当前位置： SCI文献检索 > NEUROPEPTIDES期刊下所有文献 > Prenatal ethanol exposure modifies locomotor activity and induces selective changes in Met-enk expression in adolescent rats.

Prenatal ethanol exposure modifies locomotor activity and induces selective changes in Met-enk expression in adolescent rats.

Abstract：

:Several studies suggest that prenatal ethanol exposure (PEE) facilitates ethanol intake. Opioid peptides play a main role in ethanol reinforcement during infancy and adulthood. However, PEE effects upon motor responsiveness elicited by an ethanol challenge and the participation of opioids in these actions remain to be understood. This work assessed the susceptibility of adolescent rats to prenatal and/or postnatal ethanol exposure in terms of behavioral responses, as well as alcohol effects on Met-enk expression in brain areas related to drug reinforcement. Motor parameters (horizontal locomotion, rearings and stereotyped behaviors) in pre- and postnatally ethanol-challenged adolescents were evaluated. Pregnant rats received ethanol (2g/kg) or water during gestational days 17-20. Adolescents at postnatal day 30 (PD30) were tested in a three-trial activity paradigm (habituation, vehicle and drug sessions). Met-enk content was quantitated by radioimmunoassay in several regions: ventral tegmental area [VTA], nucleus accumbens [NAcc], prefrontal cortex [PFC], substantia nigra [SN], caudate-putamen [CP], amygdala, hypothalamus and hippocampus. PEE significantly reduced rearing responses. Ethanol challenge at PD30 decreased horizontal locomotion and showed a tendency to reduce rearings and stereotyped behaviors. PEE increased Met-enk content in the PFC, CP, hypothalamus and hippocampus, but did not alter peptide levels in the amygdala, VTA and NAcc. These findings suggest that PEE selectively modifies behavioral parameters at PD30 and induces specific changes in Met-enk content in regions of the mesocortical and nigrostriatal pathways, the hypothalamus and hippocampus. Prenatal and postnatal ethanol actions on motor activity in adolescents could involve activation of specific neural enkephalinergic pathways.

journal_name

Neuropeptides

journal_title

Neuropeptides

authors

Abate P,Reyes-Guzmán AC,Hernández-Fonseca K,Méndez M

doi

10.1016/j.npep.2016.11.006

subject

Has Abstract

pub_date

2017-04-01 00:00:00

pages

45-56

eissn

0143-4179

issn

1532-2785

pii

S0143-4179(16)30094-4

journal_volume

62

pub_type

杂志文章

相关文献

NEUROPEPTIDES文献大全
  • CART expression in limbic regions of rat brain following forced swim stress: sex differences.

    abstract：:Our previous studies showed the modulation of cocaine and amphetamine regulated transcript (CART) positive neurons and CART mRNA by adrenalectomy and corticosterone replacement in hypothalamic nuclei of male rat brain. More recently, we have shown by CART immunohistochemistry that restraint and forced swim (FS) stress...

    journal_title：Neuropeptides

    pub_type： 杂志文章

    doi：10.1016/j.npep.2006.02.001

    authors： Balkan B,Gozen O,Yararbas G,Koylu EO,Akinturk S,Kuhar MJ,Pogun S

    更新日期：2006-06-01 00:00:00

  • Behavioural characteristics of the Prader-Willi syndrome related biallelic Snord116 mouse model.

    abstract：:Prader-Willi syndrome (PWS) is the predominant genetic cause of obesity in humans and is associated with several behavioural phenotypes such as altered motoric function, reduced activity, and learning disabilities. It can include mood instability and, in some cases, psychotic episodes. Recently, the Snord116 gene has ...

    journal_title：Neuropeptides

    pub_type： 杂志文章

    doi：10.1016/j.npep.2015.06.009

    authors： Zieba J,Low JK,Purtell L,Qi Y,Campbell L,Herzog H,Karl T

    更新日期：2015-10-01 00:00:00

  • Microglia polarization of hippocampus is involved in the mechanism of Apelin-13 ameliorating chronic water immersion restraint stress-induced depression-like behavior in rats.

    abstract：:Chronic stress induces the activation of hippocampal microglia, which produces many inflammatory mediators and mediates the occurrence of depression. Two phenotypes of microglia polarization, the classical M1 and alternative M2, play important regulatory roles in neuroinflammation and are involved in the occurrence an...

    journal_title：Neuropeptides

    pub_type： 杂志文章

    doi：10.1016/j.npep.2020.102006

    authors： Zhou S,Chen S,Xie W,Guo X,Zhao J

    更新日期：2020-06-01 00:00:00

  • Immunocytochemical localization of the endogenous benzodiazepine ligand octadecaneuropeptide (ODN) in the rat brain.

    abstract：:In order to study the morphological localization of the endogenous benzodiazepine ligand octadecaneuropeptide (ODN) in rat brain, we have developed antibodies against this peptide. Using a radioimmunoassay for ODN, we have observed that synthetic ODN and serial dilutions of several brain areas gave parallel displaceme...

    journal_title：Neuropeptides

    pub_type： 杂志文章

    doi：10.1016/0143-4179(90)90155-r

    authors： Tonon MC,Désy L,Nicolas P,Vaudry H,Pelletier G

    更新日期：1990-01-01 00:00:00

  • The human neurokinin B gene, TAC3, and its promoter are regulated by Neuron Restrictive Silencing Factor (NRSF) transcription factor family.

    abstract：:We have previously shown that one of the major determinants directing the expression of the preprotachykinin-A (TAC1) gene, which encodes the neuropeptide substance P, is the transcription factor Neuronal Restrictive Silencer Factor (NSRF), which is also termed Repressor Element-1 Silencing Factor (REST). In rodent mo...

    journal_title：Neuropeptides

    pub_type： 杂志文章

    doi：10.1016/j.npep.2009.05.004

    authors： Gillies S,Haddley K,Vasiliou S,Bubb VJ,Quinn JP

    更新日期：2009-08-01 00:00:00

  • Opposite effects of opiate agonists on metabolic weight loss in mice.

    abstract：:Morphine (M) produced a dose-related decrease in metabolic weight loss (MWL) over a three-hour period, despite the fact that it significantly enhanced locomotor activity in male mice. This conservation of energy was specific to opioid receptors because naltrexone HCl (N) blocked it. These receptors were localized main...

    journal_title：Neuropeptides

    pub_type： 杂志文章

    doi：10.1016/0143-4179(85)90019-8

    authors： Henry LJ,Walker J,Margules DL

    更新日期：1985-02-01 00:00:00

  • Neuropeptide Y and tyrosine hydroxylase mRNA levels in the locus coeruleus show similar increases after reserpine treatment.

    abstract：:In situ hybridisation histochemistry was used to study the effect of intra-peritoneal reserpine administration on messenger RNA (mRNA) levels in the locus coeruleus (LC) of the rat. 48h after injection, levels of mRNA encoding tyrosine hydroxylase (TH) and neuropeptide Y (NPY) in the LC increased to approximately 250%...

    journal_title：Neuropeptides

    pub_type： 杂志文章

    doi：10.1016/0143-4179(91)90105-r

    authors： Foster OJ,Biswas S,Lightman SL

    更新日期：1991-03-01 00:00:00

  • Central administration of neuropeptide Y differentially regulates monoamines and corticosterone in heat-exposed fed and fasted chicks.

    abstract：:Recently, we demonstrated that brain neuropeptide Y (NPY) mRNA expression was increased in heat exposed chicks. However, the functions of brain NPY during heat stress are unknown. This study was conducted to investigate whether centrally administered NPY affects food intake, rectal temperature, monoamines, stress horm...

    journal_title：Neuropeptides

    pub_type： 杂志文章

    doi：10.1016/j.npep.2016.11.008

    authors： Bahry MA,Chowdhury VS,Yang H,Tran PV,Do PH,Han G,Ikeda H,Cockrem JF,Furuse M

    更新日期：2017-04-01 00:00:00

  • Identification of 3H-bradykinin binding sites in PC-12 cells and brain.

    abstract：:3H-Bradykinin binding sites with the characteristics of receptors were identified in homogenates of bovine hippocampus and PC-12 cells. The characteristics of the binding were similar in both types of tissue and paralleled those of the B2 bradykinin receptor. Following exposure to nerve growth factor for 72 hours, the...

    journal_title：Neuropeptides

    pub_type： 杂志文章

    doi：10.1016/0143-4179(88)90056-x

    authors： Kozlowski MR,Rosser MP,Hall E

    更新日期：1988-11-01 00:00:00

  • Sulfhydryl reagents have different effects on substance P and neurokinin B binding sites on cortical synaptosomes in the rat.

    abstract：:The effects of several protein modifying reagents, including phenoxybenzamine, N-ethylmaleimide (NEM), 5,5'-dithiobis (2-nitro)--benzoic acid (DTNB), p-chloromercuryphenyl sulfonic acid (PCMP) and p-bromophenacylbromide (PBPB), on the binding of 125I-Bolton Hunter substance P (125I-BHSP), 125I-Bolton Hunter eledoisin ...

    journal_title：Neuropeptides

    pub_type： 杂志文章

    doi：10.1016/0143-4179(87)90053-9

    authors： Bergström L,Beaujouan JC,Torrens Y,Saffroy M,Glowinski J

    更新日期：1987-02-01 00:00:00

  • Mesotocin in the brain and plasma of an Australian marsupial, the brushtail possum (Trichosurus vulpecula).

    abstract：:Oxytocic peptides extracted from the brain and plasma of the brushtail possum, Trichosurus vulpecula, were separated by reverse-phase high pressure lipid chromatography (HPLC) and quantified by specific radioimmunoassays for oxytocin (OT) and mesotocin (MT). The pituitary, hypothalamus and cerebral cortex were found t...

    journal_title：Neuropeptides

    pub_type： 杂志文章

    doi：10.1016/0143-4179(90)90123-g

    authors： Bathgate RA,Sernia C,Gemmell RT

    更新日期：1990-07-01 00:00:00

  • Effect of a neurokinin-1 (NK1) receptor antagonist on oedema formation induced by tachykinins, carrageenin and an allergic response in guinea-pig skin.

    abstract：:The effect of the neurokinin-1 (NK1) receptor antagonist RP67580 in modulating inflammatory oedema formation has been investigated in guinea-pig skin. Oedema formation was measured over 30 min by the extravascular accumulation of intravenously-injected 125I-albumin in the anaesthetised guinea-pig. RP67580 was injected...

    journal_title：Neuropeptides

    pub_type： 杂志文章

    doi：10.1016/0143-4179(94)90026-4

    authors： Wilsoncroft P,Euzger H,Brain SD

    更新日期：1994-06-01 00:00:00

  • Comparison of the antinociceptive effect between D-Arg containing dipeptides and tetrapeptides in mice.

    abstract：:D-Arg containing dipeptides, H-Tyr-D-Arg-OMe and H-Tyr (Et)-D-Arg-OMe, and D-Arg2 substituted N-terminal tetrapeptides of dermorphin, H-Tyr-D-Arg-Phe-Gly-OEt and H-Tyr (Et)-D-Arg-Phe-Gly-OEt administered intracerebroventricularly exhibited dose-dependent antinociceptive activities in mice as measured by the tail press...

    journal_title：Neuropeptides

    pub_type： 杂志文章

    doi：10.1016/0143-4179(84)90001-5

    authors： Sato T,Sakurada S,Sakurada T,Furuta S,Nakata N,Kisara K,Sasaki Y,Suzuki K

    更新日期：1984-06-01 00:00:00

  • Glyceroltrinitrate facilitates stimulated CGRP release but not gene expression of CGRP or its receptor components in rat trigeminal ganglia.

    abstract：:Nitric oxide (NO) donors induce delayed headaches in migraineurs. In a corresponding rat model NO donors cause delayed ongoing activity in central trigeminal neurons which process intracranial afferent input. Cellular models indicate that NO may increase the release or production of calcitonin gene-related peptide (CG...

    journal_title：Neuropeptides

    pub_type： 杂志文章

    doi：10.1016/j.npep.2009.09.002

    authors： Eberhardt M,Neeb L,Vogel EM,Tiegs G,Reuter U,Messlinger K,Fischer MJ

    更新日期：2009-12-01 00:00:00

  • Effects of renal denervation on renin release induced by intracerebroventricular administration of biological active peptides in conscious rats.

    abstract：:Experiments were performed to determine whether the renal nerve mediates the renin release induced by intracerebroventricular administration of angiotensin II (ANG II), bradykinin (BK), leucine-enkephalin (Leu-ENK) and neurotensin (NT). In sham-operated rats, both ANG II and NT suppressed plasma renin activity (PRA), ...

    journal_title：Neuropeptides

    pub_type： 杂志文章

    doi：10.1016/0143-4179(85)90142-8

    authors： Iwata T,Hiwada K,Kokubu T

    更新日期：1985-09-01 00:00:00

  • Blockade of neuropeptide Y-induced potentiation of noradrenaline-evoked vasoconstriction by D-myo-inositol-1.2.6-trisphosphate (PP56) in rabbit femoral arteries.

    abstract：:Neuropeptide Y (NPY) potentiates noradrenaline (NA)-evoked constriction of circular segments of the rabbit femoral artery. The potentiation occurs exclusively in the lower concentration-range of the agonist NA (10(-8)-3 x 10(-7) M) without any change in maximum contractile effect. NPY per se is without contractile eff...

    journal_title：Neuropeptides

    pub_type： 杂志文章

    doi：10.1016/0143-4179(91)90068-t

    authors： Adamsson M,Edvinsson L

    更新日期：1991-05-01 00:00:00

  • Altered serum stress neuropeptide levels in critically ill individuals and associations with lymphocyte populations.

    abstract：OBJECTIVE:Potential physiological correlates of stress and the role of stress neuropeptides, other than those of the hypothalamic-pituitary-adrenal axis, in critical illness have not been addressed. We investigated: (a) serum levels of stress neuropeptides (ACTH, substance P (SP), neuropeptide Y (NPY), cortisol, prolac...

    journal_title：Neuropeptides

    pub_type： 杂志文章

    doi：10.1016/j.npep.2012.07.007

    authors： Mpouzika MD,Papathanassoglou ED,Giannakopoulou M,Bozas E,Middleton N,Boti S,Patiraki EI,Karabinis A

    更新日期：2013-02-01 00:00:00

  • Solubilization of two molecular forms of the frog brain opioid receptor.

    abstract：:In equilibrium binding studies, using 3H-etorphine and 3H-diprenorphine, digitonin extracts of frog brain membranes are found to contain two classes of sites, one of which is seen only in the presence of Na+ ions. Centrifugation of the extracts in sucrose gradients separates two macromolecular components (10S and 12S)...

    journal_title：Neuropeptides

    pub_type： 杂志文章

    doi：10.1016/0143-4179(84)90044-1

    authors： Puget A,Frances B,Jauzac P,Meunier JC

    更新日期：1984-12-01 00:00:00

  • Central neuropeptide FF reduces feed consumption and affects hypothalamic chemistry in chicks.

    abstract：:Information on the physiological functions of neuropeptide FF; NPFF, a morphine modulating octapeptide in avians is lacking. Thus, we designed a study to investigate the effects of central NPFF with particular emphasis on appetite-related processes. Cobb-500 chicks were intracerebroventricularly (ICV) injected with 0,...

    journal_title：Neuropeptides

    pub_type： 杂志文章

    doi：10.1016/j.npep.2007.08.003

    authors： Cline MA,Nandar W,Rogers JO

    更新日期：2007-12-01 00:00:00

  • Opiate antagonists do not alter neuronal responses to stimulation of opioid-containing pathways in rat hippocampus.

    abstract：:The opioid receptor antagonists, naloxone and beta-chlornaltrexamine, were used to determine whether activation of endogenous opioid peptide containing pathways produced pharmacologically reversible opioid actions. Extracellularly recorded responses of the hippocampal CA3 pyramidal cells were evoked by stimulation of ...

    journal_title：Neuropeptides

    pub_type： 杂志文章

    doi：10.1016/0143-4179(86)90074-0

    authors： Chavkin C,Bloom FE

    更新日期：1986-01-01 00:00:00

  • The role of nociceptin and dynorphin in chronic pain: implications of neuro-glial interaction.

    abstract：:Nociceptin-opioid peptide (NOP) receptor, also known as opioid receptor like-1 (ORL1), was identified following the cloning of the kappa-opioid peptide (KOP) receptor, and the characterization of these receptors revealed high homology. The endogenous ligand of NOP, nociceptin (NOC), which shares high homology to dynor...

    journal_title：Neuropeptides

    pub_type： 杂志文章,评审

    doi：10.1016/j.npep.2011.03.002

    authors： Mika J,Obara I,Przewlocka B

    更新日期：2011-08-01 00:00:00

  • Hypocretins/orexins as integrators of physiological information: lessons from mutant animals.

    abstract：:The hypocretins/orexins (hcrts) are two recently described neuropeptides derived from the same precursor and expressed in a few thousand neurons in the perifornical area of the lateral hypothalamus, which project throughout the brain. The hypocretins bind to two G-protein coupled receptors with different selective aff...

    journal_title：Neuropeptides

    pub_type： 杂志文章,评审

    doi：10.1054/npep.2002.0892

    authors： de Lecea L,Sutcliffe JG,Fabre V

    更新日期：2002-04-01 00:00:00

  • Influence of typical and atypical antipsychotics on neuropeptide Y-like immunoreactivity and NPY mRNA expression in rat striatum.

    abstract：:Striatal neuropeptide Y-like immunoreactivity (NPY-LI) levels were investigated in naive rats after acute, subchronic (14 days) or chronic (28 days) intraperitoneal (i.p.) treatment with chlorpromazine (2 or 10mg/kg), haloperidol (0.5 or 2 mg/kg), (+/-)sulpiride (50 or 100 mg/kg) or clozapine (10 or 25 mg/kg), and in ...

    journal_title：Neuropeptides

    pub_type： 杂志文章

    doi：10.1016/s0143-4179(98)90074-9

    authors： Obuchowicz E,Turchan J

    更新日期：1998-10-01 00:00:00

  • Stimulation of food intake after central galanin is associated with arcuate nucleus activation and does not differ between genetically selected low and high body weight lines of chickens.

    abstract：:Galanin, a 29 residue peptide found in the hypothalamus, causes orexigenic effects in a variety of species. In the present study, we investigated appetite-associated effects of galanin in chicks from lines which have been selected from a common founder population for either low or high body weight. The low line consis...

    journal_title：Neuropeptides

    pub_type： 杂志文章

    doi：10.1016/j.npep.2012.11.003

    authors： Hagen CJ,Newmyer BA,Webster RI,Gilbert ER,Siegel PB,Tachibana T,Cline MA

    更新日期：2013-08-01 00:00:00

  • Characterization of NK-3 binding sites in rat and guinea pig cortical membranes by the selective ligand [3H]Senktide.

    abstract：:We have used [3H]Senktide, a selective Neurokinin B receptor ligand, for the characterization of NK-3 receptors in rat and guinea pig CNS membranes. Scatchard analysis of saturation binding studies in cerebral cortex membranes indicated that this ligand bound to a single site with apparent high affinity (KD = 4.6 +/- ...

    journal_title：Neuropeptides

    pub_type： 杂志文章

    doi：10.1016/0143-4179(91)90101-n

    authors： Renzetti AR,Barsacchi P,Criscuoli M,Lucacchini A

    更新日期：1991-03-01 00:00:00

  • Association study of two functional single nucleotide polymorphisms of neuropeptide y gene with multiple sclerosis.

    abstract：:Multiple sclerosis (MS) is an autoimmune disease of the central nervous system characterized by brain inflammation, demyelination and axonal loss. Neuropeptide Y (NPY) has a critical role in the maintenance of homeostasis in the immune system and coping of stress condition. In the current study we analyzed 188 patient...

    journal_title：Neuropeptides

    pub_type： 杂志文章

    doi：10.1016/j.npep.2016.08.004

    authors： Mohammadi SM,Shirvani Farsani Z,Dosti R,Sahraian MA,Behmanesh M

    更新日期：2016-12-01 00:00:00

  • Effect of pentylenetetrazol-induced convulsions on somatostatin-like immunoreactivity in rat cerebrospinal fluid.

    abstract：:Somatostatin is a neuropeptide that in several experimental models of epilepsy has been suggested to modulate epileptic activity. The purpose of the present study was to investigate the role of somatostatin in seizure phenomena. We measured the somatostatin-like immunoreactivity (SLI) by radioimmunoassay of the cister...

    journal_title：Neuropeptides

    pub_type： 杂志文章

    doi：10.1016/0143-4179(87)90027-8

    authors： Pitkänen A,Jolkkonen J,Honkanen KL,Riekkinen P

    更新日期：1987-01-01 00:00:00

  • Characterization of beta-endorphin-immunoreactivity in limbic brain structures of rats self-administering heroin or cocaine.

    abstract：:The effects of intravenous self-administration of 30 micrograms infusions of either heroin or cocaine, or saline on the concentrations of beta-endorphin-immunoreactivity (beta E-IR) in the anterior part of the rat brain limbic system were studied. Self-administration of heroin and cocaine for 5 daily sessions resulted...

    journal_title：Neuropeptides

    pub_type： 杂志文章

    doi：10.1016/0143-4179(88)90060-1

    authors： Sweep CG,Van Ree JM,Wiegant VM

    更新日期：1988-11-01 00:00:00

  • The patterns of exercise-induced β-endorphin expression in the central nervous system of rats.

    abstract：:Exercise at different intensities is able to induce different physical and psychological statuses of the subjects. The β-endorphin (β-EP) in central nervous system is thought to play an important role in physical exercise. However, its expression patterns and physiological effects in the central nuclei under different...

    journal_title：Neuropeptides

    pub_type： 杂志文章

    doi：10.1016/j.npep.2020.102048

    authors： Xue L,Sun J,Zhu J,Ding Y,Chen S,Ding M,Pei H

    更新日期：2020-08-01 00:00:00

  • S14G-Humanin ameliorates Abeta25-35-induced behavioral deficits by reducing neuroinflammatory responses and apoptosis in mice.

    abstract：:Cerebral amyloid-beta protein (Abeta) deposition and associated neuroinflammation and apoptosis are increasingly recognized as an important component leading to cognitive impairment in Alzheimer's disease (AD). Humanin (HN) and its derivative, S14G-HN (HNG), are best known for their ability to suppress neuronal death ...

    journal_title：Neuropeptides

    pub_type： 杂志文章,收录出版

    doi：10.1016/j.npep.2008.08.004

    authors： Miao J,Zhang W,Yin R,Liu R,Su C,Lei G,Li Z

    更新日期：2008-10-01 00:00:00