Abstract:
:Peripheral neurons begin to express galanin after axotomy. When neurons in the superior cervical ganglion were axotomized near (about 2 mm) from the ganglion, galanin-like immunoreactivity (IR) was maximal within 72 h. Axotomy of neurons in the middle and inferior cervical ganglion complex (MICG), which could be performed 2 cm from the ganglia, led to an additional galanin increase 7 and 14 days later. This second increase was not accompanied by changes in galanin mRNA or the number of galanin-immunostained neurons. Galanin-IR was detectable in a postganglionic trunk of the MICG 2 days after axotomy. At this time, immunoreactive fibers were only seen near the lesion site, while later they were found throughout the trunk. The data suggest that galanin is actively transported toward the site of nerve crush/transection and that the second increase in galanin-IR found in the MICG may be due to a saturation of the axonal transport system.
journal_name
Neuropeptidesjournal_title
Neuropeptidesauthors
Shadiack AM,Zigmond REdoi
10.1016/s0143-4179(98)90045-2keywords:
subject
Has Abstractpub_date
1998-06-01 00:00:00pages
257-64issue
3eissn
0143-4179issn
1532-2785pii
S0143-4179(98)90045-2journal_volume
32pub_type
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