Chronic gestational cocaine treatment decreases oxytocin levels in the medial preoptic area, ventral tegmental area and hippocampus in Sprague-Dawley rats.

abstract：:The aim of the present work was to study the potential involvement of melanocortin system in the anorectic mechanism of fluoxetine, a selective serotonin reuptake inhibitors, in obese Zucker rats. Male obese Zucker (fa/fa) rats were administered fluoxetine (10 mg/kg; i.p.) daily for two weeks. The control group was gi...

journal_title：Neuropeptides

authors： Churruca I,Portillo MP,Casis L,Gutiérrez A,Macarulla MT,Echevarría E

更新日期：2008-06-01 00:00:00

abstract：OBJECTIVE:To explore the orexinergic pathway from the lateral hypothalamus (LHA) to the nucleus accumbens (NAc) and its regulation on the palatable food intake. METHODS:Fluorescent gold retrograde tracing combined with fluoro-immunohistochemical staining were used to observe the projection of orexinergic neurons from ...

journal_title：Neuropeptides

authors： Liu X,Gao S,Zhang N,Jin T,Sun X,Luan X,Xu L,Guo F

更新日期：2020-04-01 00:00:00

abstract：:The neuropharmacological actions of the agonist analog D-Trp-6-LH-RH were investigated in several tests after subcutaneous administrations to male mice. The doses applied were in the range 1-1000 micrograms/kg. D-Trp-6-LH-RH doses of 10 micrograms/kg and higher induced significant analgesic effects in the hot-plate an...

journal_title：Neuropeptides

authors： Kádár T,Telegdy G,Schally AV

更新日期：1990-10-01 00:00:00

abstract：:Dynorphin 1-8 (DYN 1-8) and Dynorphin B (DYN B) have been immunocytochemically localized to neuronal perikarya throughout the adult rat central nervous system (CNS). In order to determine if any DYN 1-8 and DYN B immunoreactive (DYN-I) cell bodies have long projections, indirect immunofluorescence was used in combinat...

journal_title：Neuropeptides

authors： Code RA,Fallon JH

更新日期：1986-08-01 00:00:00

abstract：:Various studies have shown a relationship between nerves and bones. Recent evidence suggests that both sensory and sympathetic nerves affect bone metabolism; however, little is known about how neuropeptides are involved in the differentiation of pluripotent stem cells into osteoblastic (OB) cells. To evaluate the puta...

journal_title：Neuropeptides

authors： Nagao S,Goto T,Kataoka S,Toyono T,Joujima T,Egusa H,Yatani H,Kobayashi S,Maki K

更新日期：2014-12-01 00:00:00

abstract：:This study found that dynorphin had a biphasic concentration response relationship on N-methyl-D-aspartate (NMDA) receptor-mediated currents in the CA3 region of the guinea pig hippocampal slice. A previous study demonstrated that the inhibitory effect was mediated by a kappa 2 opioid receptor. In the present study, t...

journal_title：Neuropeptides

authors： Caudle RM,Dubner R

更新日期：1998-02-01 00:00:00

abstract：:Nerve growth factor (NGF) was reported to be increased in the serum and skin of atopic dermatitis (AD) patients, to the extent that serum nerve growth factor levels were proposed to serve as a marker of disease severity. We studied NGF levels in the serum and dermis using skin microdialysis and attempted to correlate ...

journal_title：Neuropeptides

authors： Papoiu AD,Wang H,Nattkemper L,Tey HL,Ishiuji Y,Chan YH,Schmelz M,Yosipovitch G

更新日期：2011-12-01 00:00:00

abstract：:The recent surge of scientific interest in 5-hydroxytryptamine3 (5-HT3) receptors can be attributed largely to the rapid increase in the number of potent and selective 5-HT3 receptor antagonists. The availability of a large variety of chemically diverse 5-HT3 compounds allows for a unique opportunity to apply computer...

journal_title：Neuropeptides

authors： Peroutka SJ

更新日期：1991-07-01 00:00:00

abstract：:In situ hybridisation histochemistry was used to study the effect of intra-peritoneal reserpine administration on messenger RNA (mRNA) levels in the locus coeruleus (LC) of the rat. 48h after injection, levels of mRNA encoding tyrosine hydroxylase (TH) and neuropeptide Y (NPY) in the LC increased to approximately 250%...

journal_title：Neuropeptides

authors： Foster OJ,Biswas S,Lightman SL

更新日期：1991-03-01 00:00:00

abstract：:The action of corticotropin-releasing factor (CRF) is mediated by two recently identified receptors, CRFR1 and CRFR2, that differ with respect to their anatomical distribution and pharmacologic ligand-binding properties. Here we show by an analysis of circadian heartbeat interval fluctuations that CRFR2-deficiency in ...

journal_title：Neuropeptides

authors： Stiedl O,Meyer M

更新日期：2003-02-01 00:00:00

abstract：:The orally active, α-hemoglobin derived hemopressin (PVNFKFLSH, Hp(1-9)) and its truncated (PVNFKFL, Hp(1-7) and PVNFKF, Hp(1-6)) and extended ((R)VDPVNFKFLSH, VD-Hp(1-9) and RVD-Hp(1-9)) derivatives have been postulated to be the endogenous peptide ligands of the cannabinoid receptor type 1 (CB1). In an attempt to cr...

journal_title：Neuropeptides

authors： Dvorácskó S,Tömböly C,Berkecz R,Keresztes A

更新日期：2016-08-01 00:00:00

abstract：:The effects of forskolin or phorbol-13-myristate (PMA) injected intrathecally (i.t.) or intracerebroventricularly (i.c.v.) on the inhibition of the tail-flick and hotplate responses induced by morphine or beta-endorphin administered i.c.v. were studied. Animals pretreated with forskolin (20 micrograms) i.t. for 10 min...

journal_title：Neuropeptides

authors： Suh HW,Song DK,Sim YB,Chung KM,Kim YH

更新日期：1996-04-01 00:00:00

abstract：:There is now unequivocal evidence that the angiotensin-converting enzyme 2(ACE2)-Ang-(1-7)-Mas axis is a key component of the renin-angiotensin system (RAS) cascade, which is closely correlated with ischemic insult occurrence. Our previous studies demonstrated that the Ang-(1-7), was an active member of the brain RAS....

journal_title：Neuropeptides

authors： Lu J,Jiang T,Wu L,Gao L,Wang Y,Zhou F,Zhang S,Zhang Y

更新日期：2013-10-01 00:00:00

abstract：:Dermorphin (Tyr-D-Ala-Phe-Gly-Tyr-Pro-Ser-NH2), a naturally occurring peptide isolated from arboreal frog skin, is endowed with outstanding structural and biological features. It has no structural community with the sequence of mammalian opioid peptides and is a unique example of a D-aminoacid containing peptide which...

journal_title：Neuropeptides

authors： Mor A,Delfour A,Amiche M,Sagan S,Nicolas P,Grassi J,Pradelles P

更新日期：1989-01-01 00:00:00

abstract：:The biological and immunological properties of insulin-like material produced by brain cells from 12 day old mice, cultured in serum-free media were examined. Differences were seen in the rate of appearance, relative amounts and behaviour on HPLC between immunoreactive and biologically active insulin-like material. Ex...

journal_title：Neuropeptides

authors： Birch NP,Christie DL,Renwick AG

更新日期：1987-05-01 00:00:00

abstract：:Our previous study showed that intracerebroventricular (ICV) administration of corticotropin-releasing hormone (CRH) produced a significant increase in locomotor activity at a dose of 1 microgram and slow stereotypy with prominent grooming at a dose of 10 micrograms. In addition, the ICV administration of CRH caused a...

journal_title：Neuropeptides

authors： Takamatsu Y,Yamamoto H,Ogunremi OO,Matsuzaki I,Moroji T

更新日期：1991-12-01 00:00:00

abstract：:We examined whether the cholinergic mechanism is involved in the paradoxical GH responses to vasoactive intestinal peptide (VIP) and peptide histidine methionine (PHM) in acromegaly. 28 patients with active acromegaly underwent i.v. bolus injections of thyrotropin-releasing hormone (TRH, 500 micrograms), GH-releasing ...

journal_title：Neuropeptides

authors： Watanobe H,Habu S,Nasushita R,Takebe K

更新日期：1994-08-01 00:00:00

abstract：:3H-Bradykinin binding sites with the characteristics of receptors were identified in homogenates of bovine hippocampus and PC-12 cells. The characteristics of the binding were similar in both types of tissue and paralleled those of the B2 bradykinin receptor. Following exposure to nerve growth factor for 72 hours, the...

journal_title：Neuropeptides

authors： Kozlowski MR,Rosser MP,Hall E

更新日期：1988-11-01 00:00:00

abstract：:Clinical and experimental evidence have demonstrated that, use of alcohol during pregnancy can interrupt brain development. Alcohol-induced neurocognitive deficits in offspring's are involved with activation of oxidative-inflammatory cascade joined with extensive apoptotic neurodegeneration in different brain regions ...

journal_title：Neuropeptides

authors： Toosi A,Shajiee H,Khaksari M,Vaezi G,Hojati V

更新日期：2019-04-01 00:00:00

abstract：RATIONALE:Cholecystokinin and its analogs generate anxiety in humans and measurable anxiety-like behaviors in rats. Cholecystokinin receptor blockers have been reported to have variable effects in the treatment of anxiety disorders. We demonstrated that intracerebroventricular administration of Cholecystokinin-antisens...

journal_title：Neuropeptides

authors： Cohen H,Matar MA,Buriakovsky I,Zeev K,Kotler M,Bourin M

更新日期：2002-10-01 00:00:00

abstract：:Previous data from our labs and from others have demonstrated that intracerebroventricular (ICV) injection of alarin has orexigenic activity and significantly increases plasma luteinizing hormone (LH) secretion in a gonadotropin-releasing hormone (GnRH) dependent manner. The purpose of the current experiments was to d...

journal_title：Neuropeptides

authors： Fraley GS,Leathley E,Nickols A,Gerometta E,Coombs E,Colton S,Gallemore S,Lindberg A,Kofler B

更新日期：2013-02-01 00:00:00

abstract：:Injection of endothelin-1 (9 pmol) into the lateral cerebral ventricle of rats produced barrel-rotations, convulsions, tonic hindlimb extensions, facial clonus, and kinetic ataxia for up to 45 min. Quantitative metabolic autoradiographs produced from the [14C]deoxyglucose method and analyzed over 60 individual brain s...

journal_title：Neuropeptides

authors： Gross PM,Wainman DS,Espinosa FJ,Nag S,Weaver DF

更新日期：1992-04-01 00:00:00

abstract：:The Mu opioid receptor (MOR) has been shown to participate in the analgesic effect of the calcitonin gene-related peptide (CGRP) in the nucleus accumbens (NAc) of adult rats. However, it is not clear whether and how CGRP regulates the MOR at the molecular levels. In the present study, it is found that the level of MOR...

journal_title：Neuropeptides

authors： Yan H,Yu LC

更新日期：2013-04-01 00:00:00

abstract：:In previous studies, membranes from chicken gastrointestinal tissues failed to bind appreciable levels of 125I-APP labeled at the C-terminus. In order to address the suggestion that this was due to steric hindrance of the critical C-terminus, N-terminally labeled 125I-APP was utilized in in vitro membrane binding assa...

journal_title：Neuropeptides

authors： Adamo ML,Hazelwood RL

更新日期：1992-04-01 00:00:00

abstract：:In binding assays with homogenates of the myenteric plexus-longitudinal muscle of the guinea-pig, beta-funaltrexamine is more potent at displacing mu-binding than kappa-binding. Incubation of homogenates with beta-funaltrexamine (100 or 1000 nM) for 30 min at 37 degrees C followed by repeated washing with drug-free Tr...

journal_title：Neuropeptides

authors： McKnight AT,Paterson SJ,Corbett AD,Kosterlitz HW

更新日期：1984-12-01 00:00:00

abstract：:We studied head-injured patients assessed after admission to the hospital according to the Glasgow coma scale (3-8 points). All of them underwent surgical procedure after neuroradiological examination. Due to therapeutic problems, some of these patients had lumbar puncture on the fourth day following surgery. The cont...

journal_title：Neuropeptides

authors： Stachura Z,Obuchowicz E,Herman ZS

更新日期：1997-02-01 00:00:00

abstract：:Oxytocic peptides extracted from the brain and plasma of the brushtail possum, Trichosurus vulpecula, were separated by reverse-phase high pressure lipid chromatography (HPLC) and quantified by specific radioimmunoassays for oxytocin (OT) and mesotocin (MT). The pituitary, hypothalamus and cerebral cortex were found t...

journal_title：Neuropeptides

authors： Bathgate RA,Sernia C,Gemmell RT

更新日期：1990-07-01 00:00:00

abstract：:Social recognition is the sensitive domains of complex behavior critical for identification, interpretation and storage of socially meaningful information. Social recognition develops throughout childhood and adolescent, and is affected in a wide variety of psychiatric disorders. Recently, new data appeared on the mol...

journal_title：Neuropeptides

authors： Lopatina OL,Komleva YK,Gorina YV,Olovyannikova RY,Trufanova LV,Hashimoto T,Takahashi T,Kikuchi M,Minabe Y,Higashida H,Salmina AB

更新日期：2018-12-01 00:00:00

abstract：:Using field potential recording in the CA1 region of hippocampal slices from rats injected with cysteamine (200 mg/kg, s.c.), changes in activity and plasticity of Schaffer collateral-CA1 pyramidal cell synapses were examined. Extracellular field potential recording prior to and following either theta-pattern primed b...

journal_title：Neuropeptides

authors： Rostampour M,Fathollahi Y,Semnanian S,Hajizadeh S,Mirnajafizadeh J,Shafizadeh M

更新日期：2002-08-01 00:00:00

abstract：:The progesterone metabolite, allopregnanolone (AlloP), is a GABAA receptor modulating steroid and is known to have orexigenic and pro-obesity effects. The neurobiological mechanisms underpinning these effects are most likely due to enhanced GABAergic signaling in the lateral arcuate nucleus (ARC) and medial paraventri...

journal_title：Neuropeptides

authors： Löfgren M,Holmberg E,Bäckström T,Egecioglu E,Dickson SL

更新日期：2019-08-01 00:00:00