Abstract:
:Fracture repair is a complex yet well orchestrated regenerative process involving numerous signaling and cell types including osteoblasts. Here we showed that NPY, a neurotransmitter with regulatory functions in bone homeostasis, may contribute to the post-fracture bone healing in patients with traumatic brain injury-fracture combined injuries. Our results suggested NPY levels were increased in patients with the combined injuries, accomplished by arising of bone healing markers, such as ALP, OC, PICP and ICTP, than in those with simple fractures, and NPY have direct actions on MSCs to promote their osteogenic differentiation. Our results provided clinical evidences for NPY participating in the bone healing process in a nonhypothalamic manner, most probably by directly promoting osteogenesis of mesenchymal stem cells.
journal_name
Neuropeptidesjournal_title
Neuropeptidesauthors
Gu XC,Zhang XB,Hu B,Zi Y,Li Mdoi
10.1016/j.npep.2016.09.005subject
Has Abstractpub_date
2016-12-01 00:00:00pages
61-66eissn
0143-4179issn
1532-2785pii
S0143-4179(16)30028-2journal_volume
60pub_type
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