The galanin peptide family in inflammation.

abstract：:CSF methionine and leucine enkephalins were measured by high performance liquid chromatography and radioimmunoassay in diabetic patients with painful neuropathy (n = 22) and painless neuropathy (n = 5), and non-diabetic subjects with low back pain (n = 11). Wide variations in CSF enkephalin levels were found and they ...

journal_title：Neuropeptides

authors： Chan AW,Macfarlane IA,Masson EA,Bowsher D,Morley JS,Venn RF

更新日期：1992-06-01 00:00:00

abstract：:Omega Conotoxin is a peptide venom of the marine snail Conus geographus which has been postulated as a neural specific calcium channel blocker in several systems. In the present study in rat ileum strips omega-conotoxin GVIA specifically blocked neuronal responses evoked by electrical field stimulation in a dose-depen...

journal_title：Neuropeptides

authors： Allescher HD,Willis S,Schusdziarra V,Classen M

更新日期：1989-05-01 00:00:00

abstract：:AtT-20 cells are known to synthesize two molecular weight forms of the prohormone converting enzyme PC1 with molecular masses of 87 and 66 kDa. In this study we have analyzed basal and stimulated secretion of these proteins. Western blot results show that basal secretion medium of cultured AtT-20 cells contained low c...

journal_title：Neuropeptides

authors： Vindrola O,Lindberg I

更新日期：1993-08-01 00:00:00

abstract：:Recently, we demonstrated that brain neuropeptide Y (NPY) mRNA expression was increased in heat exposed chicks. However, the functions of brain NPY during heat stress are unknown. This study was conducted to investigate whether centrally administered NPY affects food intake, rectal temperature, monoamines, stress horm...

journal_title：Neuropeptides

authors： Bahry MA,Chowdhury VS,Yang H,Tran PV,Do PH,Han G,Ikeda H,Cockrem JF,Furuse M

更新日期：2017-04-01 00:00:00

abstract：:Lysine-vasopressin (LVP) at different concentrations (2 ng, 200 pg) was injected into the lateral ventricle and cisterna magna. The effect on hypothalamic self-stimulation was studied in rats. LVP (2 ng) decreased the self-stimulation rate after intracerebroventricular and cisternal application. Injection of 200 pg LV...

journal_title：Neuropeptides

authors： Günther O,Schwarzberg H

更新日期：1987-11-01 00:00:00

abstract：:Highly purified porcine neurophysin-II, prepared from pig posterior pituitary lobe tissue was injected into fifteen rabbits in the preparation of anti-neurophysin sera. All antisera, when used in association with immunohistochemical procedures, gave an immunoreaction in structures of the rat hypothalamo-neurohypophysi...

journal_title：Neuropeptides

authors： Watkins WB

更新日期：1983-10-01 00:00:00

abstract：:The regulation of neuropeptide gene expression and their receptors in a tissue specific and stimulus inducible manner will determine in part behaviour and physiology. This can be a dynamic process resulting from short term changes in response to the environment or long term modulation imposed by epigenetically determi...

journal_title：Neuropeptides

authors： Quinn JP,Warburton A,Myers P,Savage AL,Bubb VJ

更新日期：2013-12-01 00:00:00

abstract：:Several lines of evidence indicate a role for neuropeptide Y (NPY) in the modulation of the corticotroph axis. In two separate studies reported here, the concentrations of NPY and noradrenaline (NA), as well as corticotropin-releasing factor (CRF) and arginine vasopressin (AVP), were measured in extracts of individual...

journal_title：Neuropeptides

authors： Pralong FP,Corder R,Gaillard RC

更新日期：1993-10-01 00:00:00

abstract：:The desire of the pharmaceutical industry to obtain more selective agents for the treatment of anxiety with fewer or diminished side effects and a profile consistent with safety during long-term use resulted in a search which has identified the azapirones as a new class of anxiolytics which lack structural or biochemi...

journal_title：Neuropeptides

authors： Taylor DP,Moon SL

更新日期：1991-07-01 00:00:00

abstract：:Enkephalin-immunoreactive neurons have been identified in the central nervous system of the fruit fly Drosophila melanogaster by immunocytochemical techniques. Analyses of fly extracts by high performance liquid chromatography and radioimmunoassay show a relatively complex pattern of immunoreactive compounds. The most...

journal_title：Neuropeptides

authors： Pagés M,Jiménez F,Ferrús A,Peralta E,Ramírez G,Gelpí E

更新日期：1983-12-01 00:00:00

abstract：:The present study was undertaken to determine whether neurotensin is involved in the regulation of the intestinal postprandial motor response and, if so, whether the regulatory pathway depends upon peripheral or central neurotensin secretion. Neurotensin, injected by the i.v. route (5 micrograms/kg) during the fasting...

journal_title：Neuropeptides

authors： Pellissier S,Eribon O,Chabert J,Gully D,Roche M

更新日期：1996-10-01 00:00:00

abstract：:Nociceptin-opioid peptide (NOP) receptor, also known as opioid receptor like-1 (ORL1), was identified following the cloning of the kappa-opioid peptide (KOP) receptor, and the characterization of these receptors revealed high homology. The endogenous ligand of NOP, nociceptin (NOC), which shares high homology to dynor...

journal_title：Neuropeptides

authors： Mika J,Obara I,Przewlocka B

更新日期：2011-08-01 00:00:00

abstract：:The anatomical distribution of Substance P (SP) has been investigated since the development of antibodies against it in the 1970s. Although initial studies were performed with antibodies that also recognised the other endogenous neurokinins, most of the initial descriptions are surprisingly still valid today. In this ...

journal_title：Neuropeptides

authors： Ribeiro-da-Silva A,Hökfelt T

更新日期：2000-10-01 00:00:00

abstract：:Neuropeptide Y (NPY) -receptor subtypes were studied in the rat kidney in vivo by systemic administration of NPY, the two agonists [Leu(31), Pro(34)]NPY (Y1-receptor agonist) and NPY (13-36) (Y2-receptor agonist), or the Y1-receptor antagonist BIBP 3226. Effects on mean arterial blood pressure (MAP) and renal arterial...

journal_title：Neuropeptides

authors： Modin A,Malmström RE,Meister B

更新日期：1999-08-01 00:00:00

abstract：:After chronic treatment with morphine, the muscular rigidity mediated by opioid receptors in the striatum, was gradually replaced by stereotypic behaviour indicating an increased nigrostriatal dopaminergic activity. These results suggest that one behavioural pattern, originating in the striatum, was replaced by anothe...

journal_title：Neuropeptides

authors： Themann P,Havemann U,Kuschinsky K

更新日期：1984-12-01 00:00:00

abstract：:Bombesin (BN) and its mammalian counterpart gastrin-releasing peptide act as neuroregulatory hormones and tissue-specific growth factors, and have been implicated as peripheral and central satiety-inducing agents. In the present study, the immunohistochemical expression of BN in submandibular, sublingual and parotid g...

journal_title：Neuropeptides

authors： Aalto Y,Kjörell U,Henriksson R,Franzén L,Forsgren S

更新日期：1997-04-01 00:00:00

abstract：:The effects of graded amounts of centrally injected [intracerebroventricular, i.c.v.] oxytocin [OXT] have been studied on the steady-state level and pargyline-induced accumulation of serotonin [5-HT] in the hypothalamus, mesencephalon and dorsal hippocampus of rats. OXT only weakly affected the steady-state level of 5...

journal_title：Neuropeptides

authors： Schwarzberg H,Kovács GL,Telegdy G

更新日期：1984-03-01 00:00:00

abstract：:The 36-amino-acid peptide, neuropeptide Y (NPY), is the most abundant peptide in the rat brain. When administered into the brain, NPY produces a variety of physiological actions including a pronounced stimulation of feeding in satiated rats. Elevations in hypothalamic NPY have been reported after food deprivation and ...

journal_title：Neuropeptides

authors： Gehlert DR

更新日期：1999-10-01 00:00:00

abstract：:Tachykinins are a family of pronociceptive neuropeptides with a specific role in pain and inflammation. Several mechanisms regulate endogenous tachykinins and Substance P (SP) levels, including the differential expression of protachykinin mRNA and the controlled secretion of tachykinins from neurons. Proteolysis is su...

journal_title：Neuropeptides

authors： Saidi M,Kamali S,Beaudry F

更新日期：2016-10-01 00:00:00

abstract：:A role for beta-endorphin (beta-END) in the pathophysiology of major depressive disorder (MDD) is suggested by both animal research and studies examining clinical populations. The major etiological theories of depression include brain regions and neural systems that interact with opioid systems and beta-END. Recent pr...

journal_title：Neuropeptides

authors： Hegadoren KM,O'Donnell T,Lanius R,Coupland NJ,Lacaze-Masmonteil N

更新日期：2009-10-01 00:00:00

abstract：:Considerable evidence supports the existence of modulatory interactions between cholecystokinin and dopamine in the striatum. In order to explore further the nature of such interactions, the anatomical localization of CCK receptors in rat striatum was investigated autoradiographically following selective lesions. Infu...

journal_title：Neuropeptides

authors： Beresford IJ,Hall MD,Clark CR,Hill RG,Hughes J,Sirinathsinghji DJ

更新日期：1987-08-01 00:00:00

abstract：:Levels of beta-endorphin immunoreactive material (IRM) in cerebrospinal fluid (CSF) have been reported to correlate inversely with postoperative morphine requirement. Considering proopiomelanocortin (POMC) derivatives as predictors for sensitivity to postoperative pain, we determined authentic beta-endorphin (beta-end...

journal_title：Neuropeptides

authors： Matejec R,Schulz A,Mühling J,Uhlich H,Bödeker RH,Hempelmann G,Teschemacher H

更新日期：2006-02-01 00:00:00

abstract：:Neuropeptide Y (NPY) has been implicated in the modulation of important features of neuronal physiology, including calcium homeostasis, neurotransmitter release and excitability. Moreover, NPY has been involved as an important modulator of hippocampal and thalamic circuits, receiving particular attention as an endogen...

journal_title：Neuropeptides

authors： Malva JO,Xapelli S,Baptista S,Valero J,Agasse F,Ferreira R,Silva AP

更新日期：2012-12-01 00:00:00

abstract：:Paired-pulse stimulation was used to evaluate the effects of the sulfated octapeptide of cholecystokinin (CCK8-S), the gamma-aminobutyric acidB (GABAB) agonist (-) baclofen, and the GABAA antagonist (-) bicuculline on hippocampal dentate gyrus (DG) granule cell excitability. Evoked action potentials (EAPs) and excitat...

journal_title：Neuropeptides

authors： Rich-Bennett E,Dahl D,Lecompte BB 3rd

更新日期：1993-05-01 00:00:00

abstract：:Inoculation of rats at the tail-base with Mycobacterium led to arthritic swelling and inflammation of all four limbs. Immunoreactive (ir)-dynorphin (DYN) increased in anterior but not neurointermediate pituitary. In the brain, only thalamus showed a rise and, in spinal cord, a large elevation was seen. Ir-vasopressin ...

journal_title：Neuropeptides

authors： Millan MJ,Millan MH,Pilcher CW,Colpaert FC,Herz A

更新日期：1985-02-01 00:00:00

abstract：:The galanin family currently consists of four peptides, namely galanin, galanin-message associated peptide, galanin-like peptide and alarin. Unlike galanin that signals through three different G protein-coupled receptors; GAL1, GAL2, and GAL3, binding at its N-terminal end, the cognate receptors for other members of t...

journal_title：Neuropeptides

authors： Ihnatko R,Theodorsson E

更新日期：2017-06-01 00:00:00

abstract：:The human placenta contains membrane bound opioid receptors. The binding of the antagonist naloxone and the fairly kappa-selective agonist EKC were studied in the microvillous membrane fraction. In both cases high affinity binding sites were detected with Kd values in the nanomolar range. A series of kappa-selective l...

journal_title：Neuropeptides

authors： Agbas A,Simon J,Avni Oktem H,Varga E,Borsodi A

更新日期：1988-10-01 00:00:00

abstract：:The hypocretins/orexins (hcrts) are two recently described neuropeptides derived from the same precursor and expressed in a few thousand neurons in the perifornical area of the lateral hypothalamus, which project throughout the brain. The hypocretins bind to two G-protein coupled receptors with different selective aff...

journal_title：Neuropeptides

authors： de Lecea L,Sutcliffe JG,Fabre V

更新日期：2002-04-01 00:00:00

abstract：:In situ hybridisation histochemistry was used to study the effect of intra-peritoneal reserpine administration on messenger RNA (mRNA) levels in the locus coeruleus (LC) of the rat. 48h after injection, levels of mRNA encoding tyrosine hydroxylase (TH) and neuropeptide Y (NPY) in the LC increased to approximately 250%...

journal_title：Neuropeptides

authors： Foster OJ,Biswas S,Lightman SL

更新日期：1991-03-01 00:00:00

abstract：:Social conflict and defeat in mice leads to an activation of endogenous opiate systems. The effects of intracerebroventricular administration of the peptide FMRFamide (Phe-Met-Arg-Phe-NH2) and the opiate antagonist naloxone, on aggressive encounters, defeat-induced analgesia and defeat-induced feeding were examined in...

journal_title：Neuropeptides

authors： Kavaliers M,Hirst M

更新日期：1985-12-01 00:00:00