Abstract:
:Accumulating evidence suggests that blood borne hormones modulate brain mechanisms regulating blood pressure. This appears to be mediated by the circumventricular organs which are located in the walls of the brain ventricular system and lack the blood-brain barrier. Recent evidence shows that neurons of the circumventricular organs express receptors for the majority of cardiovascular hormones. Intracerebroventricular infusions of hormones and their antagonists is one approach to evaluate the influence of blood borne hormones on the neural mechanisms regulating arterial blood pressure. Interestingly, there is no clear correlation between peripheral and central effects of cardiovascular hormones. For example, angiotensin II increases blood pressure acting peripherally and centrally, whereas peripherally acting pressor catecholamines decrease blood pressure when infused intracerebroventricularly. The physiological role of such dual hemodynamic responses has not yet been clarified. In the paper we review studies on hemodynamic effects of catecholamines, neuropeptide Y, angiotensin II, aldosterone, natriuretic peptides, endothelins, histamine and bradykinin in the context of their role in a cross-talk between peripheral and brain mechanisms involved in the regulation of arterial blood pressure.
journal_name
Neuropeptidesjournal_title
Neuropeptidesauthors
Ufnal M,Skrzypecki Jdoi
10.1016/j.npep.2014.01.003subject
Has Abstractpub_date
2014-04-01 00:00:00pages
65-73issue
2eissn
0143-4179issn
1532-2785pii
S0143-4179(14)00014-6journal_volume
48pub_type
杂志文章,评审相关文献
NEUROPEPTIDES文献大全abstract::Neural stem cells (NSC) could promote the repair after spinal cord transection (SCT), the underlying mechanism, however, still keeps to be defined. This study reported that NSC grafts significantly improved sensory and locomotor functions in adult rats with SCT in acute stage after injury. NSC could survive; different...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/j.npep.2012.06.001
更新日期:2013-02-01 00:00:00
abstract::A human brain aminopeptidase, which hydrolyses low molecular weight enkephalin-containing peptides (ECPs), was purified to apparent homogeneity from the homogenate of human brain. The enzyme purification involved DEAE-cellulose chromatography and preparative polyacrylamide gel electrophoresis. The purified aminopeptid...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(88)90033-9
更新日期:1988-08-01 00:00:00
abstract::Levels of beta-endorphin immunoreactive material (IRM) in cerebrospinal fluid (CSF) have been reported to correlate inversely with postoperative morphine requirement. Considering proopiomelanocortin (POMC) derivatives as predictors for sensitivity to postoperative pain, we determined authentic beta-endorphin (beta-end...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/j.npep.2005.10.001
更新日期:2006-02-01 00:00:00
abstract::Development of transgenic mice overexpressing GH and GHR-KO mice with GH resistance provided novel animal models for study of the somatotropic axis and for identifying GH actions that may be relevant to its current and contemplated use in medicine and agriculture. Studies of phenotypic characteristics of these animals...
journal_title:Neuropeptides
pub_type: 杂志文章,评审
doi:10.1054/npep.2002.0889
更新日期:2002-04-01 00:00:00
abstract::Pyroglutamyl peptidase I activity from soluble and membrane-bound fractions of rat brain homogenates is inhibited by the presence of sodium deoxycholate but not by triton X-100. Biobeads SM2, a polystyrene adsorbent reported to be useful in removing detergents from aqueous solutions, inhibits enzymatic activity in bot...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(95)90092-6
更新日期:1995-08-01 00:00:00
abstract::We have recently documented the expression of preprothyrotropin-releasing hormone (TRH) gene in murine, human and rat testis. Moreover, we have localized TRH to rat Leydig cells immunohistochemically, and found that both prepro TRH mRNA and TRH levels are developmentally regulated in the rat testis. To investigate the...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(94)90070-1
更新日期:1994-09-01 00:00:00
abstract::HPLC techniques were used to identify peptides that possess vasopressin-like immunoreactivity in the chicken neurohypophysis. The presence of arginine vasotocin (AVT) was confirmed together with arginine vasopressin (AVP). That the presence of AVP may be confined to the chicken, and not other avian species, was conclu...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(86)90045-4
更新日期:1986-08-01 00:00:00
abstract::To study the effect of septicaemia, the temporal changes in tissue adrenomedullin (AM) and preproAM mRNA levels were studied in the heart and blood vessels after lipopolysaccharide (LPS) injection. Radioimmunoassay and solution hybridization-RNase protection assays were used to follow the changes in AM and its mRNA le...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/j.npep.2004.11.002
更新日期:2005-04-01 00:00:00
abstract::The aim of the present work was to study the potential involvement of melanocortin system in the anorectic mechanism of fluoxetine, a selective serotonin reuptake inhibitors, in obese Zucker rats. Male obese Zucker (fa/fa) rats were administered fluoxetine (10 mg/kg; i.p.) daily for two weeks. The control group was gi...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/j.npep.2008.02.002
更新日期:2008-06-01 00:00:00
abstract::Somatostatin is a neuropeptide that in several experimental models of epilepsy has been suggested to modulate epileptic activity. The purpose of the present study was to investigate the role of somatostatin in seizure phenomena. We measured the somatostatin-like immunoreactivity (SLI) by radioimmunoassay of the cister...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(87)90027-8
更新日期:1987-01-01 00:00:00
abstract::Oxytocin, intraperitoneally injected to 26-month-old male rats 60 min before testing, significantly improved social memory (at doses of 3 and 6 ng/kg) and reduced the duration of immobility in the behavioral despair test (at doses of 50 and 500 micrograms/kg). These results are in agreement with previous data obtained...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(95)90021-7
更新日期:1995-09-01 00:00:00
abstract::The effects of central (clonazepam, an agonist, and FG 7142, an inverse agonist), mixed (diazepam) or peripheral type (Ro 5-4864) benzodiazepine receptor ligands on the action of TRH on the transmurally stimulated rat duodenum and binding of [3H][3-Me-His2] TRH in the rat anterior pituitary, hypothalamus, cortex and b...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(91)90112-v
更新日期:1991-07-01 00:00:00
abstract::Spermidine is a naturally occurring endogenous polyamine synthesized from diamine putrescine. It is a well-known autophagy inducer that maintains cellular and neuronal homeostasis. Healthy brain development and function are dependent on brain polyamine concentration. Polyamines interact with the opioid system, glutama...
journal_title:Neuropeptides
pub_type: 杂志文章,评审
doi:10.1016/j.npep.2020.102083
更新日期:2020-10-01 00:00:00
abstract::Hypertension is still presently the number one "silent killer" in the Western World, and a major risk factor for the development of secondary diseases contributing to cardiovascular disease (CVD). However, despite a broad range of therapies, the mechanisms involved in the onset of hypertension remains unclear, therefo...
journal_title:Neuropeptides
pub_type: 杂志文章,评审
doi:10.1016/j.npep.2010.12.002
更新日期:2011-04-01 00:00:00
abstract:OBJECTIVES:Postmenopausal osteoporosis (PMO) is a metabolic skeletal disorder with impaired bone density and bone quality in postmenopausal women. The aim of the present study was to investigate the correlation between neuropeptides, bone microstructure and pain threshold in ovariectomized (OVX) rats. METHODS:Female r...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/j.npep.2019.101995
更新日期:2020-06-01 00:00:00
abstract:OBJECTIVE:Potential physiological correlates of stress and the role of stress neuropeptides, other than those of the hypothalamic-pituitary-adrenal axis, in critical illness have not been addressed. We investigated: (a) serum levels of stress neuropeptides (ACTH, substance P (SP), neuropeptide Y (NPY), cortisol, prolac...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/j.npep.2012.07.007
更新日期:2013-02-01 00:00:00
abstract::Immunoreactive substance P (SPI) and somatostatin (SOMI) are found in spinal cord but their physiological roles remain speculative. Several classes of neuropeptides, including endogenous opioids and thyrotropin-releasing hormone (TRH), have been implicated in the pathogenesis or recovery from spinal cord injury. In th...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(85)90092-7
更新日期:1985-06-01 00:00:00
abstract::Neuropeptide Y (NPY) has been implicated in the modulation of important features of neuronal physiology, including calcium homeostasis, neurotransmitter release and excitability. Moreover, NPY has been involved as an important modulator of hippocampal and thalamic circuits, receiving particular attention as an endogen...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/j.npep.2012.09.001
更新日期:2012-12-01 00:00:00
abstract::Plasma protein extravasation in the upper airways of anesthetized guinea pigs was measured with the FITC (Fluorescein isothiocyanate)-dextran technique. The effect of selective tachykinin (NK1 and NK2) receptor agonists and antagonists, capsaicin or antigen was studied. The tachykinin NK1 receptor agonist, [Sar9]subst...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/s0143-4179(97)90022-6
更新日期:1997-02-01 00:00:00
abstract::Cholecystokinin-B (CCK-8) is an octapeptide that was initially described in the gastrointestinal tract. Recent studies have shown that this peptide also has an extensive distribution in the central nervous system, including the cerebellum of the opossum. In addition to the protein, binding sites for CCK-8 also have be...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/s0143-4179(96)90035-9
更新日期:1996-12-01 00:00:00
abstract::Lumbar disc herniation is a common cause of radicular pain, but the mechanism remains ambiguous and the treatment stays unsatisfied. Many studies revealed a traditional Chinese medicine puerarin may moderate chronic pain from diabetes and nerve injury. Thus far, the role and mechanism of puerarin in radicular pain is ...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/j.npep.2018.10.001
更新日期:2018-12-01 00:00:00
abstract::Perivascular sensory nerves release calcitonin gene-related peptide (CGRP) and substance P, the dilator actions of which can be regulated by nitric oxide (NO). This study investigated the role of NO in the vasodilation caused by sensory nerve stimulation, by capsaicin, or exogenous CGRP and substance P in the isolated...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/s0143-4179(97)90068-8
更新日期:1997-08-01 00:00:00
abstract::Guinea-pigs were chronically treated with morphine by subcutaneous implantation of a compounded morphine pellet. After 7 days, the animals were sacrificed, and the small intestine was removed and extracted for the assay of 6 neuropeptides (substance P, vasoactive intestinal peptide, galanin, dynorphin A (1-8), dynorph...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(88)90063-7
更新日期:1988-11-01 00:00:00
abstract::Experiments were performed to determine whether the renal nerve mediates the renin release induced by intracerebroventricular administration of angiotensin II (ANG II), bradykinin (BK), leucine-enkephalin (Leu-ENK) and neurotensin (NT). In sham-operated rats, both ANG II and NT suppressed plasma renin activity (PRA), ...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(85)90142-8
更新日期:1985-09-01 00:00:00
abstract::We examined gene expression of corticotropin-releasing hormone and neuropeptide Y level in the hypothalamic paraventricular nucleus of mouse bearing a human oral squamous cell carcinoma. A cell line derived from a human oral squamous cell carcinoma was inoculated into the lower dorsal area of nude mice. Body weight, t...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/j.npep.2004.07.004
更新日期:2004-12-01 00:00:00
abstract::In equilibrium binding studies, using 3H-etorphine and 3H-diprenorphine, digitonin extracts of frog brain membranes are found to contain two classes of sites, one of which is seen only in the presence of Na+ ions. Centrifugation of the extracts in sucrose gradients separates two macromolecular components (10S and 12S)...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(84)90044-1
更新日期:1984-12-01 00:00:00
abstract::The intracerebrally administered dynorphin-B produced not only an antinociceptive response but a motor dysfunction such as "barrel-rolling", circling, jumping or ataxia in mice. These two effects were observed in a same dose range. Both responses were also produced by a nonopioid fragment, des-Tyr-dynorphin-B. Bestati...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(89)90082-6
更新日期:1989-05-01 00:00:00
abstract::Since there are conflicting reports regarding the effects of somatostatin (SS) on cyclic AMP levels in astrocytes derived from rat cerebral cortex and, to date, the SS binding to mature astrocytes is unknown, the present study has determined SS binding and its effect on cyclic AMP accumulation in a fresh astrocyte-ric...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(92)90002-e
更新日期:1992-09-01 00:00:00
abstract::A series of biologically active peptides and related compounds (opioid peptides, neurotensin, and bradykinin) were used as substrates or competitive inhibitors to study the structural requirements for peptide interaction with endopeptidase 22.19. The kinetics of hydrolysis of these peptides indicated that, in contrast...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(94)90083-3
更新日期:1994-04-01 00:00:00
abstract::Two tachykinin peptides, substance P (SP) and hemokinin-1 (HK-1), and three transient receptor potential (TRP) channels, TRPV1, TRPA1 and TRPM8, are similarly localized in the spinal dorsal horn and dorsal root ganglion, suggesting that TRP channels may be related or modulated by these tachykinin peptides. Thus, to cl...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/j.npep.2009.10.002
更新日期:2010-02-01 00:00:00