Cholecystokinin induced signaling in rat glioma C6 cells.

Abstract:

:We investigated the effect of sulphated cholecystokinin octapeptide (CCK-8S) on free intracellular calcium concentration, phosphatidylinositol metabolism, and protein phosphorylation in C6 cells, a rat glioma cell line which was shown to express CCKB type receptors. Increase in [Ca2+]i by both influx across the cell membrane and release from internal stores was demonstrated by utilizing a laser confocal imaging system. Because CCK-8S produced a transient elevation of inositol triphosphate level participation of InsP3 in calcium signaling in C6 cells is very likely. Protein kinase C seems to be involved in CCK-8S induced signaling in rat glioma C6 cells as demonstrated by using in vivo phosphorylation experiments.

journal_name

Neuropeptides

journal_title

Neuropeptides

authors

Kaufmann R,Schöneberg T,Lindschau C,Haller H,Ott T

doi

10.1016/0143-4179(95)90033-0

subject

Has Abstract

pub_date

1995-11-01 00:00:00

pages

251-6

issue

5

eissn

0143-4179

issn

1532-2785

pii

0143-4179(95)90033-0

journal_volume

29

pub_type

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