Abstract:
:Galanin and the N-terminal fragment Galanin(1-15) are involved in central cardiovascular regulation. The present paper reviews the recent cardiovascular results obtained by intracisternal injections of Galanin and Galanin(1-15) showing that: (A) the Galanin antagonist M40 blocks the central cardiovascular responses induced by Galanin(1-15) but not those elicited by Galanin; (B) both Galanin and Galanin(1-15) induce the expression of c-Fos in cardiovascular nuclei of the medulla oblongata with different temporal and spatial profiles; (C) the cardiovascular action of Galanin(1-15), but not Galanin, is mediated by peripheral beta-receptor stimulation; (D) and it is demonstrated an antagonistic Galanin/alpha2-adrenoceptors interaction as well as a differential modulation of central cardiovascular responses of Angiotensin II by Galanin or Galanin(1-15). All these data strengthen the involvement of both Galanin molecules as neuromodulators on central cardiovascular regulation.
journal_name
Neuropeptidesjournal_title
Neuropeptidesauthors
Díaz-Cabiale Z,Parrado C,Vela C,Razani H,Coveñas R,Fuxe K,Narváez JAdoi
10.1016/j.npep.2004.12.009keywords:
subject
Has Abstractpub_date
2005-06-01 00:00:00pages
185-90issue
3eissn
0143-4179issn
1532-2785pii
S0143-4179(04)00143-Xjournal_volume
39pub_type
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