Abstract：
:The microRNA-200 (miR-200) family has been reported to be vital for the inhibition of epithelial-to-mesenchymal transition (EMT) in tumor cells. The miR-200 family represents a complex multi-factorial regulatory network which has not been well described in breast cancer. This study aimed to clarify the underlying regulatory association between IL-8 and miR-200 family in the process of EMT in breast cancer cell. In estrogen-receptor (ER) positive breast cancer cell line MCF-7, IL-8 overexpression cells were performed by lentivirus transfection as endogenous regulation with additional exogenous IL-8 stimulation. Transient overexpressions of miR-200 family were performed after endogenous or exogenous IL-8 overexpression in MCF-7 cells. IL-8 knockdown cells were constructed via siRNA and shRNA transfection in triple negative breast cancer cell line MDA-MB-231. N-cadherin, vimentin and ZEB2 were down-regulated and E-cadherin was up-regulated in IL-8 knockdown group compared with control group. On the other hand, N-cadherin, vimentin and ZEB2 were up-regulated and E-cadherin was down-regulated in IL-8 overexpression group compared with control group. This indicated IL-8 promotes EMT in breast cancer cells. Transwell assay showed that IL-8 increased the migration and invasiveness of tumor cells. Furthermore, we performed transient overexpression of miR-200 family after endogenous or exogenous IL-8 overexpression in MCF-7 cells, which showed that the miR-200 family could inhibit EMT induced by IL-8. IL-8 promoted EMT via downregulation of miR-200 family expression in breast cancer cells and increases tumor cell migration and invasion.
journal_name
Technol Cancer Res Treatjournal_title
Technology in cancer research & treatmentauthors
Zhang J,Shao N,Yang X,Xie C,Shi Y,Lin Ydoi
10.1177/1533033820979672subject
Has Abstractpub_date
2020-01-01 00:00:00pages
1533033820979672eissn
1533-0346issn
1533-0338journal_volume
19pub_type
杂志文章abstract：:Stereotactic body radiation therapy is a well-tolerated modality for the treatment of primary and metastatic liver lesions, and fiducials are often used as surrogates for tumor tracking during treatment. We evaluated respiratory-induced liver deformation by measuring the rigidity of the fiducial configuration during t...
journal_title：Technology in cancer research & treatment
pub_type： 杂志文章
doi：10.1177/1533034616687193
更新日期：2017-12-01 00:00:00
abstract：:Since "Warburg effect" has been firstly uncovered in cancer cells in 1956, mounting evidence has supported the molecular mechanism underlying the energy metabolism in induced chemoresistance in cancers. MicroRNAs can mediate fine-tuning of genes in physiological process. MicroRNAs' energy metabolic role in chemoresist...
journal_title：Technology in cancer research & treatment
pub_type： 杂志文章,评审
doi：10.1177/1533033818805997
更新日期：2018-01-01 00:00:00
abstract：:Two noninvasive methods, thermography and laser Doppler imaging (LDI), were assessed for their ability to quantitatively assess parameters of vascularity in lesions of HIV-associated Kaposi's sarcoma (KS). Thermography and LDI images of a representative KS lesion were recorded in 16 patients and compared to normal ski...
journal_title：Technology in cancer research & treatment
pub_type： 杂志文章
doi：10.1177/153303460400300506
更新日期：2004-10-01 00:00:00
abstract：:Non-thermal irreversible electroporation (N-TIRE) has shown promise as an ablative therapy for a variety of soft-tissue neoplasms. Here we describe the therapeutic planning aspects and first clinical application of N-TIRE for the treatment of an inoperable, spontaneous malignant intracranial glioma in a canine patient...
journal_title：Technology in cancer research & treatment
pub_type： 杂志文章
doi：10.7785/tcrt.2012.500181
更新日期：2011-02-01 00:00:00
abstract：:Chemo-radiotherapy is standard treatment of stage IIIA-N2 bulky or IIIB non-small cell lung cancer (NSCLC). Surgical resection of residual disease in downstaged patients may improve overall survival. In this setting, restaging disease is still a challenge. 18F-FDG PET/CT represents the gold standard although accuracy ...
journal_title：Technology in cancer research & treatment
pub_type： 杂志文章
doi：10.7785/tcrt.2012.500437
更新日期：2015-12-01 00:00:00
abstract：BACKGROUND:Disabled homolog 2-interacting protein is a new member of the Ras GTPase superfamily involved in the regulation of cell proliferation, apoptosis, and metastasis. However, the expression of disabled homolog 2-interacting protein in renal cell carcinoma, its correlation with cancer prognosis, and tumor infiltr...
journal_title：Technology in cancer research & treatment
pub_type： 杂志文章
doi：10.1177/1533033820936682
更新日期：2020-01-01 00:00:00
abstract：:Electrochemotherapy is an effective antitumor treatment employing locally applied high voltage electric pulses delivered through conductive electrodes to the tumor in combination with chemotherapeutic drugs. The efficiency of electrochemotherapy strongly depends on the local electric field distribution inside the targ...
journal_title：Technology in cancer research & treatment
pub_type： 杂志文章
doi：10.1177/153303460800700507
更新日期：2008-10-01 00:00:00
abstract：:This successor phase II study evaluates the tolerability and efficacy of concomitant hyperfractionated radiation therapy (HFX-RT) and double dose intra-arterial (IA) cisplatin in patients with locally advanced squamous cell carcinoma of the head and neck (SCCHN). In doing so, this study represents further resurgence o...
journal_title：Technology in cancer research & treatment
pub_type： 临床试验,杂志文章
doi：10.1177/153303460200100206
更新日期：2002-04-01 00:00:00
abstract：:Tumor-infiltrating immune cells are part of a complex microenvironment and associated with improved clinical outcomes in a broad range of tumor types. However, a detailed map for the prognostic landscape of tumor-infiltrating immune cells and immune checkpoint modulators in glioblastoma is still lacking. Here, with th...
journal_title：Technology in cancer research & treatment
pub_type： 杂志文章
doi：10.1177/1533033819869949
更新日期：2019-01-01 00:00:00
abstract：PURPOSE:To develop and evaluate an automatic intensity-modulated radiation therapy (IMRT) program for cervical cancer, including a Convolution Neural Network (CNN)-based prediction model and an automated optimization strategy. METHODS:A CNN deep learning model was trained to predict a patient-specify set of IMRT objec...
journal_title：Technology in cancer research & treatment
pub_type： 杂志文章
doi：10.1177/1533033820957002
更新日期：2020-01-01 00:00:00
abstract：:Histological differentiation is a major pathological criterion indicating the risk of tumor invasion and metastasis in patients with hepatocellular carcinoma. The degree of tumor differentiation is controlled by a complex interacting network of associated proteins. The principal aim of the present study is to identify...
journal_title：Technology in cancer research & treatment
pub_type： 杂志文章
doi：10.1177/1533034617732426
更新日期：2017-12-01 00:00:00
abstract：PURPOSE:To investigate the role of intensity-modulated proton therapy (IMPT) for hepatocellular carcinoma (HCC) patients to be treated with stereotactic body radiation therapy (SBRT) in a risk-adapted dose prescription regimen. METHODS:A cohort of 30 patients was retrospectively selected as "at-risk" of dose de-escala...
journal_title：Technology in cancer research & treatment
pub_type： 杂志文章
doi：10.1177/1533033820980412
更新日期：2020-01-01 00:00:00
abstract：:This paper models steady state acoustic release of Doxorubicin (Dox) from Pluronic P105 micelles using Artificial Neural Networks (ANN). Previously collected release data were compiled and used to train, validate, and test an ANN model. Sensitivity analysis was then performed on the following operating conditions: ult...
journal_title：Technology in cancer research & treatment
pub_type： 杂志文章
doi：10.1177/153303460700600107
更新日期：2007-02-01 00:00:00
abstract：:Growing evidence suggests that aberration of the DNA repair pathway significantly contributes to tumorigenesis. Single-nucleotide polymorphisms in DNA repair-related genes such as WRN have been implicated in cancer risk. However, the results of published studies remain inconclusive. Therefore, we performed a meta-anal...
journal_title：Technology in cancer research & treatment
pub_type： 杂志文章,meta分析
doi：10.1177/1533034614561359
更新日期：2016-02-01 00:00:00
abstract：:Blood flow is a key parameter in studying cancer angiogenesis and hypermetabolism. Current photoacoustic blood flow estimation methods focus on either the axial or transverse component of the flow vector. However, the Doppler angle (beam-to-flow angle) is needed to calculate the total flow speed, and it cannot always ...
journal_title：Technology in cancer research & treatment
pub_type： 杂志文章
doi：10.7785/tcrt.2012.500278
更新日期：2012-08-01 00:00:00
abstract：:This review addresses the epidemiology, historical reports, current issues, data and controversies involved in the management of brain metastases. The literature regarding surgery, whole brain radiation therapy, stereotactic radiosurgery or some combination of those treatments is discussed as well as issues of cost-ef...
journal_title：Technology in cancer research & treatment
pub_type： 杂志文章,评审
doi：10.1177/153303460300200205
更新日期：2003-04-01 00:00:00
abstract：:Dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) is able to detect breast cancer with high sensitivity. Furthermore, this method provides functional information on tissue composition and vascularization. This study aims to identify the potential of DCE-MRI to predict distant metastasis in breast cancer p...
journal_title：Technology in cancer research & treatment
pub_type： 杂志文章
doi：10.7785/tcrt.2012.500266
更新日期：2012-12-01 00:00:00
abstract：:Endoscopic endonasal surgery (EES) has been shown to be a feasible approach to cranial base tumors while reducing post-operative morbidity. Using the endoscopic endonasal approach alone or in combination with open approaches may provide advantages over conventional approaches. However, the balance between maximal rese...
journal_title：Technology in cancer research & treatment
pub_type： 杂志文章
doi：10.1177/153303461000900507
更新日期：2010-10-01 00:00:00
abstract：:Our results indicate that the surface chemistry, composition, and 3-D structure of nanoparticles are critical in determining their in vivo biodistribution, and therefore the efficacy of nanodevice imaging and therapies. We demonstrate that gold/dendrimer nanocomposites in vivo, present biodistribution characteristics ...
journal_title：Technology in cancer research & treatment
pub_type： 杂志文章
doi：10.1177/153303460500400604
更新日期：2005-12-01 00:00:00
abstract：:We have constructed a multimodal contrast agent suitable for near-infrared, NIR, fluorescent imaging as well as magnetic resonance imaging, MRI. This class of agents may be useful for preoperative tumor localization and tumor functional evaluation and for intraoperative delineation of tumor margins. We have covalently...
journal_title：Technology in cancer research & treatment
pub_type： 杂志文章
doi：10.1177/153303460600500401
更新日期：2006-08-01 00:00:00
abstract：OBJECTIVE:Acute myeloid leukemia (AML) represents a hematological cancer. The aim of the investigation was to probe the regulatory relevance of long non-coding RNA (lncRNA) aspartyl-tRNA synthetase anti-sense 1 (DARS-AS1)/microRNA-425 (miR-425)/transforming growth factor-beta 1 (TGFB1) to the development of AML. METHO...
journal_title：Technology in cancer research & treatment
pub_type： 杂志文章
doi：10.1177/1533033820965580
更新日期：2020-01-01 00:00:00
abstract：:Tumstatin (Tum) is a powerful angiostatin that inhibits proliferation and induces apoptosis of tumorous vascular endothelial cells. A nonpathogenic and anaerobic bacterium, Bifidobacterium longum (BL), selectively localizes to and proliferates in the hypoxia location within solid tumor. The aims of this study were to ...
journal_title：Technology in cancer research & treatment
pub_type： 杂志文章
doi：10.1177/1533034615581977
更新日期：2016-06-01 00:00:00
abstract：:Optical mammography is one of several new techniques for breast cancer detection and characterization presently under development for clinical use that provide information other than morphologic, in particular on the biochemical and metabolic state of normal and diseased tissue. In breast tissue, scattering of red to ...
journal_title：Technology in cancer research & treatment
pub_type： 杂志文章
doi：10.1177/153303460500400503
更新日期：2005-10-01 00:00:00
abstract：OBJECTIVE:The incidence of colorectal cancer is increasing every year, and autophagy may be related closely to the pathogenesis of colorectal cancer. Autophagy is a natural catabolic mechanism that allows the degradation of cellular components in eukaryotic cells. However, autophagy plays a dual role in tumorigenesis. ...
journal_title：Technology in cancer research & treatment
pub_type： 杂志文章
doi：10.1177/1533033820984177
更新日期：2020-01-01 00:00:00
abstract：:At external beam radiotherapy, stereoscopic X-ray imaging system is responsible as tumor motion information provider. This system takes X-ray images intermittently from tumor position (1) at pretreatment step to provide training data set for model construction and (2) during treatment to control the accuracy of correl...
journal_title：Technology in cancer research & treatment
pub_type： 杂志文章
doi：10.1177/1533034616638803
更新日期：2017-04-01 00:00:00
abstract：:Glypican-3 has been reported to be one of the most promising serum markers for hepatocellular carcinoma. This study aimed to assess the clinical utility of serum glypican 3 for the diagnosis of hepatocellular carcinoma. We recruited consecutive patients on a large scale, 283 with hepatocellular carcinoma, 445 with chr...
journal_title：Technology in cancer research & treatment
pub_type： 杂志文章
doi：10.1177/1533034615605248
更新日期：2016-12-01 00:00:00
abstract：BACKGROUND:The incidence of nasopharyngeal carcinoma is increasing gradually, but the pathogenesis is not completely clear. MicroRNA, a highly conserved endogenous noncoding small molecule RNA, plays an essential role in the regulation of gene expression and is a hotspot in cancer research worldwide. OBJECTIVES:Althou...
journal_title：Technology in cancer research & treatment
pub_type： 杂志文章
doi：10.1177/1533033819892251
更新日期：2020-01-01 00:00:00
abstract：PURPOSE:The study was aimed to compare online 6 degree-of-freedom image registrations of TrueBeam cone-beam computed tomography and BrainLab ExacTrac X-ray imaging systems for intracranial radiosurgery. METHODS:Phantom and patient studies were performed on a Varian TrueBeam STx linear accelerator (version 2.5), which ...
journal_title：Technology in cancer research & treatment
pub_type： 杂志文章
doi：10.1177/1533034616683069
更新日期：2017-06-01 00:00:00
abstract：:The aim of this paper is to study the feasibility for determining the individual internal target volume (ITV) for hepatocellular carcinoma (HCC) using 3DCT associated with active breathing coordinator (ABC), comparing the ITVs defined by 3DCT associated with ABC and 4DCT. Thirteen patients with HCC after transarterial...
journal_title：Technology in cancer research & treatment
pub_type： 杂志文章
doi：10.1177/153303461101000610
更新日期：2011-12-01 00:00:00
abstract：:Breast cancer remains one of the leading causes of cancer-associated death in women. MiR-27a is highly expressed in breast cancer tissue. However, the underlying mechanisms that promote breast cancer progression are unknown. In this study, we investigated the regulatory mechanisms of miR-27a and its target glycogen Sy...
journal_title：Technology in cancer research & treatment
pub_type： 杂志文章
doi：10.1177/1533033820965576
更新日期：2020-01-01 00:00:00
