Abstract:
:The recent surge of scientific interest in 5-hydroxytryptamine3 (5-HT3) receptors can be attributed largely to the rapid increase in the number of potent and selective 5-HT3 receptor antagonists. The availability of a large variety of chemically diverse 5-HT3 compounds allows for a unique opportunity to apply computer-based modelling techniques to the analysis of the 5-HT3 receptor pharmacophore. The present review summarises recent studies performed in this laboratory. The primary goal of these studies was to elucidate the chemical requirements needed for molecular recognition at the 5-HT3 receptor binding site. A secondary goal was to determine if this type of molecular information could be assessed using computerised chemical databases.
journal_name
Neuropeptidesjournal_title
Neuropeptidesauthors
Peroutka SJdoi
10.1016/0143-4179(91)90079-xsubject
Has Abstractpub_date
1991-07-01 00:00:00pages
21-3eissn
0143-4179issn
1532-2785pii
0143-4179(91)90079-Xjournal_volume
19 Supplpub_type
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