Comparison of soluble and membrane-bound pyroglutamyl peptidase I activities in rat brain tissues in the presence of detergents.

abstract：:Galanin and the N-terminal fragment Galanin(1-15) are involved in central cardiovascular regulation. The present paper reviews the recent cardiovascular results obtained by intracisternal injections of Galanin and Galanin(1-15) showing that: (A) the Galanin antagonist M40 blocks the central cardiovascular responses in...

journal_title：Neuropeptides

authors： Díaz-Cabiale Z,Parrado C,Vela C,Razani H,Coveñas R,Fuxe K,Narváez JA

更新日期：2005-06-01 00:00:00

abstract：:The orally active, α-hemoglobin derived hemopressin (PVNFKFLSH, Hp(1-9)) and its truncated (PVNFKFL, Hp(1-7) and PVNFKF, Hp(1-6)) and extended ((R)VDPVNFKFLSH, VD-Hp(1-9) and RVD-Hp(1-9)) derivatives have been postulated to be the endogenous peptide ligands of the cannabinoid receptor type 1 (CB1). In an attempt to cr...

journal_title：Neuropeptides

authors： Dvorácskó S,Tömböly C,Berkecz R,Keresztes A

更新日期：2016-08-01 00:00:00

abstract：:After chronic treatment with morphine, the muscular rigidity mediated by opioid receptors in the striatum, was gradually replaced by stereotypic behaviour indicating an increased nigrostriatal dopaminergic activity. These results suggest that one behavioural pattern, originating in the striatum, was replaced by anothe...

journal_title：Neuropeptides

authors： Themann P,Havemann U,Kuschinsky K

更新日期：1984-12-01 00:00:00

abstract：:This study found that dynorphin had a biphasic concentration response relationship on N-methyl-D-aspartate (NMDA) receptor-mediated currents in the CA3 region of the guinea pig hippocampal slice. A previous study demonstrated that the inhibitory effect was mediated by a kappa 2 opioid receptor. In the present study, t...

journal_title：Neuropeptides

authors： Caudle RM,Dubner R

更新日期：1998-02-01 00:00:00

abstract：:We have described the binding of [125I]endothelin-1 (ET-1) to cultured rat cerebellar granule cells. Binding of [125I]ET-1 was specific, saturable, and time-dependent. Scatchard analysis of saturation binding data indicated a single class of high affinity binding site with a KD of 95 pM, and a Bmax of 8110 receptors/c...

journal_title：Neuropeptides

authors： Lysko PG,Feuerstein G,Pullen M,Wu HL,Nambi P

更新日期：1991-02-01 00:00:00

abstract：:Recently, we demonstrated that brain neuropeptide Y (NPY) mRNA expression was increased in heat exposed chicks. However, the functions of brain NPY during heat stress are unknown. This study was conducted to investigate whether centrally administered NPY affects food intake, rectal temperature, monoamines, stress horm...

journal_title：Neuropeptides

authors： Bahry MA,Chowdhury VS,Yang H,Tran PV,Do PH,Han G,Ikeda H,Cockrem JF,Furuse M

更新日期：2017-04-01 00:00:00

abstract：:In this study guinea pig, rat and bovine striatal extracts have been shown to contain putative opioid peptide precursors in the molecular weight (Mr) range 2000-greater than 70000. The material eluting greater than 70 kDalton contained bioassayable opioid activity but not Met- or Leu-enkephalin-like immunoreactivities...

journal_title：Neuropeptides

authors： Metters KM,Beaumont A,Rossier J,Hughes J

更新日期：1985-02-01 00:00:00

abstract：:Plasma levels of ghrelin, an orexigenic peptide, are increased during conditions of chronic starvation, such as in patients with anorexia nervosa. However, it is not known whether such increase can be related to the number of preproghrelin mRNA-expressing cells in the stomach, and if chronic starvation may activate a ...

journal_title：Neuropeptides

authors： François M,Barde S,Achamrah N,Breton J,do Rego JC,Coëffier M,Hökfelt T,Déchelotte P,Fetissov SO

更新日期：2015-06-01 00:00:00

abstract：:Neuropeptide Y (NPY) has been implicated in the modulation of important features of neuronal physiology, including calcium homeostasis, neurotransmitter release and excitability. Moreover, NPY has been involved as an important modulator of hippocampal and thalamic circuits, receiving particular attention as an endogen...

journal_title：Neuropeptides

authors： Malva JO,Xapelli S,Baptista S,Valero J,Agasse F,Ferreira R,Silva AP

更新日期：2012-12-01 00:00:00

abstract：:Obesity is a global public health problem. Orexin and endocannabinoid signaling in the hypothalamus have been shown to regulate feeding and are promising molecular targets for obesity treatment. In this study, we attempted to analyze effects of orexin-A and endocannabinoid signaling modulation in the arcuate nucleus (...

journal_title：Neuropeptides

authors： Yang D,Xu L,Guo F,Sun X,Zhang D,Wang M

更新日期：2018-06-01 00:00:00

abstract：:CSF methionine and leucine enkephalins were measured by high performance liquid chromatography and radioimmunoassay in diabetic patients with painful neuropathy (n = 22) and painless neuropathy (n = 5), and non-diabetic subjects with low back pain (n = 11). Wide variations in CSF enkephalin levels were found and they ...

journal_title：Neuropeptides

authors： Chan AW,Macfarlane IA,Masson EA,Bowsher D,Morley JS,Venn RF

更新日期：1992-06-01 00:00:00

abstract：:Humanin (HN) is an endogenous 24-residue peptide. A highly potent HN derivative, S14G-HN, which has a substitution of serine 14 to glycine, reduced amyloid burden and suppressed cognitive impairment in a mouse model of Alzheimer's disease. S14G-HN also suppressed amnesia induced by a muscarinic receptor antagonist in ...

journal_title：Neuropeptides

authors： Murakami M,Nagahama M,Maruyama T,Niikura T

更新日期：2017-04-01 00:00:00

abstract：:The effect of opioid peptide, D-alanine2-leucine-enkephalin and opioid homolog peptide, des-tyrosine-methionine-enkephalin in concentrations of 1 x 10(-6) and 1 x 10(-5) M was investigated on the action potential parameters of frog sciatic nerve. Des-tyrosine-methionine-enkephalin was used as the control to prove the ...

journal_title：Neuropeptides

authors： Camlica Y,Aşkin A,Cömelekoğlu U

更新日期：2004-04-01 00:00:00

abstract：:Endomorphins are newly discovered mu-opioid receptor selective immunocompetent opioid peptides. Endomorphin 1 is predominantly distributed in brain, while endomorphin 2 is widely allocated in the spinal cord. Lately, endomorphins have been investigated as modulators of reactive oxygen and nitrogen species. Nitric oxid...

journal_title：Neuropeptides

authors： Balog T,Sarić A,Sobocanec S,Kusić B,Marotti T

更新日期：2010-02-01 00:00:00

abstract：:We studied head-injured patients assessed after admission to the hospital according to the Glasgow coma scale (3-8 points). All of them underwent surgical procedure after neuroradiological examination. Due to therapeutic problems, some of these patients had lumbar puncture on the fourth day following surgery. The cont...

journal_title：Neuropeptides

authors： Stachura Z,Obuchowicz E,Herman ZS

更新日期：1997-02-01 00:00:00

abstract：:Our previous studies showed the modulation of cocaine and amphetamine regulated transcript (CART) positive neurons and CART mRNA by adrenalectomy and corticosterone replacement in hypothalamic nuclei of male rat brain. More recently, we have shown by CART immunohistochemistry that restraint and forced swim (FS) stress...

journal_title：Neuropeptides

authors： Balkan B,Gozen O,Yararbas G,Koylu EO,Akinturk S,Kuhar MJ,Pogun S

更新日期：2006-06-01 00:00:00

abstract：:Using the latency for tail-flick after thermal stimulation we have assessed the effects of alpha-, gamma(1)- and gamma(2)-MSH on nociceptive threshold in the mice. Intracisternal injections of gamma(2)-MSH induced a distinct analgesia, while gamma(1)-MSH in the same doses gave only a minor analgesia. Intracisternal al...

journal_title：Neuropeptides

authors： Klusa V,Germane S,Svirskis S,Opmane B,Wikberg JE

更新日期：2001-02-01 00:00:00

abstract：:Development of transgenic mice overexpressing GH and GHR-KO mice with GH resistance provided novel animal models for study of the somatotropic axis and for identifying GH actions that may be relevant to its current and contemplated use in medicine and agriculture. Studies of phenotypic characteristics of these animals...

journal_title：Neuropeptides

authors： Bartke A,Chandrashekar V,Bailey B,Zaczek D,Turyn D

更新日期：2002-04-01 00:00:00

abstract：:Immune system function has been shown to be under the influence of various neuromodulators and endocrine system peptides. This in vitro study describes the stimulatory effect of thyrotropin releasing hormone (thyroliberin, TRH) on thyrotropin (TSH) release from cultured human peripheral blood monocytes. The stimulator...

journal_title：Neuropeptides

authors： Komorowski J,Stepień H,Pawlikowski M

更新日期：1993-07-01 00:00:00

abstract：:In previous studies, membranes from chicken gastrointestinal tissues failed to bind appreciable levels of 125I-APP labeled at the C-terminus. In order to address the suggestion that this was due to steric hindrance of the critical C-terminus, N-terminally labeled 125I-APP was utilized in in vitro membrane binding assa...

journal_title：Neuropeptides

authors： Adamo ML,Hazelwood RL

更新日期：1992-04-01 00:00:00

abstract：:Social recognition is the sensitive domains of complex behavior critical for identification, interpretation and storage of socially meaningful information. Social recognition develops throughout childhood and adolescent, and is affected in a wide variety of psychiatric disorders. Recently, new data appeared on the mol...

journal_title：Neuropeptides

authors： Lopatina OL,Komleva YK,Gorina YV,Olovyannikova RY,Trufanova LV,Hashimoto T,Takahashi T,Kikuchi M,Minabe Y,Higashida H,Salmina AB

更新日期：2018-12-01 00:00:00

abstract：:Multiple sclerosis (MS) is an autoimmune disease of the central nervous system characterized by brain inflammation, demyelination and axonal loss. Neuropeptide Y (NPY) has a critical role in the maintenance of homeostasis in the immune system and coping of stress condition. In the current study we analyzed 188 patient...

journal_title：Neuropeptides

authors： Mohammadi SM,Shirvani Farsani Z,Dosti R,Sahraian MA,Behmanesh M

更新日期：2016-12-01 00:00:00

abstract：OBJECTIVE:Neuropeptide Y, a widely circulating neurotransmitter, plays a pivotal role in energy balance, immunomodulation and asthma, and several NPY polymorphisms are promising genetic risk factors for asthma and obesity. We explored the associations of candidate NPY gene polymorphisms with prevalent asthma and its re...

journal_title：Neuropeptides

authors： Lu Y,Andiappan AK,Lee B,Ho R,Lim TK,Kuan WS,Goh DY,Mahadevan M,Sim TB,Wang Y,Van Bever HP,Rotzschke O,Larbi A,Ng TP

更新日期：2016-10-01 00:00:00

abstract：:Immunohistochemical tests have demonstrated for the first time the presence of endothelins in the neuroendocrine cells of fish gill. We have sought co-localization of endothelins with serotonin and neuropeptides which are regarded as neuroendocrine markers of pulmonary diffuse neuroendocrine systems in higher vertebra...

journal_title：Neuropeptides

authors： Zaccone G,Mauceri A,Fasulo S,Ainis L,Lo Cascio P,Ricca MB

更新日期：1996-02-01 00:00:00

abstract：:Morphine (M) produced a dose-related decrease in metabolic weight loss (MWL) over a three-hour period, despite the fact that it significantly enhanced locomotor activity in male mice. This conservation of energy was specific to opioid receptors because naltrexone HCl (N) blocked it. These receptors were localized main...

journal_title：Neuropeptides

authors： Henry LJ,Walker J,Margules DL

更新日期：1985-02-01 00:00:00

abstract：:Glucagon-like peptide-1 (7-36)-amide (GLP-1) is a gut peptide, which exerts significant effects on glucose homeostasis. GLP-1 and GLP-1 receptors are also widely distributed in the central nervous system. In the present study, we aimed to investigate the effects of intracerebroventricularly (i.c.v.)-injected GLP-1 on ...

journal_title：Neuropeptides

authors： Gulec G,Isbil-Buyukcoskun N,Kahveci N

更新日期：2010-08-01 00:00:00

abstract：:During neonatal development exogenous oxytocin increases ERalpha immunoreactivity in the hypothalamus of female prairie voles. The purpose of this study was to determine if the increase in ERalpha is associated with an increase in ERalpha mRNA expression and to determine if the effect is specific to ER subtype or if o...

journal_title：Neuropeptides

authors： Pournajafi-Nazarloo H,Carr MS,Papademeteriou E,Schmidt JV,Cushing BS

更新日期：2007-02-01 00:00:00

abstract：:Using field potential recording in the CA1 region of hippocampal slices from rats injected with cysteamine (200 mg/kg, s.c.), changes in activity and plasticity of Schaffer collateral-CA1 pyramidal cell synapses were examined. Extracellular field potential recording prior to and following either theta-pattern primed b...

journal_title：Neuropeptides

authors： Rostampour M,Fathollahi Y,Semnanian S,Hajizadeh S,Mirnajafizadeh J,Shafizadeh M

更新日期：2002-08-01 00:00:00

abstract：:Possible positive reinforcing and aversive effects of intraperitoneally (ip) administered substance P (SP) and its C-terminal heptapeptide analog [pGlu5, MePhe8, Sar9]-SP5-11 (DIME-C7) were investigated in rats. The 'conditioned corral preference and avoidance procedure' was used for assessing positive and negative re...

journal_title：Neuropeptides

authors： Hasenöhrl RU,Gerhardt P,Huston JP

更新日期：1990-12-01 00:00:00

abstract：:Information on the physiological functions of neuropeptide FF; NPFF, a morphine modulating octapeptide in avians is lacking. Thus, we designed a study to investigate the effects of central NPFF with particular emphasis on appetite-related processes. Cobb-500 chicks were intracerebroventricularly (ICV) injected with 0,...

journal_title：Neuropeptides

authors： Cline MA,Nandar W,Rogers JO

更新日期：2007-12-01 00:00:00