Abstract:
:Neuropeptides form the largest family of modulators of synaptic transmission. Until 1995 some 60 different neuropeptides had been found. With the recognition that all neuropeptides act by binding to G protein coupled receptors (GPCRs), a new approach relying on the use of orphan GPCRs as targets was designed to identify novel neuropeptides. Thirteen new neuropeptide families have since been discovered. In this review we will describe the orphan GPCR-based approach that led to these discoveries and present its impact on two specific physiological responses, feeding and sleep. In particular, we will discuss the modulatory roles of the hypocretins/orexins and of neuropeptide S in sleep and awakening and those of ghrelin and melanin concentrating hormone in food intake.
journal_name
Neuropeptidesjournal_title
Neuropeptidesauthors
Chung S,Civelli Odoi
10.1016/j.npep.2006.04.002subject
Has Abstractpub_date
2006-08-01 00:00:00pages
233-43issue
4eissn
0143-4179issn
1532-2785pii
S0143-4179(06)00032-1journal_volume
40pub_type
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