Abstract:
:We investigated the effect of sulphated cholecystokinin octapeptide (CCK-8S) on free intracellular calcium concentration, phosphatidylinositol metabolism, and protein phosphorylation in C6 cells, a rat glioma cell line which was shown to express CCKB type receptors. Increase in [Ca2+]i by both influx across the cell membrane and release from internal stores was demonstrated by utilizing a laser confocal imaging system. Because CCK-8S produced a transient elevation of inositol triphosphate level participation of InsP3 in calcium signaling in C6 cells is very likely. Protein kinase C seems to be involved in CCK-8S induced signaling in rat glioma C6 cells as demonstrated by using in vivo phosphorylation experiments.
journal_name
Neuropeptidesjournal_title
Neuropeptidesauthors
Kaufmann R,Schöneberg T,Lindschau C,Haller H,Ott Tdoi
10.1016/0143-4179(95)90033-0subject
Has Abstractpub_date
1995-11-01 00:00:00pages
251-6issue
5eissn
0143-4179issn
1532-2785pii
0143-4179(95)90033-0journal_volume
29pub_type
杂志文章相关文献
NEUROPEPTIDES文献大全abstract::Opiates have been shown to affect prolactin secretion directly at the pituitary level. However, opiate binding sites have not been characterized on anterior pituitary tissue. In the present work we show that a soluble factor present in anterior pituitary membrane preparation inhibit opiate binding on striatal membrane...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(86)90009-0
更新日期:1986-11-01 00:00:00
abstract::Hypertension is still presently the number one "silent killer" in the Western World, and a major risk factor for the development of secondary diseases contributing to cardiovascular disease (CVD). However, despite a broad range of therapies, the mechanisms involved in the onset of hypertension remains unclear, therefo...
journal_title:Neuropeptides
pub_type: 杂志文章,评审
doi:10.1016/j.npep.2010.12.002
更新日期:2011-04-01 00:00:00
abstract::Since there are conflicting reports regarding the effects of somatostatin (SS) on cyclic AMP levels in astrocytes derived from rat cerebral cortex and, to date, the SS binding to mature astrocytes is unknown, the present study has determined SS binding and its effect on cyclic AMP accumulation in a fresh astrocyte-ric...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(92)90002-e
更新日期:1992-09-01 00:00:00
abstract::Alzheimer's disease (AD) is a progressive neurodegenerative disease that deeply affects patients, their family and society. Although scientists have made intense efforts in seeking the cure for AD, no drug available today is able to stop AD progression. In this context, compounds isolated from animal venom are potenti...
journal_title:Neuropeptides
pub_type: 杂志文章,评审
doi:10.1016/j.npep.2017.11.010
更新日期:2018-02-01 00:00:00
abstract::Noradrenaline (NA) has been implicated in both increase and reduction of anxiety. Selective destruction of nerve endings of the locus coeruleus projections by DSP-4 has been shown to reduce active behaviour in novel situations by enhancing anxiety. In the present study, DSP-4 (50 mg/kg) treatment reduced locomotor act...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1054/npep.1999.0788
更新日期:2000-02-01 00:00:00
abstract::The galanin family currently consists of four peptides, namely galanin, galanin-message associated peptide, galanin-like peptide and alarin. Unlike galanin that signals through three different G protein-coupled receptors; GAL1, GAL2, and GAL3, binding at its N-terminal end, the cognate receptors for other members of t...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/j.npep.2017.03.005
更新日期:2017-06-01 00:00:00
abstract:BACKGROUND:Chromogranin A (CgA) in plasma (P-CgA), a neuroendocrine marker of sympathetic stress, has been shown to predict mortality in medical intensive care. We hypothesized that the magnitude of CgA release would reflect stress load, and thereby injury severity in burn intensive care patients. METHODS:Fifty-one co...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/j.npep.2012.10.004
更新日期:2013-06-01 00:00:00
abstract::Stretching-yawning syndrome (SYS) and penile erections (PE) are typical components of the behavioral picture induced by intracerebroventricular (i.c.v.) injection of ACTH 1-24. The present study shows that pretreatment with alpha-difluoromethylornithine (DFMO), and irreversible inhibitor of mammalian ornithine decarbo...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(84)90105-7
更新日期:1984-05-01 00:00:00
abstract::Bone cancer pain (BCP) is a common source of pain in patients with advanced stage and metastatic cancer; however, existing treatment for this kind of pain remains deficient. Being closely related to sensory change and inflammatory pain in both the central and peripheral nervous systems, endothelin A receptor (ETAR) pl...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/j.npep.2018.01.003
更新日期:2018-04-01 00:00:00
abstract::Intravenous injections of neurotensin (NT) (0.5, 1 and 2 nmoles kg-1) evoked dose-dependent increases in histaminemia and hematocrit, and marked hypotensive effect, in anesthetized rats. The increase of plasma histamine was rapid in onset (within sec), peak plasma histamine being reached in less than 2 min. The declin...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(82)90010-5
更新日期:1982-12-01 00:00:00
abstract::Enkephalin-immunoreactive neurons have been identified in the central nervous system of the fruit fly Drosophila melanogaster by immunocytochemical techniques. Analyses of fly extracts by high performance liquid chromatography and radioimmunoassay show a relatively complex pattern of immunoreactive compounds. The most...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(83)90012-4
更新日期:1983-12-01 00:00:00
abstract:OBJECTIVE:Potential physiological correlates of stress and the role of stress neuropeptides, other than those of the hypothalamic-pituitary-adrenal axis, in critical illness have not been addressed. We investigated: (a) serum levels of stress neuropeptides (ACTH, substance P (SP), neuropeptide Y (NPY), cortisol, prolac...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/j.npep.2012.07.007
更新日期:2013-02-01 00:00:00
abstract::Pyroglutamyl diazomethyl ketone and N-benzyloxycarbonyl prolyl prolinal, specific inhibitors of pyroglutamyl peptidase I and prolyl endopeptidase respectively, were used to study the possible role of these enzymes in the regulation of thyrotropin releasing hormone turnover. In vitro thyrotropin releasing hormone relea...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(87)90010-2
更新日期:1987-05-01 00:00:00
abstract::The level of opioid peptides in several brain areas and in the pituitary was estimated in WAG/Rij rats, which are considered to be a genetic animal model for human absence epilepsy. In comparison with three groups of non-epileptic controls, these epileptic rats had an elevated level of the proenkephalin-derived peptid...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(92)90037-w
更新日期:1992-03-01 00:00:00
abstract::The aim of the present investigation was to study the effects of pituitary adenylate cyclase-activating polypeptide (PACAP) on morphine withdrawal-induced behavioral changes and hypothermia in male CFLP mice. Elevated plus maze (EPM) and jump tests were used to assess naloxone-precipitated morphine withdrawal-induced ...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/j.npep.2011.12.001
更新日期:2012-02-01 00:00:00
abstract::The role of somatostatin and a stable analogue, sandostatin (Octreotide), on the responses of spinal cord neurones in vivo was investigated in the rat. Electrical C-fibre stimulation was used as a model of acute nociception and the response to subcutaneous formalin was used as a model of longer term events. Intratheca...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(92)90115-d
更新日期:1992-11-01 00:00:00
abstract::The discriminative stimulus properties of the selective CCKB-receptor antagonist, L-365,260 were evaluated in rats trained to discriminate diazepam (2 mg/kg) or morphine (5 mg/kg) from vehicle, using a two-lever food reinforced technique. In the diazepam drug discrimination, the benzodiazepine-receptor agonist FG8205 ...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(94)90119-8
更新日期:1994-05-01 00:00:00
abstract::Acid extracts of cat adrenal medullae were found to contain neurotensin-like (0.71 +/- 0.21nmol/gm), met-enkephalin-like (11.71 +/- 2.87nmol/gm), leu-enkephalin-like (1.95 +/- 0.11nmol/gm) and somatostatin-like (1.57 +/- 0.63pmol/gm) immunoreactivities. Using isolated retrogradely perfused cat adrenal glands the secre...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(82)90061-0
更新日期:1982-10-01 00:00:00
abstract::Lumbar disc herniation is a common cause of radicular pain, but the mechanism remains ambiguous and the treatment stays unsatisfied. Many studies revealed a traditional Chinese medicine puerarin may moderate chronic pain from diabetes and nerve injury. Thus far, the role and mechanism of puerarin in radicular pain is ...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/j.npep.2018.10.001
更新日期:2018-12-01 00:00:00
abstract::The neuropharmacological actions of the agonist analog D-Trp-6-LH-RH were investigated in several tests after subcutaneous administrations to male mice. The doses applied were in the range 1-1000 micrograms/kg. D-Trp-6-LH-RH doses of 10 micrograms/kg and higher induced significant analgesic effects in the hot-plate an...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(90)90053-2
更新日期:1990-10-01 00:00:00
abstract::Utilizing a double-blind crossover design, the hormonal effects of high dose, 2 mg/kg, were compared to low dose, 0.4 mg (approx. 5 micrograms/kg), naloxone administration in physically healthy humans. A significant naloxone dose effect on plasma cortisol levels was found (p less than 0.001), but no significant effect...
journal_title:Neuropeptides
pub_type: 临床试验,杂志文章
doi:10.1016/0143-4179(85)90010-1
更新日期:1985-07-01 00:00:00
abstract::In previous studies, membranes from chicken gastrointestinal tissues failed to bind appreciable levels of 125I-APP labeled at the C-terminus. In order to address the suggestion that this was due to steric hindrance of the critical C-terminus, N-terminally labeled 125I-APP was utilized in in vitro membrane binding assa...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(92)90026-s
更新日期:1992-04-01 00:00:00
abstract::Cholecystokinin (CCK) is co-localized with dopamine (DA) in mesolimbic neurons of the CNS and appears to selectively regulate the output of this system. In an attempt to characterize the nature of CCK interactions with mesolimbic DA-containing nerve terminals, we have investigated CCK regulation of [3H]DA overflow fro...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(89)90020-6
更新日期:1989-01-01 00:00:00
abstract::During neonatal development exogenous oxytocin increases ERalpha immunoreactivity in the hypothalamus of female prairie voles. The purpose of this study was to determine if the increase in ERalpha is associated with an increase in ERalpha mRNA expression and to determine if the effect is specific to ER subtype or if o...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/j.npep.2006.10.002
更新日期:2007-02-01 00:00:00
abstract::Experiments were performed to determine whether the renal nerve mediates the renin release induced by intracerebroventricular administration of angiotensin II (ANG II), bradykinin (BK), leucine-enkephalin (Leu-ENK) and neurotensin (NT). In sham-operated rats, both ANG II and NT suppressed plasma renin activity (PRA), ...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(85)90142-8
更新日期:1985-09-01 00:00:00
abstract::Plasma protein extravasation in the upper airways of anesthetized guinea pigs was measured with the FITC (Fluorescein isothiocyanate)-dextran technique. The effect of selective tachykinin (NK1 and NK2) receptor agonists and antagonists, capsaicin or antigen was studied. The tachykinin NK1 receptor agonist, [Sar9]subst...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/s0143-4179(97)90022-6
更新日期:1997-02-01 00:00:00
abstract::The present study was undertaken to determine whether neurotensin is involved in the regulation of the intestinal postprandial motor response and, if so, whether the regulatory pathway depends upon peripheral or central neurotensin secretion. Neurotensin, injected by the i.v. route (5 micrograms/kg) during the fasting...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/s0143-4179(96)90002-5
更新日期:1996-10-01 00:00:00
abstract::Alarin is a newly identified member of the galanin family of neuropeptides that includes galanin-like peptide (GALP) and galanin. Alarin was discovered as an alternate transcript of the GALP gene in neuroblastoma cells, and subsequently alarin mRNA was detected in the brain of rodents. GALP and galanin are important c...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/j.npep.2010.04.001
更新日期:2010-08-01 00:00:00
abstract::The orally active, α-hemoglobin derived hemopressin (PVNFKFLSH, Hp(1-9)) and its truncated (PVNFKFL, Hp(1-7) and PVNFKF, Hp(1-6)) and extended ((R)VDPVNFKFLSH, VD-Hp(1-9) and RVD-Hp(1-9)) derivatives have been postulated to be the endogenous peptide ligands of the cannabinoid receptor type 1 (CB1). In an attempt to cr...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/j.npep.2016.02.001
更新日期:2016-08-01 00:00:00
abstract::The 36-amino-acid peptide, neuropeptide Y (NPY), is the most abundant peptide in the rat brain. When administered into the brain, NPY produces a variety of physiological actions including a pronounced stimulation of feeding in satiated rats. Elevations in hypothalamic NPY have been reported after food deprivation and ...
journal_title:Neuropeptides
pub_type: 杂志文章,评审
doi:10.1054/npep.1999.0057
更新日期:1999-10-01 00:00:00