Abstract:
:We have assessed the influence of acute bilateral nephrectomy, of captopril and saralasin, on the hypotensive activity of neurotensin (NT) and of various hypotensive drugs in pentobarbital-anesthetized rats. The results show that the hypotensive activity of NT and of compound 48/80 (C48/80), in contrast to that of histamine, of 5-hydroxytryptamine and of hexamethonium, is markedly reduced, especially for NT, in nephrectomized as compared to sham operated rats. The pretreatment of rats with captopril (10 mg kg-1, i.v.) or with saralasin (20 micrograms kg-1 min-1, i.v.) was found to inhibit significantly the hypotensive activity of NT and of C48/80. Adrenalectomy restored partially the hypotensive activity of NT in nephrectomized rats. The potent vasopressin antagonist [d(CH2)5 Tyr(Me)AVP] did not alter the refractoriness of nephrectomized rats to the hypotensive activity of NT. Neither nephrectomy nor saralasin were found to interfere with the ability of NT or of C48/80 to evoke an increase of plasma histamine level or of the hematocrit. The results were interpreted as an indication that NT produces part of its hypotensive effect in anesthetized rats by reducing the activity of the renin angiotensin system. The results also suggest that part of the refractoriness of nephrectomized rats to the hypotensive activity of NT could be due to the release of catecholamines from adrenal glands by NT. Endogenous vasopressin does not appear to contribute to the refractoriness of nephrectomized rats to the hypotensive action of NT.
journal_name
Neuropeptidesjournal_title
Neuropeptidesauthors
Kérouac R,St-Pierre S,Manning M,Rioux Fdoi
10.1016/0143-4179(83)90047-1subject
Has Abstractpub_date
1983-04-01 00:00:00pages
295-307issue
4eissn
0143-4179issn
1532-2785pii
0143-4179(83)90047-1journal_volume
3pub_type
杂志文章相关文献
NEUROPEPTIDES文献大全abstract::Several lines of evidence indicate a role for neuropeptide Y (NPY) in the modulation of the corticotroph axis. In two separate studies reported here, the concentrations of NPY and noradrenaline (NA), as well as corticotropin-releasing factor (CRF) and arginine vasopressin (AVP), were measured in extracts of individual...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(93)90107-l
更新日期:1993-10-01 00:00:00
abstract::Dermorphin (Tyr-D-Ala-Phe-Gly-Tyr-Pro-Ser-NH2), a naturally occurring peptide isolated from arboreal frog skin, is endowed with outstanding structural and biological features. It has no structural community with the sequence of mammalian opioid peptides and is a unique example of a D-aminoacid containing peptide which...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(89)90021-8
更新日期:1989-01-01 00:00:00
abstract::The effects of the GABAergic drugs nipecotic acid, Gabrene, baclofen and metatolylcarbamide (MTC), when given alone or in combination at subthreshold doses with AT II also at a subthreshold dose effective on PTZ-kindling in mice were studied. PTZ-kindling was provoked by intraperitoneal (i.p.) injections of PTZ (40 mg...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(95)90071-3
更新日期:1995-01-01 00:00:00
abstract::Various studies have shown a relationship between nerves and bones. Recent evidence suggests that both sensory and sympathetic nerves affect bone metabolism; however, little is known about how neuropeptides are involved in the differentiation of pluripotent stem cells into osteoblastic (OB) cells. To evaluate the puta...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/j.npep.2014.10.004
更新日期:2014-12-01 00:00:00
abstract::Orexins/hypocretins are neuropeptides that have various physiological effects, including the regulation of feeding behavior, neuroendocrine functions and sleep-wake cycles. Recent studies have suggested that the orexin system may also be involved in brain ischemic reactions. It is also known that changes in sleep patt...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/j.npep.2006.06.003
更新日期:2006-08-01 00:00:00
abstract::Angiotensin I-converting enzyme (ACE) is recognized as one of the main effector molecules involved in blood pressure regulation. In the last few years some polymorphisms of ACE such as the insertion/deletion (I/D) polymorphism have been described, but their physiologic relevance is poorly understood. In addition, few ...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/j.npep.2009.12.003
更新日期:2010-04-01 00:00:00
abstract::The role of somatostatin and a stable analogue, sandostatin (Octreotide), on the responses of spinal cord neurones in vivo was investigated in the rat. Electrical C-fibre stimulation was used as a model of acute nociception and the response to subcutaneous formalin was used as a model of longer term events. Intratheca...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(92)90115-d
更新日期:1992-11-01 00:00:00
abstract::CSF methionine and leucine enkephalins were measured by high performance liquid chromatography and radioimmunoassay in diabetic patients with painful neuropathy (n = 22) and painless neuropathy (n = 5), and non-diabetic subjects with low back pain (n = 11). Wide variations in CSF enkephalin levels were found and they ...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(92)90067-7
更新日期:1992-06-01 00:00:00
abstract::In the hot plate test the intracerebroventricular (i.c.v.) injection of oxytocin produced a significant decrease in nociception, starting from the dose of 1 microgram/rat. A comparable effect was obtained with 10-200 times higher intraperitoneal (i.p.) doses. The i.c.v. injection of the oxytocin antagonist d(CH2)5-Tyr...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(93)90075-l
更新日期:1993-03-01 00:00:00
abstract::Rats housed individually for 7 days showed a marked decrease in motor activity when tested under intense light conditions in a novel environment as compared to group-housed rats tested under low light conditions. The ACTH analogue ORG 2766 administered into the amygdala decreased the motor activity of group-housed rat...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(89)90070-x
更新日期:1989-08-01 00:00:00
abstract::We have evaluated the peripheral blood natural killer (NK) cell activity and the in vitro effect of recombinant gamma-interferon (r gamma-IFN) on NK cell activity in 23 patients with a neuroendocrine tumour of the pancreas, small intestine or liver, and 23 healthy controls. Patients with a gastrinoma showed a NK cell ...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(91)90033-f
更新日期:1991-09-01 00:00:00
abstract::A human brain aminopeptidase, which hydrolyses low molecular weight enkephalin-containing peptides (ECPs), was purified to apparent homogeneity from the homogenate of human brain. The enzyme purification involved DEAE-cellulose chromatography and preparative polyacrylamide gel electrophoresis. The purified aminopeptid...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(88)90033-9
更新日期:1988-08-01 00:00:00
abstract::Neuropeptides form the largest family of modulators of synaptic transmission. Until 1995 some 60 different neuropeptides had been found. With the recognition that all neuropeptides act by binding to G protein coupled receptors (GPCRs), a new approach relying on the use of orphan GPCRs as targets was designed to identi...
journal_title:Neuropeptides
pub_type: 杂志文章,评审
doi:10.1016/j.npep.2006.04.002
更新日期:2006-08-01 00:00:00
abstract::Nesfatin-1, a newly discovered satiety peptide, has recently been reported to be involved in the stress response. Stress-induced expression of nesfatin-1 has been reported and few studies focus on its expression in the hypothalamus, which is the center of the stress response. To test our hypothesis that peripheral and...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/j.npep.2015.08.003
更新日期:2015-12-01 00:00:00
abstract::We examined the effects of gestational cocaine treatment on oxytocin levels in the whole hippocampus (HIP), ventral tegmental area (VTA), medial preoptic area (MPOA) and amygdala (AMY) in rat dams on postpartum days (PPDs) 1 and 2. Cocaine treatment significantly reduced oxytocin levels in the MPOA within 12-16 h of d...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/s0143-4179(97)90037-8
更新日期:1997-10-01 00:00:00
abstract::Oxytocic peptides extracted from the brain and plasma of the brushtail possum, Trichosurus vulpecula, were separated by reverse-phase high pressure lipid chromatography (HPLC) and quantified by specific radioimmunoassays for oxytocin (OT) and mesotocin (MT). The pituitary, hypothalamus and cerebral cortex were found t...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(90)90123-g
更新日期:1990-07-01 00:00:00
abstract::Recent studies have shown that oxytocin reduces food intake and body weight gain and promotes lipolysis in some species, including humans. Interestingly, these effects of oxytocin are more marked in obese individuals. Although the menopausal loss of ovarian function induces increased visceral adiposity and some metabo...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/j.npep.2019.03.002
更新日期:2019-06-01 00:00:00
abstract::In situ hybridisation histochemistry was used to study the effect of intra-peritoneal reserpine administration on messenger RNA (mRNA) levels in the locus coeruleus (LC) of the rat. 48h after injection, levels of mRNA encoding tyrosine hydroxylase (TH) and neuropeptide Y (NPY) in the LC increased to approximately 250%...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(91)90105-r
更新日期:1991-03-01 00:00:00
abstract::AtT-20 cells are known to synthesize two molecular weight forms of the prohormone converting enzyme PC1 with molecular masses of 87 and 66 kDa. In this study we have analyzed basal and stimulated secretion of these proteins. Western blot results show that basal secretion medium of cultured AtT-20 cells contained low c...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(93)90096-s
更新日期:1993-08-01 00:00:00
abstract::The present study is designed to elucidate the involvement of neuronal mechanisms in corticotropin-releasing factor (CRF)-induced anti-oedema effects. Oedema was induced in the rat hind paw by subcutaneous injection of 3 nmol of serotonin (5-HT). A single dose of CRF (9.4, 37.5 or 75 pmol) was given either ipsilateral...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1054/npep.2000.0800
更新日期:2000-04-01 00:00:00
abstract::Lumbar disc herniation is a common cause of radicular pain, but the mechanism remains ambiguous and the treatment stays unsatisfied. Many studies revealed a traditional Chinese medicine puerarin may moderate chronic pain from diabetes and nerve injury. Thus far, the role and mechanism of puerarin in radicular pain is ...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/j.npep.2018.10.001
更新日期:2018-12-01 00:00:00
abstract::Prader-Willi syndrome (PWS) is the predominant genetic cause of obesity in humans and is associated with several behavioural phenotypes such as altered motoric function, reduced activity, and learning disabilities. It can include mood instability and, in some cases, psychotic episodes. Recently, the Snord116 gene has ...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/j.npep.2015.06.009
更新日期:2015-10-01 00:00:00
abstract::Cocaine- and amphetamine-regulated transcript (CART) peptides have a wide CNS distribution and appear to play an important role in a number of physiological processes including reward and reinforcement, feeding, locomotion, stress responses and perception of pain. We have further investigated the expression of CART pe...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/j.npep.2007.11.001
更新日期:2008-02-01 00:00:00
abstract::Tachykinins are a family of pronociceptive neuropeptides with a specific role in pain and inflammation. Several mechanisms regulate endogenous tachykinins and Substance P (SP) levels, including the differential expression of protachykinin mRNA and the controlled secretion of tachykinins from neurons. Proteolysis is su...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/j.npep.2016.06.002
更新日期:2016-10-01 00:00:00
abstract::We have previously shown that the kappa-opioid agonist, asimadoline, produces time-dependent changes in neuropeptide concentrations in the joints of rats with chronic arthritis. We hypothesized that asimadoline acts on peripheral terminals to modulate substance P (SP) release. To address this hypothesis, here we have ...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1054/npep.2000.0813
更新日期:2000-06-01 00:00:00
abstract::Morphine (M) produced a dose-related decrease in metabolic weight loss (MWL) over a three-hour period, despite the fact that it significantly enhanced locomotor activity in male mice. This conservation of energy was specific to opioid receptors because naltrexone HCl (N) blocked it. These receptors were localized main...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(85)90019-8
更新日期:1985-02-01 00:00:00
abstract::Familial dysautonomia (FD) patients have diminished sensory C-fibers. Calcitonin gene related peptide (CGRP) is a widely distributed neuropeptide and prominent neurotransmitter in C-fibers. We show that plasma CGRP levels measured by radioimmunoassay is significantly lower in 51 FD patients compared to controls (P<0.0...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1054/npep.2001.0863
更新日期:2001-06-01 00:00:00
abstract::The role played by the biologically active CART 55-102 peptide in NAcc AMPH induced locomotion was investigated. When microinjected alone into this site, none of the doses of CART 55-102 tested (0.1, 0.4, 1.0 or 2.5 microg/0.5 microl/side) produced effects on locomotion during a two-h test. However, when co-injected w...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/j.npep.2003.10.001
更新日期:2003-12-01 00:00:00
abstract::Previous data from our labs and from others have demonstrated that intracerebroventricular (ICV) injection of alarin has orexigenic activity and significantly increases plasma luteinizing hormone (LH) secretion in a gonadotropin-releasing hormone (GnRH) dependent manner. The purpose of the current experiments was to d...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/j.npep.2012.08.007
更新日期:2013-02-01 00:00:00
abstract::Social recognition is the sensitive domains of complex behavior critical for identification, interpretation and storage of socially meaningful information. Social recognition develops throughout childhood and adolescent, and is affected in a wide variety of psychiatric disorders. Recently, new data appeared on the mol...
journal_title:Neuropeptides
pub_type: 杂志文章,评审
doi:10.1016/j.npep.2018.09.003
更新日期:2018-12-01 00:00:00