Importance of contact surface between electrodes and treated tissue in electrochemotherapy.

Abstract:

:Electrochemotherapy is an effective antitumor treatment employing locally applied high voltage electric pulses delivered through conductive electrodes to the tumor in combination with chemotherapeutic drugs. The efficiency of electrochemotherapy strongly depends on the local electric field distribution inside the target tissue. For successful therapy the entire target tissue has to be exposed to the local electric field strength above the reversible threshold. The aim of this study is to demonstrate the influence of the contact surface between electrode and treated tissue on the coverage of the tumor tissue by sufficiently high local electric field. The electric field distribution is calculated by means of numerical modeling using finite element method. Numerical results are confirmed with in vivo experiments. We demonstrated that the placement of electrodes giving larger electrode-tissue contact surface leads to improved electrochemotherapy outcome. Our results provide guidance on electrochemotherapy for treatment of protruding cutaneous tumors using parallel plate electrodes.

authors

Corovic S,Al Sakere B,Haddad V,Miklavcic D,Mir LM

doi

10.1177/153303460800700507

subject

Has Abstract

pub_date

2008-10-01 00:00:00

pages

393-400

issue

5

eissn

1533-0346

issn

1533-0338

pii

d=3032&c=4269&p=16838&do=detail

journal_volume

7

pub_type

杂志文章
  • Influence of iMRI-guidance on the extent of resection and survival of patients with glioblastoma multiforme.

    abstract::Intraoperative MRI (iMRI) is used in glioma surgery mainly to determine the extent of resection, allowing surgeons to immediately continue resection in case of residual tumor tissue. The aim of this study is to report on the influence of the use of iMRI on the extent of resection and survival of patients with glioblas...

    journal_title:Technology in cancer research & treatment

    pub_type: 杂志文章

    doi:10.1177/153303461000900404

    authors: Senft C,Franz K,Blasel S,Oszvald A,Rathert J,Seifert V,Gasser T

    更新日期:2010-08-01 00:00:00

  • Clinical Characteristics and Prognostic Analysis of Patients With Signet Ring Cell Gastric Carcinoma.

    abstract::We do not know the clinical and prognostic factors that influence the survival of patients with gastric signet ring cell carcinoma (SRC). Therefore, a retrospective review was undertaken of 219 patients with SRC who had undergone gastrectomy between January 2009 and December 2012 in our hospital. Patient age, sex, TNM...

    journal_title:Technology in cancer research & treatment

    pub_type: 杂志文章

    doi:10.1177/1533033820983812

    authors: Yu JM,Zhan ZW,Zhen JX,Wang XJ,Chen Y,Lin J,Chen L,Chen LZ,Huang YF,Guo ZQ

    更新日期:2020-01-01 00:00:00

  • Novel Cancer Stem Marker and Its Applicability for Grading Primary Human Gliomas.

    abstract::Poorly differentiated cell populations including tumor-initiating stem cells have been demonstrated to display a unique ability to natively internalize fragmented double-stranded DNA. Using this feature as a marker, we show that 0.1% to 6% of human glioblastoma cells from the bioptates can effectively internalize a fl...

    journal_title:Technology in cancer research & treatment

    pub_type: 杂志文章

    doi:10.1177/1533034617753812

    authors: Dolgova EV,Mishinov SV,Proskurina AS,Potter EA,Efremov YR,Bayborodin SI,Tyrinova TV,Stupak VV,Ostatin AA,Chernykh ER,Bogachev SS

    更新日期:2018-01-01 00:00:00

  • High energy shock waves (HESW) increase paclitaxel efficacy in a syngeneic model of breast cancer.

    abstract::The combined effect of high energy shock waves (HESW), generated by a piezoelectric device, and paclitaxel on Mat B-III rat breast cancer cells in vitro and in an in vivo animal model is presented. A significant reduction of in vitro Mat B-III cell proliferation versus cells treated with paclitaxel alone was observed ...

    journal_title:Technology in cancer research & treatment

    pub_type: 杂志文章

    doi:10.1177/153303460800700204

    authors: Canaparo R,Serpe L,Zara GP,Chiarle R,Berta L,Frairia R

    更新日期:2008-04-01 00:00:00

  • Quantitative assessment of tumor vasculature and response to therapy in kaposi's sarcoma using functional noninvasive imaging.

    abstract::Two noninvasive methods, thermography and laser Doppler imaging (LDI), were assessed for their ability to quantitatively assess parameters of vascularity in lesions of HIV-associated Kaposi's sarcoma (KS). Thermography and LDI images of a representative KS lesion were recorded in 16 patients and compared to normal ski...

    journal_title:Technology in cancer research & treatment

    pub_type: 杂志文章

    doi:10.1177/153303460400300506

    authors: Hassan M,Little RF,Vogel A,Aleman K,Wyvill K,Yarchoan R,Gandjbakhche AH

    更新日期:2004-10-01 00:00:00

  • Histopathologic effects of hypofractionated robotic radiation therapy on malignant and benign prostate tissue.

    abstract::We describe the first histopathologic analysis of prostatic tissue following hypofractionated robotic radiation therapy. A 66 year-old man presented with stage II, low risk adenocarcinoma of the prostate and underwent elective conformal hypofractionated radiation therapy. His pretreatment evaluation revealed T1c adeno...

    journal_title:Technology in cancer research & treatment

    pub_type: 杂志文章

    doi:10.1177/153303461000900606

    authors: Suy S,Oermann E,Hanscom H,Lei S,Vahdat S,Yu X,Park HU,Chen V,Collins BT,McGeagh K,Dawson N,Jha R,Azumi N,Dritschilo A,Lynch J,Collins SP

    更新日期:2010-12-01 00:00:00

  • Robotic Stereotactic Body Radiation Therapy in Patients With Recurrent or Metastatic Abdominopelvic Tumors: A Single Institute Experience.

    abstract:BACKGROUND:The aim of this study was to evaluate the efficacy and toxicity of robotic CyberKnife (Accuray Incorporated, Sunnyvale, California)-based stereotactic body radiation therapy (SBRT) in patients with recurrent or metastatic abdominopelvic tumors. METHODS AND MATERIALS:A total of 69 patients treated between Ma...

    journal_title:Technology in cancer research & treatment

    pub_type: 杂志文章

    doi:10.1177/1533034615571353

    authors: Sezen D,Gurkaynak M,Gultekin M,Cengiz M,Yildiz F,Zorlu F,Akyol F,Yazici G,Hurmuz P,Ozyigit G

    更新日期:2016-02-01 00:00:00

  • MicroRNA-494-3p Promotes Cell Growth, Migration, and Invasion of Nasopharyngeal Carcinoma by Targeting Sox7.

    abstract:BACKGROUND:There is mounting evidence that microRNAs play an important role in nasopharyngeal carcinoma, which is widely prevalent in South China and is the most prevalent metastatic cancer among head and neck cancers. Recently, it has been shown that miR-494 is involved in the progression and prognosis of nasopharynge...

    journal_title:Technology in cancer research & treatment

    pub_type: 杂志文章

    doi:10.1177/1533033818809993

    authors: He H,Liao X,Yang Q,Liu Y,Peng Y,Zhong H,Yang J,Zhang H,Yu Z,Zuo Y,Guan C,Xu Z

    更新日期:2018-01-01 00:00:00

  • DAB2IP Plays Important Clinical Significance and Correlates With Immune Infiltration in Renal Cell Carcinoma.

    abstract:BACKGROUND:Disabled homolog 2-interacting protein is a new member of the Ras GTPase superfamily involved in the regulation of cell proliferation, apoptosis, and metastasis. However, the expression of disabled homolog 2-interacting protein in renal cell carcinoma, its correlation with cancer prognosis, and tumor infiltr...

    journal_title:Technology in cancer research & treatment

    pub_type: 杂志文章

    doi:10.1177/1533033820936682

    authors: Cao H,Zhang J,Wang W

    更新日期:2020-01-01 00:00:00

  • Interleukin-8 Promotes Epithelial-to-Mesenchymal Transition via Downregulation of Mir-200 Family in Breast Cancer Cells.

    abstract::The microRNA-200 (miR-200) family has been reported to be vital for the inhibition of epithelial-to-mesenchymal transition (EMT) in tumor cells. The miR-200 family represents a complex multi-factorial regulatory network which has not been well described in breast cancer. This study aimed to clarify the underlying regu...

    journal_title:Technology in cancer research & treatment

    pub_type: 杂志文章

    doi:10.1177/1533033820979672

    authors: Zhang J,Shao N,Yang X,Xie C,Shi Y,Lin Y

    更新日期:2020-01-01 00:00:00

  • Brain metastases from gynecological cancers: factors that affect overall survival.

    abstract::We retrospectively reviewed factors that affected overall survival for patients with gynecological cancers that had metastasized to the brain. Between January 1985 to November 1999, we treated 25 patients with brain metastases from gynecological malignancies (cervix n=6, endometrium n=10, and ovary n=9). Various patie...

    journal_title:Technology in cancer research & treatment

    pub_type: 杂志文章

    doi:10.1177/153303460200100412

    authors: Mahmoud-Ahmed AS,Kupelian PA,Reddy CA,Suh JH

    更新日期:2002-08-01 00:00:00

  • Recombinant Newcastle Disease virus Expressing IL15 Demonstrates Promising Antitumor Efficiency in Melanoma Model.

    abstract::Recombinant Newcastle Disease Virus (rNDV) has shown oncolytic therapeutic effect in preclinical studies. Previous data indicate that rNDV carrying IL2 has shown promise in cancer therapy. Due to the significant side effects of IL2, IL15 has been introduced into cancer therapy. A number of studies have suggested that ...

    journal_title:Technology in cancer research & treatment

    pub_type: 杂志文章

    doi:10.7785/tcrt.2012.500414

    authors: Niu Z,Bai F,Sun T,Tian H,Yu D,Yin J,Li S,Li T,Cao H,Yu Q,Wu Y,Ren G,Li D

    更新日期:2015-10-01 00:00:00

  • On correlated sources of uncertainty in four dimensional computed tomography data sets.

    abstract::The purpose of this work is to estimate the degree of uncertainty inherent to a given four dimensional computed tomography (4D-CT) imaging modality and to test for interaction of the investigated factors (i.e., object displacement, velocity, and the period of motion) when determining the object motion coordinates, mot...

    journal_title:Technology in cancer research & treatment

    pub_type: 杂志文章

    doi:10.1177/153303461000900309

    authors: Ehler E,Tome W

    更新日期:2010-06-01 00:00:00

  • Linear Accelerator-Based Radiotherapy Simulation Using On-Board Kilovoltage Cone-Beam Computed Tomography for 3-Dimensional Volumetric Planning and Rapid Treatment in the Palliative Setting.

    abstract:BACKGROUND:Palliation of advanced disease using radiotherapy can create difficult clinical situations where standard computed tomography simulation and immobilization techniques are not feasible. We developed a linear accelerator-based radiotherapy simulation technique using nonstandard patient positioning for head and...

    journal_title:Technology in cancer research & treatment

    pub_type: 杂志文章

    doi:10.1177/1533033819865623

    authors: Dyer BA,Nair CK,Deardorff CE,Wright CL,Perks JR,Rao SS

    更新日期:2019-01-01 00:00:00

  • Identical Quality Assurance for Volumetric Modulated Arc Therapy in Elekta and Varian Machines.

    abstract::Volumetric modulated arc therapy (VMAT) has been adopted by many clinics for its higher delivery efficiency compared to conventional intensity modulated radiotherapy techniques. Currently, the quality assurance (QA) has remained a challenge in that no identical tests are available for accelerators from different vendo...

    journal_title:Technology in cancer research & treatment

    pub_type: 杂志文章

    doi:10.1177/1533034614500419

    authors: Wang J,Hu W,Peng J,Lu S,Zhao J,Xiao Y,Zhang Z

    更新日期:2015-08-01 00:00:00

  • Fascin Overexpression Promotes Cholangiocarcinoma RBE Cell Proliferation, Migration, and Invasion.

    abstract::Fascin is overexpressed in various tumor tissues and is closely related to tumor metastasis and invasion. However, the role of fascin in cholangiocarcinoma RBE cells has not been clearly reported. This study aimed to establish a cholangiocarcinoma cell line with stable and high expression of fascin to observe the effe...

    journal_title:Technology in cancer research & treatment

    pub_type: 杂志文章

    doi:10.1177/1533034615580696

    authors: Zhao H,Yang F,Zhao W,Zhang C,Liu J

    更新日期:2016-04-01 00:00:00

  • Key Genes and Prognostic Analysis in HER2+ Breast Cancer.

    abstract::Human epidermal growth factor 2 (HER2)+ breast cancer is considered the most dangerous type of breast cancers. Herein, we used bioinformatics methods to identify potential key genes in HER2+ breast cancer to enable its diagnosis, treatment, and prognosis prediction. Datasets of HER2+ breast cancer and normal tissue sa...

    journal_title:Technology in cancer research & treatment

    pub_type: 杂志文章

    doi:10.1177/1533033820983298

    authors: Weng Y,Liang W,Ji Y,Li Z,Jia R,Liang Y,Ning P,Xu Y

    更新日期:2021-01-01 00:00:00

  • Adenovirus-mediated ING4 Gene Transfer in Osteosarcoma Suppresses Tumor Growth via Induction of Apoptosis and Inhibition of Tumor Angiogenesis.

    abstract::The inhibitor of growth (ING) family proteins have been defined as candidate tumor suppressors. ING4 as a novel member of ING family has potential tumor-suppressive effects via multiple pathways. However, the therapeutic effect of adenovirus-mediated ING4 (Ad-ING4) gene transfer in human osteosarcoma is still unknown....

    journal_title:Technology in cancer research & treatment

    pub_type: 杂志文章

    doi:10.7785/tcrt.2012.500424

    authors: Xu M,Xie Y,Sheng W,Miao J,Yang J

    更新日期:2015-10-01 00:00:00

  • LncRNA-SRA1 Suppresses Osteosarcoma Cell Proliferation While Promoting Cell Apoptosis.

    abstract:OBJECTIVE:Osteosarcoma is a common malignant bone tumor that is frequently found in the long bones of children and adolescents. The aim of this study is to examine long noncoding RNA-steroid receptor RNA activator 1 expression in osteosarcoma to explore the biological function of long noncoding RNA steroid receptor RNA...

    journal_title:Technology in cancer research & treatment

    pub_type: 杂志文章

    doi:10.1177/1533033819841438

    authors: Guo W,Jiang H,Li H,Li F,Yu Q,Liu Y,Jiang W,Zhang M

    更新日期:2019-01-01 00:00:00

  • Helical tomotherapy for brain metastases: dosimetric evaluation of treatment plans and early clinical results.

    abstract::The purpose of this study was to evaluate the feasibility and treatment plans of intensity-modulated radiation therapy using helical tomotherapy (HT) for brain metastases. Twenty-three patients with 1 to 4 brain metastases were treated with HT. In combination with whole-brain radiotherapy (simultaneous plans), metasta...

    journal_title:Technology in cancer research & treatment

    pub_type: 杂志文章

    doi:10.1177/153303460800700602

    authors: Tomita N,Kodaira T,Tachibana H,Nakamura T,Nakahara R,Inokuchi H,Shibamoto Y

    更新日期:2008-12-01 00:00:00

  • Delineation of the cardiac substructures based on PET-CT and contrast-enhanced CT in patients with left breast cancer treated with postoperative radiotherapy.

    abstract::The aim of this study is to evaluate the volume differences between contrast-enhanced CT-based left ventricle (LV) and PET-CT-based LV and assess the impact of dose on the substructure volume differences in patients with left breast cancer treated with adjuvant radiotherapy. From October 2008 to February 2009, 14 pati...

    journal_title:Technology in cancer research & treatment

    pub_type: 杂志文章

    doi:10.7785/tcrt.2012.500299

    authors: Yu XL,Zhang Q,Chen JY,Zhang Z,Wang JZ,Hu WG,Pan ZQ,Hu SL,Zhang YJ,Feng Y,Shao ZM,Orecchia R,Guo XM

    更新日期:2013-04-01 00:00:00

  • Novel advances in drug delivery to brain cancer.

    abstract::The therapy of brain tumors has been limited by a lack of effective methods of drug delivery to the brain. Systemic administration is often associated with toxic side effects and ultimately fails to achieve therapeutic concentrations within a tumor. An attractive strategy that has gained importance in brain tumor ther...

    journal_title:Technology in cancer research & treatment

    pub_type: 杂志文章,评审

    doi:10.1177/153303460500400409

    authors: Lesniak MS

    更新日期:2005-08-01 00:00:00

  • Perineural invasion of squamous cell carcinoma of the lip with occult involvement of the infra-orbital nerve detected by PET-CT and treated with MRI-based IMRT: a case report.

    abstract::A 51 year old male with a history of right facial numbness developed progressive upper lip swelling for one year, but an MRI of the head was unremarkable. A wide local excision of the upper lip was performed and pathology revealed a 1.7 cm mass, poorly differentiated squamous cell carcinoma with perineural invasion. S...

    journal_title:Technology in cancer research & treatment

    pub_type: 杂志文章

    doi:10.1177/153303460500400304

    authors: Bhatnagar AK,Heron DE,Schaitkin B

    更新日期:2005-06-01 00:00:00

  • Anti-HER3 Monoclonal Antibody Inhibits Acquired Trastuzumab-Resistant Gynecologic Cancers.

    abstract:BACKGROUND:Antibody resistance, both de novo and acquired, is usually related to high risk of recurrence and lower survival rate in gynecologic cancers. Prevention or reversal of the resistance often yields beneficial clinical results. It was reported that anti-human epidermal growth factor receptor 3 monoclonal antibo...

    journal_title:Technology in cancer research & treatment

    pub_type: 杂志文章

    doi:10.1177/1533034615588422

    authors: Li X,Duan Y,Qiao C,Zhou T,Yu M,Geng J,Feng J,Shen B,Lv M,Li Y

    更新日期:2016-08-01 00:00:00

  • A two-step optimization method for improving multiple brain lesion treatments with robotic radiosurgery.

    abstract::Planning robotic radiosurgery treatments for multiple (n > 3) metastatic brain lesions is challenging due to the need of satisfying a large number of dose-volume constraints and the requirement of prescribing different dose levels to individual targets. In this study, we developed a sequential two-step optimization te...

    journal_title:Technology in cancer research & treatment

    pub_type: 杂志文章

    doi:10.7785/tcrt.2012.500210

    authors: Ma L,Sahgal A,Hwang A,Hu W,Descovich M,Chuang C,Barani I,Sneed PK,McDermott M,Larson DA

    更新日期:2011-08-01 00:00:00

  • PET-CT: evolving role in 3-D radiation therapy.

    abstract::Traditional imaging techniques, such as computed tomography (CT), have high spatial resolution for changes in the anatomy or structure of organs, but are not very useful for detecting early biochemical changes. Conversely, positron emission tomography (PET) relies on changes in molecular biology to identify the earlie...

    journal_title:Technology in cancer research & treatment

    pub_type: 杂志文章,评审

    doi:10.1177/153303460600500204

    authors: Levy RP

    更新日期:2006-04-01 00:00:00

  • Cryosurgery for lung cancer: clinical results and technical aspects.

    abstract::Lung carcinoma is the most frequently diagnosed malignancy in the world, with the incidence increasing through the 20th century. Presentation may be as a tumor mass primarily obstructing the central bronchial lumen, or a mass infiltrating lung tissue. Cryosurgery can be used as a method of palliative treatment for bot...

    journal_title:Technology in cancer research & treatment

    pub_type: 杂志文章

    doi:10.1177/153303460400300207

    authors: Maiwand MO,Asimakopoulos G

    更新日期:2004-04-01 00:00:00

  • Diagnostic Value of Contrast-Enhanced Ultrasonography With SonoVue in the Differentiation of Benign and Malignant Breast Lesions: A Meta-Analysis.

    abstract:PURPOSE:A meta-analysis was conducted to evaluate the diagnostic performance of contrast-enhanced ultrasonography using the contrast agent SonoVue to differentiate benign from malignant breast lesions. METHOD:A comprehensive search of the literature was performed using the Embase, PubMed, and Web of Science databases ...

    journal_title:Technology in cancer research & treatment

    pub_type: 杂志文章

    doi:10.1177/1533033820971583

    authors: Lu J,Zhou P,Jin C,Xu L,Zhu X,Lian Q,Gong X

    更新日期:2020-01-01 00:00:00

  • Photodynamic therapy for the treatment of skin disease.

    abstract::The efficacy of photodynamic therapy for the treatment of a large number of skin diseases, in particular non-malignant skin cancer, has been reported by a number of studies. It has been demonstrated to be particularly beneficial for large or multiple lesions, especially where good cosmesis is required. However for PDT...

    journal_title:Technology in cancer research & treatment

    pub_type: 杂志文章,评审

    doi:10.1177/153303460300200402

    authors: Kendall CA,Morton CA

    更新日期:2003-08-01 00:00:00

  • Current status of salvage cryoablation for prostate cancer following radiation failure.

    abstract::The role of salvage cryoablation of the prostate for patients with clinically localized prostate cancer that have failed radiotherapy to the prostate is reviewed with reference to alternatives including salvage radical prostatectomy and brachytherapy. The diagnosis and work-up of local recurrence/persistence of cancer...

    journal_title:Technology in cancer research & treatment

    pub_type: 杂志文章,评审

    doi:10.1177/153303460500400210

    authors: Chin JL,Touma N

    更新日期:2005-04-01 00:00:00