Cholecystokinin induced signaling in rat glioma C6 cells.


:We investigated the effect of sulphated cholecystokinin octapeptide (CCK-8S) on free intracellular calcium concentration, phosphatidylinositol metabolism, and protein phosphorylation in C6 cells, a rat glioma cell line which was shown to express CCKB type receptors. Increase in [Ca2+]i by both influx across the cell membrane and release from internal stores was demonstrated by utilizing a laser confocal imaging system. Because CCK-8S produced a transient elevation of inositol triphosphate level participation of InsP3 in calcium signaling in C6 cells is very likely. Protein kinase C seems to be involved in CCK-8S induced signaling in rat glioma C6 cells as demonstrated by using in vivo phosphorylation experiments.






Kaufmann R,Schöneberg T,Lindschau C,Haller H,Ott T




Has Abstract


1995-11-01 00:00:00














  • Interference of endogenous B endorphin with opiate binding in the anterior pituitary.

    abstract::Opiates have been shown to affect prolactin secretion directly at the pituitary level. However, opiate binding sites have not been characterized on anterior pituitary tissue. In the present work we show that a soluble factor present in anterior pituitary membrane preparation inhibit opiate binding on striatal membrane...


    pub_type: 杂志文章


    authors: Rotten D,Leblanc P,Kordon C,Weiner RI,Enjalbert A

    更新日期:1986-11-01 00:00:00

  • Calcitonin gene-related peptide (CGRP) and its role in hypertension.

    abstract::Hypertension is still presently the number one "silent killer" in the Western World, and a major risk factor for the development of secondary diseases contributing to cardiovascular disease (CVD). However, despite a broad range of therapies, the mechanisms involved in the onset of hypertension remains unclear, therefo...


    pub_type: 杂志文章,评审


    authors: Smillie SJ,Brain SD

    更新日期:2011-04-01 00:00:00

  • Somatostatin binding to a fresh rat astrocyte-enriched suspension.

    abstract::Since there are conflicting reports regarding the effects of somatostatin (SS) on cyclic AMP levels in astrocytes derived from rat cerebral cortex and, to date, the SS binding to mature astrocytes is unknown, the present study has determined SS binding and its effect on cyclic AMP accumulation in a fresh astrocyte-ric...


    pub_type: 杂志文章


    authors: Colás B,Arilla E,Prieto JP

    更新日期:1992-09-01 00:00:00

  • Peptides isolated from animal venom as a platform for new therapeutics for the treatment of Alzheimer's disease.

    abstract::Alzheimer's disease (AD) is a progressive neurodegenerative disease that deeply affects patients, their family and society. Although scientists have made intense efforts in seeking the cure for AD, no drug available today is able to stop AD progression. In this context, compounds isolated from animal venom are potenti...


    pub_type: 杂志文章,评审


    authors: Camargo LC,Campos GAA,Galante P,Biolchi AM,Gonçalves JC,Lopes KS,Mortari MR

    更新日期:2018-02-01 00:00:00

  • Neuropeptide Y attenuates the effect of locus coeruleus denervation by DSP-4 treatment on social behaviour in the rat.

    abstract::Noradrenaline (NA) has been implicated in both increase and reduction of anxiety. Selective destruction of nerve endings of the locus coeruleus projections by DSP-4 has been shown to reduce active behaviour in novel situations by enhancing anxiety. In the present study, DSP-4 (50 mg/kg) treatment reduced locomotor act...


    pub_type: 杂志文章


    authors: Kask A,Eller M,Oreland L,Harro J

    更新日期:2000-02-01 00:00:00

  • Short N-terminal galanin fragments are occurring naturally in vivo.

    abstract::The galanin family currently consists of four peptides, namely galanin, galanin-message associated peptide, galanin-like peptide and alarin. Unlike galanin that signals through three different G protein-coupled receptors; GAL1, GAL2, and GAL3, binding at its N-terminal end, the cognate receptors for other members of t...


    pub_type: 杂志文章


    authors: Ihnatko R,Theodorsson E

    更新日期:2017-06-01 00:00:00

  • Plasma chromogranin A after severe burn trauma.

    abstract:BACKGROUND:Chromogranin A (CgA) in plasma (P-CgA), a neuroendocrine marker of sympathetic stress, has been shown to predict mortality in medical intensive care. We hypothesized that the magnitude of CgA release would reflect stress load, and thereby injury severity in burn intensive care patients. METHODS:Fifty-one co...


    pub_type: 杂志文章


    authors: Lindahl AE,Low A,Stridsberg M,Sjöberg F,Ekselius L,Gerdin B

    更新日期:2013-06-01 00:00:00

  • Effect of alpha-difluoromethylornithine (DFMO) on the behavioral syndrome induced by intracerebroventricular injection of ACTH 1-24, in rats.

    abstract::Stretching-yawning syndrome (SYS) and penile erections (PE) are typical components of the behavioral picture induced by intracerebroventricular (i.c.v.) injection of ACTH 1-24. The present study shows that pretreatment with alpha-difluoromethylornithine (DFMO), and irreversible inhibitor of mammalian ornithine decarbo...


    pub_type: 杂志文章


    authors: Genedani S,Bernardi M,Bertolini A

    更新日期:1984-05-01 00:00:00

  • Blockage of spinal endothelin A receptors attenuates bone cancer pain via regulation of the Akt/ERK signaling pathway in mice.

    abstract::Bone cancer pain (BCP) is a common source of pain in patients with advanced stage and metastatic cancer; however, existing treatment for this kind of pain remains deficient. Being closely related to sensory change and inflammatory pain in both the central and peripheral nervous systems, endothelin A receptor (ETAR) pl...


    pub_type: 杂志文章


    authors: Han MM,Yang CW,Cheung CW,Li J

    更新日期:2018-04-01 00:00:00

  • Influence of various drugs on the variations of blood pressure, hematocrit and plasma histamine caused by neurotensin and compound 48/80 in rats.

    abstract::Intravenous injections of neurotensin (NT) (0.5, 1 and 2 nmoles kg-1) evoked dose-dependent increases in histaminemia and hematocrit, and marked hypotensive effect, in anesthetized rats. The increase of plasma histamine was rapid in onset (within sec), peak plasma histamine being reached in less than 2 min. The declin...


    pub_type: 杂志文章


    authors: Kérouac R,St-Pierre S,Rioux F

    更新日期:1982-12-01 00:00:00

  • Enkephalin-like immunoreactivity in Drosophila melanogaster.

    abstract::Enkephalin-immunoreactive neurons have been identified in the central nervous system of the fruit fly Drosophila melanogaster by immunocytochemical techniques. Analyses of fly extracts by high performance liquid chromatography and radioimmunoassay show a relatively complex pattern of immunoreactive compounds. The most...


    pub_type: 杂志文章


    authors: Pagés M,Jiménez F,Ferrús A,Peralta E,Ramírez G,Gelpí E

    更新日期:1983-12-01 00:00:00

  • Altered serum stress neuropeptide levels in critically ill individuals and associations with lymphocyte populations.

    abstract:OBJECTIVE:Potential physiological correlates of stress and the role of stress neuropeptides, other than those of the hypothalamic-pituitary-adrenal axis, in critical illness have not been addressed. We investigated: (a) serum levels of stress neuropeptides (ACTH, substance P (SP), neuropeptide Y (NPY), cortisol, prolac...


    pub_type: 杂志文章


    authors: Mpouzika MD,Papathanassoglou ED,Giannakopoulou M,Bozas E,Middleton N,Boti S,Patiraki EI,Karabinis A

    更新日期:2013-02-01 00:00:00

  • Specific inhibitors of pyroglutamyl peptidase I and prolyl endopeptidase do not change the in vitro release of TRH or its content in rodent brain.

    abstract::Pyroglutamyl diazomethyl ketone and N-benzyloxycarbonyl prolyl prolinal, specific inhibitors of pyroglutamyl peptidase I and prolyl endopeptidase respectively, were used to study the possible role of these enzymes in the regulation of thyrotropin releasing hormone turnover. In vitro thyrotropin releasing hormone relea...


    pub_type: 杂志文章


    authors: Charli JL,Mendez M,Joseph-Bravo P,Wilk S

    更新日期:1987-05-01 00:00:00

  • Endogenous opioid peptides in brain and pituitary of rats with absence epilepsy.

    abstract::The level of opioid peptides in several brain areas and in the pituitary was estimated in WAG/Rij rats, which are considered to be a genetic animal model for human absence epilepsy. In comparison with three groups of non-epileptic controls, these epileptic rats had an elevated level of the proenkephalin-derived peptid...


    pub_type: 杂志文章


    authors: Lasoń W,Przewłocka B,Van Luijtelaar EL,Coenen AM,Przewłocki R

    更新日期:1992-03-01 00:00:00

  • The effect of pituitary adenylate cyclase-activating polypeptide on elevated plus maze behavior and hypothermia induced by morphine withdrawal.

    abstract::The aim of the present investigation was to study the effects of pituitary adenylate cyclase-activating polypeptide (PACAP) on morphine withdrawal-induced behavioral changes and hypothermia in male CFLP mice. Elevated plus maze (EPM) and jump tests were used to assess naloxone-precipitated morphine withdrawal-induced ...


    pub_type: 杂志文章


    authors: Lipták N,Dochnal R,Babits A,Csabafi K,Szakács J,Tóth G,Szabó G

    更新日期:2012-02-01 00:00:00

  • The effects of sandostatin and somatostatin on nociceptive transmission in the dorsal horn of the rat spinal cord.

    abstract::The role of somatostatin and a stable analogue, sandostatin (Octreotide), on the responses of spinal cord neurones in vivo was investigated in the rat. Electrical C-fibre stimulation was used as a model of acute nociception and the response to subcutaneous formalin was used as a model of longer term events. Intratheca...


    pub_type: 杂志文章


    authors: Chapman V,Dickenson AH

    更新日期:1992-11-01 00:00:00

  • An investigation into the discriminative stimulus and reinforcing properties of the CCKB-receptor antagonist, L-365,260 in rats.

    abstract::The discriminative stimulus properties of the selective CCKB-receptor antagonist, L-365,260 were evaluated in rats trained to discriminate diazepam (2 mg/kg) or morphine (5 mg/kg) from vehicle, using a two-lever food reinforced technique. In the diazepam drug discrimination, the benzodiazepine-receptor agonist FG8205 ...


    pub_type: 杂志文章


    authors: Jackson A,Tattersall D,Bentley G,Rycroft W,Bourson A,Hargreaves R,Tricklebank M,Iversen S

    更新日期:1994-05-01 00:00:00

  • Simultaneous release of neurotensin, somatostatin, enkephalins and catecholamines from perfused cat adrenal glands.

    abstract::Acid extracts of cat adrenal medullae were found to contain neurotensin-like (0.71 +/- 0.21nmol/gm), met-enkephalin-like (11.71 +/- 2.87nmol/gm), leu-enkephalin-like (1.95 +/- 0.11nmol/gm) and somatostatin-like (1.57 +/- 0.63pmol/gm) immunoreactivities. Using isolated retrogradely perfused cat adrenal glands the secre...


    pub_type: 杂志文章


    authors: Corder R,Mason DF,Perrett D,Lowry PJ,Clement-Jones V,Linton EA,Besser GM,Rees LH

    更新日期:1982-10-01 00:00:00

  • Puerarin alleviate radicular pain from lumbar disc herniation by inhibiting ERK-dependent spinal microglia activation.

    abstract::Lumbar disc herniation is a common cause of radicular pain, but the mechanism remains ambiguous and the treatment stays unsatisfied. Many studies revealed a traditional Chinese medicine puerarin may moderate chronic pain from diabetes and nerve injury. Thus far, the role and mechanism of puerarin in radicular pain is ...


    pub_type: 杂志文章


    authors: Zhong Y,Huang YL,Hu YM,Zhu LR,Zhao YS

    更新日期:2018-12-01 00:00:00

  • Neuropharmacological actions of the superactive agonist analog D-TRP-6-LH-RH after peripheral injection into mice.

    abstract::The neuropharmacological actions of the agonist analog D-Trp-6-LH-RH were investigated in several tests after subcutaneous administrations to male mice. The doses applied were in the range 1-1000 micrograms/kg. D-Trp-6-LH-RH doses of 10 micrograms/kg and higher induced significant analgesic effects in the hot-plate an...


    pub_type: 杂志文章


    authors: Kádár T,Telegdy G,Schally AV

    更新日期:1990-10-01 00:00:00

  • Hormonal effects of high dose naloxone in humans.

    abstract::Utilizing a double-blind crossover design, the hormonal effects of high dose, 2 mg/kg, were compared to low dose, 0.4 mg (approx. 5 micrograms/kg), naloxone administration in physically healthy humans. A significant naloxone dose effect on plasma cortisol levels was found (p less than 0.001), but no significant effect...


    pub_type: 临床试验,杂志文章


    authors: Cohen MR,Cohen RM,Pickar D,Kreger D,McLellan C,Murphy DL

    更新日期:1985-07-01 00:00:00

  • The effect of C-terminus and N-terminus iodination on avian pancreatic polypeptide (APP) binding to its chicken brain receptor.

    abstract::In previous studies, membranes from chicken gastrointestinal tissues failed to bind appreciable levels of 125I-APP labeled at the C-terminus. In order to address the suggestion that this was due to steric hindrance of the critical C-terminus, N-terminally labeled 125I-APP was utilized in in vitro membrane binding assa...


    pub_type: 杂志文章


    authors: Adamo ML,Hazelwood RL

    更新日期:1992-04-01 00:00:00

  • Pharmacological and mechanistic studies of cholecystokinin-facilitated [3H]dopamine efflux from rat nucleus accumbens.

    abstract::Cholecystokinin (CCK) is co-localized with dopamine (DA) in mesolimbic neurons of the CNS and appears to selectively regulate the output of this system. In an attempt to characterize the nature of CCK interactions with mesolimbic DA-containing nerve terminals, we have investigated CCK regulation of [3H]DA overflow fro...


    pub_type: 杂志文章


    authors: Vickroy TW,Bianchi BR

    更新日期:1989-01-01 00:00:00

  • Oxytocin selectively increases ERalpha mRNA in the neonatal hypothalamus and hippocampus of female prairie voles.

    abstract::During neonatal development exogenous oxytocin increases ERalpha immunoreactivity in the hypothalamus of female prairie voles. The purpose of this study was to determine if the increase in ERalpha is associated with an increase in ERalpha mRNA expression and to determine if the effect is specific to ER subtype or if o...


    pub_type: 杂志文章


    authors: Pournajafi-Nazarloo H,Carr MS,Papademeteriou E,Schmidt JV,Cushing BS

    更新日期:2007-02-01 00:00:00

  • Effects of renal denervation on renin release induced by intracerebroventricular administration of biological active peptides in conscious rats.

    abstract::Experiments were performed to determine whether the renal nerve mediates the renin release induced by intracerebroventricular administration of angiotensin II (ANG II), bradykinin (BK), leucine-enkephalin (Leu-ENK) and neurotensin (NT). In sham-operated rats, both ANG II and NT suppressed plasma renin activity (PRA), ...


    pub_type: 杂志文章


    authors: Iwata T,Hiwada K,Kokubu T

    更新日期:1985-09-01 00:00:00

  • Involvement of tachykinin NK1 receptors in plasma protein extravasation induced by tachykinins in the guinea pig upper airways.

    abstract::Plasma protein extravasation in the upper airways of anesthetized guinea pigs was measured with the FITC (Fluorescein isothiocyanate)-dextran technique. The effect of selective tachykinin (NK1 and NK2) receptor agonists and antagonists, capsaicin or antigen was studied. The tachykinin NK1 receptor agonist, [Sar9]subst...


    pub_type: 杂志文章


    authors: Evangelista S,Paoli S,Giachetti A,Manzini S

    更新日期:1997-02-01 00:00:00

  • Peripheral neurotensin participates in the modulation of pre- and postprandial intestinal motility in rats.

    abstract::The present study was undertaken to determine whether neurotensin is involved in the regulation of the intestinal postprandial motor response and, if so, whether the regulatory pathway depends upon peripheral or central neurotensin secretion. Neurotensin, injected by the i.v. route (5 micrograms/kg) during the fasting...


    pub_type: 杂志文章


    authors: Pellissier S,Eribon O,Chabert J,Gully D,Roche M

    更新日期:1996-10-01 00:00:00

  • Alarin stimulates food intake in male rats and LH secretion in castrated male rats.

    abstract::Alarin is a newly identified member of the galanin family of neuropeptides that includes galanin-like peptide (GALP) and galanin. Alarin was discovered as an alternate transcript of the GALP gene in neuroblastoma cells, and subsequently alarin mRNA was detected in the brain of rodents. GALP and galanin are important c...


    pub_type: 杂志文章


    authors: Van Der Kolk N,Madison FN,Mohr M,Eberhard N,Kofler B,Fraley GS

    更新日期:2010-08-01 00:00:00

  • Investigation of receptor binding and functional characteristics of hemopressin(1-7).

    abstract::The orally active, α-hemoglobin derived hemopressin (PVNFKFLSH, Hp(1-9)) and its truncated (PVNFKFL, Hp(1-7) and PVNFKF, Hp(1-6)) and extended ((R)VDPVNFKFLSH, VD-Hp(1-9) and RVD-Hp(1-9)) derivatives have been postulated to be the endogenous peptide ligands of the cannabinoid receptor type 1 (CB1). In an attempt to cr...


    pub_type: 杂志文章


    authors: Dvorácskó S,Tömböly C,Berkecz R,Keresztes A

    更新日期:2016-08-01 00:00:00

  • Role of hypothalamic neuropeptide Y in feeding and obesity.

    abstract::The 36-amino-acid peptide, neuropeptide Y (NPY), is the most abundant peptide in the rat brain. When administered into the brain, NPY produces a variety of physiological actions including a pronounced stimulation of feeding in satiated rats. Elevations in hypothalamic NPY have been reported after food deprivation and ...


    pub_type: 杂志文章,评审


    authors: Gehlert DR

    更新日期:1999-10-01 00:00:00