Abstract：
:Paired-pulse stimulation was used to evaluate the effects of the sulfated octapeptide of cholecystokinin (CCK8-S), the gamma-aminobutyric acidB (GABAB) agonist (-) baclofen, and the GABAA antagonist (-) bicuculline on hippocampal dentate gyrus (DG) granule cell excitability. Evoked action potentials (EAPs) and excitatory postsynaptic potentials (EPSPs) were recorded in response to orthodromic stimulation of the medial (MPP) or lateral (LPP) perforant pathway. Paired-pulse indices were determined using interpulse intervals (IPIs) across the range of 5-1000 ms. As reported by others, three phases of paired-pulse effects were revealed under control (drug-free ACSF) conditions: early paired-pulse inhibition (PPI), intermediate paired-pulse facilitation (PPF) and late PPI. With EAPs, CCK8-S enhanced only the intermediate PPF on both pathways, with no effect on the early or late PPIs. The effects of (-) baclofen were similar to CCK8-S. (-) Bicuculline attenuated the early and late PPI as well as the PPF. No differences were measured on the MPP- or LPP-evoked EPSPs in any of the drug conditions. These results indicate a similarity of CCK8-S- with GABAB-mediated modulation on neuronal activation in the DG. CCK8-S disinhibition of DG granule cells may play a role in the induction of long-lasting synaptic modifications.
journal_name
Neuropeptidesjournal_title
Neuropeptidesauthors
Rich-Bennett E,Dahl D,Lecompte BB 3rddoi
10.1016/0143-4179(93)90014-2subject
Has Abstractpub_date
1993-05-01 00:00:00pages
263-70issue
5eissn
0143-4179issn
1532-2785pii
0143-4179(93)90014-2journal_volume
24pub_type
杂志文章相关文献
NEUROPEPTIDES文献大全abstract：:Oxytocin, either intraperitoneally injected (200 ng/rat) or intracerebroventricularly infused (1 ng/rat in 4 microliters saline) 60 and 15 min respectively before testing, significantly increased the lordosis response to the mounting male of ovariectomized, estrogen/progesterone treated rats. The intracerebroventricul...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/0143-4179(85)90095-2
更新日期：1985-06-01 00:00:00
abstract：:The role played by the biologically active CART 55-102 peptide in NAcc AMPH induced locomotion was investigated. When microinjected alone into this site, none of the doses of CART 55-102 tested (0.1, 0.4, 1.0 or 2.5 microg/0.5 microl/side) produced effects on locomotion during a two-h test. However, when co-injected w...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/j.npep.2003.10.001
更新日期：2003-12-01 00:00:00
abstract：:We have developed an extraction method and radioimmunoassay for the measurement of interleukin-1 beta (IL-1 beta) in rat tissues, using an antibody specific for IL-1 beta, IL-1 beta was detected in the spleen and thymus of control rats. Adrenalectomy (ADX) had no effect upon control levels of IL-1 beta. In animals wit...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/0143-4179(93)90008-x
更新日期：1993-06-01 00:00:00
abstract：:Galanin and the N-terminal fragment Galanin(1-15) are involved in central cardiovascular regulation. The present paper reviews the recent cardiovascular results obtained by intracisternal injections of Galanin and Galanin(1-15) showing that: (A) the Galanin antagonist M40 blocks the central cardiovascular responses in...
journal_title：Neuropeptides
pub_type： 杂志文章,评审
doi：10.1016/j.npep.2004.12.009
更新日期：2005-06-01 00:00:00
abstract：:Oxytocin, intraperitoneally injected to 26-month-old male rats 60 min before testing, significantly improved social memory (at doses of 3 and 6 ng/kg) and reduced the duration of immobility in the behavioral despair test (at doses of 50 and 500 micrograms/kg). These results are in agreement with previous data obtained...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/0143-4179(95)90021-7
更新日期：1995-09-01 00:00:00
abstract：:In this study the influence of acute exposure of gastric mucosa to the sensory neurotoxin capsaicin on basal gastric acid secretion and on secretion induced by 2-deoxy-D-glucose or histamine in conscious dogs with gastric fistulae has been investigated. Under basal conditions intragastric capsaicin (160 microM, 50 ml ...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/0143-4179(92)90128-j
更新日期：1992-12-01 00:00:00
abstract：:Attempts have been made to confirm reports that naloxonazine and Mr2034 are able to selectively antagonise morphine-induced analgesia and respiratory depression respectively. In the present studies these antagonists proved to be equi-effective against both the analgesic and respiratory depressant effects of morphine, ...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/0143-4179(84)90033-7
更新日期：1984-12-01 00:00:00
abstract：BACKGROUND:Chromogranin A (CgA) in plasma (P-CgA), a neuroendocrine marker of sympathetic stress, has been shown to predict mortality in medical intensive care. We hypothesized that the magnitude of CgA release would reflect stress load, and thereby injury severity in burn intensive care patients. METHODS:Fifty-one co...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/j.npep.2012.10.004
更新日期：2013-06-01 00:00:00
abstract：:Pyroglutamyl diazomethyl ketone and N-benzyloxycarbonyl prolyl prolinal, specific inhibitors of pyroglutamyl peptidase I and prolyl endopeptidase respectively, were used to study the possible role of these enzymes in the regulation of thyrotropin releasing hormone turnover. In vitro thyrotropin releasing hormone relea...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/0143-4179(87)90010-2
更新日期：1987-05-01 00:00:00
abstract：:Social conflict and defeat in mice leads to an activation of endogenous opiate systems. The effects of intracerebroventricular administration of the peptide FMRFamide (Phe-Met-Arg-Phe-NH2) and the opiate antagonist naloxone, on aggressive encounters, defeat-induced analgesia and defeat-induced feeding were examined in...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/0143-4179(85)90110-6
更新日期：1985-12-01 00:00:00
abstract：:The pathophysiological basis for the pain of migraine has been the subject of substantial attention and must include activation of elements of the trigeminal innervation of the cranial vessels, the trigeminovascular system. Recently, consideration of trigeminal-evoked neurogenic plasma protein extravasation (PPE) as a...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1054/npep.1999.0009
更新日期：1999-02-01 00:00:00
abstract：:Experiments were performed to determine whether the renal nerve mediates the renin release induced by intracerebroventricular administration of angiotensin II (ANG II), bradykinin (BK), leucine-enkephalin (Leu-ENK) and neurotensin (NT). In sham-operated rats, both ANG II and NT suppressed plasma renin activity (PRA), ...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/0143-4179(85)90142-8
更新日期：1985-09-01 00:00:00
abstract：:125I-Neuropeptide Y (NPY) bound specifically with high affinity to rat atrial and ventricular membranes. Scatchard analysis revealed the presence of single class of binding sites in both atrial and ventricular membranes. The apparent Kd and Bmax for atrial membranes were 0.63 nM and 70 fmol/mg protein, respectively; v...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/0143-4179(90)90148-r
更新日期：1990-03-01 00:00:00
abstract：:The effects of the GABAergic drugs nipecotic acid, Gabrene, baclofen and metatolylcarbamide (MTC), when given alone or in combination at subthreshold doses with AT II also at a subthreshold dose effective on PTZ-kindling in mice were studied. PTZ-kindling was provoked by intraperitoneal (i.p.) injections of PTZ (40 mg...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/0143-4179(95)90071-3
更新日期：1995-01-01 00:00:00
abstract：:The orexins (hypocretins) are lateral hypothalamic (LH) neuropeptides that have been implicated in a variety of behaviors ranging from feeding to sleep and arousal. Evidence from animal models suggests a role for orexins in reward processing and drug addiction. In the present study, we investigated the direct effect o...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/j.npep.2014.04.003
更新日期：2014-06-01 00:00:00
abstract：:The central control of feeding in animals depends upon the alternating actions of orexigenic and anorectic peptides. Studies at understanding the food intake mechanisms have emphasised the role of Neuropeptide Y as a potent orexigenic peptide in the brain. The aim of this study is to investigate the response of NPY sy...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/j.npep.2018.06.001
更新日期：2018-10-01 00:00:00
abstract：:In critical patients, sepsis-induced muscle wasting is considered to be an important contributor to complications and mortality. Previous work mainly focuses on the peripheral molecular mechanism of muscle degradation, however little evidence exists for the role of central nervous system in the process. In the present...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/j.npep.2014.10.002
更新日期：2014-12-01 00:00:00
abstract：:Cocaine-regulated and amphetamine-regulated transcript (CART) is a neuropeptide with reported neuroprotective effects in ischemic cerebral injury. However, its mechanism has not yet been elucidated. Herein, we investigated the role and mechanism of CART in synaptic plasticity in neurons after ischemic cerebral stroke....
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/j.npep.2020.102023
更新日期：2020-06-01 00:00:00
abstract：:We have evaluated the peripheral blood natural killer (NK) cell activity and the in vitro effect of recombinant gamma-interferon (r gamma-IFN) on NK cell activity in 23 patients with a neuroendocrine tumour of the pancreas, small intestine or liver, and 23 healthy controls. Patients with a gastrinoma showed a NK cell ...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/0143-4179(91)90033-f
更新日期：1991-09-01 00:00:00
abstract：:Opiates have been shown to affect prolactin secretion directly at the pituitary level. However, opiate binding sites have not been characterized on anterior pituitary tissue. In the present work we show that a soluble factor present in anterior pituitary membrane preparation inhibit opiate binding on striatal membrane...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/0143-4179(86)90009-0
更新日期：1986-11-01 00:00:00
abstract：:The regulation of neuropeptide gene expression and their receptors in a tissue specific and stimulus inducible manner will determine in part behaviour and physiology. This can be a dynamic process resulting from short term changes in response to the environment or long term modulation imposed by epigenetically determi...
journal_title：Neuropeptides
pub_type： 杂志文章,评审
doi：10.1016/j.npep.2013.10.003
更新日期：2013-12-01 00:00:00
abstract：:In vitro structure-activity studies with cholecystokinin (CCK)/gastrin-related peptides, including C- and N-terminal fragments of CCK 26-33, were undertaken in guinea pig gallbladder and ileum. The general order of potency in both smooth muscle preparations is CCK 26-33 greater than CCK 1-33 greater than 27-33 much mu...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/0143-4179(87)90084-9
更新日期：1987-07-01 00:00:00
abstract：:Striatal neuropeptide Y-like immunoreactivity (NPY-LI) levels were investigated in naive rats after acute, subchronic (14 days) or chronic (28 days) intraperitoneal (i.p.) treatment with chlorpromazine (2 or 10mg/kg), haloperidol (0.5 or 2 mg/kg), (+/-)sulpiride (50 or 100 mg/kg) or clozapine (10 or 25 mg/kg), and in ...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/s0143-4179(98)90074-9
更新日期：1998-10-01 00:00:00
abstract：:Recent studies have shown that oxytocin reduces food intake and body weight gain and promotes lipolysis in some species, including humans. Interestingly, these effects of oxytocin are more marked in obese individuals. Although the menopausal loss of ovarian function induces increased visceral adiposity and some metabo...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/j.npep.2019.03.002
更新日期：2019-06-01 00:00:00
abstract：:Peripheral neurons begin to express galanin after axotomy. When neurons in the superior cervical ganglion were axotomized near (about 2 mm) from the ganglion, galanin-like immunoreactivity (IR) was maximal within 72 h. Axotomy of neurons in the middle and inferior cervical ganglion complex (MICG), which could be perfo...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/s0143-4179(98)90045-2
更新日期：1998-06-01 00:00:00
abstract：:We examined gene expression of corticotropin-releasing hormone and neuropeptide Y level in the hypothalamic paraventricular nucleus of mouse bearing a human oral squamous cell carcinoma. A cell line derived from a human oral squamous cell carcinoma was inoculated into the lower dorsal area of nude mice. Body weight, t...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/j.npep.2004.07.004
更新日期：2004-12-01 00:00:00
abstract：:Brain insulin receptors adsorb to and are recoverable from wheat germ agglutinin-agarose (WGA) columns. Similar results are obtained using dissuccinimidyl suberate (DSS)-crosslinked receptors or photo-affinity labeled receptors. WGA can be used for partial purification of brain insulin receptors provided the appropria...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/0143-4179(87)90025-4
更新日期：1987-01-01 00:00:00
abstract：:Neuropeptide Y (NPY) has been implicated in anxiolytic- and antidepressant-like behaviour as well as seizure-suppressant effects in rodents. Although these effects appear to be predominantly mediated via other NPY receptors (Y1 and/or Y2), several studies have also indicated a role for Y5 receptors. Gene therapy using...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/j.npep.2012.01.002
更新日期：2012-04-01 00:00:00
abstract：:[3H]-Dynorphin A (1-8) was degraded in brain homogenates at 25 degrees and even at 0 degree C. The peptidase inhibitors bestatin and captopril almost completely protected[3H]-dynorphin A (1-8) from degradation at 0 degree C but had only little effect on binding at this temperature. At 25 degrees C, the binding of [3H]...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/0143-4179(85)90072-1
更新日期：1985-02-01 00:00:00
abstract：:Bombesin (BN) and its mammalian counterpart gastrin-releasing peptide act as neuroregulatory hormones and tissue-specific growth factors, and have been implicated as peripheral and central satiety-inducing agents. In the present study, the immunohistochemical expression of BN in submandibular, sublingual and parotid g...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/s0143-4179(97)90086-x
更新日期：1997-04-01 00:00:00
