Abstract:
:Two noninvasive methods, thermography and laser Doppler imaging (LDI), were assessed for their ability to quantitatively assess parameters of vascularity in lesions of HIV-associated Kaposi's sarcoma (KS). Thermography and LDI images of a representative KS lesion were recorded in 16 patients and compared to normal skin either adjacent to the lesion or on the contralateral side. Eleven of the 16 patients had greater than 0.5 degrees C increased temperature and 12 of the 16 patients had increased flux (measured by LDI) as compared to normal skin. There was a strong correlation between these two parameters (R = 0.81, p < 0.001). In ten patients, measurements were obtained prior to therapy and after receiving a regimen of liposomal doxorubicin and interleukin-12. After 18 weeks of therapy, temperature and blood flow of the lesions were significantly reduced from the baseline (p = 0.004 and 0.002 respectively). These techniques hold promise to assess physiologic parameters in KS lesions and their changes with therapy.
journal_name
Technol Cancer Res Treatjournal_title
Technology in cancer research & treatmentauthors
Hassan M,Little RF,Vogel A,Aleman K,Wyvill K,Yarchoan R,Gandjbakhche AHdoi
10.1177/153303460400300506keywords:
subject
Has Abstractpub_date
2004-10-01 00:00:00pages
451-7issue
5eissn
1533-0346issn
1533-0338pii
d=3018&c=4161&p=12479&do=detailjournal_volume
3pub_type
杂志文章abstract::The use of electric pulses to transfect cells has recently been extended to show the utility of this procedure in vivo. Electrotransfer has been performed in vivo on several tissue types including skin, blood vessels, liver, tumor, muscle, cornea, brain and spleen. The most widely targeted tissue has been skeletal mus...
journal_title:Technology in cancer research & treatment
pub_type: 杂志文章,评审
doi:10.1177/153303460200100505
更新日期:2002-10-01 00:00:00
abstract::Tumstatin (Tum) is a powerful angiostatin that inhibits proliferation and induces apoptosis of tumorous vascular endothelial cells. A nonpathogenic and anaerobic bacterium, Bifidobacterium longum (BL), selectively localizes to and proliferates in the hypoxia location within solid tumor. The aims of this study were to ...
journal_title:Technology in cancer research & treatment
pub_type: 杂志文章
doi:10.1177/1533034615581977
更新日期:2016-06-01 00:00:00
abstract::A 51 year old male with a history of right facial numbness developed progressive upper lip swelling for one year, but an MRI of the head was unremarkable. A wide local excision of the upper lip was performed and pathology revealed a 1.7 cm mass, poorly differentiated squamous cell carcinoma with perineural invasion. S...
journal_title:Technology in cancer research & treatment
pub_type: 杂志文章
doi:10.1177/153303460500400304
更新日期:2005-06-01 00:00:00
abstract:BACKGROUND:Circulating tumor cells (CTCs) hold huge potential for both clinical applications and basic research into the management of cancer, but the relationship between CTC count and cervical cancer prognosis remains unclear. Therefore, research on this topic is urgently required. OBJECTIVE:This study investigated ...
journal_title:Technology in cancer research & treatment
pub_type: 杂志文章
doi:10.1177/1533033820957005
更新日期:2020-01-01 00:00:00
abstract::The treatment of patients with malignant brain tumors, in particular glioblastoma multiforme (GBM) is very challenging because of their diffuse infiltrative nature and the cytological heterogeneity. The median survival of patients with newly diagnosed GBM is only 12-15 months, and only 8-12% of them survive for two ye...
journal_title:Technology in cancer research & treatment
pub_type: 杂志文章,评审
doi:10.1177/153303460600500307
更新日期:2006-06-01 00:00:00
abstract::Malignant pleural mesothelioma (MPM) is a rare and aggressive tumor with generally disappointing results in terms of survival, however, there are occasional long-term survivors probably due to the biologic characteristics of the disease. Standard uptake value (SUV) of [(18)F] Fluorodeoxyglucose (FDG) evaluated by phot...
journal_title:Technology in cancer research & treatment
pub_type: 杂志文章
doi:10.7785/tcrt.2012.500245
更新日期:2012-04-01 00:00:00
abstract::We attempted to characterize the cellular autofluorescence phenomenon of living HL-60 cells and to appraise its modifications under oxidative stress conditions induced by 1 alpha,25(OH)(2)D(3) (VD(3)) and its analog EB1089. Autofluorescence emission spectra of human promyelocytic HL-60 leukemic cells were monitored us...
journal_title:Technology in cancer research & treatment
pub_type: 杂志文章
doi:10.1177/153303460400300409
更新日期:2004-08-01 00:00:00
abstract::Many conventional chemotherapeutic drugs, as well as DNA for cancer gene therapy, require efficient access to the cell interior to be effective. The cell membrane is a formidable barrier to many of these drugs, including therapeutic DNA constructs. Electropermeabilization (EP, often used synonymously with "electropora...
journal_title:Technology in cancer research & treatment
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1177/153303460200100110
更新日期:2002-02-01 00:00:00
abstract:INTRODUCTION:Osteosarcoma is the most common primary tumor of bone, although some molecular markers have been identified, the detailed molecular mechanisms underlying osteosarcoma are currently not fully understood. In the present study, we attempted to identify the potential key genes and pathways in osteosarcoma usin...
journal_title:Technology in cancer research & treatment
pub_type: 杂志文章
doi:10.1177/1533033820965605
更新日期:2020-01-01 00:00:00
abstract::Intraoperative magnetic resonance imaging has been applied to a number of neurosurgical disease processes since the late 1990's. The ability to visualize the operative site in near-real time has added a significant degree of safety to the treatment of lesions such as a cystic craniopharyngioma which can be located in ...
journal_title:Technology in cancer research & treatment
pub_type: 杂志文章
doi:10.1177/153303460300200103
更新日期:2003-02-01 00:00:00
abstract::Since "Warburg effect" has been firstly uncovered in cancer cells in 1956, mounting evidence has supported the molecular mechanism underlying the energy metabolism in induced chemoresistance in cancers. MicroRNAs can mediate fine-tuning of genes in physiological process. MicroRNAs' energy metabolic role in chemoresist...
journal_title:Technology in cancer research & treatment
pub_type: 杂志文章,评审
doi:10.1177/1533033818805997
更新日期:2018-01-01 00:00:00
abstract::The aim of this study is to evaluate the volume differences between contrast-enhanced CT-based left ventricle (LV) and PET-CT-based LV and assess the impact of dose on the substructure volume differences in patients with left breast cancer treated with adjuvant radiotherapy. From October 2008 to February 2009, 14 pati...
journal_title:Technology in cancer research & treatment
pub_type: 杂志文章
doi:10.7785/tcrt.2012.500299
更新日期:2013-04-01 00:00:00
abstract::This study quantifies the setup uncertainties to optimize the planning target volume (PTV) margin based on daily image guidance, its dosimetric impact, and radiobiological implication for intensity-modulated radiation therapy (IMRT) in head and neck cancer. Ten patients were retrospectively chosen who had been treated...
journal_title:Technology in cancer research & treatment
pub_type: 杂志文章
doi:10.1177/1533034614561162
更新日期:2016-02-01 00:00:00
abstract::The aim of this study was to evaluate the relationship of prognosis of patients with multiple myeloma having extramedullary involvement (EMM) with the 18F- fluorodeoxyglucose(18F-FDG) maximum standardized uptake value and the expression of Ki-67 in biopsy samples. Sixty-five patients were newly diagnosed with multiple...
journal_title:Technology in cancer research & treatment
pub_type: 杂志文章
doi:10.1177/1533033819849067
更新日期:2019-01-01 00:00:00
abstract:PURPOSE:We investigated the dosimetric effect of intrafraction tumor motion in lung stereotactic body radiotherapy using the CyberKnife static tracking system. METHODS:Four-dimensional computed tomography scans of a dynamic thorax phantom were acquired. Two motion ranges, 3 collimator sizes, and 4 treatment starting p...
journal_title:Technology in cancer research & treatment
pub_type: 杂志文章
doi:10.1177/1533033819859448
更新日期:2019-01-01 00:00:00
abstract::We investigated the technique, early results and toxicity of curative stereotactic radiotherapy with the CyberKnife (Accuray Incorporated, Sunnyvale, California, USA) in 15 extracranial, extrapulmonary, extrahepatic, and extraspinal tumors. Fourteen tumors were located close to the bowel or esophagus. The PTV = GTV + ...
journal_title:Technology in cancer research & treatment
pub_type: 杂志文章
doi:10.1177/153303460700600603
更新日期:2007-12-01 00:00:00
abstract:PURPOSE:The study was aimed to compare online 6 degree-of-freedom image registrations of TrueBeam cone-beam computed tomography and BrainLab ExacTrac X-ray imaging systems for intracranial radiosurgery. METHODS:Phantom and patient studies were performed on a Varian TrueBeam STx linear accelerator (version 2.5), which ...
journal_title:Technology in cancer research & treatment
pub_type: 杂志文章
doi:10.1177/1533034616683069
更新日期:2017-06-01 00:00:00
abstract:PURPOSE:To evaluate 2 simultaneous integrated boost treatment planning techniques using helical tomotherapy for breast conserving therapy with regard to acute skin toxicity and dosimetry. METHODS:Thirty-two patients were studied. The original approach was for 16 patients and incorporated a directional block of the ips...
journal_title:Technology in cancer research & treatment
pub_type: 杂志文章
doi:10.1177/1533034615574387
更新日期:2016-04-01 00:00:00
abstract::Hepatocellular carcinoma (HCC) is the most aggressive type of gastrointestinal tumor, with a high rate of mortality. However, identifying biomarkers for the treatment of HCC remains to be developed. We aimed to determine whether cell division cycle 25C (CDC25C) could be used as a novel diagnostic and therapeutic bioma...
journal_title:Technology in cancer research & treatment
pub_type: 杂志文章
doi:10.1177/1533033820967474
更新日期:2020-01-01 00:00:00
abstract:OBJECTIVE:To investigate the application value of apparent diffusion coefficient value in the pathological type, histologic grade, and presence of lymph node metastases of esophageal carcinoma. MATERIALS AND METHODS:Eighty-six patients with pathologically confirmed esophageal carcinoma were divided into different grou...
journal_title:Technology in cancer research & treatment
pub_type: 杂志文章
doi:10.1177/1533033819892254
更新日期:2019-01-01 00:00:00
abstract::Endoscopic endonasal surgery (EES) has been shown to be a feasible approach to cranial base tumors while reducing post-operative morbidity. Using the endoscopic endonasal approach alone or in combination with open approaches may provide advantages over conventional approaches. However, the balance between maximal rese...
journal_title:Technology in cancer research & treatment
pub_type: 杂志文章
doi:10.1177/153303461000900507
更新日期:2010-10-01 00:00:00
abstract::MicroRNAs are reported as a vital important factor in cancer cell initiation and progression processes. MicroRNA-19-3p has drawn the attention of many researchers in recent years because of its wide expression and its key role in serious kinds of tumor cells. However, the detailed mechanism of microRNA-19a-3p in these...
journal_title:Technology in cancer research & treatment
pub_type: 杂志文章
doi:10.1177/1533033820917978
更新日期:2020-01-01 00:00:00
abstract::Our study was designed to investigate the role of B4GalT1 in glioblastoma, in vitro and in vivo, to detect whether B4GalT1 knockdown could regulate the development of glioblastoma, and further observe the relationship between B4GalT1 knockdown and the apoptosis and autophagy of glioblastoma. To begin, we looked at TCG...
journal_title:Technology in cancer research & treatment
pub_type: 杂志文章
doi:10.1177/1533033820980104
更新日期:2020-01-01 00:00:00
abstract::Although an MRI scanner is a single stand-alone modality, different acquisition techniques may be applied to collect structural and functional information, including vascular or angiogenic properties measured by dynamic contrast enhanced MRI (DCE-MRI) and Choline (Cho) metabolism measured by proton MR spectroscopy ima...
journal_title:Technology in cancer research & treatment
pub_type: 杂志文章
doi:
更新日期:2006-08-01 00:00:00
abstract:BACKGROUND:Gene expression profiles from early-onset breast cancer and normal tissues were analyzed to explore the genes and prognostic factors associated with breast cancer. METHODS:GSE109169 and GSE89116 were obtained from the database of Gene Expression Omnibus. We firstly screened the differentially expressed gene...
journal_title:Technology in cancer research & treatment
pub_type: 杂志文章
doi:10.1177/1533033819893670
更新日期:2020-01-01 00:00:00
abstract::The purpose of this research is to establish a process of irradiating mice using the Gamma Knife as a versatile system for small animal irradiation and to validate accurate intracranial and extracranial dose delivery using this system. A stereotactic immobilization device was developed for small animals for the Gamma ...
journal_title:Technology in cancer research & treatment
pub_type: 杂志文章
doi:10.1177/1533034616658394
更新日期:2017-04-01 00:00:00
abstract:OBJECTIVE:We aimed to identify the expression of Sal-like 4 (SALL4) in breast cancer tissues and to explore the role of this gene in the carcinogenesis of breast cancer cells. METHODS:A total of 62 paired breast cancer and noncancerous tissue samples were obtained from patients with breast cancer. SALL4 expression pat...
journal_title:Technology in cancer research & treatment
pub_type: 杂志文章
doi:10.1177/1533033820980074
更新日期:2020-01-01 00:00:00
abstract:PURPOSE:To investigate the role of intensity-modulated proton therapy (IMPT) for hepatocellular carcinoma (HCC) patients to be treated with stereotactic body radiation therapy (SBRT) in a risk-adapted dose prescription regimen. METHODS:A cohort of 30 patients was retrospectively selected as "at-risk" of dose de-escala...
journal_title:Technology in cancer research & treatment
pub_type: 杂志文章
doi:10.1177/1533033820980412
更新日期:2020-01-01 00:00:00
abstract:OBJECTIVE:The incidence of colorectal cancer is increasing every year, and autophagy may be related closely to the pathogenesis of colorectal cancer. Autophagy is a natural catabolic mechanism that allows the degradation of cellular components in eukaryotic cells. However, autophagy plays a dual role in tumorigenesis. ...
journal_title:Technology in cancer research & treatment
pub_type: 杂志文章
doi:10.1177/1533033820984177
更新日期:2020-01-01 00:00:00
abstract::Mesenchymal stromal cells are proven to be likely induce the angiogenic response in multiple myeloma and thus represent an enticing target for antiangiogenesis therapies for multiple myeloma. Substantial evidence indicates that angiogenesis in multiple myeloma is complex and involves direct production of angiogenic cy...
journal_title:Technology in cancer research & treatment
pub_type: 杂志文章
doi:10.1177/1533033818764473
更新日期:2018-01-01 00:00:00