Abstract:
:Specific antagonists were used to determine NK1 and NK2 receptor mediation of the expression of c-Jun and c-Fos inducible transcription factors. (ITFs) in dorsal horn neurons. The induction of c-Jun by C-fiber stimulation was strongly reduced in the superficial laminae by NK1 and NK2 antagonists, but only weakly in the deep laminae by NK2 antagonism. c-Fos induction was reduced in all laminae by both NK1 and NK2 antagonism but less than with c-Jun. The potentiation of c-Jun expression, caused by a preceding stimulus, was abolished in all laminae by NK1 and NK2 antagonists, whereas that of c-Fos was reduced in all laminae but again less than that of c-Jun. Thus, the expressions of ITFs mediated by NK1 and NK2 receptors are complex, depending upon the neurons and stimulus considered, and they are not a measure of the neurons' electrophysiological responsiveness.
journal_name
Neuropeptidesjournal_title
Neuropeptidesauthors
Redburn JL,Leah JDdoi
10.1054/npep.1999.0005keywords:
subject
Has Abstractpub_date
1999-04-01 00:00:00pages
115-9issue
2eissn
0143-4179issn
1532-2785pii
S0143-4179(99)90005-7journal_volume
33pub_type
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