Cholecystokinin induced signaling in rat glioma C6 cells.

abstract：:Humanin (HN) is an endogenous 24-residue peptide. A highly potent HN derivative, S14G-HN, which has a substitution of serine 14 to glycine, reduced amyloid burden and suppressed cognitive impairment in a mouse model of Alzheimer's disease. S14G-HN also suppressed amnesia induced by a muscarinic receptor antagonist in ...

journal_title：Neuropeptides

authors： Murakami M,Nagahama M,Maruyama T,Niikura T

更新日期：2017-04-01 00:00:00

abstract：:Pyroglutamyl diazomethyl ketone and N-benzyloxycarbonyl prolyl prolinal, specific inhibitors of pyroglutamyl peptidase I and prolyl endopeptidase respectively, were used to study the possible role of these enzymes in the regulation of thyrotropin releasing hormone turnover. In vitro thyrotropin releasing hormone relea...

journal_title：Neuropeptides

authors： Charli JL,Mendez M,Joseph-Bravo P,Wilk S

更新日期：1987-05-01 00:00:00

abstract：:We have evaluated the peripheral blood natural killer (NK) cell activity and the in vitro effect of recombinant gamma-interferon (r gamma-IFN) on NK cell activity in 23 patients with a neuroendocrine tumour of the pancreas, small intestine or liver, and 23 healthy controls. Patients with a gastrinoma showed a NK cell ...

journal_title：Neuropeptides

authors： Aparicio-Pagés MN,Verspaget HW,Peña AS,Jansen JB,Lamers CB

更新日期：1991-09-01 00:00:00

abstract：:Desensitization is induced by the repeated administration of high doses of substance P (SP) or hemokinin-1 (HK-1). However, little information is available about the mechanisms involved in the induction of desensitization by these peptides. Thus, to characterize this desensitization, we examined the dose-dependent eff...

journal_title：Neuropeptides

authors： Naono R,Nakayama T,Ikeda T,Matsusima O,Nishimori T

更新日期：2008-02-01 00:00:00

abstract：:We have previously shown that the kappa-opioid agonist, asimadoline, produces time-dependent changes in neuropeptide concentrations in the joints of rats with chronic arthritis. We hypothesized that asimadoline acts on peripheral terminals to modulate substance P (SP) release. To address this hypothesis, here we have ...

journal_title：Neuropeptides

authors： Walker JS,Scott C,Bush KA,Kirkham BW

更新日期：2000-06-01 00:00:00

abstract：:In this study, we examined whether the mechanisms mediating the induction of grooming behavior by oxytocin (OT) is similar to mechanisms mediating the effects of OT on uterine contractility. Sprague-Dawley strain female rats were injected intracerebroventricularly (ICV) with OT or OT analogues and then were observed f...

journal_title：Neuropeptides

authors： Caldwell JD,Hruby VJ,Hill P,Prange AJ Jr,Pedersen CA

更新日期：1986-07-01 00:00:00

abstract：:We examined gene expression of corticotropin-releasing hormone and neuropeptide Y level in the hypothalamic paraventricular nucleus of mouse bearing a human oral squamous cell carcinoma. A cell line derived from a human oral squamous cell carcinoma was inoculated into the lower dorsal area of nude mice. Body weight, t...

journal_title：Neuropeptides

authors： Lee JH,Cha MJ,Choi SH,Hwang SJ,Kim DG,Jahng JW

更新日期：2004-12-01 00:00:00

abstract：:In rat preprogalanin, galanin is C-terminally flanked by a 60 amino acid long peptide: galanin message-associated peptide (GMAP). GMAP sequences in different species show high degree of homology, suggesting a biological role. However, the study of the physiological and pharmacological actions of this peptide have been...

journal_title：Neuropeptides

authors： Andell-Jonsson S,Bartfai T

更新日期：1998-04-01 00:00:00

abstract：:The present study was undertaken to determine whether neurotensin is involved in the regulation of the intestinal postprandial motor response and, if so, whether the regulatory pathway depends upon peripheral or central neurotensin secretion. Neurotensin, injected by the i.v. route (5 micrograms/kg) during the fasting...

journal_title：Neuropeptides

authors： Pellissier S,Eribon O,Chabert J,Gully D,Roche M

更新日期：1996-10-01 00:00:00

abstract：:Galanin, a 29 residue peptide found in the hypothalamus, causes orexigenic effects in a variety of species. In the present study, we investigated appetite-associated effects of galanin in chicks from lines which have been selected from a common founder population for either low or high body weight. The low line consis...

journal_title：Neuropeptides

authors： Hagen CJ,Newmyer BA,Webster RI,Gilbert ER,Siegel PB,Tachibana T,Cline MA

更新日期：2013-08-01 00:00:00

abstract：:Neuropeptide Y (NPY) -receptor subtypes were studied in the rat kidney in vivo by systemic administration of NPY, the two agonists [Leu(31), Pro(34)]NPY (Y1-receptor agonist) and NPY (13-36) (Y2-receptor agonist), or the Y1-receptor antagonist BIBP 3226. Effects on mean arterial blood pressure (MAP) and renal arterial...

journal_title：Neuropeptides

authors： Modin A,Malmström RE,Meister B

更新日期：1999-08-01 00:00:00

abstract：:Proenkephalin peptides produced by endocrine and nervous tissues are involved in stress-induced immunosuppression. However, the role of peptides produced by immune cells remains unknown. The present study examines the effect of acute and chronic foot-shock stress on proenkephalin peptide content in bone marrow (BMMC),...

journal_title：Neuropeptides

authors： Saravia F,Padros MR,Ase A,Aloyz R,Duran S,Vindrola O

更新日期：1998-08-01 00:00:00

abstract：:Neuropeptide Y (NPY) causes anxiolytic- and antidepressant-like effects after central administration in rodents. These effects could theoretically be utilized in future gene therapy for anxiety and depression using viral vectors for induction of overexpression of NPY in specific brain regions. Using a recombinant aden...

journal_title：Neuropeptides

authors： Christiansen SH,Olesen MV,Gøtzsche CR,Woldbye DP

更新日期：2014-12-01 00:00:00

abstract：:Orexins/hypocretins are neuropeptides that have various physiological effects, including the regulation of feeding behavior, neuroendocrine functions and sleep-wake cycles. Recent studies have suggested that the orexin system may also be involved in brain ischemic reactions. It is also known that changes in sleep patt...

journal_title：Neuropeptides

authors： Dohi K,Nishino S,Nakamachi T,Ohtaki H,Morikawa K,Takeda T,Shioda S,Aruga T

更新日期：2006-08-01 00:00:00

abstract：:In vitro structure-activity studies with cholecystokinin (CCK)/gastrin-related peptides, including C- and N-terminal fragments of CCK 26-33, were undertaken in guinea pig gallbladder and ileum. The general order of potency in both smooth muscle preparations is CCK 26-33 greater than CCK 1-33 greater than 27-33 much mu...

journal_title：Neuropeptides

authors： Gaudreau P,St-Pierre S,Pert CB,Quirion R

更新日期：1987-07-01 00:00:00

abstract：:Prader-Willi syndrome (PWS) is the predominant genetic cause of obesity in humans and is associated with several behavioural phenotypes such as altered motoric function, reduced activity, and learning disabilities. It can include mood instability and, in some cases, psychotic episodes. Recently, the Snord116 gene has ...

journal_title：Neuropeptides

authors： Zieba J,Low JK,Purtell L,Qi Y,Campbell L,Herzog H,Karl T

更新日期：2015-10-01 00:00:00

abstract：:Our previous study showed that intracerebroventricular (ICV) administration of corticotropin-releasing hormone (CRH) produced a significant increase in locomotor activity at a dose of 1 microgram and slow stereotypy with prominent grooming at a dose of 10 micrograms. In addition, the ICV administration of CRH caused a...

journal_title：Neuropeptides

authors： Takamatsu Y,Yamamoto H,Ogunremi OO,Matsuzaki I,Moroji T

更新日期：1991-12-01 00:00:00

abstract：:Brain insulin receptors adsorb to and are recoverable from wheat germ agglutinin-agarose (WGA) columns. Similar results are obtained using dissuccinimidyl suberate (DSS)-crosslinked receptors or photo-affinity labeled receptors. WGA can be used for partial purification of brain insulin receptors provided the appropria...

journal_title：Neuropeptides

authors： Shemer J,LeRoith D

更新日期：1987-01-01 00:00:00

abstract：:We have recently documented the expression of preprothyrotropin-releasing hormone (TRH) gene in murine, human and rat testis. Moreover, we have localized TRH to rat Leydig cells immunohistochemically, and found that both prepro TRH mRNA and TRH levels are developmentally regulated in the rat testis. To investigate the...

journal_title：Neuropeptides

authors： Satoh T,Feng P,Kim UJ,Wilber JF

更新日期：1994-09-01 00:00:00

abstract：:Development of transgenic mice overexpressing GH and GHR-KO mice with GH resistance provided novel animal models for study of the somatotropic axis and for identifying GH actions that may be relevant to its current and contemplated use in medicine and agriculture. Studies of phenotypic characteristics of these animals...

journal_title：Neuropeptides

authors： Bartke A,Chandrashekar V,Bailey B,Zaczek D,Turyn D

更新日期：2002-04-01 00:00:00

abstract：:The effects of FMRFamide on passive avoidance behaviour and electroshock-induced amnesia following intracerebroventricular administration were studied in rats. FMRFamide given immediately after the learning trial, or 20 min before the retention trial, attenuated the avoidance response, thereby impairing the consolidat...

journal_title：Neuropeptides

authors： Telegdy G,Bollók I

更新日期：1987-08-01 00:00:00

abstract：:Using field potential recording in the CA1 region of hippocampal slices from rats injected with cysteamine (200 mg/kg, s.c.), changes in activity and plasticity of Schaffer collateral-CA1 pyramidal cell synapses were examined. Extracellular field potential recording prior to and following either theta-pattern primed b...

journal_title：Neuropeptides

authors： Rostampour M,Fathollahi Y,Semnanian S,Hajizadeh S,Mirnajafizadeh J,Shafizadeh M

更新日期：2002-08-01 00:00:00

abstract：:The hypocretins/orexins (hcrts) are two recently described neuropeptides derived from the same precursor and expressed in a few thousand neurons in the perifornical area of the lateral hypothalamus, which project throughout the brain. The hypocretins bind to two G-protein coupled receptors with different selective aff...

journal_title：Neuropeptides

authors： de Lecea L,Sutcliffe JG,Fabre V

更新日期：2002-04-01 00:00:00

abstract：:Lysine-vasopressin (LVP) at different concentrations (2 ng, 200 pg) was injected into the lateral ventricle and cisterna magna. The effect on hypothalamic self-stimulation was studied in rats. LVP (2 ng) decreased the self-stimulation rate after intracerebroventricular and cisternal application. Injection of 200 pg LV...

journal_title：Neuropeptides

authors： Günther O,Schwarzberg H

更新日期：1987-11-01 00:00:00

abstract：:Pituitary adenylate cyclase activating peptide and vasoactive intestinal peptide belong to the same neuropeptide family. Both peptides are present in nerve fibers in the gastric wall and are thought to be involved in the regulation of inflammatory processes. Experimental ulcers were induced in the rat gastric mucosa b...

journal_title：Neuropeptides

authors： Mei Q,Sundler F

更新日期：1998-12-01 00:00:00

abstract：:3H-Bradykinin binding sites with the characteristics of receptors were identified in homogenates of bovine hippocampus and PC-12 cells. The characteristics of the binding were similar in both types of tissue and paralleled those of the B2 bradykinin receptor. Following exposure to nerve growth factor for 72 hours, the...

journal_title：Neuropeptides

authors： Kozlowski MR,Rosser MP,Hall E

更新日期：1988-11-01 00:00:00

abstract：:Gestational cocaine treatment in rat dams results in decreased oxytocin (OT) levels, up-regulated oxytocin receptor (OTR) binding density and decreased receptor affinity in the whole amygdala, all concomitant with a significant increase in maternal aggression on postpartum day six. Rat dams with no gestational drug tr...

journal_title：Neuropeptides

authors： Jarrett TM,McMurray MS,Walker CH,Johns JM

更新日期：2006-06-01 00:00:00

abstract：:Ghrelin (gh) is a peptide hormone that may affect learning and memory. There is some evidence that ghrelin can have antiepileptic effects. So we decided to investigate the possible effects of ghrelin on spatial memory following PTZ-induced seizures in male rats. Ninety male rats were divided into 9 groups including co...

journal_title：Neuropeptides

authors： Babri S,Amani M,Mohaddes G,Mirzaei F,Mahmoudi F

更新日期：2013-10-01 00:00:00

abstract：:The desire of the pharmaceutical industry to obtain more selective agents for the treatment of anxiety with fewer or diminished side effects and a profile consistent with safety during long-term use resulted in a search which has identified the azapirones as a new class of anxiolytics which lack structural or biochemi...

journal_title：Neuropeptides

authors： Taylor DP,Moon SL

更新日期：1991-07-01 00:00:00

abstract：:Attempts have been made to confirm reports that naloxonazine and Mr2034 are able to selectively antagonise morphine-induced analgesia and respiratory depression respectively. In the present studies these antagonists proved to be equi-effective against both the analgesic and respiratory depressant effects of morphine, ...

journal_title：Neuropeptides

authors： Rourke JD,Shaw JS

更新日期：1984-12-01 00:00:00