Abstract：
:PTHrP and its receptor PTHR1 are found in the CNS and peripheral nervous system. The presence of PTHrP mRNA has been detected in the superior cervical ganglion (SCG), but there are no data on the cellular distribution of PTHrP and PTHR1 in the SCG. Although it is known that ovarian activity and reproductive status influence sympathetic activity, and the PTHrP/PTHR1 system is influenced by estrogens in different tissues, it is not known whether these factors have a similar effect on expression of PTHrP and PTHR1 in the nervous system. Hence, we investigated the presence and distribution of PTHrP and PTHR1 in neurons and glia of the SCG of rats, as well as the influence of ovariectomy on their expression, by using immunohistochemistry. PTHrP and PTHR1 immunoreactivity was observed in cytoplasm as well as in nuclei of almost all neurons in the SCG. In male rats, intensity of PTHrP fluorescence was significantly higher in cytoplasm of NPY-, in comparison to NPY+ neurons (p < 0.05). In female rats, 2 months post-ovariectomy, significantly lower intensity of PTHrP fluorescence in cytoplasm of the SCG neurons was observed in comparison to sham operated animals (p < 0.05). In addition to neurons, PTHrP and PTHR1 immunoreactivity was observed in most of the glia and was not influenced by ovariectomy. Results show the expression of PTHrP and its receptor, PTHR1, in the majority of neurons and glial cells in the SCG of rats. Expression of PTHrP, but not PTHR1 in the cytoplasm of SCG neurons is influenced by ovarian activity.
journal_name
Neuropeptidesjournal_title
Neuropeptidesauthors
Filipović N,Vrdoljak M,Vuica A,Jerić M,Jeličić Kadić A,Utrobičić T,Mašek T,Grković Idoi
10.1016/j.npep.2014.09.005subject
Has Abstractpub_date
2014-12-01 00:00:00pages
353-9issue
6eissn
0143-4179issn
1532-2785pii
S0143-4179(14)00082-1journal_volume
48pub_type
杂志文章相关文献
NEUROPEPTIDES文献大全abstract：:Orexins/hypocretins are neuropeptides that have various physiological effects, including the regulation of feeding behavior, neuroendocrine functions and sleep-wake cycles. Recent studies have suggested that the orexin system may also be involved in brain ischemic reactions. It is also known that changes in sleep patt...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/j.npep.2006.06.003
更新日期：2006-08-01 00:00:00
abstract：:Endomorphins are newly discovered mu-opioid receptor selective immunocompetent opioid peptides. Endomorphin 1 is predominantly distributed in brain, while endomorphin 2 is widely allocated in the spinal cord. Lately, endomorphins have been investigated as modulators of reactive oxygen and nitrogen species. Nitric oxid...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/j.npep.2009.11.004
更新日期：2010-02-01 00:00:00
abstract：:Oxytocic peptides extracted from the brain and plasma of the brushtail possum, Trichosurus vulpecula, were separated by reverse-phase high pressure lipid chromatography (HPLC) and quantified by specific radioimmunoassays for oxytocin (OT) and mesotocin (MT). The pituitary, hypothalamus and cerebral cortex were found t...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/0143-4179(90)90123-g
更新日期：1990-07-01 00:00:00
abstract：:The effects of acute and chronic treatment with LSD and acute treatment with mescaline, m-CPP, citalopram and fenfluramine on leu-enkephalin (LENK) content in rat brain were examined. The acute LSD treatment was found to decrease and chronic treatment to increase the LENK content in the frontal cortex. In the thalamus...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/0143-4179(86)90028-4
更新日期：1986-05-01 00:00:00
abstract：:The present study is designed to elucidate the involvement of neuronal mechanisms in corticotropin-releasing factor (CRF)-induced anti-oedema effects. Oedema was induced in the rat hind paw by subcutaneous injection of 3 nmol of serotonin (5-HT). A single dose of CRF (9.4, 37.5 or 75 pmol) was given either ipsilateral...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1054/npep.2000.0800
更新日期：2000-04-01 00:00:00
abstract：:We investigated the effect of sulphated cholecystokinin octapeptide (CCK-8S) on free intracellular calcium concentration, phosphatidylinositol metabolism, and protein phosphorylation in C6 cells, a rat glioma cell line which was shown to express CCKB type receptors. Increase in [Ca2+]i by both influx across the cell m...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/0143-4179(95)90033-0
更新日期：1995-11-01 00:00:00
abstract：:The effects of forskolin or phorbol-13-myristate (PMA) injected intrathecally (i.t.) or intracerebroventricularly (i.c.v.) on the inhibition of the tail-flick and hotplate responses induced by morphine or beta-endorphin administered i.c.v. were studied. Animals pretreated with forskolin (20 micrograms) i.t. for 10 min...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/s0143-4179(96)90085-2
更新日期：1996-04-01 00:00:00
abstract：:Neuromedin U (NMU), a neuropeptide implicated in feeding, inflammation, pain control and anxiety-related behaviours, is widely distributed in peripheral organs and the CNS. These effects are thought to be mediated by its receptors NMU(1) and NMU(2). Since its precise sites of interaction in the CNS were to date unknow...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/j.npep.2008.04.008
更新日期：2008-08-01 00:00:00
abstract：:The human placenta contains membrane bound opioid receptors. The binding of the antagonist naloxone and the fairly kappa-selective agonist EKC were studied in the microvillous membrane fraction. In both cases high affinity binding sites were detected with Kd values in the nanomolar range. A series of kappa-selective l...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/0143-4179(88)90050-9
更新日期：1988-10-01 00:00:00
abstract：:Recently, we demonstrated that brain neuropeptide Y (NPY) mRNA expression was increased in heat exposed chicks. However, the functions of brain NPY during heat stress are unknown. This study was conducted to investigate whether centrally administered NPY affects food intake, rectal temperature, monoamines, stress horm...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/j.npep.2016.11.008
更新日期：2017-04-01 00:00:00
abstract：:The present study was undertaken to determine whether neurotensin is involved in the regulation of the intestinal postprandial motor response and, if so, whether the regulatory pathway depends upon peripheral or central neurotensin secretion. Neurotensin, injected by the i.v. route (5 micrograms/kg) during the fasting...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/s0143-4179(96)90002-5
更新日期：1996-10-01 00:00:00
abstract：:In the present study, electrophysiological recordings were made from hippocampal slices obtained from mice overexpressing galanin under the promoter for the platelet-derived growth factor-B (GalOE mice). In these mice, a particularly strong galanin expression is seen in the granule cell layer/mossy fibers. Paired-puls...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/j.npep.2005.02.005
更新日期：2005-06-01 00:00:00
abstract：:Two tachykinin peptides, substance P (SP) and hemokinin-1 (HK-1), and three transient receptor potential (TRP) channels, TRPV1, TRPA1 and TRPM8, are similarly localized in the spinal dorsal horn and dorsal root ganglion, suggesting that TRP channels may be related or modulated by these tachykinin peptides. Thus, to cl...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/j.npep.2009.10.002
更新日期：2010-02-01 00:00:00
abstract：:Dermorphin (Tyr-D-Ala-Phe-Gly-Tyr-Pro-Ser-NH2), a naturally occurring peptide isolated from arboreal frog skin, is endowed with outstanding structural and biological features. It has no structural community with the sequence of mammalian opioid peptides and is a unique example of a D-aminoacid containing peptide which...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/0143-4179(89)90021-8
更新日期：1989-01-01 00:00:00
abstract：:The selectivity of a series of opioid peptides towards the mu-, delta- and kappa-opioid receptors mediating differential inhibition of electrically-induced neurotransmitter release from rat brain slices was studied, viz. cortical [3H]noradrenaline release (inhibited via mu-receptors), striatal [3H]dopamine release (in...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/0143-4179(89)90065-6
更新日期：1989-08-01 00:00:00
abstract：:HPLC techniques were used to identify peptides that possess vasopressin-like immunoreactivity in the chicken neurohypophysis. The presence of arginine vasotocin (AVT) was confirmed together with arginine vasopressin (AVP). That the presence of AVP may be confined to the chicken, and not other avian species, was conclu...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/0143-4179(86)90045-4
更新日期：1986-08-01 00:00:00
abstract：:Noradrenaline (NA) has been implicated in both increase and reduction of anxiety. Selective destruction of nerve endings of the locus coeruleus projections by DSP-4 has been shown to reduce active behaviour in novel situations by enhancing anxiety. In the present study, DSP-4 (50 mg/kg) treatment reduced locomotor act...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1054/npep.1999.0788
更新日期：2000-02-01 00:00:00
abstract：:The neuropharmacological actions of the agonist analog D-Trp-6-LH-RH were investigated in several tests after subcutaneous administrations to male mice. The doses applied were in the range 1-1000 micrograms/kg. D-Trp-6-LH-RH doses of 10 micrograms/kg and higher induced significant analgesic effects in the hot-plate an...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/0143-4179(90)90053-2
更新日期：1990-10-01 00:00:00
abstract：:The distribution of beta-endorphin (1-27) immunoreactive cell bodies and fibres was studied in the diencephalon of the cat using an indirect immunoperoxidase technique. In the thalamus, almost all the immunoreactive fibres were found in the midline region and in nuclei located near the midline, whereas in the hypothal...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/s0143-4179(96)90072-4
更新日期：1996-06-01 00:00:00
abstract：:Pituitary adenylate cyclase activating peptide and vasoactive intestinal peptide belong to the same neuropeptide family. Both peptides are present in nerve fibers in the gastric wall and are thought to be involved in the regulation of inflammatory processes. Experimental ulcers were induced in the rat gastric mucosa b...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/s0143-4179(98)90081-6
更新日期：1998-12-01 00:00:00
abstract：:CSF methionine and leucine enkephalins were measured by high performance liquid chromatography and radioimmunoassay in diabetic patients with painful neuropathy (n = 22) and painless neuropathy (n = 5), and non-diabetic subjects with low back pain (n = 11). Wide variations in CSF enkephalin levels were found and they ...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/0143-4179(92)90067-7
更新日期：1992-06-01 00:00:00
abstract：:The action of corticotropin-releasing factor (CRF) is mediated by two recently identified receptors, CRFR1 and CRFR2, that differ with respect to their anatomical distribution and pharmacologic ligand-binding properties. Here we show by an analysis of circadian heartbeat interval fluctuations that CRFR2-deficiency in ...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/s0143-4179(02)00135-x
更新日期：2003-02-01 00:00:00
abstract：:We have assessed the influence of acute bilateral nephrectomy, of captopril and saralasin, on the hypotensive activity of neurotensin (NT) and of various hypotensive drugs in pentobarbital-anesthetized rats. The results show that the hypotensive activity of NT and of compound 48/80 (C48/80), in contrast to that of his...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/0143-4179(83)90047-1
更新日期：1983-04-01 00:00:00
abstract：:Orexins are neuropeptides that are localized to neurons in the lateral and dorsal hypothalamus but its receptors are distributed to many different regions of the central nervous system. Orexins are implicated in a variety of physiological functions including sleep regulation, energy homeostats, and stress reactions. F...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/j.npep.2016.12.007
更新日期：2017-02-01 00:00:00
abstract：:Glucocorticoid deficiency is associated with a decrease of food intake. Orexigenic peptides, neuropeptide Y (NPY) and agouti related protein (AgRP), and the anorexigenic peptide proopiomelanocortin (POMC), expressed in the arcuate nucleus of the hypothalamus (ARC), are regulated by meal-induced signals. Orexigenic neu...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/j.npep.2012.02.002
更新日期：2012-06-01 00:00:00
abstract：:The effects of H-Phe-Ile-Tyr-His-Ser-Tyr-Lys-OH, a hypothalamic heptapeptide with weak CRF activity were investigated on the in vitro uptake and release of radiolabelled dopamine (DA), noradrenaline (NA) and serotonin (5-HT) in rat brain hypothalamic slices. In a doses of 5 X 10(-6) M and 10(-5) M the heptapeptide sig...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/0143-4179(84)90106-9
更新日期：1984-05-01 00:00:00
abstract：:Endothelins (ET) are a family of highly active neuropeptides with manifold influences via ET receptors (ETR) in both the peripheral and central nervous systems. We have shown previously that satellite glial cells (SGCs) in mouse trigeminal ganglia (TG) are extremely sensitive to ET-1 in evoking [Ca2+]in increase, appa...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/j.npep.2017.03.002
更新日期：2017-06-01 00:00:00
abstract：:We have used [3H]Senktide, a selective Neurokinin B receptor ligand, for the characterization of NK-3 receptors in rat and guinea pig CNS membranes. Scatchard analysis of saturation binding studies in cerebral cortex membranes indicated that this ligand bound to a single site with apparent high affinity (KD = 4.6 +/- ...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/0143-4179(91)90101-n
更新日期：1991-03-01 00:00:00
abstract：:Acid extracts from mouse Neuroblastoma x rat Glioma hybrid cells have been purified by means of Sep-Pak C-18 and fractionated by high performance liquid chromatography. Each fraction has been submitted to a sensitive beta-endorphin radioimmunoassay and an immunoreactivity peak at camel beta-endorphin retention time wa...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/0143-4179(85)90130-1
更新日期：1985-03-01 00:00:00
abstract：:Cocaine-regulated and amphetamine-regulated transcript (CART) is a neuropeptide with reported neuroprotective effects in ischemic cerebral injury. However, its mechanism has not yet been elucidated. Herein, we investigated the role and mechanism of CART in synaptic plasticity in neurons after ischemic cerebral stroke....
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/j.npep.2020.102023
更新日期：2020-06-01 00:00:00
