Localization of immunoreactive endothelin in the neuroendocrine cells of fish gill.

abstract：:Cholecystokinin (CCK) is co-localized with dopamine (DA) in mesolimbic neurons of the CNS and appears to selectively regulate the output of this system. In an attempt to characterize the nature of CCK interactions with mesolimbic DA-containing nerve terminals, we have investigated CCK regulation of [3H]DA overflow fro...

journal_title：Neuropeptides

authors： Vickroy TW,Bianchi BR

更新日期：1989-01-01 00:00:00

abstract：:The effect of the selective non-peptide antagonist for NK1 receptors (+/-)CP 96,345 on cellular transduction mechanisms elicited by the NK1 selective agonist [Sar9]-substance P-sulfone ([Sar9]-SP) was investigated in a stabilized culture of human skin fibroblasts (HF) and compared to the effects of two peptide antagon...

journal_title：Neuropeptides

authors： Ziche M,Parenti A,Amerini S,Zawieja D,Maggi CA,Ledda F

更新日期：1996-08-01 00:00:00

abstract：:Injection of endothelin-1 (9 pmol) into the lateral cerebral ventricle of rats produced barrel-rotations, convulsions, tonic hindlimb extensions, facial clonus, and kinetic ataxia for up to 45 min. Quantitative metabolic autoradiographs produced from the [14C]deoxyglucose method and analyzed over 60 individual brain s...

journal_title：Neuropeptides

authors： Gross PM,Wainman DS,Espinosa FJ,Nag S,Weaver DF

更新日期：1992-04-01 00:00:00

abstract：:We examined the effects of gestational cocaine treatment on oxytocin levels in the whole hippocampus (HIP), ventral tegmental area (VTA), medial preoptic area (MPOA) and amygdala (AMY) in rat dams on postpartum days (PPDs) 1 and 2. Cocaine treatment significantly reduced oxytocin levels in the MPOA within 12-16 h of d...

journal_title：Neuropeptides

authors： Johns JM,Lubin DA,Walker CH,Meter KE,Mason GA

更新日期：1997-10-01 00:00:00

abstract：:Stretching-yawning syndrome (SYS) and penile erections (PE) are typical components of the behavioral picture induced by intracerebroventricular (i.c.v.) injection of ACTH 1-24. The present study shows that pretreatment with alpha-difluoromethylornithine (DFMO), and irreversible inhibitor of mammalian ornithine decarbo...

journal_title：Neuropeptides

authors： Genedani S,Bernardi M,Bertolini A

更新日期：1984-05-01 00:00:00

abstract：:Highly purified porcine neurophysin-II, prepared from pig posterior pituitary lobe tissue was injected into fifteen rabbits in the preparation of anti-neurophysin sera. All antisera, when used in association with immunohistochemical procedures, gave an immunoreaction in structures of the rat hypothalamo-neurohypophysi...

journal_title：Neuropeptides

authors： Watkins WB

更新日期：1983-10-01 00:00:00

abstract：:Male Wistar rats were injected intraperitoneally with chlorpromazine (2 or 10 mg/kg), haloperidol (0.5 or 2 mg/kg), sulpiride (50 or 100 mg/kg) or clozapine (10 or 25 mg/kg) once, for 14 or 28 consecutive days. Hypothalamic neuropeptide Y-like (NPY-like) immunoreactivity (NPY-LI) was determined 24 h after the last dos...

journal_title：Neuropeptides

authors： Obuchowicz E

更新日期：1996-10-01 00:00:00

abstract：:In the hot plate test the intracerebroventricular (i.c.v.) injection of oxytocin produced a significant decrease in nociception, starting from the dose of 1 microgram/rat. A comparable effect was obtained with 10-200 times higher intraperitoneal (i.p.) doses. The i.c.v. injection of the oxytocin antagonist d(CH2)5-Tyr...

journal_title：Neuropeptides

authors： Arletti R,Benelli A,Bertolini A

更新日期：1993-03-01 00:00:00

abstract：:Multiple sclerosis (MS) is an autoimmune disease of the central nervous system characterized by brain inflammation, demyelination and axonal loss. Neuropeptide Y (NPY) has a critical role in the maintenance of homeostasis in the immune system and coping of stress condition. In the current study we analyzed 188 patient...

journal_title：Neuropeptides

authors： Mohammadi SM,Shirvani Farsani Z,Dosti R,Sahraian MA,Behmanesh M

更新日期：2016-12-01 00:00:00

abstract：:In an attempt to determine the localization of the messenger RNA (mRNA) encoding somatostatin in the rat retina, we studied Sprague-Dawley rats by in situ hybridization histochemistry using radiolabelled oligodeoxyribonucleotides complementary for rat somatostatin mRNA. Among the layers of retina, we found specific la...

journal_title：Neuropeptides

authors： Yamaguchi K,Gaur VP,Spira AW,Turner JE

更新日期：1990-09-01 00:00:00

abstract：:Possible positive reinforcing and aversive effects of intraperitoneally (ip) administered substance P (SP) and its C-terminal heptapeptide analog [pGlu5, MePhe8, Sar9]-SP5-11 (DIME-C7) were investigated in rats. The 'conditioned corral preference and avoidance procedure' was used for assessing positive and negative re...

journal_title：Neuropeptides

authors： Hasenöhrl RU,Gerhardt P,Huston JP

更新日期：1990-12-01 00:00:00

abstract：:Two tachykinin peptides, substance P (SP) and hemokinin-1 (HK-1), and three transient receptor potential (TRP) channels, TRPV1, TRPA1 and TRPM8, are similarly localized in the spinal dorsal horn and dorsal root ganglion, suggesting that TRP channels may be related or modulated by these tachykinin peptides. Thus, to cl...

journal_title：Neuropeptides

authors： Naono-Nakayama R,Sunakawa N,Ikeda T,Nishimori T

更新日期：2010-02-01 00:00:00

abstract：:Superfusion of the dorsal surface of the septum with artificial cerebrospinal fluid containing 10(-10) M [Arg8]-vasopressin (VP) significantly increased the negative (N) wave in field potentials (FPs) elicited in the lateral septum (LS) of rats by stimulation of the fimbria-fornix. A similar increase in the FPs negati...

journal_title：Neuropeptides

authors： Urban IJ,De Wied D

更新日期：1986-01-01 00:00:00

abstract：:The aim of the present work was to study the potential involvement of melanocortin system in the anorectic mechanism of fluoxetine, a selective serotonin reuptake inhibitors, in obese Zucker rats. Male obese Zucker (fa/fa) rats were administered fluoxetine (10 mg/kg; i.p.) daily for two weeks. The control group was gi...

journal_title：Neuropeptides

authors： Churruca I,Portillo MP,Casis L,Gutiérrez A,Macarulla MT,Echevarría E

更新日期：2008-06-01 00:00:00

abstract：:Acid extracts from mouse Neuroblastoma x rat Glioma hybrid cells have been purified by means of Sep-Pak C-18 and fractionated by high performance liquid chromatography. Each fraction has been submitted to a sensitive beta-endorphin radioimmunoassay and an immunoreactivity peak at camel beta-endorphin retention time wa...

journal_title：Neuropeptides

authors： Di Marzo V,Etienne A,Marino G,Morris HR,Palmisano A

更新日期：1985-03-01 00:00:00

abstract：:The effects of a potent serine protease inhibitor, Boc-D-Phe-Pro-Arg-H, on the secretion and content of ACTH and beta-endorphin-like immunoreactivities of cultured rat anterior pituitary cells were studied. Basal release of the hormones was not affected by the drug but secretion in response to stalk-median eminence ex...

journal_title：Neuropeptides

authors： Barna I,Gráf L,Makara GB,Rappay G

更新日期：1982-10-01 00:00:00

abstract：BACKGROUND:Chromogranin A (CgA) in plasma (P-CgA), a neuroendocrine marker of sympathetic stress, has been shown to predict mortality in medical intensive care. We hypothesized that the magnitude of CgA release would reflect stress load, and thereby injury severity in burn intensive care patients. METHODS:Fifty-one co...

journal_title：Neuropeptides

authors： Lindahl AE,Low A,Stridsberg M,Sjöberg F,Ekselius L,Gerdin B

更新日期：2013-06-01 00:00:00

abstract：:Chronic stress induces the activation of hippocampal microglia, which produces many inflammatory mediators and mediates the occurrence of depression. Two phenotypes of microglia polarization, the classical M1 and alternative M2, play important regulatory roles in neuroinflammation and are involved in the occurrence an...

journal_title：Neuropeptides

authors： Zhou S,Chen S,Xie W,Guo X,Zhao J

更新日期：2020-06-01 00:00:00

abstract：:To study the effect of septicaemia, the temporal changes in tissue adrenomedullin (AM) and preproAM mRNA levels were studied in the heart and blood vessels after lipopolysaccharide (LPS) injection. Radioimmunoassay and solution hybridization-RNase protection assays were used to follow the changes in AM and its mRNA le...

journal_title：Neuropeptides

authors： Li YY,Cheung BM,Wong LY,Hwang IS,Kumana CR,Tang F

更新日期：2005-04-01 00:00:00

abstract：:Cocaine-regulated and amphetamine-regulated transcript (CART) is a neuropeptide with reported neuroprotective effects in ischemic cerebral injury. However, its mechanism has not yet been elucidated. Herein, we investigated the role and mechanism of CART in synaptic plasticity in neurons after ischemic cerebral stroke....

journal_title：Neuropeptides

authors： Zhang Z,Cao X,Bao X,Zhang Y,Xu Y,Sha D

更新日期：2020-06-01 00:00:00

abstract：:Cerebral amyloid-beta protein (Abeta) deposition and associated neuroinflammation and apoptosis are increasingly recognized as an important component leading to cognitive impairment in Alzheimer's disease (AD). Humanin (HN) and its derivative, S14G-HN (HNG), are best known for their ability to suppress neuronal death ...

journal_title：Neuropeptides

authors： Miao J,Zhang W,Yin R,Liu R,Su C,Lei G,Li Z

更新日期：2008-10-01 00:00:00

abstract：:Neuropeptide Y (NPY) neurons abundantly innervate the hypothalamus, where NPY is involved in the regulation and integration of a broad range of homeostatic functions. In order to understand NPY-mediated behavioral, autonomic and neuroendocrine effects, it is important to characterize in detail the distribution of the ...

journal_title：Neuropeptides

authors： Fetissov SO,Kopp J,Hökfelt T

更新日期：2004-08-01 00:00:00

abstract：:Proenkephalin peptides produced by endocrine and nervous tissues are involved in stress-induced immunosuppression. However, the role of peptides produced by immune cells remains unknown. The present study examines the effect of acute and chronic foot-shock stress on proenkephalin peptide content in bone marrow (BMMC),...

journal_title：Neuropeptides

authors： Saravia F,Padros MR,Ase A,Aloyz R,Duran S,Vindrola O

更新日期：1998-08-01 00:00:00

abstract：:Release of [3H]-acetylcholine (3H-ACh) and muscle contractions in response to cholecystokinin (CCK) were measured and recorded simultaneously from isolated guinea-pig gallbladder. Cholecystokinin octapeptide (CCK8) (10(-10)-10(-7) M) enhanced the release of [3H]ACh and the contractions of the muscle. TTX (10(-6) M) in...

journal_title：Neuropeptides

authors： Rakovska A,Sgaragli G,Mantovani P,Valoti M,Milenov K

更新日期：1993-11-01 00:00:00

abstract：:We have assessed the influence of acute bilateral nephrectomy, of captopril and saralasin, on the hypotensive activity of neurotensin (NT) and of various hypotensive drugs in pentobarbital-anesthetized rats. The results show that the hypotensive activity of NT and of compound 48/80 (C48/80), in contrast to that of his...

journal_title：Neuropeptides

authors： Kérouac R,St-Pierre S,Manning M,Rioux F

更新日期：1983-04-01 00:00:00

abstract：:Kyotorphin (KTP), first isolated in the bovine brain and now having been identified in a variety of species, is known most extensively for its analgesic-like properties. KTP indirectly stimulates opioid receptors by releasing methionine enkephalin (met-enkephalin). Stimulation of opioid receptors is linked to hunger p...

journal_title：Neuropeptides

authors： Webster RI,Newmyer BA,Furuse M,Gilbert ER,Cline MA

更新日期：2013-06-01 00:00:00

abstract：:The effects of several mu and kappa opioid receptor agonists on urinary excretion were examined in the water-loaded rat. Mu agonists induced anti-diuresis whereas kappa agonists caused diuresis. Furthermore, high efficacy kappa agonists eg. U50, 488H and tifluadom, produced marked diuretic effects, whereas kappa parti...

journal_title：Neuropeptides

authors： Skingle M,Hayes AG,Tyers MB

更新日期：1985-02-01 00:00:00

abstract：:Omega Conotoxin is a peptide venom of the marine snail Conus geographus which has been postulated as a neural specific calcium channel blocker in several systems. In the present study in rat ileum strips omega-conotoxin GVIA specifically blocked neuronal responses evoked by electrical field stimulation in a dose-depen...

journal_title：Neuropeptides

authors： Allescher HD,Willis S,Schusdziarra V,Classen M

更新日期：1989-05-01 00:00:00

abstract：:CSF methionine and leucine enkephalins were measured by high performance liquid chromatography and radioimmunoassay in diabetic patients with painful neuropathy (n = 22) and painless neuropathy (n = 5), and non-diabetic subjects with low back pain (n = 11). Wide variations in CSF enkephalin levels were found and they ...

journal_title：Neuropeptides

authors： Chan AW,Macfarlane IA,Masson EA,Bowsher D,Morley JS,Venn RF

更新日期：1992-06-01 00:00:00

abstract：:The central control of feeding in animals depends upon the alternating actions of orexigenic and anorectic peptides. Studies at understanding the food intake mechanisms have emphasised the role of Neuropeptide Y as a potent orexigenic peptide in the brain. The aim of this study is to investigate the response of NPY sy...

journal_title：Neuropeptides

authors： Shewale S,Ali I,Hadawale K,Bhargava S

更新日期：2018-10-01 00:00:00