Abstract：
:Microchemotaxis chambers were used to investigate whether one aspect of ciliary neurotrophic factor CNTF's role as a lesion factor might be to promote the initial early recruitment of macrophages, which express the signal transducing receptor components, gp130 and LIFRbeta. CNTFRalpha alone, or in combination with CNTF, elicited concentration-dependent macrophage chemotaxis that was inhibited by a neutralizing gp 130 antibody. IL-6, but not LIF, similarly promoted gp 130-dependent macrophage chemotaxis. Stimulation of macrophages with either CNTFRalpha in combination with CNTF or IL-6 alone resulted in tyrosine phosphorylation of an approximately 130 kD protein, presumed to be gp130. Macrophage chemotaxis induced by the combination of CNTFRalpha and CNTF was inhibited in a dose-dependent fashion by wortmannin, LY294002 or PD98059, suggesting the involvement of the phosphoinositide-3 kinase and mitogen-activated protein kinase signaling proteins. As CNTFRalpha and CNTF are present, or have immediate access to nerves after injury, these data point to the possibility that this soluble receptor alone or in combination with its ligand may promote the initial early recruitment of macrophages in vivo.
journal_name
Neuropeptidesjournal_title
Neuropeptidesauthors
Kobayashi H,Mizisin APdoi
10.1054/npep.2000.0829keywords:
subject
Has Abstractpub_date
2000-12-01 00:00:00pages
338-47issue
6eissn
0143-4179issn
1532-2785pii
S0143-4179(00)90829-1journal_volume
34pub_type
杂志文章相关文献
NEUROPEPTIDES文献大全abstract：:Neuropeptides form the largest family of modulators of synaptic transmission. Until 1995 some 60 different neuropeptides had been found. With the recognition that all neuropeptides act by binding to G protein coupled receptors (GPCRs), a new approach relying on the use of orphan GPCRs as targets was designed to identi...
journal_title：Neuropeptides
pub_type： 杂志文章,评审
doi：10.1016/j.npep.2006.04.002
更新日期：2006-08-01 00:00:00
abstract：:Both endothelins and corticotropin releasing factor (CRF) appear in capsaicin-sensitive neurons. We have investigated the effects of human endothelin-1 (ET-1) and CRF in the guinea-pig ileum longitudinal and circular preparations and sought for ways of specific antagonism. With the aid of tachyphylaxis to capsaicin (i...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/s0143-4179(03)00048-9
更新日期：2003-08-01 00:00:00
abstract：:The effects of several protein modifying reagents, including phenoxybenzamine, N-ethylmaleimide (NEM), 5,5'-dithiobis (2-nitro)--benzoic acid (DTNB), p-chloromercuryphenyl sulfonic acid (PCMP) and p-bromophenacylbromide (PBPB), on the binding of 125I-Bolton Hunter substance P (125I-BHSP), 125I-Bolton Hunter eledoisin ...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/0143-4179(87)90053-9
更新日期：1987-02-01 00:00:00
abstract：:Down syndrome is the most common genetic disorder associated with mental retardation. Subjects and mice models for Down syndrome (such as Ts65Dn) show defects in the formation of neuronal networks in both the hippocampus and the cerebral cortex. The principal neurons display alterations in the morphology, density and ...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/j.npep.2011.10.002
更新日期：2012-02-01 00:00:00
abstract：:We have measured cerebrospinal fluid (CSF) neuropeptide Y-like immunoreactivity (NPY-LI) and somatostatin-like immunoreactivity (SLI) in control subjects and in patients with various neurologic disorders. We observed a significant reduction in CSF SLI in control subjects over 60 years of age, compared with the younger...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/0143-4179(94)90058-2
更新日期：1994-12-01 00:00:00
abstract：:We have assessed the influence of acute bilateral nephrectomy, of captopril and saralasin, on the hypotensive activity of neurotensin (NT) and of various hypotensive drugs in pentobarbital-anesthetized rats. The results show that the hypotensive activity of NT and of compound 48/80 (C48/80), in contrast to that of his...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/0143-4179(83)90047-1
更新日期：1983-04-01 00:00:00
abstract：:Several lines of evidence indicate a role for neuropeptide Y (NPY) in the modulation of the corticotroph axis. In two separate studies reported here, the concentrations of NPY and noradrenaline (NA), as well as corticotropin-releasing factor (CRF) and arginine vasopressin (AVP), were measured in extracts of individual...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/0143-4179(93)90107-l
更新日期：1993-10-01 00:00:00
abstract：:Clinical and experimental evidence have demonstrated that, use of alcohol during pregnancy can interrupt brain development. Alcohol-induced neurocognitive deficits in offspring's are involved with activation of oxidative-inflammatory cascade joined with extensive apoptotic neurodegeneration in different brain regions ...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/j.npep.2019.01.001
更新日期：2019-04-01 00:00:00
abstract：:In order to further test whether or not psychostimulant drugs activate CART peptide-containing cells in the nucleus accumbens, we examined the fraction of CART positive cells that co-immunostained for c-Fos after administration of saline or cocaine (10 and 25 mg/kg i.p.). There was about a 45% increase in the fraction...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/j.npep.2008.01.001
更新日期：2008-06-01 00:00:00
abstract：:Oxytocin (OXT), a nonapeptide hormone of posterior pituitary, reaches the central nervous system from systemic blood circulation with a difficulty because of the blood-brain barrier (BBB). The interest has been expressed in the use of the nasal route for delivery of OXT to the brain directly, exploiting the olfactory ...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/j.npep.2012.12.003
更新日期：2013-04-01 00:00:00
abstract：:Lysine-vasopressin (LVP) at different concentrations (2 ng, 200 pg) was injected into the lateral ventricle and cisterna magna. The effect on hypothalamic self-stimulation was studied in rats. LVP (2 ng) decreased the self-stimulation rate after intracerebroventricular and cisternal application. Injection of 200 pg LV...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/s0143-4179(87)90119-3
更新日期：1987-11-01 00:00:00
abstract：:Spermidine is a naturally occurring endogenous polyamine synthesized from diamine putrescine. It is a well-known autophagy inducer that maintains cellular and neuronal homeostasis. Healthy brain development and function are dependent on brain polyamine concentration. Polyamines interact with the opioid system, glutama...
journal_title：Neuropeptides
pub_type： 杂志文章,评审
doi：10.1016/j.npep.2020.102083
更新日期：2020-10-01 00:00:00
abstract：:Quantitative evaluation of octadecaneuropeptide-like immunoreactivity (ODN-Li) was carried out in hippocampus, cortex and cerebellum of group-reared or three month isolated male Wistar rats, whether muricidal or not. ODN-Li was lower in cortex and cerebellum of isolated animals, (mainly in muricidal) than of group-rea...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/0143-4179(91)90116-z
更新日期：1991-07-01 00:00:00
abstract：:Rats housed individually for 7 days showed a marked decrease in motor activity when tested under intense light conditions in a novel environment as compared to group-housed rats tested under low light conditions. The ACTH analogue ORG 2766 administered into the amygdala decreased the motor activity of group-housed rat...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/0143-4179(89)90070-x
更新日期：1989-08-01 00:00:00
abstract：:The effects of central (clonazepam, an agonist, and FG 7142, an inverse agonist), mixed (diazepam) or peripheral type (Ro 5-4864) benzodiazepine receptor ligands on the action of TRH on the transmurally stimulated rat duodenum and binding of [3H][3-Me-His2] TRH in the rat anterior pituitary, hypothalamus, cortex and b...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/0143-4179(91)90112-v
更新日期：1991-07-01 00:00:00
abstract：:The effects of FMRFamide on passive avoidance behaviour and electroshock-induced amnesia following intracerebroventricular administration were studied in rats. FMRFamide given immediately after the learning trial, or 20 min before the retention trial, attenuated the avoidance response, thereby impairing the consolidat...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/0143-4179(87)90017-5
更新日期：1987-08-01 00:00:00
abstract：:Germline ablation of VGF, a secreted neuronal, neuroendocrine, and endocrine peptide precursor, results in lean, hypermetabolic, and infertile adult mice that are resistant to diet-, lesion-, and genetically-induced obesity and diabetes (Hahm et al., 1999, 2002). To assess whether this phenotype is predominantly drive...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/j.npep.2016.12.005
更新日期：2017-08-01 00:00:00
abstract：:Nerve growth factor (NGF) was reported to be increased in the serum and skin of atopic dermatitis (AD) patients, to the extent that serum nerve growth factor levels were proposed to serve as a marker of disease severity. We studied NGF levels in the serum and dermis using skin microdialysis and attempted to correlate ...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/j.npep.2011.07.008
更新日期：2011-12-01 00:00:00
abstract：:Orexins are neuropeptides that are localized to neurons in the lateral and dorsal hypothalamus but its receptors are distributed to many different regions of the central nervous system. Orexins are implicated in a variety of physiological functions including sleep regulation, energy homeostats, and stress reactions. F...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/j.npep.2016.12.007
更新日期：2017-02-01 00:00:00
abstract：:The orally active, α-hemoglobin derived hemopressin (PVNFKFLSH, Hp(1-9)) and its truncated (PVNFKFL, Hp(1-7) and PVNFKF, Hp(1-6)) and extended ((R)VDPVNFKFLSH, VD-Hp(1-9) and RVD-Hp(1-9)) derivatives have been postulated to be the endogenous peptide ligands of the cannabinoid receptor type 1 (CB1). In an attempt to cr...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/j.npep.2016.02.001
更新日期：2016-08-01 00:00:00
abstract：:Recently, we demonstrated that brain neuropeptide Y (NPY) mRNA expression was increased in heat exposed chicks. However, the functions of brain NPY during heat stress are unknown. This study was conducted to investigate whether centrally administered NPY affects food intake, rectal temperature, monoamines, stress horm...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/j.npep.2016.11.008
更新日期：2017-04-01 00:00:00
abstract：:Development of transgenic mice overexpressing GH and GHR-KO mice with GH resistance provided novel animal models for study of the somatotropic axis and for identifying GH actions that may be relevant to its current and contemplated use in medicine and agriculture. Studies of phenotypic characteristics of these animals...
journal_title：Neuropeptides
pub_type： 杂志文章,评审
doi：10.1054/npep.2002.0889
更新日期：2002-04-01 00:00:00
abstract：:Alzheimer's disease (AD) is a progressive neurodegenerative disease that deeply affects patients, their family and society. Although scientists have made intense efforts in seeking the cure for AD, no drug available today is able to stop AD progression. In this context, compounds isolated from animal venom are potenti...
journal_title：Neuropeptides
pub_type： 杂志文章,评审
doi：10.1016/j.npep.2017.11.010
更新日期：2018-02-01 00:00:00
abstract：:The effects of intravenous self-administration of 30 micrograms infusions of either heroin or cocaine, or saline on the concentrations of beta-endorphin-immunoreactivity (beta E-IR) in the anterior part of the rat brain limbic system were studied. Self-administration of heroin and cocaine for 5 daily sessions resulted...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/0143-4179(88)90060-1
更新日期：1988-11-01 00:00:00
abstract：:The effects of a potent serine protease inhibitor, Boc-D-Phe-Pro-Arg-H, on the secretion and content of ACTH and beta-endorphin-like immunoreactivities of cultured rat anterior pituitary cells were studied. Basal release of the hormones was not affected by the drug but secretion in response to stalk-median eminence ex...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/0143-4179(82)90066-x
更新日期：1982-10-01 00:00:00
abstract：:Oxytocin, either intraperitoneally injected (200 ng/rat) or intracerebroventricularly infused (1 ng/rat in 4 microliters saline) 60 and 15 min respectively before testing, significantly increased the lordosis response to the mounting male of ovariectomized, estrogen/progesterone treated rats. The intracerebroventricul...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/0143-4179(85)90095-2
更新日期：1985-06-01 00:00:00
abstract：:The present study was undertaken to determine whether neurotensin is involved in the regulation of the intestinal postprandial motor response and, if so, whether the regulatory pathway depends upon peripheral or central neurotensin secretion. Neurotensin, injected by the i.v. route (5 micrograms/kg) during the fasting...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/s0143-4179(96)90002-5
更新日期：1996-10-01 00:00:00
abstract：:Utilizing a double-blind crossover design, the hormonal effects of high dose, 2 mg/kg, were compared to low dose, 0.4 mg (approx. 5 micrograms/kg), naloxone administration in physically healthy humans. A significant naloxone dose effect on plasma cortisol levels was found (p less than 0.001), but no significant effect...
journal_title：Neuropeptides
pub_type： 临床试验,杂志文章
doi：10.1016/0143-4179(85)90010-1
更新日期：1985-07-01 00:00:00
abstract：OBJECTIVES:Postmenopausal osteoporosis (PMO) is a metabolic skeletal disorder with impaired bone density and bone quality in postmenopausal women. The aim of the present study was to investigate the correlation between neuropeptides, bone microstructure and pain threshold in ovariectomized (OVX) rats. METHODS:Female r...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/j.npep.2019.101995
更新日期：2020-06-01 00:00:00
abstract：:In this study guinea pig, rat and bovine striatal extracts have been shown to contain putative opioid peptide precursors in the molecular weight (Mr) range 2000-greater than 70000. The material eluting greater than 70 kDalton contained bioassayable opioid activity but not Met- or Leu-enkephalin-like immunoreactivities...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/0143-4179(85)90069-1
更新日期：1985-02-01 00:00:00
