Abstract:
:The chromosome damage induced by carboplatin (CBDCA) was evaluated in vitro. In human lymphocytes 5 micrograms/ml CBDCA produced a 7-fold increase in the frequency of sister chromatid exchanges (SCE) and a 3-fold increase in the number of cells with structural abnormalities compared with the control. Likewise, at this highest dose a significant increase was induced in the value of micronuclei (MN) and an important delay in the lymphocyte cycle progression was observed. In Chinese hamster ovary (CHO) cells, CBDCA showed a significant increase in chromosome aberrations (CA) at the doses assayed. The increase of SCE, CA and MN by CBDCA remained much lower than that produced by mitomycin C (positive control). The results suggest that CBDCA is a DNA-damaging drug with similar behaviour as an alkylating agent.
journal_name
Toxicol Lettjournal_title
Toxicology lettersauthors
González Cid M,Mudry M,Larripa Idoi
10.1016/0378-4274(94)03202-isubject
Has Abstractpub_date
1995-03-01 00:00:00pages
97-103issue
2eissn
0378-4274issn
1879-3169pii
037842749403202Ijournal_volume
76pub_type
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