Abstract：
:Neurokinin A (NKA) and substance P (SP) are often co-localized in small sensory neurons and have been suggested to subserve similar roles. We have now compared tissue levels of NKA and SP in rat cervical dorsal root ganglia with those in the central and peripheral terminations of the same neurons. We found that NKA content was less than that of SP in dorsal root neuron perikarya and in two peripheral tissues (superior cervical ganglion and ear skin) containing SP axon terminals from cervical spinal ganglia; in a third peripheral tissue, trachea, equal amounts of NKA and SP were present. By contrast, in the spinal cord containing the central terminals of these sensory neurons there was almost twice as much NKA as SP. Our results indicate that, although NKA and SP are co-localized in sensory neurons, their levels vary independently, suggesting distinct functional roles.
journal_name
Neuropeptidesjournal_title
Neuropeptidesauthors
Bakhle YS,Bell Cdoi
10.1016/0143-4179(95)90027-6subject
Has Abstractpub_date
1995-04-01 00:00:00pages
237-41issue
4eissn
0143-4179issn
1532-2785pii
0143-4179(95)90027-6journal_volume
28pub_type
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