Abstract：
:Using canine spleen and lung membranes as model systems, we have shown the presence of subtypes of ETB receptors. This classification was done based on the binding profiles of various analogs of ET-1 that have been identified as ETB-selective. Saturation binding experiments performed with [125I] ET-3 and [125I] IRL-1260 (ETB-selective ligands) indicated that [125I] IRL-1620 labeled 80-90% of [125I] ET-3 binding sites in canine lung, whereas in canine spleen, the binding of [125I] IRL-1620 was 10-20% of [125I] ET-3 binding. In addition, competition binding experiments using ETB-selective agonists [Ala1,3,11,15]-ET-1 (also known as 4-Ala ET-1), N-acetyl-[Ala11,15] ET-1 (6-21) also known as BQ3020 and Suc-[Glu9, Ala11,15] ET-1 (8-21) also known as IRL-1620 indicated that all three ligands displaced [125I] ET-3 from canine lung membranes with approximately 500-1000 fold greater affinity than canine spleen membranes. On the other hand, ET-1, ET-3, S6a, S6b, and S6d displayed very similar IC50 values in both preparations, except S6c which was approximately 20 fold less potent in canine spleen compared to lung. These data indicate that ETB receptors present in canine spleen are different from those present in lung and that ETB-selective linear as well as truncated analogs of ET-1 are good tools to identify these subtypes of ETB receptors.
journal_name
Neuropeptidesjournal_title
Neuropeptidesauthors
Nambi P,Pullen M,Brooks DP,Gellai Mdoi
10.1016/0143-4179(95)90004-7subject
Has Abstractpub_date
1995-12-01 00:00:00pages
331-6issue
6eissn
0143-4179issn
1532-2785pii
0143-4179(95)90004-7journal_volume
29pub_type
杂志文章相关文献
NEUROPEPTIDES文献大全abstract：:The 36-amino-acid peptide, neuropeptide Y (NPY), is the most abundant peptide in the rat brain. When administered into the brain, NPY produces a variety of physiological actions including a pronounced stimulation of feeding in satiated rats. Elevations in hypothalamic NPY have been reported after food deprivation and ...
journal_title：Neuropeptides
pub_type： 杂志文章,评审
doi：10.1054/npep.1999.0057
更新日期：1999-10-01 00:00:00
abstract：:Quantitative evaluation of octadecaneuropeptide-like immunoreactivity (ODN-Li) was carried out in hippocampus, cortex and cerebellum of group-reared or three month isolated male Wistar rats, whether muricidal or not. ODN-Li was lower in cortex and cerebellum of isolated animals, (mainly in muricidal) than of group-rea...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/0143-4179(91)90116-z
更新日期：1991-07-01 00:00:00
abstract：:The central control of feeding in animals depends upon the alternating actions of orexigenic and anorectic peptides. Studies at understanding the food intake mechanisms have emphasised the role of Neuropeptide Y as a potent orexigenic peptide in the brain. The aim of this study is to investigate the response of NPY sy...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/j.npep.2018.06.001
更新日期：2018-10-01 00:00:00
abstract：:Arginine vasopressin mediates its effects through vasopressin receptor activation and second messenger production. Recent cloning of the V1a receptor provided the opportunity to investigate the possible signal transduction pathways associated with this single vasopressin receptor subtype. When stably expressed in CHO ...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/0143-4179(94)90017-5
更新日期：1994-07-01 00:00:00
abstract：:The present study was planned to evaluate role of tachykinins (TKs) and neurokinin (NK) receptors in the regulation of gastric motility in sheep. We examined the effects of intravenous (i.v.) injection of neurokinin A (NKA) and substance P (SP) on motility of the rumen, omasum, and abomasum in conscious sheep and the ...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/j.npep.2012.07.005
更新日期：2013-02-01 00:00:00
abstract：:The effects of a potent serine protease inhibitor, Boc-D-Phe-Pro-Arg-H, on the secretion and content of ACTH and beta-endorphin-like immunoreactivities of cultured rat anterior pituitary cells were studied. Basal release of the hormones was not affected by the drug but secretion in response to stalk-median eminence ex...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/0143-4179(82)90066-x
更新日期：1982-10-01 00:00:00
abstract：:Hippocampal neurogenesis is important for modulating the behavioural responses to stress and for certain forms of learning and memory. The mechanisms underlying the necessary coupling of neuronal activity to neural stem/progenitor cell (NSPC) function remain poorly understood. Within the dentate subgranular stem cell ...
journal_title：Neuropeptides
pub_type： 杂志文章,评审
doi：10.1016/j.npep.2013.10.002
更新日期：2013-12-01 00:00:00
abstract：:Various studies have shown a relationship between nerves and bones. Recent evidence suggests that both sensory and sympathetic nerves affect bone metabolism; however, little is known about how neuropeptides are involved in the differentiation of pluripotent stem cells into osteoblastic (OB) cells. To evaluate the puta...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/j.npep.2014.10.004
更新日期：2014-12-01 00:00:00
abstract：:In vitro structure-activity studies with cholecystokinin (CCK)/gastrin-related peptides, including C- and N-terminal fragments of CCK 26-33, were undertaken in guinea pig gallbladder and ileum. The general order of potency in both smooth muscle preparations is CCK 26-33 greater than CCK 1-33 greater than 27-33 much mu...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/0143-4179(87)90084-9
更新日期：1987-07-01 00:00:00
abstract：:The effects of thyroliberin (TRH), a TRH-like tripeptide colon mitosis inhibitor (CMI), a somatostatin analog SMS 201-995 and metoclopramide (dopamine receptor antagonist enhancing prolactin secretion) on rat thymus cell proliferation were investigated. The incorporation of bromodeoxyuridine (BrDU) into thymic cell nu...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/0143-4179(92)90123-e
更新日期：1992-11-01 00:00:00
abstract：:Galanin, a 29 residue peptide found in the hypothalamus, causes orexigenic effects in a variety of species. In the present study, we investigated appetite-associated effects of galanin in chicks from lines which have been selected from a common founder population for either low or high body weight. The low line consis...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/j.npep.2012.11.003
更新日期：2013-08-01 00:00:00
abstract：:Endothelins (ET) are a family of highly active neuropeptides with manifold influences via ET receptors (ETR) in both the peripheral and central nervous systems. We have shown previously that satellite glial cells (SGCs) in mouse trigeminal ganglia (TG) are extremely sensitive to ET-1 in evoking [Ca2+]in increase, appa...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/j.npep.2017.03.002
更新日期：2017-06-01 00:00:00
abstract：:Intravenous injections of neurotensin (NT) (0.5, 1 and 2 nmoles kg-1) evoked dose-dependent increases in histaminemia and hematocrit, and marked hypotensive effect, in anesthetized rats. The increase of plasma histamine was rapid in onset (within sec), peak plasma histamine being reached in less than 2 min. The declin...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/0143-4179(82)90010-5
更新日期：1982-12-01 00:00:00
abstract：:Utilizing a double-blind crossover design, the hormonal effects of high dose, 2 mg/kg, were compared to low dose, 0.4 mg (approx. 5 micrograms/kg), naloxone administration in physically healthy humans. A significant naloxone dose effect on plasma cortisol levels was found (p less than 0.001), but no significant effect...
journal_title：Neuropeptides
pub_type： 临床试验,杂志文章
doi：10.1016/0143-4179(85)90010-1
更新日期：1985-07-01 00:00:00
abstract：:Nociceptin/Orphanin FQ (N/OFQ) is a 17-amino acid peptide that binds to the nociceptin receptor (NOP). N/OFQ and NOP receptors are expressed in numerous brain areas. The generation of specific agonists, antagonists and receptor-deficient mice or rats has enabled progress in elucidating the biological functions of N/OF...
journal_title：Neuropeptides
pub_type： 杂志文章,评审
doi：10.1016/j.npep.2015.03.005
更新日期：2015-04-01 00:00:00
abstract：:We have described the binding of [125I]endothelin-1 (ET-1) to cultured rat cerebellar granule cells. Binding of [125I]ET-1 was specific, saturable, and time-dependent. Scatchard analysis of saturation binding data indicated a single class of high affinity binding site with a KD of 95 pM, and a Bmax of 8110 receptors/c...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/0143-4179(91)90005-4
更新日期：1991-02-01 00:00:00
abstract：:Enkephalin-immunoreactive neurons have been identified in the central nervous system of the fruit fly Drosophila melanogaster by immunocytochemical techniques. Analyses of fly extracts by high performance liquid chromatography and radioimmunoassay show a relatively complex pattern of immunoreactive compounds. The most...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/0143-4179(83)90012-4
更新日期：1983-12-01 00:00:00
abstract：:The antinociceptive effect of intrathecally (i.t.) administered protease inhibitors was tested against capsaicin (800 ng) injected into the dorsal surface of a hindpaw. Both p-hydroxymercuribenzoate (2-8 nmol), a cysteine protease inhibitor, and phosphoramidon (1-4 nmol), an endopeptidase 24.11 inhibitor in the presen...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/s0143-4179(98)90064-6
更新日期：1998-10-01 00:00:00
abstract：:The neuropharmacological actions of the agonist analog D-Trp-6-LH-RH were investigated in several tests after subcutaneous administrations to male mice. The doses applied were in the range 1-1000 micrograms/kg. D-Trp-6-LH-RH doses of 10 micrograms/kg and higher induced significant analgesic effects in the hot-plate an...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/0143-4179(90)90053-2
更新日期：1990-10-01 00:00:00
abstract：:The effects of several mu and kappa opioid receptor agonists on urinary excretion were examined in the water-loaded rat. Mu agonists induced anti-diuresis whereas kappa agonists caused diuresis. Furthermore, high efficacy kappa agonists eg. U50, 488H and tifluadom, produced marked diuretic effects, whereas kappa parti...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/0143-4179(85)90047-2
更新日期：1985-02-01 00:00:00
abstract：:Possible positive reinforcing and aversive effects of intraperitoneally (ip) administered substance P (SP) and its C-terminal heptapeptide analog [pGlu5, MePhe8, Sar9]-SP5-11 (DIME-C7) were investigated in rats. The 'conditioned corral preference and avoidance procedure' was used for assessing positive and negative re...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/0143-4179(90)90037-y
更新日期：1990-12-01 00:00:00
abstract：:In this study the influence of acute exposure of gastric mucosa to the sensory neurotoxin capsaicin on basal gastric acid secretion and on secretion induced by 2-deoxy-D-glucose or histamine in conscious dogs with gastric fistulae has been investigated. Under basal conditions intragastric capsaicin (160 microM, 50 ml ...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/0143-4179(92)90128-j
更新日期：1992-12-01 00:00:00
abstract：:Orexins/hypocretins are neuropeptides that have various physiological effects, including the regulation of feeding behavior, neuroendocrine functions and sleep-wake cycles. Recent studies have suggested that the orexin system may also be involved in brain ischemic reactions. It is also known that changes in sleep patt...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/j.npep.2006.06.003
更新日期：2006-08-01 00:00:00
abstract：:Cocaine- and amphetamine-regulated transcript (CART) peptides have a wide CNS distribution and appear to play an important role in a number of physiological processes including reward and reinforcement, feeding, locomotion, stress responses and perception of pain. We have further investigated the expression of CART pe...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/j.npep.2007.11.001
更新日期：2008-02-01 00:00:00
abstract：:We have previously shown that the kappa-opioid agonist, asimadoline, produces time-dependent changes in neuropeptide concentrations in the joints of rats with chronic arthritis. We hypothesized that asimadoline acts on peripheral terminals to modulate substance P (SP) release. To address this hypothesis, here we have ...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1054/npep.2000.0813
更新日期：2000-06-01 00:00:00
abstract：:We have evaluated the peripheral blood natural killer (NK) cell activity and the in vitro effect of recombinant gamma-interferon (r gamma-IFN) on NK cell activity in 23 patients with a neuroendocrine tumour of the pancreas, small intestine or liver, and 23 healthy controls. Patients with a gastrinoma showed a NK cell ...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/0143-4179(91)90033-f
更新日期：1991-09-01 00:00:00
abstract：:The tetra-peptide FMRF-NH(2) is a cardioexcitatory peptide in the clam. Using the antibody against this peptide, FMRF-NH(2)-like immunoreactive material was detected in mammalian CNS. Subsequently, mammalian FMRF-NH(2) immunoreactive peptides were isolated from bovine brain and characterized to be FLFQPQRF-NH(2) (NPFF...
journal_title：Neuropeptides
pub_type： 杂志文章,评审
doi：10.1016/j.npep.2007.06.004
更新日期：2008-02-01 00:00:00
abstract：:The desire of the pharmaceutical industry to obtain more selective agents for the treatment of anxiety with fewer or diminished side effects and a profile consistent with safety during long-term use resulted in a search which has identified the azapirones as a new class of anxiolytics which lack structural or biochemi...
journal_title：Neuropeptides
pub_type： 临床试验,杂志文章,评审
doi：10.1016/0143-4179(91)90078-w
更新日期：1991-07-01 00:00:00
abstract：:Social conflict and defeat in mice leads to an activation of endogenous opiate systems. The effects of intracerebroventricular administration of the peptide FMRFamide (Phe-Met-Arg-Phe-NH2) and the opiate antagonist naloxone, on aggressive encounters, defeat-induced analgesia and defeat-induced feeding were examined in...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/0143-4179(85)90110-6
更新日期：1985-12-01 00:00:00
abstract：:The orally active, α-hemoglobin derived hemopressin (PVNFKFLSH, Hp(1-9)) and its truncated (PVNFKFL, Hp(1-7) and PVNFKF, Hp(1-6)) and extended ((R)VDPVNFKFLSH, VD-Hp(1-9) and RVD-Hp(1-9)) derivatives have been postulated to be the endogenous peptide ligands of the cannabinoid receptor type 1 (CB1). In an attempt to cr...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/j.npep.2016.02.001
更新日期：2016-08-01 00:00:00
