Abstract:
:Non-thermal irreversible electroporation (N-TIRE) has shown promise as an ablative therapy for a variety of soft-tissue neoplasms. Here we describe the therapeutic planning aspects and first clinical application of N-TIRE for the treatment of an inoperable, spontaneous malignant intracranial glioma in a canine patient. The N-TIRE ablation was performed safely, effectively reduced the tumor volume and associated intracranial hypertension, and provided sufficient improvement in neurological function of the patient to safely undergo adjunctive fractionated radiotherapy (RT) according to current standards of care. Complete remission was achieved based on serial magnetic resonance imaging examinations of the brain, although progressive radiation encephalopathy resulted in the death of the dog 149 days after N-TIRE therapy. The length of survival of this patient was comparable to dogs with intracranial tumors treated via standard excisional surgery and adjunctive fractionated external beam RT. Our results illustrate the potential benefits of N-TIRE for in vivo ablation of undesirable brain tissue, especially when traditional methods of cytoreductive surgery are not possible or ideal, and highlight the potential radiosensitizing effects of N-TIRE on the brain.
journal_name
Technol Cancer Res Treatjournal_title
Technology in cancer research & treatmentauthors
Garcia PA,Pancotto T,Rossmeisl JH Jr,Henao-Guerrero N,Gustafson NR,Daniel GB,Robertson JL,Ellis TL,Davalos RVdoi
10.7785/tcrt.2012.500181subject
Has Abstractpub_date
2011-02-01 00:00:00pages
73-83issue
1eissn
1533-0346issn
1533-0338pii
c4311/c4312/Non-Thermal-Irreversible-Electroporatijournal_volume
10pub_type
杂志文章abstract::Complement 3a (C3a) and complement 5a (C5a), small cleavage fragments generated by complement activation, has been previously shown to be obviously up-regulated in highly metastatic hepatocellular carcinoma (HCC) cells. However, their functional roles in HCC cells remains unclear. Here, we investigated the biological ...
journal_title:Technology in cancer research & treatment
pub_type: 杂志文章
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abstract:OBJECTIVE:The aim of the study was to investigate the prognostic role of neutrophil to lymphocyte ratio in ovarian cancer. Growing number of articles reported the relationship between neutrophil to lymphocyte ratio and prognosis in ovarian cancer, but the results remains inconclusive. The meta-analysis was conducted to...
journal_title:Technology in cancer research & treatment
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abstract::Stereotactic radiosurgery (SRS) refers to a single radiation treatment delivering a high dose to an intra-cranial target localized in three-dimensions by CT and/or MRI imaging. Traditionally, immobilization of the patient's head has been achieved using a rigid stereotactic head frame as the key step in allowing for ac...
journal_title:Technology in cancer research & treatment
pub_type: 杂志文章,评审
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journal_title:Technology in cancer research & treatment
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journal_title:Technology in cancer research & treatment
pub_type: 临床试验,杂志文章
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pub_type: 临床试验,杂志文章,多中心研究
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journal_title:Technology in cancer research & treatment
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