HPLC separation of vasopressin-like hormones in chicken neurohypophysial extracts.

abstract：:In rat preprogalanin, galanin is C-terminally flanked by a 60 amino acid long peptide: galanin message-associated peptide (GMAP). GMAP sequences in different species show high degree of homology, suggesting a biological role. However, the study of the physiological and pharmacological actions of this peptide have been...

journal_title：Neuropeptides

authors： Andell-Jonsson S,Bartfai T

更新日期：1998-04-01 00:00:00

abstract：:In this study guinea pig, rat and bovine striatal extracts have been shown to contain putative opioid peptide precursors in the molecular weight (Mr) range 2000-greater than 70000. The material eluting greater than 70 kDalton contained bioassayable opioid activity but not Met- or Leu-enkephalin-like immunoreactivities...

journal_title：Neuropeptides

authors： Metters KM,Beaumont A,Rossier J,Hughes J

更新日期：1985-02-01 00:00:00

abstract：:Neuropeptide Y (NPY) has been implicated in anxiolytic- and antidepressant-like behaviour as well as seizure-suppressant effects in rodents. Although these effects appear to be predominantly mediated via other NPY receptors (Y1 and/or Y2), several studies have also indicated a role for Y5 receptors. Gene therapy using...

journal_title：Neuropeptides

authors： Olesen MV,Christiansen SH,Gøtzsche CR,Holst B,Kokaia M,Woldbye DP

更新日期：2012-04-01 00:00:00

abstract：:Immunoreactive substance P (SPI) and somatostatin (SOMI) are found in spinal cord but their physiological roles remain speculative. Several classes of neuropeptides, including endogenous opioids and thyrotropin-releasing hormone (TRH), have been implicated in the pathogenesis or recovery from spinal cord injury. In th...

journal_title：Neuropeptides

authors： Faden AI,Jacobs TP,Helke CJ

更新日期：1985-06-01 00:00:00

abstract：:The effects of stimulation and blockade of neurotensin receptors on striatal acetylcholine release were examined in anaesthetized rats using microdialysis. Local perfusion with neurotensin (100 nM) did not influence the release of acetylcholine. Application of neurotensin (100 nM) 30 min after haloperidol (125 microgr...

journal_title：Neuropeptides

authors： Steinberg R,Rodier D,Mons G,Gully D,Le Fur G,Soubrié P

更新日期：1995-07-01 00:00:00

abstract：:We have described the binding of [125I]endothelin-1 (ET-1) to cultured rat cerebellar granule cells. Binding of [125I]ET-1 was specific, saturable, and time-dependent. Scatchard analysis of saturation binding data indicated a single class of high affinity binding site with a KD of 95 pM, and a Bmax of 8110 receptors/c...

journal_title：Neuropeptides

authors： Lysko PG,Feuerstein G,Pullen M,Wu HL,Nambi P

更新日期：1991-02-01 00:00:00

abstract：:The hypocretins/orexins (hcrts) are two recently described neuropeptides derived from the same precursor and expressed in a few thousand neurons in the perifornical area of the lateral hypothalamus, which project throughout the brain. The hypocretins bind to two G-protein coupled receptors with different selective aff...

journal_title：Neuropeptides

authors： de Lecea L,Sutcliffe JG,Fabre V

更新日期：2002-04-01 00:00:00

abstract：:Endothelins (ET) are a family of highly active neuropeptides with manifold influences via ET receptors (ETR) in both the peripheral and central nervous systems. We have shown previously that satellite glial cells (SGCs) in mouse trigeminal ganglia (TG) are extremely sensitive to ET-1 in evoking [Ca2+]in increase, appa...

journal_title：Neuropeptides

authors： Feldman-Goriachnik R,Hanani M

更新日期：2017-06-01 00:00:00

abstract：:Noradrenaline (NA) has been implicated in both increase and reduction of anxiety. Selective destruction of nerve endings of the locus coeruleus projections by DSP-4 has been shown to reduce active behaviour in novel situations by enhancing anxiety. In the present study, DSP-4 (50 mg/kg) treatment reduced locomotor act...

journal_title：Neuropeptides

authors： Kask A,Eller M,Oreland L,Harro J

更新日期：2000-02-01 00:00:00

abstract：:3H-Bradykinin binding sites with the characteristics of receptors were identified in homogenates of bovine hippocampus and PC-12 cells. The characteristics of the binding were similar in both types of tissue and paralleled those of the B2 bradykinin receptor. Following exposure to nerve growth factor for 72 hours, the...

journal_title：Neuropeptides

authors： Kozlowski MR,Rosser MP,Hall E

更新日期：1988-11-01 00:00:00

abstract：:The role of somatostatin and a stable analogue, sandostatin (Octreotide), on the responses of spinal cord neurones in vivo was investigated in the rat. Electrical C-fibre stimulation was used as a model of acute nociception and the response to subcutaneous formalin was used as a model of longer term events. Intratheca...

journal_title：Neuropeptides

authors： Chapman V,Dickenson AH

更新日期：1992-11-01 00:00:00

abstract：:Paired-pulse stimulation was used to evaluate the effects of the sulfated octapeptide of cholecystokinin (CCK8-S), the gamma-aminobutyric acidB (GABAB) agonist (-) baclofen, and the GABAA antagonist (-) bicuculline on hippocampal dentate gyrus (DG) granule cell excitability. Evoked action potentials (EAPs) and excitat...

journal_title：Neuropeptides

authors： Rich-Bennett E,Dahl D,Lecompte BB 3rd

更新日期：1993-05-01 00:00:00

abstract：:A role for beta-endorphin (beta-END) in the pathophysiology of major depressive disorder (MDD) is suggested by both animal research and studies examining clinical populations. The major etiological theories of depression include brain regions and neural systems that interact with opioid systems and beta-END. Recent pr...

journal_title：Neuropeptides

authors： Hegadoren KM,O'Donnell T,Lanius R,Coupland NJ,Lacaze-Masmonteil N

更新日期：2009-10-01 00:00:00

abstract：:Since there are conflicting reports regarding the effects of somatostatin (SS) on cyclic AMP levels in astrocytes derived from rat cerebral cortex and, to date, the SS binding to mature astrocytes is unknown, the present study has determined SS binding and its effect on cyclic AMP accumulation in a fresh astrocyte-ric...

journal_title：Neuropeptides

authors： Colás B,Arilla E,Prieto JP

更新日期：1992-09-01 00:00:00

abstract：:The effects of the GABAergic drugs nipecotic acid, Gabrene, baclofen and metatolylcarbamide (MTC), when given alone or in combination at subthreshold doses with AT II also at a subthreshold dose effective on PTZ-kindling in mice were studied. PTZ-kindling was provoked by intraperitoneal (i.p.) injections of PTZ (40 mg...

journal_title：Neuropeptides

authors： Georgiev VP,Lazarova MB,Kambourova TS

更新日期：1995-01-01 00:00:00

abstract：:The progesterone metabolite, allopregnanolone (AlloP), is a GABAA receptor modulating steroid and is known to have orexigenic and pro-obesity effects. The neurobiological mechanisms underpinning these effects are most likely due to enhanced GABAergic signaling in the lateral arcuate nucleus (ARC) and medial paraventri...

journal_title：Neuropeptides

authors： Löfgren M,Holmberg E,Bäckström T,Egecioglu E,Dickson SL

更新日期：2019-08-01 00:00:00

abstract：:CSF methionine and leucine enkephalins were measured by high performance liquid chromatography and radioimmunoassay in diabetic patients with painful neuropathy (n = 22) and painless neuropathy (n = 5), and non-diabetic subjects with low back pain (n = 11). Wide variations in CSF enkephalin levels were found and they ...

journal_title：Neuropeptides

authors： Chan AW,Macfarlane IA,Masson EA,Bowsher D,Morley JS,Venn RF

更新日期：1992-06-01 00:00:00

abstract：:The action of corticotropin-releasing factor (CRF) is mediated by two recently identified receptors, CRFR1 and CRFR2, that differ with respect to their anatomical distribution and pharmacologic ligand-binding properties. Here we show by an analysis of circadian heartbeat interval fluctuations that CRFR2-deficiency in ...

journal_title：Neuropeptides

authors： Stiedl O,Meyer M

更新日期：2003-02-01 00:00:00

abstract：:The biological and immunological properties of insulin-like material produced by brain cells from 12 day old mice, cultured in serum-free media were examined. Differences were seen in the rate of appearance, relative amounts and behaviour on HPLC between immunoreactive and biologically active insulin-like material. Ex...

journal_title：Neuropeptides

authors： Birch NP,Christie DL,Renwick AG

更新日期：1987-05-01 00:00:00

abstract：:Cerebral amyloid-beta protein (Abeta) deposition and associated neuroinflammation and apoptosis are increasingly recognized as an important component leading to cognitive impairment in Alzheimer's disease (AD). Humanin (HN) and its derivative, S14G-HN (HNG), are best known for their ability to suppress neuronal death ...

journal_title：Neuropeptides

authors： Miao J,Zhang W,Yin R,Liu R,Su C,Lei G,Li Z

更新日期：2008-10-01 00:00:00

abstract：:The distributions of four prodynorphin-derived peptides, dynorphin A (1-17), dynorphin A (1-8), dynorphin B, and alpha-neo-endorphin were determined in 10 cortical regions and the striatum of the old world monkey (Macaca nemestrina). alpha-neo-endorphin was the most abundant peptide in both cortex and striatum. The co...

journal_title：Neuropeptides

authors： Healy DJ,Meador-Woodruff JH

更新日期：1994-11-01 00:00:00

abstract：:Oxytocin, intraperitoneally injected to 26-month-old male rats 60 min before testing, significantly improved social memory (at doses of 3 and 6 ng/kg) and reduced the duration of immobility in the behavioral despair test (at doses of 50 and 500 micrograms/kg). These results are in agreement with previous data obtained...

journal_title：Neuropeptides

authors： Arletti R,Benelli A,Poggioli R,Luppi P,Menozzi B,Bertolini A

更新日期：1995-09-01 00:00:00

abstract：:Nociceptin/Orphanin FQ (N/OFQ) is a 17-amino acid peptide that binds to the nociceptin receptor (NOP). N/OFQ and NOP receptors are expressed in numerous brain areas. The generation of specific agonists, antagonists and receptor-deficient mice or rats has enabled progress in elucidating the biological functions of N/OF...

journal_title：Neuropeptides

authors： Baiula M,Bedini A,Spampinato SM

更新日期：2015-04-01 00:00:00

abstract：:Neuropeptide Y (NPY) has been implicated in the modulation of important features of neuronal physiology, including calcium homeostasis, neurotransmitter release and excitability. Moreover, NPY has been involved as an important modulator of hippocampal and thalamic circuits, receiving particular attention as an endogen...

journal_title：Neuropeptides

authors： Malva JO,Xapelli S,Baptista S,Valero J,Agasse F,Ferreira R,Silva AP

更新日期：2012-12-01 00:00:00

abstract：:Humanin (HN) is an endogenous 24-residue peptide. A highly potent HN derivative, S14G-HN, which has a substitution of serine 14 to glycine, reduced amyloid burden and suppressed cognitive impairment in a mouse model of Alzheimer's disease. S14G-HN also suppressed amnesia induced by a muscarinic receptor antagonist in ...

journal_title：Neuropeptides

authors： Murakami M,Nagahama M,Maruyama T,Niikura T

更新日期：2017-04-01 00:00:00

abstract：:Stretching-yawning syndrome (SYS) and penile erections (PE) are typical components of the behavioral picture induced by intracerebroventricular (i.c.v.) injection of ACTH 1-24. The present study shows that pretreatment with alpha-difluoromethylornithine (DFMO), and irreversible inhibitor of mammalian ornithine decarbo...

journal_title：Neuropeptides

authors： Genedani S,Bernardi M,Bertolini A

更新日期：1984-05-01 00:00:00

abstract：:The effects of 6-hydroxydopamine (6-OHDA) injected into either the ventral tegmental area (VTA) or the nucleus accumbens on dopamine and its metabolite DOPAC and CCK-immunoreactivity in the nucleus accumbens were studied. Measurements were made 1, 3 and 6 weeks after the lesion in both the anterior and posterior part ...

journal_title：Neuropeptides

authors： Igarashi Y,Wiegant VM,Van Ree JM

更新日期：1989-08-01 00:00:00

abstract：:During neonatal development exogenous oxytocin increases ERalpha immunoreactivity in the hypothalamus of female prairie voles. The purpose of this study was to determine if the increase in ERalpha is associated with an increase in ERalpha mRNA expression and to determine if the effect is specific to ER subtype or if o...

journal_title：Neuropeptides

authors： Pournajafi-Nazarloo H,Carr MS,Papademeteriou E,Schmidt JV,Cushing BS

更新日期：2007-02-01 00:00:00

abstract：:Cholecystokinin (CCK) is a widely expressed neuropeptide system originally discovered in the gut. Both cerebral and peripheral neurons as well as endocrine I-cells in the small intestine process proCCK to tyrosyl-O-sulfated and α-carboxyamidated peptides. Recently, we reported that gut endocrine I-cells also synthetiz...

journal_title：Neuropeptides

authors： Agersnap M,Zhang MD,Harkany T,Hökfelt T,Rehfeld JF

更新日期：2016-12-01 00:00:00

abstract：:Neuropeptide Y (NPY) is involved in multiple processes such as behavior, energy and bone metabolism. Previous studies have relied on global NPY depletion to examine its effects on bone. However, this approach is unable to distinguish the central or local source of NPY influencing bone. Our aim was to identify which ce...

journal_title：Neuropeptides

authors： Wee NKY,Sinder BP,Novak S,Wang X,Stoddard C,Matthews BG,Kalajzic I

更新日期：2019-02-01 00:00:00