The evidence of thyroliberin/triiodothyronine control of TSH secretory response from human peripheral blood monocytes cultured in vitro.

abstract：:The neuropharmacological actions of the agonist analog D-Trp-6-LH-RH were investigated in several tests after subcutaneous administrations to male mice. The doses applied were in the range 1-1000 micrograms/kg. D-Trp-6-LH-RH doses of 10 micrograms/kg and higher induced significant analgesic effects in the hot-plate an...

journal_title：Neuropeptides

authors： Kádár T,Telegdy G,Schally AV

更新日期：1990-10-01 00:00:00

abstract：:Cholecystokinin (CCK) is co-localized with dopamine (DA) in mesolimbic neurons of the CNS and appears to selectively regulate the output of this system. In an attempt to characterize the nature of CCK interactions with mesolimbic DA-containing nerve terminals, we have investigated CCK regulation of [3H]DA overflow fro...

journal_title：Neuropeptides

authors： Vickroy TW,Bianchi BR

更新日期：1989-01-01 00:00:00

abstract：:The effects of stimulation and blockade of neurotensin receptors on striatal acetylcholine release were examined in anaesthetized rats using microdialysis. Local perfusion with neurotensin (100 nM) did not influence the release of acetylcholine. Application of neurotensin (100 nM) 30 min after haloperidol (125 microgr...

journal_title：Neuropeptides

authors： Steinberg R,Rodier D,Mons G,Gully D,Le Fur G,Soubrié P

更新日期：1995-07-01 00:00:00

abstract：:Neurokinin A (NKA) and substance P (SP) are often co-localized in small sensory neurons and have been suggested to subserve similar roles. We have now compared tissue levels of NKA and SP in rat cervical dorsal root ganglia with those in the central and peripheral terminations of the same neurons. We found that NKA co...

journal_title：Neuropeptides

authors： Bakhle YS,Bell C

更新日期：1995-04-01 00:00:00

abstract：:Morphine (M) produced a dose-related decrease in metabolic weight loss (MWL) over a three-hour period, despite the fact that it significantly enhanced locomotor activity in male mice. This conservation of energy was specific to opioid receptors because naltrexone HCl (N) blocked it. These receptors were localized main...

journal_title：Neuropeptides

authors： Henry LJ,Walker J,Margules DL

更新日期：1985-02-01 00:00:00

abstract：:Available data concerning the effect of oxytocin on memory are often inconsistent. In the present study it was found that oxytocin, intracerebroventricularly injected to adult male rats in a dose range of 1 fg-10 ng/rat immediately after a 5-minute encounter with a juvenile, significantly reduces the social investigat...

journal_title：Neuropeptides

authors： Benelli A,Bertolini A,Poggioli R,Menozzi B,Basaglia R,Arletti R

更新日期：1995-04-01 00:00:00

abstract：:The orally active, α-hemoglobin derived hemopressin (PVNFKFLSH, Hp(1-9)) and its truncated (PVNFKFL, Hp(1-7) and PVNFKF, Hp(1-6)) and extended ((R)VDPVNFKFLSH, VD-Hp(1-9) and RVD-Hp(1-9)) derivatives have been postulated to be the endogenous peptide ligands of the cannabinoid receptor type 1 (CB1). In an attempt to cr...

journal_title：Neuropeptides

authors： Dvorácskó S,Tömböly C,Berkecz R,Keresztes A

更新日期：2016-08-01 00:00:00

abstract：:The effects of graded amounts of centrally injected [intracerebroventricular, i.c.v.] oxytocin [OXT] have been studied on the steady-state level and pargyline-induced accumulation of serotonin [5-HT] in the hypothalamus, mesencephalon and dorsal hippocampus of rats. OXT only weakly affected the steady-state level of 5...

journal_title：Neuropeptides

authors： Schwarzberg H,Kovács GL,Telegdy G

更新日期：1984-03-01 00:00:00

abstract：:Pyroglutamyl diazomethyl ketone and N-benzyloxycarbonyl prolyl prolinal, specific inhibitors of pyroglutamyl peptidase I and prolyl endopeptidase respectively, were used to study the possible role of these enzymes in the regulation of thyrotropin releasing hormone turnover. In vitro thyrotropin releasing hormone relea...

journal_title：Neuropeptides

authors： Charli JL,Mendez M,Joseph-Bravo P,Wilk S

更新日期：1987-05-01 00:00:00

abstract：:Cholecystokinin (CCK) is a widely expressed neuropeptide system originally discovered in the gut. Both cerebral and peripheral neurons as well as endocrine I-cells in the small intestine process proCCK to tyrosyl-O-sulfated and α-carboxyamidated peptides. Recently, we reported that gut endocrine I-cells also synthetiz...

journal_title：Neuropeptides

authors： Agersnap M,Zhang MD,Harkany T,Hökfelt T,Rehfeld JF

更新日期：2016-12-01 00:00:00

abstract：:We have evaluated the peripheral blood natural killer (NK) cell activity and the in vitro effect of recombinant gamma-interferon (r gamma-IFN) on NK cell activity in 23 patients with a neuroendocrine tumour of the pancreas, small intestine or liver, and 23 healthy controls. Patients with a gastrinoma showed a NK cell ...

journal_title：Neuropeptides

authors： Aparicio-Pagés MN,Verspaget HW,Peña AS,Jansen JB,Lamers CB

更新日期：1991-09-01 00:00:00

abstract：:Information on the physiological functions of neuropeptide FF; NPFF, a morphine modulating octapeptide in avians is lacking. Thus, we designed a study to investigate the effects of central NPFF with particular emphasis on appetite-related processes. Cobb-500 chicks were intracerebroventricularly (ICV) injected with 0,...

journal_title：Neuropeptides

authors： Cline MA,Nandar W,Rogers JO

更新日期：2007-12-01 00:00:00

abstract：:The effects of the GABAergic drugs nipecotic acid, Gabrene, baclofen and metatolylcarbamide (MTC), when given alone or in combination at subthreshold doses with AT II also at a subthreshold dose effective on PTZ-kindling in mice were studied. PTZ-kindling was provoked by intraperitoneal (i.p.) injections of PTZ (40 mg...

journal_title：Neuropeptides

authors： Georgiev VP,Lazarova MB,Kambourova TS

更新日期：1995-01-01 00:00:00

abstract：:The regulation of neuropeptide gene expression and their receptors in a tissue specific and stimulus inducible manner will determine in part behaviour and physiology. This can be a dynamic process resulting from short term changes in response to the environment or long term modulation imposed by epigenetically determi...

journal_title：Neuropeptides

authors： Quinn JP,Warburton A,Myers P,Savage AL,Bubb VJ

更新日期：2013-12-01 00:00:00

abstract：:Nerve growth factor (NGF) was reported to be increased in the serum and skin of atopic dermatitis (AD) patients, to the extent that serum nerve growth factor levels were proposed to serve as a marker of disease severity. We studied NGF levels in the serum and dermis using skin microdialysis and attempted to correlate ...

journal_title：Neuropeptides

authors： Papoiu AD,Wang H,Nattkemper L,Tey HL,Ishiuji Y,Chan YH,Schmelz M,Yosipovitch G

更新日期：2011-12-01 00:00:00

abstract：:In vitro structure-activity studies with cholecystokinin (CCK)/gastrin-related peptides, including C- and N-terminal fragments of CCK 26-33, were undertaken in guinea pig gallbladder and ileum. The general order of potency in both smooth muscle preparations is CCK 26-33 greater than CCK 1-33 greater than 27-33 much mu...

journal_title：Neuropeptides

authors： Gaudreau P,St-Pierre S,Pert CB,Quirion R

更新日期：1987-07-01 00:00:00

abstract：:Fracture repair is a complex yet well orchestrated regenerative process involving numerous signaling and cell types including osteoblasts. Here we showed that NPY, a neurotransmitter with regulatory functions in bone homeostasis, may contribute to the post-fracture bone healing in patients with traumatic brain injury-...

journal_title：Neuropeptides

authors： Gu XC,Zhang XB,Hu B,Zi Y,Li M

更新日期：2016-12-01 00:00:00

abstract：:Spermidine is a naturally occurring endogenous polyamine synthesized from diamine putrescine. It is a well-known autophagy inducer that maintains cellular and neuronal homeostasis. Healthy brain development and function are dependent on brain polyamine concentration. Polyamines interact with the opioid system, glutama...

journal_title：Neuropeptides

authors： Ghosh I,Sankhe R,Mudgal J,Arora D,Nampoothiri M

更新日期：2020-10-01 00:00:00

abstract：:Neuropeptide Y (NPY) is known to bind to at least two types of receptors (Y1 & Y2). One type (Y2) is able to bind and undergo activation by both NPY and its C-terminal fragments with good potency while the other (Y1) requires the full length of NPY for good potency. For most NPY analogs that have been examined, potenc...

journal_title：Neuropeptides

authors： Krstenansky JL,Owen TJ,Payne MH,Shatzer SA,Buck SH

更新日期：1990-11-01 00:00:00

abstract：:Endothelins (ET) are a family of highly active neuropeptides with manifold influences via ET receptors (ETR) in both the peripheral and central nervous systems. We have shown previously that satellite glial cells (SGCs) in mouse trigeminal ganglia (TG) are extremely sensitive to ET-1 in evoking [Ca2+]in increase, appa...

journal_title：Neuropeptides

authors： Feldman-Goriachnik R,Hanani M

更新日期：2017-06-01 00:00:00

abstract：:The selectivity of a series of opioid peptides towards the mu-, delta- and kappa-opioid receptors mediating differential inhibition of electrically-induced neurotransmitter release from rat brain slices was studied, viz. cortical [3H]noradrenaline release (inhibited via mu-receptors), striatal [3H]dopamine release (in...

journal_title：Neuropeptides

authors： Mulder AH,Wardeh G,Hogenboom F,Frankhuyzen AL

更新日期：1989-08-01 00:00:00

abstract：:Guinea-pigs were chronically treated with morphine by subcutaneous implantation of a compounded morphine pellet. After 7 days, the animals were sacrificed, and the small intestine was removed and extracted for the assay of 6 neuropeptides (substance P, vasoactive intestinal peptide, galanin, dynorphin A (1-8), dynorph...

journal_title：Neuropeptides

authors： Shuttleworth CW,Murphy R

更新日期：1988-11-01 00:00:00

abstract：:The discriminative stimulus properties of the selective CCKB-receptor antagonist, L-365,260 were evaluated in rats trained to discriminate diazepam (2 mg/kg) or morphine (5 mg/kg) from vehicle, using a two-lever food reinforced technique. In the diazepam drug discrimination, the benzodiazepine-receptor agonist FG8205 ...

journal_title：Neuropeptides

authors： Jackson A,Tattersall D,Bentley G,Rycroft W,Bourson A,Hargreaves R,Tricklebank M,Iversen S

更新日期：1994-05-01 00:00:00

abstract：:Desensitization is induced by the repeated administration of high doses of substance P (SP) or hemokinin-1 (HK-1). However, little information is available about the mechanisms involved in the induction of desensitization by these peptides. Thus, to characterize this desensitization, we examined the dose-dependent eff...

journal_title：Neuropeptides

authors： Naono R,Nakayama T,Ikeda T,Matsusima O,Nishimori T

更新日期：2008-02-01 00:00:00

abstract：:The distributions of four prodynorphin-derived peptides, dynorphin A (1-17), dynorphin A (1-8), dynorphin B, and alpha-neo-endorphin were determined in 10 cortical regions and the striatum of the old world monkey (Macaca nemestrina). alpha-neo-endorphin was the most abundant peptide in both cortex and striatum. The co...

journal_title：Neuropeptides

authors： Healy DJ,Meador-Woodruff JH

更新日期：1994-11-01 00:00:00

abstract：:The effects of central (clonazepam, an agonist, and FG 7142, an inverse agonist), mixed (diazepam) or peripheral type (Ro 5-4864) benzodiazepine receptor ligands on the action of TRH on the transmurally stimulated rat duodenum and binding of [3H][3-Me-His2] TRH in the rat anterior pituitary, hypothalamus, cortex and b...

journal_title：Neuropeptides

authors： Järvinen A,Paakkari I,Männistö PT

更新日期：1991-07-01 00:00:00

abstract：:Neuropeptide Y (NPY) potentiates noradrenaline (NA)-evoked constriction of circular segments of the rabbit femoral artery. The potentiation occurs exclusively in the lower concentration-range of the agonist NA (10(-8)-3 x 10(-7) M) without any change in maximum contractile effect. NPY per se is without contractile eff...

journal_title：Neuropeptides

authors： Adamsson M,Edvinsson L

更新日期：1991-05-01 00:00:00

abstract：:The orexins (hypocretins) are lateral hypothalamic (LH) neuropeptides that have been implicated in a variety of behaviors ranging from feeding to sleep and arousal. Evidence from animal models suggests a role for orexins in reward processing and drug addiction. In the present study, we investigated the direct effect o...

journal_title：Neuropeptides

authors： Zarepour L,Fatahi Z,Sarihi A,Haghparast A

更新日期：2014-06-01 00:00:00

abstract：:Striatal neuropeptide Y-like immunoreactivity (NPY-LI) levels were investigated in naive rats after acute, subchronic (14 days) or chronic (28 days) intraperitoneal (i.p.) treatment with chlorpromazine (2 or 10mg/kg), haloperidol (0.5 or 2 mg/kg), (+/-)sulpiride (50 or 100 mg/kg) or clozapine (10 or 25 mg/kg), and in ...

journal_title：Neuropeptides

authors： Obuchowicz E,Turchan J

更新日期：1998-10-01 00:00:00

abstract：:We have used immunohistochemistry and in situ hybridization histochemistry to visualize CGRP and the mRNA encoding the CGRP precursor in the stomach. CGRP is present in nerve fibers in the mucosa. CGRP mRNA and CGRP itself are also found in non-neural cells in the lamina propria. These cells are likely to be macrophag...

journal_title：Neuropeptides

authors： Jakab G,Webster HD,Salamon I,Mezey E

更新日期：1993-02-01 00:00:00