Orphan neuropeptides. Novel neuropeptides modulating sleep or feeding.

Abstract:

:Neuropeptides form the largest family of modulators of synaptic transmission. Until 1995 some 60 different neuropeptides had been found. With the recognition that all neuropeptides act by binding to G protein coupled receptors (GPCRs), a new approach relying on the use of orphan GPCRs as targets was designed to identify novel neuropeptides. Thirteen new neuropeptide families have since been discovered. In this review we will describe the orphan GPCR-based approach that led to these discoveries and present its impact on two specific physiological responses, feeding and sleep. In particular, we will discuss the modulatory roles of the hypocretins/orexins and of neuropeptide S in sleep and awakening and those of ghrelin and melanin concentrating hormone in food intake.

journal_name

Neuropeptides

journal_title

Neuropeptides

authors

Chung S,Civelli O

doi

10.1016/j.npep.2006.04.002

subject

Has Abstract

pub_date

2006-08-01 00:00:00

pages

233-43

issue

4

eissn

0143-4179

issn

1532-2785

pii

S0143-4179(06)00032-1

journal_volume

40

pub_type

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