Galanin induced in sympathetic neurons after axotomy is anterogradely transported toward regenerating nerve endings.

Abstract:

:Peripheral neurons begin to express galanin after axotomy. When neurons in the superior cervical ganglion were axotomized near (about 2 mm) from the ganglion, galanin-like immunoreactivity (IR) was maximal within 72 h. Axotomy of neurons in the middle and inferior cervical ganglion complex (MICG), which could be performed 2 cm from the ganglia, led to an additional galanin increase 7 and 14 days later. This second increase was not accompanied by changes in galanin mRNA or the number of galanin-immunostained neurons. Galanin-IR was detectable in a postganglionic trunk of the MICG 2 days after axotomy. At this time, immunoreactive fibers were only seen near the lesion site, while later they were found throughout the trunk. The data suggest that galanin is actively transported toward the site of nerve crush/transection and that the second increase in galanin-IR found in the MICG may be due to a saturation of the axonal transport system.

journal_name

Neuropeptides

journal_title

Neuropeptides

authors

Shadiack AM,Zigmond RE

doi

10.1016/s0143-4179(98)90045-2

keywords:

subject

Has Abstract

pub_date

1998-06-01 00:00:00

pages

257-64

issue

3

eissn

0143-4179

issn

1532-2785

pii

S0143-4179(98)90045-2

journal_volume

32

pub_type

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