Presence of neurophysin-like material in the pituitary corticotrophs and melanotrophs and cells of the arcuate nucleus of the rat as revealed by immunocytochemistry.

abstract：:The neurokinin-1 (NK-1) receptor interacts with peptides that belong to the tachykinin family. NK-1 is inducible in bone marrow (BM) stroma. In neural cells, its expression is high to constitutive. Screening of three cDNA libraries indicated that this different in NK-1 expression in neural and BM cells could not be ex...

journal_title：Neuropeptides

authors： Bandari PS,Qian J,Yehia G,Seegopaul HP,Harrison JS,Gascon P,Fernandes H,Rameshwar P

更新日期：2002-02-01 00:00:00

abstract：:Tachykinins are a family of pronociceptive neuropeptides with a specific role in pain and inflammation. Several mechanisms regulate endogenous tachykinins and Substance P (SP) levels, including the differential expression of protachykinin mRNA and the controlled secretion of tachykinins from neurons. Proteolysis is su...

journal_title：Neuropeptides

authors： Saidi M,Kamali S,Beaudry F

更新日期：2016-10-01 00:00:00

abstract：:Using field potential recording in the CA1 region of hippocampal slices from rats injected with cysteamine (200 mg/kg, s.c.), changes in activity and plasticity of Schaffer collateral-CA1 pyramidal cell synapses were examined. Extracellular field potential recording prior to and following either theta-pattern primed b...

journal_title：Neuropeptides

authors： Rostampour M,Fathollahi Y,Semnanian S,Hajizadeh S,Mirnajafizadeh J,Shafizadeh M

更新日期：2002-08-01 00:00:00

abstract：:The aim of the present investigation was to determine if chronic activation of kappa-opioid receptor induces development of tolerance and dependence to kappa-opioid agonists on the isolated right atrium of the rat. Tolerance to the kappa-agonist was induced by chronic administration of U-50,488H, a selective kappa-ago...

journal_title：Neuropeptides

authors： Milanés MV,Rabadan JV,Laorden ML

更新日期：1997-10-01 00:00:00

abstract：:Neuropeptide Y (NPY) has been implicated in the modulation of important features of neuronal physiology, including calcium homeostasis, neurotransmitter release and excitability. Moreover, NPY has been involved as an important modulator of hippocampal and thalamic circuits, receiving particular attention as an endogen...

journal_title：Neuropeptides

authors： Malva JO,Xapelli S,Baptista S,Valero J,Agasse F,Ferreira R,Silva AP

更新日期：2012-12-01 00:00:00

abstract：:Male Wistar rats were injected intraperitoneally with chlorpromazine (2 or 10 mg/kg), haloperidol (0.5 or 2 mg/kg), sulpiride (50 or 100 mg/kg) or clozapine (10 or 25 mg/kg) once, for 14 or 28 consecutive days. Hypothalamic neuropeptide Y-like (NPY-like) immunoreactivity (NPY-LI) was determined 24 h after the last dos...

journal_title：Neuropeptides

authors： Obuchowicz E

更新日期：1996-10-01 00:00:00

abstract：:The opioid receptor antagonists, naloxone and beta-chlornaltrexamine, were used to determine whether activation of endogenous opioid peptide containing pathways produced pharmacologically reversible opioid actions. Extracellularly recorded responses of the hippocampal CA3 pyramidal cells were evoked by stimulation of ...

journal_title：Neuropeptides

authors： Chavkin C,Bloom FE

更新日期：1986-01-01 00:00:00

abstract：:Immune system function has been shown to be under the influence of various neuromodulators and endocrine system peptides. This in vitro study describes the stimulatory effect of thyrotropin releasing hormone (thyroliberin, TRH) on thyrotropin (TSH) release from cultured human peripheral blood monocytes. The stimulator...

journal_title：Neuropeptides

authors： Komorowski J,Stepień H,Pawlikowski M

更新日期：1993-07-01 00:00:00

abstract：:In order to further test whether or not psychostimulant drugs activate CART peptide-containing cells in the nucleus accumbens, we examined the fraction of CART positive cells that co-immunostained for c-Fos after administration of saline or cocaine (10 and 25 mg/kg i.p.). There was about a 45% increase in the fraction...

journal_title：Neuropeptides

authors： Hubert GW,Kuhar MJ

更新日期：2008-06-01 00:00:00

abstract：:Intravenous injections of neurotensin (NT) (0.5, 1 and 2 nmoles kg-1) evoked dose-dependent increases in histaminemia and hematocrit, and marked hypotensive effect, in anesthetized rats. The increase of plasma histamine was rapid in onset (within sec), peak plasma histamine being reached in less than 2 min. The declin...

journal_title：Neuropeptides

authors： Kérouac R,St-Pierre S,Rioux F

更新日期：1982-12-01 00:00:00

abstract：OBJECTIVE:To explore the orexinergic pathway from the lateral hypothalamus (LHA) to the nucleus accumbens (NAc) and its regulation on the palatable food intake. METHODS:Fluorescent gold retrograde tracing combined with fluoro-immunohistochemical staining were used to observe the projection of orexinergic neurons from ...

journal_title：Neuropeptides

authors： Liu X,Gao S,Zhang N,Jin T,Sun X,Luan X,Xu L,Guo F

更新日期：2020-04-01 00:00:00

abstract：:Pyroglutamyl peptidase I activity from soluble and membrane-bound fractions of rat brain homogenates is inhibited by the presence of sodium deoxycholate but not by triton X-100. Biobeads SM2, a polystyrene adsorbent reported to be useful in removing detergents from aqueous solutions, inhibits enzymatic activity in bot...

journal_title：Neuropeptides

authors： Alba F,Arenas JC,Lopez MA

更新日期：1995-08-01 00:00:00

abstract：:Enkephalin-immunoreactive neurons have been identified in the central nervous system of the fruit fly Drosophila melanogaster by immunocytochemical techniques. Analyses of fly extracts by high performance liquid chromatography and radioimmunoassay show a relatively complex pattern of immunoreactive compounds. The most...

journal_title：Neuropeptides

authors： Pagés M,Jiménez F,Ferrús A,Peralta E,Ramírez G,Gelpí E

更新日期：1983-12-01 00:00:00

abstract：:The orexins (hypocretins) are lateral hypothalamic (LH) neuropeptides that have been implicated in a variety of behaviors ranging from feeding to sleep and arousal. Evidence from animal models suggests a role for orexins in reward processing and drug addiction. In the present study, we investigated the direct effect o...

journal_title：Neuropeptides

authors： Zarepour L,Fatahi Z,Sarihi A,Haghparast A

更新日期：2014-06-01 00:00:00

abstract：:Rat/mouse hemokinin-1 (r/m HK-1) has been identified as a member of the tachykinin family and its effect in colonic contractile activity remains unknown. We investigated the effects and mechanisms of actions of r/m HK-1 on the mouse colonic contractile activity in vitro by comparing it with that of substance P (SP). R...

journal_title：Neuropeptides

authors： Kong ZQ,Han M,Yang WL,Zhao YL,Fu CY,Tao Y,Chen Q,Wang R

更新日期：2009-06-01 00:00:00

abstract：:In equilibrium binding studies, using 3H-etorphine and 3H-diprenorphine, digitonin extracts of frog brain membranes are found to contain two classes of sites, one of which is seen only in the presence of Na+ ions. Centrifugation of the extracts in sucrose gradients separates two macromolecular components (10S and 12S)...

journal_title：Neuropeptides

authors： Puget A,Frances B,Jauzac P,Meunier JC

更新日期：1984-12-01 00:00:00

abstract：:Ghrelin (gh) is a peptide hormone that may affect learning and memory. There is some evidence that ghrelin can have antiepileptic effects. So we decided to investigate the possible effects of ghrelin on spatial memory following PTZ-induced seizures in male rats. Ninety male rats were divided into 9 groups including co...

journal_title：Neuropeptides

authors： Babri S,Amani M,Mohaddes G,Mirzaei F,Mahmoudi F

更新日期：2013-10-01 00:00:00

abstract：:Perivascular sensory nerves release calcitonin gene-related peptide (CGRP) and substance P, the dilator actions of which can be regulated by nitric oxide (NO). This study investigated the role of NO in the vasodilation caused by sensory nerve stimulation, by capsaicin, or exogenous CGRP and substance P in the isolated...

journal_title：Neuropeptides

authors： Mitchell JA,Williams FM,Williams TJ,Larkin SW

更新日期：1997-08-01 00:00:00

abstract：:We have used immunohistochemistry and in situ hybridization histochemistry to visualize CGRP and the mRNA encoding the CGRP precursor in the stomach. CGRP is present in nerve fibers in the mucosa. CGRP mRNA and CGRP itself are also found in non-neural cells in the lamina propria. These cells are likely to be macrophag...

journal_title：Neuropeptides

authors： Jakab G,Webster HD,Salamon I,Mezey E

更新日期：1993-02-01 00:00:00

abstract：:Cholecystokinin (CCK) is co-localized with dopamine (DA) in mesolimbic neurons of the CNS and appears to selectively regulate the output of this system. In an attempt to characterize the nature of CCK interactions with mesolimbic DA-containing nerve terminals, we have investigated CCK regulation of [3H]DA overflow fro...

journal_title：Neuropeptides

authors： Vickroy TW,Bianchi BR

更新日期：1989-01-01 00:00:00

abstract：:The effects of the GABAergic drugs nipecotic acid, Gabrene, baclofen and metatolylcarbamide (MTC), when given alone or in combination at subthreshold doses with AT II also at a subthreshold dose effective on PTZ-kindling in mice were studied. PTZ-kindling was provoked by intraperitoneal (i.p.) injections of PTZ (40 mg...

journal_title：Neuropeptides

authors： Georgiev VP,Lazarova MB,Kambourova TS

更新日期：1995-01-01 00:00:00

abstract：:Oxytocin, intraperitoneally injected to 26-month-old male rats 60 min before testing, significantly improved social memory (at doses of 3 and 6 ng/kg) and reduced the duration of immobility in the behavioral despair test (at doses of 50 and 500 micrograms/kg). These results are in agreement with previous data obtained...

journal_title：Neuropeptides

authors： Arletti R,Benelli A,Poggioli R,Luppi P,Menozzi B,Bertolini A

更新日期：1995-09-01 00:00:00

abstract：:Oxytocin, either intraperitoneally injected (200 ng/rat) or intracerebroventricularly infused (1 ng/rat in 4 microliters saline) 60 and 15 min respectively before testing, significantly increased the lordosis response to the mounting male of ovariectomized, estrogen/progesterone treated rats. The intracerebroventricul...

journal_title：Neuropeptides

authors： Arletti R,Bertolini A

更新日期：1985-06-01 00:00:00

abstract：:To find out, whether microheterogeneity of neurophysins is due to aging of neurosecretory granules we investigated neurophysin proteins of porcine origin from newly formed and aged granules, as well as from two different extraction methods from whole posterior pituitary glands by high performance liquid chromatography...

journal_title：Neuropeptides

authors： Richter WO,Schwandt P

更新日期：1983-12-01 00:00:00

abstract：:Galanin (GAL) is known to stimulate feeding behavior. This peptide has different properties and functions from other feeding stimulants, e.g., neuropeptide Y and agouti-related protein. Hypothalamic GAL is relatively unresponsive to food deprivation and to changes in corticosterone, glucose utilization, dietary carboh...

journal_title：Neuropeptides

authors： Leibowitz SF

更新日期：2005-06-01 00:00:00

abstract：:In previous studies, membranes from chicken gastrointestinal tissues failed to bind appreciable levels of 125I-APP labeled at the C-terminus. In order to address the suggestion that this was due to steric hindrance of the critical C-terminus, N-terminally labeled 125I-APP was utilized in in vitro membrane binding assa...

journal_title：Neuropeptides

authors： Adamo ML,Hazelwood RL

更新日期：1992-04-01 00:00:00

abstract：:In this study, we examined whether the mechanisms mediating the induction of grooming behavior by oxytocin (OT) is similar to mechanisms mediating the effects of OT on uterine contractility. Sprague-Dawley strain female rats were injected intracerebroventricularly (ICV) with OT or OT analogues and then were observed f...

journal_title：Neuropeptides

authors： Caldwell JD,Hruby VJ,Hill P,Prange AJ Jr,Pedersen CA

更新日期：1986-07-01 00:00:00

abstract：:Levels of beta-endorphin immunoreactive material (IRM) in cerebrospinal fluid (CSF) have been reported to correlate inversely with postoperative morphine requirement. Considering proopiomelanocortin (POMC) derivatives as predictors for sensitivity to postoperative pain, we determined authentic beta-endorphin (beta-end...

journal_title：Neuropeptides

authors： Matejec R,Schulz A,Mühling J,Uhlich H,Bödeker RH,Hempelmann G,Teschemacher H

更新日期：2006-02-01 00:00:00

abstract：:Using the latency for tail-flick after thermal stimulation we have assessed the effects of alpha-, gamma(1)- and gamma(2)-MSH on nociceptive threshold in the mice. Intracisternal injections of gamma(2)-MSH induced a distinct analgesia, while gamma(1)-MSH in the same doses gave only a minor analgesia. Intracisternal al...

journal_title：Neuropeptides

authors： Klusa V,Germane S,Svirskis S,Opmane B,Wikberg JE

更新日期：2001-02-01 00:00:00

abstract：:Acid extracts of cat adrenal medullae were found to contain neurotensin-like (0.71 +/- 0.21nmol/gm), met-enkephalin-like (11.71 +/- 2.87nmol/gm), leu-enkephalin-like (1.95 +/- 0.11nmol/gm) and somatostatin-like (1.57 +/- 0.63pmol/gm) immunoreactivities. Using isolated retrogradely perfused cat adrenal glands the secre...

journal_title：Neuropeptides

authors： Corder R,Mason DF,Perrett D,Lowry PJ,Clement-Jones V,Linton EA,Besser GM,Rees LH

更新日期：1982-10-01 00:00:00