and analyzed over 60 individual brain s...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(92)90025-r
更新日期:1992-04-01 00:00:00
abstract::Possible positive reinforcing and aversive effects of intraperitoneally (ip) administered substance P (SP) and its C-terminal heptapeptide analog [pGlu5, MePhe8, Sar9]-SP5-11 (DIME-C7) were investigated in rats. The 'conditioned corral preference and avoidance procedure' was used for assessing positive and negative re...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(90)90037-y
更新日期:1990-12-01 00:00:00
abstract::Neuropeptides form the largest family of modulators of synaptic transmission. Until 1995 some 60 different neuropeptides had been found. With the recognition that all neuropeptides act by binding to G protein coupled receptors (GPCRs), a new approach relying on the use of orphan GPCRs as targets was designed to identi...
journal_title:Neuropeptides
pub_type: 杂志文章,评审
doi:10.1016/j.npep.2006.04.002
更新日期:2006-08-01 00:00:00
abstract::In vitro structure-activity studies with cholecystokinin (CCK)/gastrin-related peptides, including C- and N-terminal fragments of CCK 26-33, were undertaken in guinea pig gallbladder and ileum. The general order of potency in both smooth muscle preparations is CCK 26-33 greater than CCK 1-33 greater than 27-33 much mu...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(87)90084-9
更新日期:1987-07-01 00:00:00
abstract::Omega Conotoxin is a peptide venom of the marine snail Conus geographus which has been postulated as a neural specific calcium channel blocker in several systems. In the present study in rat ileum strips omega-conotoxin GVIA specifically blocked neuronal responses evoked by electrical field stimulation in a dose-depen...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(89)90078-4
更新日期:1989-05-01 00:00:00
abstract::Gestational cocaine treatment in rat dams results in decreased oxytocin (OT) levels, up-regulated oxytocin receptor (OTR) binding density and decreased receptor affinity in the whole amygdala, all concomitant with a significant increase in maternal aggression on postpartum day six. Rat dams with no gestational drug tr...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/j.npep.2006.03.002
更新日期:2006-06-01 00:00:00
abstract::The effect of opioid peptide, D-alanine2-leucine-enkephalin and opioid homolog peptide, des-tyrosine-methionine-enkephalin in concentrations of 1 x 10(-6) and 1 x 10(-5) M was investigated on the action potential parameters of frog sciatic nerve. Des-tyrosine-methionine-enkephalin was used as the control to prove the ...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/j.npep.2004.03.003
更新日期:2004-04-01 00:00:00
abstract::Nociceptin-opioid peptide (NOP) receptor, also known as opioid receptor like-1 (ORL1), was identified following the cloning of the kappa-opioid peptide (KOP) receptor, and the characterization of these receptors revealed high homology. The endogenous ligand of NOP, nociceptin (NOC), which shares high homology to dynor...
journal_title:Neuropeptides
pub_type: 杂志文章,评审
doi:10.1016/j.npep.2011.03.002
更新日期:2011-08-01 00:00:00
abstract::We investigated the effect of sulphated cholecystokinin octapeptide (CCK-8S) on free intracellular calcium concentration, phosphatidylinositol metabolism, and protein phosphorylation in C6 cells, a rat glioma cell line which was shown to express CCKB type receptors. Increase in [Ca2+]i by both influx across the cell m...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(95)90033-0
更新日期:1995-11-01 00:00:00
abstract::Neural stem cells (NSC) could promote the repair after spinal cord transection (SCT), the underlying mechanism, however, still keeps to be defined. This study reported that NSC grafts significantly improved sensory and locomotor functions in adult rats with SCT in acute stage after injury. NSC could survive; different...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/j.npep.2012.06.001
更新日期:2013-02-01 00:00:00
abstract::Social recognition is the sensitive domains of complex behavior critical for identification, interpretation and storage of socially meaningful information. Social recognition develops throughout childhood and adolescent, and is affected in a wide variety of psychiatric disorders. Recently, new data appeared on the mol...
journal_title:Neuropeptides
pub_type: 杂志文章,评审
doi:10.1016/j.npep.2018.09.003
更新日期:2018-12-01 00:00:00
abstract::Experiments were performed to determine whether the renal nerve mediates the renin release induced by intracerebroventricular administration of angiotensin II (ANG II), bradykinin (BK), leucine-enkephalin (Leu-ENK) and neurotensin (NT). In sham-operated rats, both ANG II and NT suppressed plasma renin activity (PRA), ...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(85)90142-8
更新日期:1985-09-01 00:00:00
abstract::The immune system defends the organism against invading pathogens. In recent decades it became evident that elimination of such pathogens, termination of inflammation, and restoration of host homeostasis all depend on bidirectional crosstalk between the immune system and the neuroendocrine system. This crosstalk is me...
journal_title:Neuropeptides
pub_type: 杂志文章,评审
doi:10.1016/j.npep.2010.10.005
更新日期:2011-02-01 00:00:00
abstract::There is now considerable evidence that putative neuropeptides are involved in epileptogenic processes. Neurotensin (NT), which affects neuronal excitability in many parts of the CNS, is potentially relevant to the kindling phenomenon, but has not previously been studied in the kindling model of epilepsy. This study c...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(88)90014-5
更新日期:1988-02-01 00:00:00
abstract::Cerebral amyloid-beta protein (Abeta) deposition and associated neuroinflammation and apoptosis are increasingly recognized as an important component leading to cognitive impairment in Alzheimer's disease (AD). Humanin (HN) and its derivative, S14G-HN (HNG), are best known for their ability to suppress neuronal death ...
journal_title:Neuropeptides
pub_type: 杂志文章,收录出版
doi:10.1016/j.npep.2008.08.004
更新日期:2008-10-01 00:00:00
abstract::Ghrelin (gh) is a peptide hormone that may affect learning and memory. There is some evidence that ghrelin can have antiepileptic effects. So we decided to investigate the possible effects of ghrelin on spatial memory following PTZ-induced seizures in male rats. Ninety male rats were divided into 9 groups including co...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/j.npep.2013.05.005
更新日期:2013-10-01 00:00:00
abstract::D-Arg containing dipeptides, H-Tyr-D-Arg-OMe and H-Tyr (Et)-D-Arg-OMe, and D-Arg2 substituted N-terminal tetrapeptides of dermorphin, H-Tyr-D-Arg-Phe-Gly-OEt and H-Tyr (Et)-D-Arg-Phe-Gly-OEt administered intracerebroventricularly exhibited dose-dependent antinociceptive activities in mice as measured by the tail press...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(84)90001-5
更新日期:1984-06-01 00:00:00
abstract::Information on the physiological functions of neuropeptide FF; NPFF, a morphine modulating octapeptide in avians is lacking. Thus, we designed a study to investigate the effects of central NPFF with particular emphasis on appetite-related processes. Cobb-500 chicks were intracerebroventricularly (ICV) injected with 0,...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/j.npep.2007.08.003
更新日期:2007-12-01 00:00:00
abstract::Angiotensin I-converting enzyme (ACE) is recognized as one of the main effector molecules involved in blood pressure regulation. In the last few years some polymorphisms of ACE such as the insertion/deletion (I/D) polymorphism have been described, but their physiologic relevance is poorly understood. In addition, few ...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/j.npep.2009.12.003
更新日期:2010-04-01 00:00:00
abstract::In critical patients, sepsis-induced muscle wasting is considered to be an important contributor to complications and mortality. Previous work mainly focuses on the peripheral molecular mechanism of muscle degradation, however little evidence exists for the role of central nervous system in the process. In the present...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/j.npep.2014.10.002
更新日期:2014-12-01 00:00:00
abstract::Several studies suggest that prenatal ethanol exposure (PEE) facilitates ethanol intake. Opioid peptides play a main role in ethanol reinforcement during infancy and adulthood. However, PEE effects upon motor responsiveness elicited by an ethanol challenge and the participation of opioids in these actions remain to be...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/j.npep.2016.11.006
更新日期:2017-04-01 00:00:00
abstract::The role of somatostatin and a stable analogue, sandostatin (Octreotide), on the responses of spinal cord neurones in vivo was investigated in the rat. Electrical C-fibre stimulation was used as a model of acute nociception and the response to subcutaneous formalin was used as a model of longer term events. Intratheca...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(92)90115-d
更新日期:1992-11-01 00:00:00
abstract::Intravenous injections of neurotensin (NT) (0.5, 1 and 2 nmoles kg-1) evoked dose-dependent increases in histaminemia and hematocrit, and marked hypotensive effect, in anesthetized rats. The increase of plasma histamine was rapid in onset (within sec), peak plasma histamine being reached in less than 2 min. The declin...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(82)90010-5
更新日期:1982-12-01 00:00:00
abstract::Brain extracts from 3 to 4 day old final (eighth) instar larvae of Opisina arenosella (Lepidoptera) stimulate amylase release from midgut preparations maintained in vitro. This effect of the brain extract was both time and dose dependent. The brain factor stimulating enzyme release may be a peptide as it is heat stabl...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/s0143-4179(03)00025-8
更新日期:2003-06-01 00:00:00
abstract::Neurokinin A (NKA) and substance P (SP) are often co-localized in small sensory neurons and have been suggested to subserve similar roles. We have now compared tissue levels of NKA and SP in rat cervical dorsal root ganglia with those in the central and peripheral terminations of the same neurons. We found that NKA co...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(95)90027-6
更新日期:1995-04-01 00:00:00
abstract::Recent studies have shown that oxytocin reduces food intake and body weight gain and promotes lipolysis in some species, including humans. Interestingly, these effects of oxytocin are more marked in obese individuals. Although the menopausal loss of ovarian function induces increased visceral adiposity and some metabo...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/j.npep.2019.03.002
更新日期:2019-06-01 00:00:00