Abstract：
:The present study was undertaken in order to establish the possible involvement of melatonin in the mechanisms underlying the arginine-vasopressin (AVP) responses to physical exercise and angiotensin II (ANG II). On two mornings at least 1 week apart, normal male subjects were tested with exercise on a bicycle ergometer (the workload was gradually increased at 3-min intervals until exhaustion and lasted about 15 min in all subjects) or ANG II (60-min infusion of ANG II (Asp 1, IIe 5 angiotensin II) dissolved in 5% glucose in successively increasing doses of 4, 8, 16 ng/kg/min; each dose for 20 min). Tests were carried out with the administration of either 6 mg melatonin or placebo. Melatonin treatment neither modified the basal concentrations of AVP nor changed the AVP response to ANG II. In contrast, plasma AVP levels rose 3.6 times during exercise in the absence of melatonin, but only 2.3 times in the presence of melatonin. These data indicate an involvement of melatonin in the mechanism underlying the AVP response to physical exercise, but not ANG II, in normal men.
journal_name
Neuropeptidesjournal_title
Neuropeptidesauthors
Chiodera P,Volpi R,Capretti L,Giuliani N,Maffei ML,Coiro Vdoi
10.1016/s0143-4179(98)90027-0subject
Has Abstractpub_date
1998-04-01 00:00:00pages
125-9issue
2eissn
0143-4179issn
1532-2785pii
S0143-4179(98)90027-0journal_volume
32pub_type
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