Abstract：
:The effects of intravenous self-administration of 30 micrograms infusions of either heroin or cocaine, or saline on the concentrations of beta-endorphin-immunoreactivity (beta E-IR) in the anterior part of the rat brain limbic system were studied. Self-administration of heroin and cocaine for 5 daily sessions resulted in a marked reduction of the concentrations of beta E-IR in the nucleus accumbens, rostral striatum, septum and hippocampus at the time of the scheduled next session on day 6. In pooled extracts of these regions from rats receiving saline, combined application of high-pressure liquid chromatography (HPLC) fractionation and specific radioimmunoassays revealed the presence of a number of beta E-related peptides co-chromatographing with synthetic non-acetylated and acetylated alpha, beta- and gamma-type endorphins. Similar profiles were found after HPLC fractionation of extracts of these regions from rats self-administering heroin and cocaine. Rats self-administering heroin or cocaine, however, showed decreased amounts of all detected forms of beta-endorphin as compared to saline rats. These findings indicate that both self-administration of an opiate that induces psychic as well as physical dependence and of a non-opiate stimulant inducing psychic but not physical dependence, results in a significant decrease of beta E and related peptides in limbic brain regions of the rat. All forms of beta E detected after HPLC were equally affected, suggesting an overall effect of the drugs on peptide turnover. These results suggest that beta E and related peptides may be involved in the neurochemical mechanisms underlying psychic dependence to drugs.
journal_name
Neuropeptidesjournal_title
Neuropeptidesauthors
Sweep CG,Van Ree JM,Wiegant VMdoi
10.1016/0143-4179(88)90060-1subject
Has Abstractpub_date
1988-11-01 00:00:00pages
229-36issue
4eissn
0143-4179issn
1532-2785pii
0143-4179(88)90060-1journal_volume
12pub_type
杂志文章相关文献
NEUROPEPTIDES文献大全abstract：:Several studies suggest that prenatal ethanol exposure (PEE) facilitates ethanol intake. Opioid peptides play a main role in ethanol reinforcement during infancy and adulthood. However, PEE effects upon motor responsiveness elicited by an ethanol challenge and the participation of opioids in these actions remain to be...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/j.npep.2016.11.006
更新日期：2017-04-01 00:00:00
abstract：:The effects of vasoactive intestinal peptide (VIP) on spatial cognitive deficits induced in the rat by injections of scopolamine were examined in a radial arm maze. A single intraperitoneal (i.p.), subcutaneous (s.c.) or intracerebroventricular (i.c.v.) injection of VIP inhibited the reduction in the number of initial...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/0143-4179(94)90124-4
更新日期：1994-03-01 00:00:00
abstract：:Oxytocin, intraperitoneally injected to 26-month-old male rats 60 min before testing, significantly improved social memory (at doses of 3 and 6 ng/kg) and reduced the duration of immobility in the behavioral despair test (at doses of 50 and 500 micrograms/kg). These results are in agreement with previous data obtained...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/0143-4179(95)90021-7
更新日期：1995-09-01 00:00:00
abstract：:We examined the effects of gestational cocaine treatment on oxytocin levels in the whole hippocampus (HIP), ventral tegmental area (VTA), medial preoptic area (MPOA) and amygdala (AMY) in rat dams on postpartum days (PPDs) 1 and 2. Cocaine treatment significantly reduced oxytocin levels in the MPOA within 12-16 h of d...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/s0143-4179(97)90037-8
更新日期：1997-10-01 00:00:00
abstract：:Dermorphin (Tyr-D-Ala-Phe-Gly-Tyr-Pro-Ser-NH2), a naturally occurring peptide isolated from arboreal frog skin, is endowed with outstanding structural and biological features. It has no structural community with the sequence of mammalian opioid peptides and is a unique example of a D-aminoacid containing peptide which...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/0143-4179(89)90021-8
更新日期：1989-01-01 00:00:00
abstract：:Regulation of cholecystokinin (CCK) expression was studied in the human neuroepithelioma cell line SK-N-MCIXC and the rat medullary thyroid carcinoma cell line WE 4/2. The cells were treated with the beta-adrenergic agonist isoproterenol and retinoic acid, a natural derivative of vitamin A, which plays a role in cell ...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/0143-4179(95)90064-0
更新日期：1995-10-01 00:00:00
abstract：:The Third Galanin Symposium presented many different and exciting results on galanin research reflecting a major progress since the previous symposium in 1998. A major impression was the many possible relationships of galaninergic mechanisms to important brain functions such as development, cognition and ageing as wel...
journal_title：Neuropeptides
pub_type：
doi：10.1016/j.npep.2005.03.002
更新日期：2005-06-01 00:00:00
abstract：:The level of opioid peptides in several brain areas and in the pituitary was estimated in WAG/Rij rats, which are considered to be a genetic animal model for human absence epilepsy. In comparison with three groups of non-epileptic controls, these epileptic rats had an elevated level of the proenkephalin-derived peptid...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/0143-4179(92)90037-w
更新日期：1992-03-01 00:00:00
abstract：:Alarin is a newly identified member of the galanin family of neuropeptides that includes galanin-like peptide (GALP) and galanin. Alarin was discovered as an alternate transcript of the GALP gene in neuroblastoma cells, and subsequently alarin mRNA was detected in the brain of rodents. GALP and galanin are important c...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/j.npep.2010.04.001
更新日期：2010-08-01 00:00:00
abstract：:Dynorphins are important neuropeptides with a central role in nociception and pain alleviation. Many mechanisms regulate endogenous dynorphin concentrations, including proteolysis. Proprotein convertases (PCs) are widely expressed in the central nervous system and specifically cleave at C-terminal of either a pair of ...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/j.npep.2015.10.008
更新日期：2016-06-01 00:00:00
abstract：:The aim of the present work was to study the potential involvement of melanocortin system in the anorectic mechanism of fluoxetine, a selective serotonin reuptake inhibitors, in obese Zucker rats. Male obese Zucker (fa/fa) rats were administered fluoxetine (10 mg/kg; i.p.) daily for two weeks. The control group was gi...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/j.npep.2008.02.002
更新日期：2008-06-01 00:00:00
abstract：:Multiple sclerosis (MS) is an autoimmune disease of the central nervous system characterized by brain inflammation, demyelination and axonal loss. Neuropeptide Y (NPY) has a critical role in the maintenance of homeostasis in the immune system and coping of stress condition. In the current study we analyzed 188 patient...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/j.npep.2016.08.004
更新日期：2016-12-01 00:00:00
abstract：:Oxytocin (OXT), a nonapeptide hormone of posterior pituitary, reaches the central nervous system from systemic blood circulation with a difficulty because of the blood-brain barrier (BBB). The interest has been expressed in the use of the nasal route for delivery of OXT to the brain directly, exploiting the olfactory ...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/j.npep.2012.12.003
更新日期：2013-04-01 00:00:00
abstract：:We have used [3H]Senktide, a selective Neurokinin B receptor ligand, for the characterization of NK-3 receptors in rat and guinea pig CNS membranes. Scatchard analysis of saturation binding studies in cerebral cortex membranes indicated that this ligand bound to a single site with apparent high affinity (KD = 4.6 +/- ...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/0143-4179(91)90101-n
更新日期：1991-03-01 00:00:00
abstract：:The role of somatostatin on inhibition of both normal and tumor cell cycle, secretion of endocrine and exocrine cells, as well as induction apoptosis is well documented. However, its effect on T cell development and thymic structure is not fully clarified. In order to investigate the influence of somatostatin in vivo ...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/j.npep.2007.06.003
更新日期：2007-12-01 00:00:00
abstract：:Nitric oxide (NO) donors induce delayed headaches in migraineurs. In a corresponding rat model NO donors cause delayed ongoing activity in central trigeminal neurons which process intracranial afferent input. Cellular models indicate that NO may increase the release or production of calcitonin gene-related peptide (CG...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/j.npep.2009.09.002
更新日期：2009-12-01 00:00:00
abstract：:Galanin (GAL) is known to stimulate feeding behavior. This peptide has different properties and functions from other feeding stimulants, e.g., neuropeptide Y and agouti-related protein. Hypothalamic GAL is relatively unresponsive to food deprivation and to changes in corticosterone, glucose utilization, dietary carboh...
journal_title：Neuropeptides
pub_type： 杂志文章,评审
doi：10.1016/j.npep.2004.12.022
更新日期：2005-06-01 00:00:00
abstract：:The Mu opioid receptor (MOR) has been shown to participate in the analgesic effect of the calcitonin gene-related peptide (CGRP) in the nucleus accumbens (NAc) of adult rats. However, it is not clear whether and how CGRP regulates the MOR at the molecular levels. In the present study, it is found that the level of MOR...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/j.npep.2012.10.008
更新日期：2013-04-01 00:00:00
abstract：:The distributions of four prodynorphin-derived peptides, dynorphin A (1-17), dynorphin A (1-8), dynorphin B, and alpha-neo-endorphin were determined in 10 cortical regions and the striatum of the old world monkey (Macaca nemestrina). alpha-neo-endorphin was the most abundant peptide in both cortex and striatum. The co...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/0143-4179(94)90108-2
更新日期：1994-11-01 00:00:00
abstract：:The effects of central (clonazepam, an agonist, and FG 7142, an inverse agonist), mixed (diazepam) or peripheral type (Ro 5-4864) benzodiazepine receptor ligands on the action of TRH on the transmurally stimulated rat duodenum and binding of [3H][3-Me-His2] TRH in the rat anterior pituitary, hypothalamus, cortex and b...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/0143-4179(91)90112-v
更新日期：1991-07-01 00:00:00
abstract：:Ghrelin (gh) is a peptide hormone that may affect learning and memory. There is some evidence that ghrelin can have antiepileptic effects. So we decided to investigate the possible effects of ghrelin on spatial memory following PTZ-induced seizures in male rats. Ninety male rats were divided into 9 groups including co...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/j.npep.2013.05.005
更新日期：2013-10-01 00:00:00
abstract：:Endothelins (ET) are a family of highly active neuropeptides with manifold influences via ET receptors (ETR) in both the peripheral and central nervous systems. We have shown previously that satellite glial cells (SGCs) in mouse trigeminal ganglia (TG) are extremely sensitive to ET-1 in evoking [Ca2+]in increase, appa...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/j.npep.2017.03.002
更新日期：2017-06-01 00:00:00
abstract：:Neural stem cells (NSC) could promote the repair after spinal cord transection (SCT), the underlying mechanism, however, still keeps to be defined. This study reported that NSC grafts significantly improved sensory and locomotor functions in adult rats with SCT in acute stage after injury. NSC could survive; different...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/j.npep.2012.06.001
更新日期：2013-02-01 00:00:00
abstract：:Arginine vasopressin mediates its effects through vasopressin receptor activation and second messenger production. Recent cloning of the V1a receptor provided the opportunity to investigate the possible signal transduction pathways associated with this single vasopressin receptor subtype. When stably expressed in CHO ...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/0143-4179(94)90017-5
更新日期：1994-07-01 00:00:00
abstract：:The distribution of beta-endorphin (1-27) immunoreactive cell bodies and fibres was studied in the diencephalon of the cat using an indirect immunoperoxidase technique. In the thalamus, almost all the immunoreactive fibres were found in the midline region and in nuclei located near the midline, whereas in the hypothal...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/s0143-4179(96)90072-4
更新日期：1996-06-01 00:00:00
abstract：:In situ hybridisation histochemistry was used to study the effect of intra-peritoneal reserpine administration on messenger RNA (mRNA) levels in the locus coeruleus (LC) of the rat. 48h after injection, levels of mRNA encoding tyrosine hydroxylase (TH) and neuropeptide Y (NPY) in the LC increased to approximately 250%...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/0143-4179(91)90105-r
更新日期：1991-03-01 00:00:00
abstract：:The discriminative stimulus properties of the selective CCKB-receptor antagonist, L-365,260 were evaluated in rats trained to discriminate diazepam (2 mg/kg) or morphine (5 mg/kg) from vehicle, using a two-lever food reinforced technique. In the diazepam drug discrimination, the benzodiazepine-receptor agonist FG8205 ...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/0143-4179(94)90119-8
更新日期：1994-05-01 00:00:00
abstract：:Social recognition is the sensitive domains of complex behavior critical for identification, interpretation and storage of socially meaningful information. Social recognition develops throughout childhood and adolescent, and is affected in a wide variety of psychiatric disorders. Recently, new data appeared on the mol...
journal_title：Neuropeptides
pub_type： 杂志文章,评审
doi：10.1016/j.npep.2018.09.003
更新日期：2018-12-01 00:00:00
abstract：:Available data concerning the effect of oxytocin on memory are often inconsistent. In the present study it was found that oxytocin, intracerebroventricularly injected to adult male rats in a dose range of 1 fg-10 ng/rat immediately after a 5-minute encounter with a juvenile, significantly reduces the social investigat...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/0143-4179(95)90029-2
更新日期：1995-04-01 00:00:00
abstract：:AtT-20 cells are known to synthesize two molecular weight forms of the prohormone converting enzyme PC1 with molecular masses of 87 and 66 kDa. In this study we have analyzed basal and stimulated secretion of these proteins. Western blot results show that basal secretion medium of cultured AtT-20 cells contained low c...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/0143-4179(93)90096-s
更新日期：1993-08-01 00:00:00
