Abstract：
:Neuromedin U (NMU), a neuropeptide implicated in feeding, inflammation, pain control and anxiety-related behaviours, is widely distributed in peripheral organs and the CNS. These effects are thought to be mediated by its receptors NMU(1) and NMU(2). Since its precise sites of interaction in the CNS were to date unknown, we studied the distribution of in vitro binding sites for (125)I-NMU-23 in the rat CNS by receptor autoradiography. High-density specific binding was found in discrete areas of the brain and spinal cord, namely in the limbic system (hippocampal formation, septohippocampal nucleus, indusium griseum, hypothalamus, amygdaloid nuclei), superior colliculus, dorsal raphé, and substantia gelatinosa of the spinal cord. Our findings provide further supportive evidence for a multifunctional role for the peptide in the brain and spinal cord.
journal_name
Neuropeptidesjournal_title
Neuropeptidesauthors
Mangold C,Ksiazek I,Yun SW,Berger E,Binkert Cdoi
10.1016/j.npep.2008.04.008subject
Has Abstractpub_date
2008-08-01 00:00:00pages
377-86issue
4eissn
0143-4179issn
1532-2785pii
S0143-4179(08)00056-5journal_volume
42pub_type
杂志文章相关文献
NEUROPEPTIDES文献大全abstract：:In equilibrium binding studies, using 3H-etorphine and 3H-diprenorphine, digitonin extracts of frog brain membranes are found to contain two classes of sites, one of which is seen only in the presence of Na+ ions. Centrifugation of the extracts in sucrose gradients separates two macromolecular components (10S and 12S)...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/0143-4179(84)90044-1
更新日期：1984-12-01 00:00:00
abstract：:Bombesin (BN) and its mammalian counterpart gastrin-releasing peptide act as neuroregulatory hormones and tissue-specific growth factors, and have been implicated as peripheral and central satiety-inducing agents. In the present study, the immunohistochemical expression of BN in submandibular, sublingual and parotid g...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/s0143-4179(97)90086-x
更新日期：1997-04-01 00:00:00
abstract：:We have measured cerebrospinal fluid (CSF) neuropeptide Y-like immunoreactivity (NPY-LI) and somatostatin-like immunoreactivity (SLI) in control subjects and in patients with various neurologic disorders. We observed a significant reduction in CSF SLI in control subjects over 60 years of age, compared with the younger...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/0143-4179(94)90058-2
更新日期：1994-12-01 00:00:00
abstract：:Available data concerning the effect of oxytocin on memory are often inconsistent. In the present study it was found that oxytocin, intracerebroventricularly injected to adult male rats in a dose range of 1 fg-10 ng/rat immediately after a 5-minute encounter with a juvenile, significantly reduces the social investigat...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/0143-4179(95)90029-2
更新日期：1995-04-01 00:00:00
abstract：:Superfusion of the dorsal surface of the septum with artificial cerebrospinal fluid containing 10(-10) M [Arg8]-vasopressin (VP) significantly increased the negative (N) wave in field potentials (FPs) elicited in the lateral septum (LS) of rats by stimulation of the fimbria-fornix. A similar increase in the FPs negati...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/0143-4179(86)90078-8
更新日期：1986-01-01 00:00:00
abstract：:Acid extracts of cat adrenal medullae were found to contain neurotensin-like (0.71 +/- 0.21nmol/gm), met-enkephalin-like (11.71 +/- 2.87nmol/gm), leu-enkephalin-like (1.95 +/- 0.11nmol/gm) and somatostatin-like (1.57 +/- 0.63pmol/gm) immunoreactivities. Using isolated retrogradely perfused cat adrenal glands the secre...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/0143-4179(82)90061-0
更新日期：1982-10-01 00:00:00
abstract：:The Third Galanin Symposium presented many different and exciting results on galanin research reflecting a major progress since the previous symposium in 1998. A major impression was the many possible relationships of galaninergic mechanisms to important brain functions such as development, cognition and ageing as wel...
journal_title：Neuropeptides
pub_type：
doi：10.1016/j.npep.2005.03.002
更新日期：2005-06-01 00:00:00
abstract：:The intracerebrally administered dynorphin-B produced not only an antinociceptive response but a motor dysfunction such as "barrel-rolling", circling, jumping or ataxia in mice. These two effects were observed in a same dose range. Both responses were also produced by a nonopioid fragment, des-Tyr-dynorphin-B. Bestati...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/0143-4179(89)90082-6
更新日期：1989-05-01 00:00:00
abstract：:The effects of vasoactive intestinal peptide (VIP) on spatial cognitive deficits induced in the rat by injections of scopolamine were examined in a radial arm maze. A single intraperitoneal (i.p.), subcutaneous (s.c.) or intracerebroventricular (i.c.v.) injection of VIP inhibited the reduction in the number of initial...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/0143-4179(94)90124-4
更新日期：1994-03-01 00:00:00
abstract：:In order to further test whether or not psychostimulant drugs activate CART peptide-containing cells in the nucleus accumbens, we examined the fraction of CART positive cells that co-immunostained for c-Fos after administration of saline or cocaine (10 and 25 mg/kg i.p.). There was about a 45% increase in the fraction...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/j.npep.2008.01.001
更新日期：2008-06-01 00:00:00
abstract：:The discriminative stimulus properties of the selective CCKB-receptor antagonist, L-365,260 were evaluated in rats trained to discriminate diazepam (2 mg/kg) or morphine (5 mg/kg) from vehicle, using a two-lever food reinforced technique. In the diazepam drug discrimination, the benzodiazepine-receptor agonist FG8205 ...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/0143-4179(94)90119-8
更新日期：1994-05-01 00:00:00
abstract：:We have assessed the influence of acute bilateral nephrectomy, of captopril and saralasin, on the hypotensive activity of neurotensin (NT) and of various hypotensive drugs in pentobarbital-anesthetized rats. The results show that the hypotensive activity of NT and of compound 48/80 (C48/80), in contrast to that of his...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/0143-4179(83)90047-1
更新日期：1983-04-01 00:00:00
abstract：:Kyotorphin (KTP), first isolated in the bovine brain and now having been identified in a variety of species, is known most extensively for its analgesic-like properties. KTP indirectly stimulates opioid receptors by releasing methionine enkephalin (met-enkephalin). Stimulation of opioid receptors is linked to hunger p...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/j.npep.2012.10.007
更新日期：2013-06-01 00:00:00
abstract：:Accumulating evidence suggests that blood borne hormones modulate brain mechanisms regulating blood pressure. This appears to be mediated by the circumventricular organs which are located in the walls of the brain ventricular system and lack the blood-brain barrier. Recent evidence shows that neurons of the circumvent...
journal_title：Neuropeptides
pub_type： 杂志文章,评审
doi：10.1016/j.npep.2014.01.003
更新日期：2014-04-01 00:00:00
abstract：:Noradrenaline (NA) has been implicated in both increase and reduction of anxiety. Selective destruction of nerve endings of the locus coeruleus projections by DSP-4 has been shown to reduce active behaviour in novel situations by enhancing anxiety. In the present study, DSP-4 (50 mg/kg) treatment reduced locomotor act...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1054/npep.1999.0788
更新日期：2000-02-01 00:00:00
abstract：:Social conflict and defeat in mice leads to an activation of endogenous opiate systems. The effects of intracerebroventricular administration of the peptide FMRFamide (Phe-Met-Arg-Phe-NH2) and the opiate antagonist naloxone, on aggressive encounters, defeat-induced analgesia and defeat-induced feeding were examined in...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/0143-4179(85)90110-6
更新日期：1985-12-01 00:00:00
abstract：:Experiments were performed to determine whether the renal nerve mediates the renin release induced by intracerebroventricular administration of angiotensin II (ANG II), bradykinin (BK), leucine-enkephalin (Leu-ENK) and neurotensin (NT). In sham-operated rats, both ANG II and NT suppressed plasma renin activity (PRA), ...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/0143-4179(85)90142-8
更新日期：1985-09-01 00:00:00
abstract：OBJECTIVES:Postmenopausal osteoporosis (PMO) is a metabolic skeletal disorder with impaired bone density and bone quality in postmenopausal women. The aim of the present study was to investigate the correlation between neuropeptides, bone microstructure and pain threshold in ovariectomized (OVX) rats. METHODS:Female r...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/j.npep.2019.101995
更新日期：2020-06-01 00:00:00
abstract：:Proenkephalin peptides produced by endocrine and nervous tissues are involved in stress-induced immunosuppression. However, the role of peptides produced by immune cells remains unknown. The present study examines the effect of acute and chronic foot-shock stress on proenkephalin peptide content in bone marrow (BMMC),...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/s0143-4179(98)90058-0
更新日期：1998-08-01 00:00:00
abstract：:Dermorphin (Tyr-D-Ala-Phe-Gly-Tyr-Pro-Ser-NH2), a naturally occurring peptide isolated from arboreal frog skin, is endowed with outstanding structural and biological features. It has no structural community with the sequence of mammalian opioid peptides and is a unique example of a D-aminoacid containing peptide which...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/0143-4179(89)90021-8
更新日期：1989-01-01 00:00:00
abstract：:Pyroglutamyl diazomethyl ketone and N-benzyloxycarbonyl prolyl prolinal, specific inhibitors of pyroglutamyl peptidase I and prolyl endopeptidase respectively, were used to study the possible role of these enzymes in the regulation of thyrotropin releasing hormone turnover. In vitro thyrotropin releasing hormone relea...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/0143-4179(87)90010-2
更新日期：1987-05-01 00:00:00
abstract：:Galanin, a 29 residue peptide found in the hypothalamus, causes orexigenic effects in a variety of species. In the present study, we investigated appetite-associated effects of galanin in chicks from lines which have been selected from a common founder population for either low or high body weight. The low line consis...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/j.npep.2012.11.003
更新日期：2013-08-01 00:00:00
abstract：:The galanin family currently consists of four peptides, namely galanin, galanin-message associated peptide, galanin-like peptide and alarin. Unlike galanin that signals through three different G protein-coupled receptors; GAL1, GAL2, and GAL3, binding at its N-terminal end, the cognate receptors for other members of t...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/j.npep.2017.03.005
更新日期：2017-06-01 00:00:00
abstract：:Obesity is a global public health problem. Orexin and endocannabinoid signaling in the hypothalamus have been shown to regulate feeding and are promising molecular targets for obesity treatment. In this study, we attempted to analyze effects of orexin-A and endocannabinoid signaling modulation in the arcuate nucleus (...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/j.npep.2018.04.001
更新日期：2018-06-01 00:00:00
abstract：:The orexins (hypocretins) are lateral hypothalamic (LH) neuropeptides that have been implicated in a variety of behaviors ranging from feeding to sleep and arousal. Evidence from animal models suggests a role for orexins in reward processing and drug addiction. In the present study, we investigated the direct effect o...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/j.npep.2014.04.003
更新日期：2014-06-01 00:00:00
abstract：:Spermidine is a naturally occurring endogenous polyamine synthesized from diamine putrescine. It is a well-known autophagy inducer that maintains cellular and neuronal homeostasis. Healthy brain development and function are dependent on brain polyamine concentration. Polyamines interact with the opioid system, glutama...
journal_title：Neuropeptides
pub_type： 杂志文章,评审
doi：10.1016/j.npep.2020.102083
更新日期：2020-10-01 00:00:00
abstract：:Neuropeptide Y (NPY) potentiates noradrenaline (NA)-evoked constriction of circular segments of the rabbit femoral artery. The potentiation occurs exclusively in the lower concentration-range of the agonist NA (10(-8)-3 x 10(-7) M) without any change in maximum contractile effect. NPY per se is without contractile eff...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/0143-4179(91)90068-t
更新日期：1991-05-01 00:00:00
abstract：:Neuropeptide Y (NPY) is a 36 amino acid peptide, which among others, plays a pivotal role in stress response. Although previous studies confirmed that NPY release is increased by stress in several species, the exact mechanism of the stress-induced NPY release has not been elucidated yet. In the present study, we exami...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/j.npep.2011.02.001
更新日期：2011-06-01 00:00:00
abstract：:Endothelins (ET) are a family of highly active neuropeptides with manifold influences via ET receptors (ETR) in both the peripheral and central nervous systems. We have shown previously that satellite glial cells (SGCs) in mouse trigeminal ganglia (TG) are extremely sensitive to ET-1 in evoking [Ca2+]in increase, appa...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/j.npep.2017.03.002
更新日期：2017-06-01 00:00:00
abstract：:Desensitization is induced by the repeated administration of high doses of substance P (SP) or hemokinin-1 (HK-1). However, little information is available about the mechanisms involved in the induction of desensitization by these peptides. Thus, to characterize this desensitization, we examined the dose-dependent eff...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/j.npep.2007.10.004
更新日期：2008-02-01 00:00:00
