Abstract：
:Recent studies have shown that oxytocin reduces food intake and body weight gain and promotes lipolysis in some species, including humans. Interestingly, these effects of oxytocin are more marked in obese individuals. Although the menopausal loss of ovarian function induces increased visceral adiposity and some metabolic disorders, no safe medical interventions for these conditions have been established. In this study, we evaluated the effects of oxytocin on appetite, body weight, and fat mass in ovariectomized rats. Six-day oxytocin treatment attenuated cumulative food intake and body weight gain, and reduced visceral and subcutaneous fat weight and adipocyte cell area in ovariectomized rats. Blood examinations indicated that 6-day oxytocin treatment did not alter renal or hepatic functions. Instead, it might prevent ovariectomy-induced liver damage. In addition, acute oxytocin treatment did not affect body temperature or locomotor activity. These results indicate that oxytocin might be useful for treating or preventing menopause-induced metabolic disorders, without causing any adverse effects.
journal_name
Neuropeptidesjournal_title
Neuropeptidesauthors
Iwasa T,Matsuzaki T,Mayila Y,Yanagihara R,Yamamoto Y,Kawakita T,Kuwahara A,Irahara Mdoi
10.1016/j.npep.2019.03.002subject
Has Abstractpub_date
2019-06-01 00:00:00pages
49-57eissn
0143-4179issn
1532-2785pii
S0143-4179(18)30211-7journal_volume
75pub_type
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