Abstract：
:Available data concerning the effect of oxytocin on memory are often inconsistent. In the present study it was found that oxytocin, intracerebroventricularly injected to adult male rats in a dose range of 1 fg-10 ng/rat immediately after a 5-minute encounter with a juvenile, significantly reduces the social investigation time of the adult rat towards the same juvenile during a second encounter (120 min later) with two peaks of activity, at 10 fg and 1 ng/rat. Larger doses of oxytocin were ineffective. The oxytocin antagonist d(CH2)5Tyr(Me)-Orn8-vasotocin, injected 5 min before oxytocin by the same route and at the same doses, while being ineffective per se, completely abolished the memory-improving effect of a low dose of oxytocin (1 ng/rat) and, on the other hand, turned into memory-improving the effect of a high dose of oxytocin (500 ng/rat).
journal_name
Neuropeptidesjournal_title
Neuropeptidesauthors
Benelli A,Bertolini A,Poggioli R,Menozzi B,Basaglia R,Arletti Rdoi
10.1016/0143-4179(95)90029-2subject
Has Abstractpub_date
1995-04-01 00:00:00pages
251-5issue
4eissn
0143-4179issn
1532-2785pii
0143-4179(95)90029-2journal_volume
28pub_type
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