Distribution of NPY receptors in the hypothalamus.

Abstract:

:Neuropeptide Y (NPY) neurons abundantly innervate the hypothalamus, where NPY is involved in the regulation and integration of a broad range of homeostatic functions. In order to understand NPY-mediated behavioral, autonomic and neuroendocrine effects, it is important to characterize in detail the distribution of the hypothalamic NPY receptors. In this review, we briefly summarize the origin of NPY and its two related peptides, peptide YY and pancreatic polypeptide in the hypothalamus. Moreover, based on the results obtained with histological techniques such as in situ hybridization, immunohistochemistry and ligand binding, we summarize data on the hypothalamic distribution of the known NPY receptors, the Y1 Y2, Y4 and Y5 receptors as best characterized to date. These NPY receptors are found with individual distribution patterns in many hypothalamic neurons including neuroendocrine motoneurons, magnocellular neurosecretory neurons and numerous neurons connecting the hypothalamus with the limbic and the autonomic nervous systems. The histochemical analyses allow characterization of coexisting molecules and in this way definition of the neurochemistry of NPY circuitries. By showing coexistence of various NPY receptors they provide a morphological basis for in vitro studies showing heterodimerization of NPY receptors. The NPY neurons and their circuitries underlie the integrative role of NPY as a pleiotropic neuropeptide in the regulation of homeostasis.

journal_name

Neuropeptides

journal_title

Neuropeptides

authors

Fetissov SO,Kopp J,Hökfelt T

doi

10.1016/j.npep.2004.05.009

keywords:

subject

Has Abstract

pub_date

2004-08-01 00:00:00

pages

175-88

issue

4

eissn

0143-4179

issn

1532-2785

pii

S0143417904000514

journal_volume

38

pub_type

杂志文章,评审
  • Modulation of CCK mRNA in cell lines in response to isoproterenol and retinoic acid.

    abstract::Regulation of cholecystokinin (CCK) expression was studied in the human neuroepithelioma cell line SK-N-MCIXC and the rat medullary thyroid carcinoma cell line WE 4/2. The cells were treated with the beta-adrenergic agonist isoproterenol and retinoic acid, a natural derivative of vitamin A, which plays a role in cell ...

    journal_title:Neuropeptides

    pub_type: 杂志文章

    doi:10.1016/0143-4179(95)90064-0

    authors: Mania-Farnell BL,Botros IW,Davis TP

    更新日期:1995-10-01 00:00:00

  • Pharmacological and mechanistic studies of cholecystokinin-facilitated [3H]dopamine efflux from rat nucleus accumbens.

    abstract::Cholecystokinin (CCK) is co-localized with dopamine (DA) in mesolimbic neurons of the CNS and appears to selectively regulate the output of this system. In an attempt to characterize the nature of CCK interactions with mesolimbic DA-containing nerve terminals, we have investigated CCK regulation of [3H]DA overflow fro...

    journal_title:Neuropeptides

    pub_type: 杂志文章

    doi:10.1016/0143-4179(89)90020-6

    authors: Vickroy TW,Bianchi BR

    更新日期:1989-01-01 00:00:00

  • Modulating Aβ Fibrillogenesis with 'Trojan' peptides.

    abstract::Abnormal aggregation of beta-amyloid (Aβ) peptide into amyloid plaques in the brain has been identified as one of the key factors in instigating AD pathogenesis. Inhibition of Aβ aggregation can be an important therapeutic strategy in disease management. In this work, we demonstrate the application of structure-based ...

    journal_title:Neuropeptides

    pub_type: 杂志文章

    doi:10.1016/j.npep.2020.102030

    authors: Pandey G,Morla S,Kumar S,Ramakrishnan V

    更新日期:2020-06-01 00:00:00

  • Puerarin alleviate radicular pain from lumbar disc herniation by inhibiting ERK-dependent spinal microglia activation.

    abstract::Lumbar disc herniation is a common cause of radicular pain, but the mechanism remains ambiguous and the treatment stays unsatisfied. Many studies revealed a traditional Chinese medicine puerarin may moderate chronic pain from diabetes and nerve injury. Thus far, the role and mechanism of puerarin in radicular pain is ...

    journal_title:Neuropeptides

    pub_type: 杂志文章

    doi:10.1016/j.npep.2018.10.001

    authors: Zhong Y,Huang YL,Hu YM,Zhu LR,Zhao YS

    更新日期:2018-12-01 00:00:00

  • Pharmacological characterization of desensitization in scratching behavior induced by intrathecal administration of hemokinin-1 in the rat.

    abstract::Desensitization is induced by the repeated administration of high doses of substance P (SP) or hemokinin-1 (HK-1). However, little information is available about the mechanisms involved in the induction of desensitization by these peptides. Thus, to characterize this desensitization, we examined the dose-dependent eff...

    journal_title:Neuropeptides

    pub_type: 杂志文章

    doi:10.1016/j.npep.2007.10.004

    authors: Naono R,Nakayama T,Ikeda T,Matsusima O,Nishimori T

    更新日期:2008-02-01 00:00:00

  • Short N-terminal galanin fragments are occurring naturally in vivo.

    abstract::The galanin family currently consists of four peptides, namely galanin, galanin-message associated peptide, galanin-like peptide and alarin. Unlike galanin that signals through three different G protein-coupled receptors; GAL1, GAL2, and GAL3, binding at its N-terminal end, the cognate receptors for other members of t...

    journal_title:Neuropeptides

    pub_type: 杂志文章

    doi:10.1016/j.npep.2017.03.005

    authors: Ihnatko R,Theodorsson E

    更新日期:2017-06-01 00:00:00

  • Effects of centrally-injected glucagon-like peptide-1 on pilocarpine-induced seizures, anxiety and locomotor and exploratory activity in rat.

    abstract::Glucagon-like peptide-1 (7-36)-amide (GLP-1) is a gut peptide, which exerts significant effects on glucose homeostasis. GLP-1 and GLP-1 receptors are also widely distributed in the central nervous system. In the present study, we aimed to investigate the effects of intracerebroventricularly (i.c.v.)-injected GLP-1 on ...

    journal_title:Neuropeptides

    pub_type: 杂志文章

    doi:10.1016/j.npep.2010.02.002

    authors: Gulec G,Isbil-Buyukcoskun N,Kahveci N

    更新日期:2010-08-01 00:00:00

  • FMRFamide, a putative endogenous opiate antagonist: evidence from suppression of defeat-induced analgesia and feeding in mice.

    abstract::Social conflict and defeat in mice leads to an activation of endogenous opiate systems. The effects of intracerebroventricular administration of the peptide FMRFamide (Phe-Met-Arg-Phe-NH2) and the opiate antagonist naloxone, on aggressive encounters, defeat-induced analgesia and defeat-induced feeding were examined in...

    journal_title:Neuropeptides

    pub_type: 杂志文章

    doi:10.1016/0143-4179(85)90110-6

    authors: Kavaliers M,Hirst M

    更新日期:1985-12-01 00:00:00

  • HPLC separation of vasopressin-like hormones in chicken neurohypophysial extracts.

    abstract::HPLC techniques were used to identify peptides that possess vasopressin-like immunoreactivity in the chicken neurohypophysis. The presence of arginine vasotocin (AVT) was confirmed together with arginine vasopressin (AVP). That the presence of AVP may be confined to the chicken, and not other avian species, was conclu...

    journal_title:Neuropeptides

    pub_type: 杂志文章

    doi:10.1016/0143-4179(86)90045-4

    authors: Choy VJ,Watkins WB

    更新日期:1986-08-01 00:00:00

  • Identification of the spinal degradation products and inhibition of adenylate cyclase by recombinant rat galanin message-associated peptide.

    abstract::In rat preprogalanin, galanin is C-terminally flanked by a 60 amino acid long peptide: galanin message-associated peptide (GMAP). GMAP sequences in different species show high degree of homology, suggesting a biological role. However, the study of the physiological and pharmacological actions of this peptide have been...

    journal_title:Neuropeptides

    pub_type: 杂志文章

    doi:10.1016/s0143-4179(98)90037-3

    authors: Andell-Jonsson S,Bartfai T

    更新日期:1998-04-01 00:00:00

  • Humanin ameliorates diazepam-induced memory deficit in mice.

    abstract::Humanin (HN) is an endogenous 24-residue peptide. A highly potent HN derivative, S14G-HN, which has a substitution of serine 14 to glycine, reduced amyloid burden and suppressed cognitive impairment in a mouse model of Alzheimer's disease. S14G-HN also suppressed amnesia induced by a muscarinic receptor antagonist in ...

    journal_title:Neuropeptides

    pub_type: 杂志文章

    doi:10.1016/j.npep.2016.10.008

    authors: Murakami M,Nagahama M,Maruyama T,Niikura T

    更新日期:2017-04-01 00:00:00

  • Association study of two functional single nucleotide polymorphisms of neuropeptide y gene with multiple sclerosis.

    abstract::Multiple sclerosis (MS) is an autoimmune disease of the central nervous system characterized by brain inflammation, demyelination and axonal loss. Neuropeptide Y (NPY) has a critical role in the maintenance of homeostasis in the immune system and coping of stress condition. In the current study we analyzed 188 patient...

    journal_title:Neuropeptides

    pub_type: 杂志文章

    doi:10.1016/j.npep.2016.08.004

    authors: Mohammadi SM,Shirvani Farsani Z,Dosti R,Sahraian MA,Behmanesh M

    更新日期:2016-12-01 00:00:00

  • C-terminal modifications of neuropeptide Y and its analogs leading to selectivity for the mouse brain receptor over the porcine spleen receptor.

    abstract::Neuropeptide Y (NPY) is known to bind to at least two types of receptors (Y1 & Y2). One type (Y2) is able to bind and undergo activation by both NPY and its C-terminal fragments with good potency while the other (Y1) requires the full length of NPY for good potency. For most NPY analogs that have been examined, potenc...

    journal_title:Neuropeptides

    pub_type: 杂志文章

    doi:10.1016/0143-4179(90)90073-8

    authors: Krstenansky JL,Owen TJ,Payne MH,Shatzer SA,Buck SH

    更新日期:1990-11-01 00:00:00

  • Cholecystokinin modulation of spontaneous and excitatory amino acid-induced activity in the opossum cerebellum.

    abstract::Cholecystokinin-B (CCK-8) is an octapeptide that was initially described in the gastrointestinal tract. Recent studies have shown that this peptide also has an extensive distribution in the central nervous system, including the cerebellum of the opossum. In addition to the protein, binding sites for CCK-8 also have be...

    journal_title:Neuropeptides

    pub_type: 杂志文章

    doi:10.1016/s0143-4179(96)90035-9

    authors: Bishop GA

    更新日期:1996-12-01 00:00:00

  • The analgesic effect of orexin-A in a murine model of chemotherapy-induced neuropathic pain.

    abstract::Orexins are neuropeptides that are localized to neurons in the lateral and dorsal hypothalamus but its receptors are distributed to many different regions of the central nervous system. Orexins are implicated in a variety of physiological functions including sleep regulation, energy homeostats, and stress reactions. F...

    journal_title:Neuropeptides

    pub_type: 杂志文章

    doi:10.1016/j.npep.2016.12.007

    authors: Toyama S,Shimoyama N,Shimoyama M

    更新日期:2017-02-01 00:00:00

  • Endotoxemia-induced muscle wasting is associated with the change of hypothalamic neuropeptides in rats.

    abstract::In critical patients, sepsis-induced muscle wasting is considered to be an important contributor to complications and mortality. Previous work mainly focuses on the peripheral molecular mechanism of muscle degradation, however little evidence exists for the role of central nervous system in the process. In the present...

    journal_title:Neuropeptides

    pub_type: 杂志文章

    doi:10.1016/j.npep.2014.10.002

    authors: Duan K,Yu W,Lin Z,Tan S,Bai X,Gao T,Xi F,Li N

    更新日期:2014-12-01 00:00:00

  • Isolation and characterization of human brain aminopeptidase which hydrolysis enkephalin-containing peptides.

    abstract::A human brain aminopeptidase, which hydrolyses low molecular weight enkephalin-containing peptides (ECPs), was purified to apparent homogeneity from the homogenate of human brain. The enzyme purification involved DEAE-cellulose chromatography and preparative polyacrylamide gel electrophoresis. The purified aminopeptid...

    journal_title:Neuropeptides

    pub_type: 杂志文章

    doi:10.1016/0143-4179(88)90033-9

    authors: Duarte GI,Souza FG,Bruno JA,Camargo AC,Carvalho KM

    更新日期:1988-08-01 00:00:00

  • Involvement of tachykinin NK1 receptors in plasma protein extravasation induced by tachykinins in the guinea pig upper airways.

    abstract::Plasma protein extravasation in the upper airways of anesthetized guinea pigs was measured with the FITC (Fluorescein isothiocyanate)-dextran technique. The effect of selective tachykinin (NK1 and NK2) receptor agonists and antagonists, capsaicin or antigen was studied. The tachykinin NK1 receptor agonist, [Sar9]subst...

    journal_title:Neuropeptides

    pub_type: 杂志文章

    doi:10.1016/s0143-4179(97)90022-6

    authors: Evangelista S,Paoli S,Giachetti A,Manzini S

    更新日期:1997-02-01 00:00:00

  • The interaction between the oxytocin and pain modulation in headache patients.

    abstract::Oxytocin (OXT), a nonapeptide hormone of posterior pituitary, reaches the central nervous system from systemic blood circulation with a difficulty because of the blood-brain barrier (BBB). The interest has been expressed in the use of the nasal route for delivery of OXT to the brain directly, exploiting the olfactory ...

    journal_title:Neuropeptides

    pub_type: 杂志文章

    doi:10.1016/j.npep.2012.12.003

    authors: Wang YL,Yuan Y,Yang J,Wang CH,Pan YJ,Lu L,Wu YQ,Wang DX,Lv LX,Li RR,Xue L,Wang XH,Bi JW,Liu XF,Qian YN,Deng ZK,Zhang ZJ,Zhai XH,Zhou XJ,Wang GL,Zhai JX,Liu WY

    更新日期:2013-04-01 00:00:00

  • The additive effect of allopregnanolone on ghrelin's orexigenic effect in rats.

    abstract::The progesterone metabolite, allopregnanolone (AlloP), is a GABAA receptor modulating steroid and is known to have orexigenic and pro-obesity effects. The neurobiological mechanisms underpinning these effects are most likely due to enhanced GABAergic signaling in the lateral arcuate nucleus (ARC) and medial paraventri...

    journal_title:Neuropeptides

    pub_type: 杂志文章

    doi:10.1016/j.npep.2019.101937

    authors: Löfgren M,Holmberg E,Bäckström T,Egecioglu E,Dickson SL

    更新日期:2019-08-01 00:00:00

  • The effects of endothelin-1 on satellite glial cells in peripheral ganglia.

    abstract::Endothelins (ET) are a family of highly active neuropeptides with manifold influences via ET receptors (ETR) in both the peripheral and central nervous systems. We have shown previously that satellite glial cells (SGCs) in mouse trigeminal ganglia (TG) are extremely sensitive to ET-1 in evoking [Ca2+]in increase, appa...

    journal_title:Neuropeptides

    pub_type: 杂志文章

    doi:10.1016/j.npep.2017.03.002

    authors: Feldman-Goriachnik R,Hanani M

    更新日期:2017-06-01 00:00:00

  • Influence of typical and atypical antipsychotics on neuropeptide Y-like immunoreactivity and NPY mRNA expression in rat striatum.

    abstract::Striatal neuropeptide Y-like immunoreactivity (NPY-LI) levels were investigated in naive rats after acute, subchronic (14 days) or chronic (28 days) intraperitoneal (i.p.) treatment with chlorpromazine (2 or 10mg/kg), haloperidol (0.5 or 2 mg/kg), (+/-)sulpiride (50 or 100 mg/kg) or clozapine (10 or 25 mg/kg), and in ...

    journal_title:Neuropeptides

    pub_type: 杂志文章

    doi:10.1016/s0143-4179(98)90074-9

    authors: Obuchowicz E,Turchan J

    更新日期:1998-10-01 00:00:00

  • Regulation of glucose and insulin release following acute and repeated treatment with the synthetic galanin analog NAX-5055.

    abstract::The neuropeptide galanin is widely expressed in both the central and peripheral nervous systems. However there is limited understanding of how individual galanin receptor (GalR1, 2, and 3) subtypes mediate the physiological activity of galanin in vivo. To address this issue we utilized NAX-5055, a systemically availab...

    journal_title:Neuropeptides

    pub_type: 杂志文章

    doi:10.1016/j.npep.2015.01.001

    authors: Flynn SP,White HS

    更新日期:2015-04-01 00:00:00

  • The orexigenic effect of kyotorphin in chicks involves hypothalamus and brainstem activity and opioid receptors.

    abstract::Kyotorphin (KTP), first isolated in the bovine brain and now having been identified in a variety of species, is known most extensively for its analgesic-like properties. KTP indirectly stimulates opioid receptors by releasing methionine enkephalin (met-enkephalin). Stimulation of opioid receptors is linked to hunger p...

    journal_title:Neuropeptides

    pub_type: 杂志文章

    doi:10.1016/j.npep.2012.10.007

    authors: Webster RI,Newmyer BA,Furuse M,Gilbert ER,Cline MA

    更新日期:2013-06-01 00:00:00

  • Differential effects of substance P or hemokinin-1 on transient receptor potential channels, TRPV1, TRPA1 and TRPM8, in the rat.

    abstract::Two tachykinin peptides, substance P (SP) and hemokinin-1 (HK-1), and three transient receptor potential (TRP) channels, TRPV1, TRPA1 and TRPM8, are similarly localized in the spinal dorsal horn and dorsal root ganglion, suggesting that TRP channels may be related or modulated by these tachykinin peptides. Thus, to cl...

    journal_title:Neuropeptides

    pub_type: 杂志文章

    doi:10.1016/j.npep.2009.10.002

    authors: Naono-Nakayama R,Sunakawa N,Ikeda T,Nishimori T

    更新日期:2010-02-01 00:00:00

  • The effects of receptor blockers on brain natriuretic peptide-32-induced action on passive avoidance behavior in rats.

    abstract::The effects of several doses of porcine brain natriuretic peptide-32 (pBNP-32) administered into the lateral brain ventricle were tested as regards the consolidation of passive avoidance learning in rats. The peptide was found to increase the passive avoidance latency in a dose-dependent manner. In order to clarify wh...

    journal_title:Neuropeptides

    pub_type: 杂志文章

    doi:10.1016/0143-4179(92)90064-4

    authors: Bidzseranova A,Várga J,Telegdy G

    更新日期:1992-06-01 00:00:00

  • Neuropeptide Y associated with asthma in young adults.

    abstract:OBJECTIVE:Neuropeptide Y, a widely circulating neurotransmitter, plays a pivotal role in energy balance, immunomodulation and asthma, and several NPY polymorphisms are promising genetic risk factors for asthma and obesity. We explored the associations of candidate NPY gene polymorphisms with prevalent asthma and its re...

    journal_title:Neuropeptides

    pub_type: 杂志文章

    doi:10.1016/j.npep.2016.07.003

    authors: Lu Y,Andiappan AK,Lee B,Ho R,Lim TK,Kuan WS,Goh DY,Mahadevan M,Sim TB,Wang Y,Van Bever HP,Rotzschke O,Larbi A,Ng TP

    更新日期:2016-10-01 00:00:00

  • Investigation of receptor binding and functional characteristics of hemopressin(1-7).

    abstract::The orally active, α-hemoglobin derived hemopressin (PVNFKFLSH, Hp(1-9)) and its truncated (PVNFKFL, Hp(1-7) and PVNFKF, Hp(1-6)) and extended ((R)VDPVNFKFLSH, VD-Hp(1-9) and RVD-Hp(1-9)) derivatives have been postulated to be the endogenous peptide ligands of the cannabinoid receptor type 1 (CB1). In an attempt to cr...

    journal_title:Neuropeptides

    pub_type: 杂志文章

    doi:10.1016/j.npep.2016.02.001

    authors: Dvorácskó S,Tömböly C,Berkecz R,Keresztes A

    更新日期:2016-08-01 00:00:00

  • Interactions between adrenergic systems, anaesthetic and TRH analogue induced analeptic effects on VBT transmission.

    abstract::Previous behavioural and electrophysiological studies have indicated an antinarcotic action of thyrotropin-releasing hormone (TRH) and its analogues in antagonizing the action of CNS depressant drugs, including baclofen and a variety of anesthetics. While beta-adrenergic receptors are implicated in the level of anaest...

    journal_title:Neuropeptides

    pub_type: 杂志文章

    doi:10.1016/0143-4179(91)90034-g

    authors: Clarke KA,Djouhri L

    更新日期:1991-09-01 00:00:00

  • Consequences of growth hormone (GH) overexpression and GH resistance.

    abstract::Development of transgenic mice overexpressing GH and GHR-KO mice with GH resistance provided novel animal models for study of the somatotropic axis and for identifying GH actions that may be relevant to its current and contemplated use in medicine and agriculture. Studies of phenotypic characteristics of these animals...

    journal_title:Neuropeptides

    pub_type: 杂志文章,评审

    doi:10.1054/npep.2002.0889

    authors: Bartke A,Chandrashekar V,Bailey B,Zaczek D,Turyn D

    更新日期:2002-04-01 00:00:00