Abstract:
:Nesfatin-1, a newly discovered satiety peptide, has recently been reported to be involved in the stress response. Stress-induced expression of nesfatin-1 has been reported and few studies focus on its expression in the hypothalamus, which is the center of the stress response. To test our hypothesis that peripheral and hypothalamic nesfatin-1 overexpression should play an important role in the stress response and the associated hyperactivity of hypothalamic-pituitary-adrenal (HPA) axis, acute stress (AS) was induced using water avoidance stress (WAS), and chronic unpredictable mild stress (CUMS) was also induced using 3 consecutive weeks of 7 different stressors. The behavior of CUMS rats was evaluated by an open field test (OFT), sucrose preference test (SPT), and forced swimming test (FST). The activity of the HPA axis was detected by measurement of the plasma corticosterone concentration and hypothalamic mRNA expression of corticotropin-releasing-hormone (CRH). The plasma concentration and hypothalamic mRNA expression of nesfatin-1 were measured with an enzyme-linked immunosorbent assay (ELISA) and real-time fluorescent quantitative PCR, respectively. The results showed that both AS and CUMS increased the plasma corticosterone concentration and hypothalamic CRH mRNA expression. Depression-like behavior was induced in CUMS rats, as indicated by a decreased movement distance, frequency of rearing and grooming in the OFT, and sucrose preference index and increased immobility in the FST. Moreover, the AS rats showed increased plasma concentration and hypothalamic mRNA expression of nesfatin-1, which were positively correlated with the plasma corticosterone concentration and hypothalamic CRH expression, respectively. These results indicated that acute stress, but not chronic stress, increased the plasma concentration and hypothalamic mRNA expression of NUCB2/nesfatin-1 in rats.
journal_name
Neuropeptidesjournal_title
Neuropeptidesauthors
Xu YY,Ge JF,Qin G,Peng YN,Zhang CF,Liu XR,Liang LC,Wang ZZ,Chen FH,Li Jdoi
10.1016/j.npep.2015.08.003subject
Has Abstractpub_date
2015-12-01 00:00:00pages
47-53eissn
0143-4179issn
1532-2785pii
S0143-4179(15)00082-7journal_volume
54pub_type
杂志文章相关文献
NEUROPEPTIDES文献大全abstract::The opioid receptor antagonists, naloxone and beta-chlornaltrexamine, were used to determine whether activation of endogenous opioid peptide containing pathways produced pharmacologically reversible opioid actions. Extracellularly recorded responses of the hippocampal CA3 pyramidal cells were evoked by stimulation of ...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(86)90074-0
更新日期:1986-01-01 00:00:00
abstract::The role of somatostatin and a stable analogue, sandostatin (Octreotide), on the responses of spinal cord neurones in vivo was investigated in the rat. Electrical C-fibre stimulation was used as a model of acute nociception and the response to subcutaneous formalin was used as a model of longer term events. Intratheca...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(92)90115-d
更新日期:1992-11-01 00:00:00
abstract::Endothelins (ET) are a family of highly active neuropeptides with manifold influences via ET receptors (ETR) in both the peripheral and central nervous systems. We have shown previously that satellite glial cells (SGCs) in mouse trigeminal ganglia (TG) are extremely sensitive to ET-1 in evoking [Ca2+]in increase, appa...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/j.npep.2017.03.002
更新日期:2017-06-01 00:00:00
abstract::Available data concerning the effect of oxytocin on memory are often inconsistent. In the present study it was found that oxytocin, intracerebroventricularly injected to adult male rats in a dose range of 1 fg-10 ng/rat immediately after a 5-minute encounter with a juvenile, significantly reduces the social investigat...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(95)90029-2
更新日期:1995-04-01 00:00:00
abstract::Kyotorphin (KTP), first isolated in the bovine brain and now having been identified in a variety of species, is known most extensively for its analgesic-like properties. KTP indirectly stimulates opioid receptors by releasing methionine enkephalin (met-enkephalin). Stimulation of opioid receptors is linked to hunger p...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/j.npep.2012.10.007
更新日期:2013-06-01 00:00:00
abstract::A series of analogues of substance P, where the Met11 residue was replaced by Glu(OCH2CH3), Glu(OBzl) and Hse(CH3), were synthesized in order to investigate the effect on agonist activity of modifications at the C-terminal residue. The biological activities in the guinea-pig ileum assay (NK1 receptor) and rat [text sa...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(94)90013-2
更新日期:1994-07-01 00:00:00
abstract::Plasma protein extravasation in the upper airways of anesthetized guinea pigs was measured with the FITC (Fluorescein isothiocyanate)-dextran technique. The effect of selective tachykinin (NK1 and NK2) receptor agonists and antagonists, capsaicin or antigen was studied. The tachykinin NK1 receptor agonist, [Sar9]subst...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/s0143-4179(97)90022-6
更新日期:1997-02-01 00:00:00
abstract::Desensitization is induced by the repeated administration of high doses of substance P (SP) or hemokinin-1 (HK-1). However, little information is available about the mechanisms involved in the induction of desensitization by these peptides. Thus, to characterize this desensitization, we examined the dose-dependent eff...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/j.npep.2007.10.004
更新日期:2008-02-01 00:00:00
abstract::D-Arg containing dipeptides, H-Tyr-D-Arg-OMe and H-Tyr (Et)-D-Arg-OMe, and D-Arg2 substituted N-terminal tetrapeptides of dermorphin, H-Tyr-D-Arg-Phe-Gly-OEt and H-Tyr (Et)-D-Arg-Phe-Gly-OEt administered intracerebroventricularly exhibited dose-dependent antinociceptive activities in mice as measured by the tail press...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(84)90001-5
更新日期:1984-06-01 00:00:00
abstract::Superfusion of the dorsal surface of the septum with artificial cerebrospinal fluid containing 10(-10) M [Arg8]-vasopressin (VP) significantly increased the negative (N) wave in field potentials (FPs) elicited in the lateral septum (LS) of rats by stimulation of the fimbria-fornix. A similar increase in the FPs negati...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(86)90078-8
更新日期:1986-01-01 00:00:00
abstract::Gestational cocaine treatment in rat dams results in decreased oxytocin (OT) levels, up-regulated oxytocin receptor (OTR) binding density and decreased receptor affinity in the whole amygdala, all concomitant with a significant increase in maternal aggression on postpartum day six. Rat dams with no gestational drug tr...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/j.npep.2006.03.002
更新日期:2006-06-01 00:00:00
abstract::This study investigated the nature of the cholecystokinin-like immunoreactivity (CCKLI) in the dorsal horn of the rat spinal cord. Indeed, using the same antiserum, no variation of radioimmunoassayable CCKLI in the dorsal horn of rats treated neonatally with capsaicin could be seen, whereas the density of immunoreacti...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(90)90033-u
更新日期:1990-12-01 00:00:00
abstract::Cerebral amyloid-beta protein (Abeta) deposition and associated neuroinflammation and apoptosis are increasingly recognized as an important component leading to cognitive impairment in Alzheimer's disease (AD). Humanin (HN) and its derivative, S14G-HN (HNG), are best known for their ability to suppress neuronal death ...
journal_title:Neuropeptides
pub_type: 杂志文章,收录出版
doi:10.1016/j.npep.2008.08.004
更新日期:2008-10-01 00:00:00
abstract::Glucocorticoid deficiency is associated with a decrease of food intake. Orexigenic peptides, neuropeptide Y (NPY) and agouti related protein (AgRP), and the anorexigenic peptide proopiomelanocortin (POMC), expressed in the arcuate nucleus of the hypothalamus (ARC), are regulated by meal-induced signals. Orexigenic neu...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/j.npep.2012.02.002
更新日期:2012-06-01 00:00:00
abstract::The effects of graded amounts of centrally injected [intracerebroventricular, i.c.v.] oxytocin [OXT] have been studied on the steady-state level and pargyline-induced accumulation of serotonin [5-HT] in the hypothalamus, mesencephalon and dorsal hippocampus of rats. OXT only weakly affected the steady-state level of 5...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(84)90125-2
更新日期:1984-03-01 00:00:00
abstract::The effects of central (clonazepam, an agonist, and FG 7142, an inverse agonist), mixed (diazepam) or peripheral type (Ro 5-4864) benzodiazepine receptor ligands on the action of TRH on the transmurally stimulated rat duodenum and binding of [3H][3-Me-His2] TRH in the rat anterior pituitary, hypothalamus, cortex and b...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(91)90112-v
更新日期:1991-07-01 00:00:00
abstract::In situ hybridisation histochemistry was used to study the effect of intra-peritoneal reserpine administration on messenger RNA (mRNA) levels in the locus coeruleus (LC) of the rat. 48h after injection, levels of mRNA encoding tyrosine hydroxylase (TH) and neuropeptide Y (NPY) in the LC increased to approximately 250%...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(91)90105-r
更新日期:1991-03-01 00:00:00
abstract::We examined whether the cholinergic mechanism is involved in the paradoxical GH responses to vasoactive intestinal peptide (VIP) and peptide histidine methionine (PHM) in acromegaly. 28 patients with active acromegaly underwent i.v. bolus injections of thyrotropin-releasing hormone (TRH, 500 micrograms), GH-releasing ...
journal_title:Neuropeptides
pub_type: 临床试验,杂志文章
doi:10.1016/0143-4179(94)90047-7
更新日期:1994-08-01 00:00:00
abstract::Social conflict and defeat in mice leads to an activation of endogenous opiate systems. The effects of intracerebroventricular administration of the peptide FMRFamide (Phe-Met-Arg-Phe-NH2) and the opiate antagonist naloxone, on aggressive encounters, defeat-induced analgesia and defeat-induced feeding were examined in...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(85)90110-6
更新日期:1985-12-01 00:00:00
abstract::The effect of opioid peptide, D-alanine2-leucine-enkephalin and opioid homolog peptide, des-tyrosine-methionine-enkephalin in concentrations of 1 x 10(-6) and 1 x 10(-5) M was investigated on the action potential parameters of frog sciatic nerve. Des-tyrosine-methionine-enkephalin was used as the control to prove the ...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/j.npep.2004.03.003
更新日期:2004-04-01 00:00:00
abstract::Lysine-vasopressin (LVP) at different concentrations (2 ng, 200 pg) was injected into the lateral ventricle and cisterna magna. The effect on hypothalamic self-stimulation was studied in rats. LVP (2 ng) decreased the self-stimulation rate after intracerebroventricular and cisternal application. Injection of 200 pg LV...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/s0143-4179(87)90119-3
更新日期:1987-11-01 00:00:00
abstract::Abnormal aggregation of beta-amyloid (Aβ) peptide into amyloid plaques in the brain has been identified as one of the key factors in instigating AD pathogenesis. Inhibition of Aβ aggregation can be an important therapeutic strategy in disease management. In this work, we demonstrate the application of structure-based ...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/j.npep.2020.102030
更新日期:2020-06-01 00:00:00
abstract::The effects of intravenous self-administration of 30 micrograms infusions of either heroin or cocaine, or saline on the concentrations of beta-endorphin-immunoreactivity (beta E-IR) in the anterior part of the rat brain limbic system were studied. Self-administration of heroin and cocaine for 5 daily sessions resulted...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(88)90060-1
更新日期:1988-11-01 00:00:00
abstract::A series of biologically active peptides and related compounds (opioid peptides, neurotensin, and bradykinin) were used as substrates or competitive inhibitors to study the structural requirements for peptide interaction with endopeptidase 22.19. The kinetics of hydrolysis of these peptides indicated that, in contrast...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(94)90083-3
更新日期:1994-04-01 00:00:00
abstract::We have developed an extraction method and radioimmunoassay for the measurement of interleukin-1 beta (IL-1 beta) in rat tissues, using an antibody specific for IL-1 beta, IL-1 beta was detected in the spleen and thymus of control rats. Adrenalectomy (ADX) had no effect upon control levels of IL-1 beta. In animals wit...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(93)90008-x
更新日期:1993-06-01 00:00:00
abstract::In equilibrium binding studies, using 3H-etorphine and 3H-diprenorphine, digitonin extracts of frog brain membranes are found to contain two classes of sites, one of which is seen only in the presence of Na+ ions. Centrifugation of the extracts in sucrose gradients separates two macromolecular components (10S and 12S)...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(84)90044-1
更新日期:1984-12-01 00:00:00
abstract::Various studies have shown a relationship between nerves and bones. Recent evidence suggests that both sensory and sympathetic nerves affect bone metabolism; however, little is known about how neuropeptides are involved in the differentiation of pluripotent stem cells into osteoblastic (OB) cells. To evaluate the puta...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/j.npep.2014.10.004
更新日期:2014-12-01 00:00:00
abstract::Attempts have been made to confirm reports that naloxonazine and Mr2034 are able to selectively antagonise morphine-induced analgesia and respiratory depression respectively. In the present studies these antagonists proved to be equi-effective against both the analgesic and respiratory depressant effects of morphine, ...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(84)90033-7
更新日期:1984-12-01 00:00:00
abstract::In vitro structure-activity studies with cholecystokinin (CCK)/gastrin-related peptides, including C- and N-terminal fragments of CCK 26-33, were undertaken in guinea pig gallbladder and ileum. The general order of potency in both smooth muscle preparations is CCK 26-33 greater than CCK 1-33 greater than 27-33 much mu...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(87)90084-9
更新日期:1987-07-01 00:00:00
abstract::Neurokinin A (NKA) and substance P (SP) are often co-localized in small sensory neurons and have been suggested to subserve similar roles. We have now compared tissue levels of NKA and SP in rat cervical dorsal root ganglia with those in the central and peripheral terminations of the same neurons. We found that NKA co...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(95)90027-6
更新日期:1995-04-01 00:00:00